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1. 发明申请

WO2007127382A1 HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开
标题翻译：羟基取代的氨基酸，其组合物及其处理方法
公开(公告)号：WO2007127382A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/010258
申请日：2007-04-25
申请人： SIGNAL PHARMACEUTICALS, LLC , ALBERS, Ronald, J. , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, Mercedes , HILGRAF, Robert , HEGDE, Sayee, G. , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI, Moorthy, S.S. , SAHASRAMUDHE, Kiran , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marianne, K. , SUDBECK, Elise , WRIGHT, Jonathan
发明人： ALBERS, Ronald, J. , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, Mercedes , HILGRAF, Robert , HEGDE, Sayee, G. , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI, Moorthy, S.S. , SAHASRAMUDHE, Kiran , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marianne, K. , SUDBECK, Elise , WRIGHT, Jonathan
IPC分类号： A61K31/52 , A61P3/10
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure (I), wherein R 1 , R 2 and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine. Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构（I）的氨基嘌呤化合物，其中R 1，R 2和R 3如本文所定义，组合物包含有效量的氨基嘌呤。治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫性疾病，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消瘦，石棉相关病症，肺部疾病高血压或通过抑制JNK途径可治疗或可预防的病症包括向有需要的患者施用有效量的氨基嘌呤化合物。

2. 发明申请

WO2009049028A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS 审中-公开
标题翻译：吡咯啉化合物及其作为JANUS KINASE调节剂的用途
公开(公告)号：WO2009049028A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079315
申请日：2008-10-09
申请人： TARGEGEN INC. , NORONHA, Glenn , CAO, Jianguo , CHOW, Chun, P. , MAK, Chi Ching , PALANKI, Moorthy, S.S. , DNEPROVSKAIA, Elena , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , ZENG, Binqi
发明人： NORONHA, Glenn , CAO, Jianguo , CHOW, Chun, P. , MAK, Chi Ching , PALANKI, Moorthy, S.S. , DNEPROVSKAIA, Elena , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , ZENG, Binqi
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519
CPC分类号： C07D487/04
摘要： Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.
摘要翻译：本文提供了式（I）的吡咯并嘧啶化合物，其中R 1是含有至少一个S原子的杂芳基，并且任选地在环碳上被一个，两个或三个取代基取代，所述取代基各自独立地选自：卤素，羟基，硝基，甲酰基，甲酰氨基，氰基，磺酰基，羧基，氨基，酰氨基，酰氨基，氨基甲酰基，氨磺酰基，烷基，烯基，CF 3，脲基，炔基，烷氧基，烷酰基，烷氧羰基，甲醛肟，N-烷基氨磺酰，N-烷基氨基甲酰基， OR13R11或-R13R11; R2是苯基或吡啶基，其中R2任选地在环碳上被一个，两个或三个取代基取代，每个独立地选自：卤素，羟基，氰基，硝基，甲酰基，甲酰氨基，羧基，磺酰基，氨基，酰氨基，-N-烷基氨基，氨基甲酰基，氨磺酰基，CF 3，脲基，烷基，烯基，炔基，烷氧基，烷酰基，烷氧基羰基，N-烷基氨磺酰基，N-烷基氨基甲酰基，-OR 11，-OR 12 R 11或-R 12 R 11; 以及制作和使用它们的方法。这些化合物可用于炎性或骨髓增生性疾病。本公开还提供治疗癌症。

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