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1. 发明申请

WO2005047301A1 IMPROVEMENTS IN OR RELATING TO POLYNUCLEOTIDE ARRAYS 审中-公开
标题翻译：对多核苷酸序列的改善或相关
公开(公告)号：WO2005047301A1
公开(公告)日：2005-05-26
申请号：PCT/GB2004/004707
申请日：2004-11-08
申请人： SOLEXA LIMITED , ELLIS, Darren, James , BARNES, Colin, Lloyd , SWERDLOW, Harold, Philip , BROWN, Tom
发明人： ELLIS, Darren, James , BARNES, Colin, Lloyd , SWERDLOW, Harold, Philip , BROWN, Tom
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , C12Q1/6837 , C12Q2525/301 , C12Q2525/113
摘要： The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.
摘要翻译：本发明提供了具有环和茎区的发夹多核苷酸，其特征在于通过连接体将硫基亲核试剂连接到发夹中的内部核苷酸以使得能够结合固体支持物。

2. 发明申请

WO03048387A3 LABELLED NUCLEOTIDES 审中-公开
标题翻译：标签核心
公开(公告)号：WO03048387A3
公开(公告)日：2003-10-16
申请号：PCT/GB0205474
申请日：2002-12-04
申请人： SOLEXA LTD , BALASUBRAMANIAN SHANKAR , BARNES COLIN , LIU XIAOHAI , SWERDLOW HAROLD
发明人： BALASUBRAMANIAN SHANKAR , BARNES COLIN , LIU XIAOHAI , SWERDLOW HAROLD
IPC分类号： G01N33/53 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N15/09 , G01N33/533 , G01N33/566 , C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。

3. 发明申请

WO2004076692A1 DNA SEQUENCE ANALYSIS 审中-公开
标题翻译： DNA序列分析
公开(公告)号：WO2004076692A1
公开(公告)日：2004-09-10
申请号：PCT/GB2004/000770
申请日：2004-02-26
申请人： SOLEXA LIMITED , SWERDLOW, Harold, Philip , BARNES, Colin , TODD, John, Andrew , DURBIN, Richard, Michael
发明人： SWERDLOW, Harold, Philip , BARNES, Colin , TODD, John, Andrew , DURBIN, Richard, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2525/301 , C12Q2561/125
摘要： There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a. contacting a sample genome, under conditions which permit template dependant oligonucleotide ligation, with a plurality of different oligonucleotide molecules which comprise (i) a first set of oligonucleotides each comprising a sequence of nucleotides that is complementary to a region on said genome that includes a known SNP site and which oligonucleotides are complementary to said region other than at a base at or near the 5' end of said oligonucleotides that is to be tested for complementarity to a base at the SNP site, each of said oligonucleotides comprising a unique label to identify both the base to be tested and the position of the SNP to be scored, (ii) a second set of oligonucleotides each comprising a sequence of nucleotides complementary to a region on said target genome for hybridisation with said target genome adjacent the 5' end of an oligonucleotide of said first oligonucleotide set, and a surface capture moiety, a phosphate moiety being located at any of either the 5' end of said first set of oligonucleotides or the 3' end of said second set of oligonucleotides, any resulting ligated oligonucleotide being immobilised on a solid support via the surface capture moiety, b. analysing said solid support for the identity of one or more of said unique labels and comparing the defined bases in any of said immobilised oligonucleotides to those of the reference one or more SNPs.
摘要翻译：公开了一种确定基因组中一个或多个突变或单核苷酸多态性（SNP）的身份的方法，其包括：a。在允许模板依赖性寡核苷酸连接的条件下使样品基因组与多个不同的寡核苷酸分子接触，所述寡核苷酸分子包含（i）第一组寡核苷酸，每一寡核苷酸包含与所述基因组上的区域互补的核苷酸序列，其包括已知的 SNP位点，哪些寡核苷酸与所述区域互补，而不是在待测试的寡核苷酸的5'端或附近的碱基处，与SNP位点的碱基互补，所述寡核苷酸中的每一个包含唯一的标记以鉴定要测试的碱基和待评估的SNP的位置，（ii）第二组寡核苷酸，每个寡核苷酸包含与所述靶基因组上的区域互补的核苷酸序列，用于与邻近5'末端的所述靶基因组杂交所述第一寡核苷酸组的寡核苷酸和表面捕获部分，磷酸酯部分位于5'末端的任一个所述第一组寡核苷酸或所述第二组寡核苷酸的3'端的任何所得连接的寡核苷酸经由表面捕获部分固定在固体支持物上，b。分析所述固体支持物中的一种或多种所述独特标记的身份，并将任何所述固定的寡核苷酸中的所定义的碱基与所述参考的一个或多个SNP的那些进行比较。

