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1. 发明授权

US5948631A Stable mixture for the detection of alkaline phosphatase containing a salt of o-cresolphthalein monophosphoric acid 失效
标题翻译：用于检测含有邻甲酚酞单磷酸盐的碱性磷酸酶的稳定混合物
公开(公告)号：US5948631A
公开(公告)日：1999-09-07
申请号：US924480
申请日：1997-08-07
申请人： Rolf Nagel , Steffen Bossert-Reuther , Thomas Zeibig
发明人： Rolf Nagel , Steffen Bossert-Reuther , Thomas Zeibig
IPC分类号： C07F9/655 , C12Q1/42 , G01N33/52 , C07F9/06 , G01N21/78 , G01N31/22
CPC分类号： C12Q1/42 , G01N33/526 , C12Q2334/00
摘要： The subject matter of the invention is a stable mixture for the detection of alkaline phosphatase, wherein it contains the N-methylglucamine salt of o-cresolphthalein monophosphoric acid and N-methylglucamine as well as an analytical element for the detection of alkaline phosphatase with a matrix that carries this mixture. In addition the invention concerns a method for the determination of alkaline phosphatase using a salt of o-cresolphthalein monophosphoric acid, wherein the sample is brought into contact with a mixture according to the invention or an analytical element according to the invention and a change in color is observed in the presence of alkaline phosphatase.A subject matter of the invention is also a salt of o-cresolphthalein monophosphoric acid with N-methylglucamine as well as a process for producing such a salt.
摘要翻译：本发明的主题是用于检测碱性磷酸酶的稳定混合物，其中含有邻甲酚酞单磷酸的N-甲基葡糖胺盐和N-甲基葡糖胺，以及用于检测碱性磷酸酶与基质的分析元件携带这种混合物。此外，本发明涉及使用邻甲酚酞单磷酸盐测定碱性磷酸酶的方法，其中样品与根据本发明的混合物或根据本发明的分析元件和颜色变化相接触在碱性磷酸酶的存在下观察到。本发明的主题也是邻甲酚酞单磷酸与N-甲基葡糖胺的盐以及其制备方法。

2. 发明授权

US5374546A Process for stabilizing 1-methylhydantoinase, use and method of it for determining an analyte and agents suitable for this 失效
标题翻译：用于稳定1-甲基乙内酰脲酶的方法，其用于测定分析物的用途和方法以及适用于此的试剂
公开(公告)号：US5374546A
公开(公告)日：1994-12-20
申请号：US822176
申请日：1992-01-16
申请人： Rolf Nagel , Ulfert Deneke , Jurgen Mistele
发明人： Rolf Nagel , Ulfert Deneke , Jurgen Mistele
IPC分类号： C12N9/86 , C12N9/96 , C12Q1/26 , C12Q1/28 , C12Q1/34 , C12N9/78
CPC分类号： C12N9/86 , C12Q1/34 , G01N2333/986
摘要： The invention concerns a process for stabilizing the enzyme 1-methylhydantoinase (NMHase) which is characterized in that the NMHase is treated with divalent metal ions, a nucleoside triphosphate and a complexing agent which complexes these divalent metal ions. In addition the invention concerns the use of an enzyme stabilized in this way in a method for the determination of an analyte in which 1-methylhydantoin is converted, as well as a corresponding reagent.
摘要翻译：本发明涉及一种稳定酶1-甲基乙内酰脲酶（NMHase）的方法，其特征在于用二价金属离子，核苷三磷酸和与这些二价金属离子复合的络合剂处理NMHase。此外，本发明涉及以这种方式稳定的酶用于测定其中转化有1-甲基乙内酰脲的分析物以及相应试剂的方法。

