会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 10. 发明申请
    • PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS
    • 吡咯啉化合物及其作为JANUS KINASE调节剂的用途
    • WO2009049028A1
    • 2009-04-16
    • PCT/US2008/079315
    • 2008-10-09
    • TARGEGEN INC.NORONHA, GlennCAO, JianguoCHOW, Chun, P.MAK, Chi ChingPALANKI, Moorthy, S.S.DNEPROVSKAIA, ElenaMCPHERSON, AndrewPATHAK, Ved, PrakashRENICK, JoelZENG, Binqi
    • NORONHA, GlennCAO, JianguoCHOW, Chun, P.MAK, Chi ChingPALANKI, Moorthy, S.S.DNEPROVSKAIA, ElenaMCPHERSON, AndrewPATHAK, Ved, PrakashRENICK, JoelZENG, Binqi
    • C07D487/04C07D519/00A61K31/519
    • C07D487/04
    • Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.
    • 本文提供了式(I)的吡咯并嘧啶化合物,其中R 1是含有至少一个S原子的杂芳基,并且任选地在环碳上被一个,两个或三个取代基取代,所述取代基各自独立地选自:卤素,羟基, 硝基,甲酰基,甲酰氨基,氰基,磺酰基,羧基,氨基,酰氨基,酰氨基,氨基甲酰基,氨磺酰基,烷基,烯基,CF 3,脲基,炔基,烷氧基,烷酰基,烷氧羰基,甲醛肟,N-烷基氨磺酰,N-烷基氨基甲酰基, OR13R11或-R13R11; R2是苯基或吡啶基,其中R2任选地在环碳上被一个,两个或三个取代基取代,每个独立地选自:卤素,羟基,氰基,硝基,甲酰基,甲酰氨基,羧基,磺酰基,氨基,酰氨基 ,-N-烷基氨基,氨基甲酰基,氨磺酰基,CF 3,脲基,烷基,烯基,炔基,烷氧基,烷酰基,烷氧基羰基,N-烷基氨磺酰基,N-烷基氨基甲酰基,-OR 11,-OR 12 R 11或-R 12 R 11; 以及制作和使用它们的方法。 这些化合物可用于炎性或骨髓增生性疾病。 本公开还提供治疗癌症。