4. 发明申请

WO2007123744A3 SYSTEMS AND DEVICES FOR SEQUENCE BY SYNTHESIS ANALYSIS 审中-公开
公开(公告)号：WO2007123744A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/007991
申请日：2007-03-30
申请人： SOLEXA, INC. , BANERJEE, Saibal , BARNES, Colin , BENSON, Kevin , BRIDGHAM, John , BRYANT, Jason , BUERMANN, Dale , ETCHIN, Sergey , HO, Jonny , LEE, Xavier , LUNDBERG, Peter , MAISINGER, Klaus , OBRADOVIC, Bojan , PRATT, Mark , RASOLONJATOVO, Isabelle , REED, Mark , RODIGHIERO, Chiara , SANKAR, Subra , SCHROTH, Gary , SIZTO, Ning , SWERDLOW, Harold , VERMAAS, Eric
发明人： BANERJEE, Saibal , BARNES, Colin , BENSON, Kevin , BRIDGHAM, John , BRYANT, Jason , BUERMANN, Dale , ETCHIN, Sergey , HO, Jonny , LEE, Xavier , LUNDBERG, Peter , MAISINGER, Klaus , OBRADOVIC, Bojan , PRATT, Mark , RASOLONJATOVO, Isabelle , REED, Mark , RODIGHIERO, Chiara , SANKAR, Subra , SCHROTH, Gary , SIZTO, Ning , SWERDLOW, Harold , VERMAAS, Eric
IPC分类号： G06F19/00 , C12M1/00
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.

5. 发明申请

WO2007010263A2 METHODS FOR SEQUENCING A POLYNUCLEOTIDE TEMPLATE 审中-公开
标题翻译：用于测序多核苷酸模板的方法
公开(公告)号：WO2007010263A2
公开(公告)日：2007-01-25
申请号：PCT/GB2006/002709
申请日：2006-07-20
申请人： SOLEXA LIMITED , SWERDLOW, Harold, Philip
发明人： SWERDLOW, Harold, Philip
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6853 , C12Q2565/525 , C12Q2533/101 , C12Q2525/119 , C12Q2525/301 , C12Q2535/119 , C12Q2565/537
摘要： The invention relates to methods for pairwise sequencing of a polynucleotide template which result in the sequential determination of nucleotide sequence in two distinct and separate regions of the polynucleotide template.
摘要翻译：本发明涉及多核苷酸模板的成对测序方法，其导致多核苷酸模板的两个不同和分离的区域中的核苷酸序列的顺序测定。

6. 发明申请

WO2006111729A1 METHOD AND DEVICE FOR NUCLEIC ACID SEQUENCING USING A PLANAR WAVE GUIDE 审中-公开
标题翻译：使用平面波导指示核酸序列的方法和装置
公开(公告)号：WO2006111729A1
公开(公告)日：2006-10-26
申请号：PCT/GB2006/001405
申请日：2006-04-18
申请人： SOLEXA LIMITED , OBRADOVIC, Bojan , WEST, John, Stephen , SWERDLOW, Harold, Philip
发明人： OBRADOVIC, Bojan , WEST, John, Stephen , SWERDLOW, Harold, Philip
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6874 , C12Q2565/607 , C12Q2563/107
摘要： The present invention is concerned with improvements to methods of imaging nucleotides incorporated into polynucleotides and in particular with improved methods of determining the sequence of template nucleic acid molecules using multiple cycle nucleic acid "sequencing-by-synthesis" reactions.
摘要翻译：本发明涉及对掺入多核苷酸的核苷酸成像方法的改进，特别是使用多周期核酸“按合成测序”反应测定模板核酸分子的序列的改进方法。

7. 发明申请

WO02055997A3 SUBSTRATE FOR FLUORESCENCE ANALYSIS 审中-公开
标题翻译：荧光分析基础
公开(公告)号：WO02055997A3
公开(公告)日：2003-05-08
申请号：PCT/SE0102824
申请日：2001-12-19
申请人： KAROLINSKA INNOVATIONS AB , DE PRADIER BENOIT , SWERDLOW HAROLD , JESSON GERALD
发明人： DE PRADIER BENOIT , SWERDLOW HAROLD , JESSON GERALD
IPC分类号： B01L3/00 , G01N21/64
CPC分类号： G01N21/6452 , B01L3/5085 , Y10T428/31678
摘要： The present invention relates to an improved substrate for use in detection of fluorescence. More specifically the improved substrate exhibits a supported surface layer of silicon dioxide on a silicon support material, on another solid support material, or on a silicon layer supported on another solid support material. The inventive substrate allows for a significantly higher sensitivity to be obtained when used in fluorescence analysis. The invention also relates to a method of preparing the inventive substrate, which substrate in one embodiment of the invention takes the form of silicon a slide exhibiting an oxidised surface. The invention also relates to the application of the inventive substrate in microarray analysis.
摘要翻译：本发明涉及用于荧光检测的改进的底物。更具体地，改进的基板在硅载体材料上，在另一固体支撑材料上或在支撑在另一固体支撑材料上的硅层上表现出二氧化硅的支撑表面层。当用于荧光分析时，本发明的底物允许获得显着更高的灵敏度。本发明还涉及一种制备本发明基底的方法，该基底在本发明的一个实施方案中以硅的形式呈现呈现氧化表面的载片。本发明还涉及本发明基质在微阵列分析中的应用。