3. 发明授权

US4812356A Coating composition for flexible substrates and the use thereof, and a method for the production of a protective coating 失效
标题翻译：柔性基材的涂料组合物及其用途，以及制备保护涂层的方法
公开(公告)号：US4812356A
公开(公告)日：1989-03-14
申请号：US3404
申请日：1987-03-11
申请人： Rainer-Leo Meyer , Reinmar John , Rolf Nagel , Gunter Muller
发明人： Rainer-Leo Meyer , Reinmar John , Rolf Nagel , Gunter Muller
IPC分类号： C08G18/08 , C08G18/10 , C08G18/30 , C08G18/72 , C08K5/521 , C08K13/02 , C08K13/04 , C09D175/00 , B05D3/02 , B32B27/40 , B32B9/00 , C08L75/04
CPC分类号： C08K13/04 , C08G18/0885 , C08G18/10 , C08G18/307 , C08G18/724 , C08K13/02 , C08K5/521 , C09D175/00 , C08G2150/90 , Y10T428/31551 , Y10T428/31554 , Y10T428/31565 , Y10T428/31576 , Y10T428/3158
摘要： A one-component coating composition of35 to 60 wt.-% isocyanate prepolymer8 to 15 wt.-% plasticizer0.3 to 2 wt.-% antisettling agent2 to 10 wt.-% flaky extender5 to 25 wt.-% colorant pigments1 to 3 wt.-% moisture-binding agent, and10 to 20 wt.-% aliphatic estersprovides, on a flexible substrate such as artifical leather, plastic film, paper, roofing felt, polyurethane hard and soft foams, metal foils, concrete and the like, an extraordinarily elastic, tightly adherent coating film of high covering power and light resistance. Furthermore, it has good resistance to abrasion and to weathering, even to aggressive media such as sea water and chemicals.
摘要翻译： PCT No.PCT / EP85 / 00210 Sec。 371日期1987年3月11日 102（e）1987年3月11日PCT PCT。1985年5月8日PCT公布。公开号WO86 / 06737 日期为1986年11月20日。具有35至60重量％异氰酸酯预聚物的单组分涂料组合物8至15重量％增塑剂0.3至2重量％的抗沉降剂2至10重量％片状延长剂5 至25重量％的着色剂颜料1至3重量％的湿粘结剂和10至20重量％的脂肪族酯在柔性基材上提供，例如人造革，塑料膜，纸，屋顶毡，聚氨酯硬和软泡沫，金属箔，混凝土等，具有高覆盖力和耐光性的非常弹性，紧密粘合的涂膜。此外，它具有良好的耐磨性和耐候性，甚至对海水和化学品等侵蚀性介质也是如此。

4. 发明授权

US4567230A 1-Component coating composition, utilization thereof and process for manufacturing a protection coating 失效
标题翻译： 1组分涂料组合物，其用途和制备保护涂层的方法
公开(公告)号：US4567230A
公开(公告)日：1986-01-28
申请号：US611009
申请日：1984-05-14
申请人： Rainer-Leo Meyer , Reinmar John , Rolf Nagel , Gunter Muller
发明人： Rainer-Leo Meyer , Reinmar John , Rolf Nagel , Gunter Muller
IPC分类号： C08G18/08 , C08G18/32 , C08G18/64 , C09D175/04 , E04B1/66 , E04D7/00 , E04F13/02 , C08K3/08
CPC分类号： E04F13/02 , C08G18/0885 , C08G18/3215 , C08G18/6476 , C08K3/0033 , C09D175/04 , E04B1/66 , E04D7/00 , C08G2150/90
摘要： A moisture-setting single-component coating composition has a content of 15 to 70 wt.-% of polyurethane-forming isocyanate, 5 to 25 wt.-% of light-colored, liquid, aromatic hydrocarbon resin of low molecular weight containing hydroxyl groups, 0.2 to 2 wt.-% of antisettling agent, 10 to 35 wt.-% of foliated filler, 2 to 25 wt.-% of tinting pigments, 1 to 5 wt.-% of moisture-binding agent, remainder, but no less than 5 wt.-% of conventional paint solvent. This coating composition can be applied in a conventional manner to a dirt- and dust-free substrate in a thickness of at least 20 microns, and sets of itself by the access of moisture from the ambient atmosphere. The coating composition is suitable especially for the protection of roofs of all kinds, for coating concrete, for protecting reinforced concrete against corrosion, for the painting of steel roofs and/or for the sealing of flat roofs covered with roofing felt.
摘要翻译： PCT No.PCT / EP83 / 00246 Sec。 371日期1984年5月14日 102（e）日期1984年5月14日PCT提交1983年9月15日PCT公布。出版物WO84 / 01158 日期：1984年3月29日。湿度调节单组分涂料组合物的含量为聚氨酯形成异氰酸酯的15-70重量％，浅色液体芳族烃树脂为5至25重量％含有羟基的低分子量，0.2至2重量％的抗沉降剂，10至35重量％的叶酸填料，2至25重量％的着色颜料，1至5重量％的水分结合剂，余量，但不小于5重量％的常规涂料溶剂。该涂料组合物可以以常规方式施用至厚度为至少20微米的无尘和无尘的基材，并且可以通过从环境气氛中获得水分而将其自身组合。涂料组合物特别适用于保护各种屋顶，用于涂层混凝土，用于保护钢筋混凝土免受腐蚀，用于钢屋顶的涂漆和/或用于覆盖屋顶毡的平屋顶的密封。