8. 发明申请

WO2005065814A1 MODIFIED MOLECULAR ARRAYS 审中-公开
标题翻译：改性分子阵列
公开(公告)号：WO2005065814A1
公开(公告)日：2005-07-21
申请号：PCT/GB2005/000033
申请日：2005-01-07
申请人： SOLEXA LIMITED , SMITH, Mark, Edward, Brennan , SABOT, Andrea , RASALONJATOVO, Isabelle, Marie, Julia , SOHNA SOHNA, Jean-Ernest , HORGAN, Adrian, Martin , SWERDLOW, Harold, Philip
发明人： SMITH, Mark, Edward, Brennan , SABOT, Andrea , RASALONJATOVO, Isabelle, Marie, Julia , SOHNA SOHNA, Jean-Ernest , HORGAN, Adrian, Martin , SWERDLOW, Harold, Philip
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00716 , B01J2219/0072 , B01J2219/00722 , C08F222/38 , C12Q1/6806 , C12Q1/6834 , C12Q1/6837 , C12Q1/6876 , C40B40/06 , C40B50/18 , Y10T428/265
摘要： The invention relates to the preparation of a hydrogel surface useful in the formation and manipulation of arrays of molecules, particularly polynucleotides and to the chemical modification of these and other arrays. In particular, the invention relates to a method of preparing a hydrogel immobilised to a solid support comprising polymerising on the support a mixture of a first comonomer which is acrylamide, methacrylamide, hydroxyethyl methacrylate or N-vinyl pyrrolidinone and a second comonomer which is a functionalised acrylamide or acrylate.
摘要翻译：本发明涉及可用于形成和操纵分子阵列，特别是多核苷酸以及这些和其它阵列的化学修饰的水凝胶表面的制备。特别地，本发明涉及一种制备固定在固体支持物上的水凝胶的方法，包括在载体上聚合第一共聚单体的混合物，第一共聚单体是丙烯酰胺，甲基丙烯酰胺，甲基丙烯酸羟乙酯或N-乙烯基吡咯烷酮，第二共聚单体是官能化的丙烯酰胺或丙烯酸酯。

9. 发明申请

WO2003060589A1 AUTO FOCUSSING DEVICE AND METHOD 审中-公开
标题翻译：自动聚焦装置和方法
公开(公告)号：WO2003060589A1
公开(公告)日：2003-07-24
申请号：PCT/GB2003/000151
申请日：2003-01-15
申请人： SOLEXA LTD. , OSBORNE, Mark , SWERDLOW, Harold
发明人： OSBORNE, Mark , SWERDLOW, Harold
IPC分类号： G02B21/24
CPC分类号： G02B21/244
摘要： There is disclosed an apparatus for detecting the distance of a surface from a lens, for example for use in a microscope autofocus arrangement. A light beam is directed into the lens, displaced sideways from the lens axis. The displacement of the reflected beam emerging from the lens is used to determine the required distance or to operate a focussing actuator.
摘要翻译：公开了一种用于检测表面与透镜的距离的装置，例如用于显微镜自动对焦装置。光束被引导到透镜中，从透镜轴线侧向偏移。使用从透镜出射的反射光束的位移来确定所需的距离或操作聚焦致动器。

10. 发明申请

WO2003048387A2 LABELLED NUCLEOTIDES 审中-公开
标题翻译：标记的核苷酸
公开(公告)号：WO2003048387A2
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005474
申请日：2002-12-04
申请人： SOLEXA LIMITED , BALASUBRAMANIAN, Shankar , BARNES, Colin , LIU, Xiaohai , SWERDLOW, Harold
发明人： BALASUBRAMANIAN, Shankar , BARNES, Colin , LIU, Xiaohai , SWERDLOW, Harold
IPC分类号： C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了核苷和核苷酸，其通过可切割的接头基团与可检测标记相连。

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