5. 发明授权

US09540702B2 Stabilization of enzymes with stable coenzymes 有权
标题翻译：用稳定的辅酶稳定酶
公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/04
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

6. 发明申请

US20070178546A1 STABILIZED CHOLINESTERASE SUBSTRATE SOLUTION 审中-公开
标题翻译：稳定的胆碱酯底物溶液
公开(公告)号：US20070178546A1
公开(公告)日：2007-08-02
申请号：US11566788
申请日：2006-12-05
申请人： Friederike Weber , Norbert Gottschalk , Hans-Joachim Kytzia , Matthias Muecke , Rolf Nagel
发明人： Friederike Weber , Norbert Gottschalk , Hans-Joachim Kytzia , Matthias Muecke , Rolf Nagel
IPC分类号： C12Q1/34
CPC分类号： C12Q1/46
摘要： The present invention relates to the use of a polar organic solvent for the stabilization of a cholinesterase substrate solution, wherein at least one substrate is stabilized by at least one species of a polar organic solvent in a buffered solution, and to the use of said solution for determining the activity of cholinesterase in a sample. Also within the scope of the present invention is a stabilized cholinesterase substrate solution for determining the activity of a cholinesterase in a sample, wherein at least one substrate is stabilized by at least one species of a polar organic solvent. Furthermore, the invention relates to a method for determining the activity of a cholinesterase in a sample, as well as a kit for determining the activity of a cholinesterase in a sample and a kit for conducting a method for determining the activity of a cholinesterase in a sample.
摘要翻译：本发明涉及极性有机溶剂用于稳定胆碱酯酶底物溶液的用途，其中至少一种底物由缓冲溶液中的至少一种极性有机溶剂稳定，并且使用所述溶液用于确定样品中胆碱酯酶的活性。在本发明的范围内也是用于测定样品中胆碱酯酶活性的稳定化胆碱酯酶底物溶液，其中至少一种底物由至少一种极性有机溶剂稳定。此外，本发明涉及一种用于测定样品中胆碱酯酶的活性的方法，以及用于测定样品中胆碱酯酶的活性的试剂盒和用于进行确定胆碱酯酶活性的方法的试剂盒样品。

7. 发明授权

US06413733B1 Stabilized reagent and method for determining creatine kinase 有权
标题翻译：稳定试剂和测定肌酸激酶的方法
公开(公告)号：US06413733B1
公开(公告)日：2002-07-02
申请号：US09581357
申请日：2000-06-09
申请人： Rolf Nagel , Juergen Mistele , Norbert Schroeder
发明人： Rolf Nagel , Juergen Mistele , Norbert Schroeder
IPC分类号： C12Q150
CPC分类号： C12Q1/50
摘要： A stabilized reagent for the photometric enzymatic determination of creatine kinase (CK) in biological sample material by forming ATP from creatine phosphate and ADP and detecting the ATP formed, containing an organic or inorganic sulphur compound preferably in a submolar amount relative to the added CK activator. A corresponding reagent in a liquid form is stable at 2 to 8° C. for up to 12 months without significant loss of function.
摘要翻译：一种用于通过从磷酸肌酸和ADP形成ATP并检测形成的ATP而测定生物样品材料中的肌酸激酶（CK）的稳定化试剂，所述ATP含有相对于添加的CK激活剂优选为亚摩尔量的有机或无机硫化合物。液体形式的相应试剂在2至8℃下稳定长达12个月，不会明显损失功能。

8. 发明授权

US6071553A Method for producing melt-bonding wires 失效
标题翻译：熔接线生产方法
公开(公告)号：US6071553A
公开(公告)日：2000-06-06
申请号：US901356
申请日：1997-07-28
申请人： Maurice Ferne , Rolf Nagel , Pierre Yves Le Tiec
发明人： Maurice Ferne , Rolf Nagel , Pierre Yves Le Tiec
IPC分类号： H01B13/06 , B05D1/18 , B05D5/12
CPC分类号： H01B13/065
摘要： In a method for the production of melt-bonding wires to enable the use of non-solvent-containing thermoplastic or thermosetting coating materials, meltable thermoplastic or thermosetting materials are supplied to a fusion chamber (8) where they are melted. The insulated electrical conductor (1) to be coated is drawn through the melt and after the coating process leaves the coating chamber (12) through a calibration device (5), which is followed by cooling.
摘要翻译：在用于生产熔接线的方法中，能够使用不含溶剂的热塑性或热固性涂层材料，可熔融的热塑性或热固性材料被供应到熔化室（8），在熔化室（8）中它们被熔化。要涂覆的绝缘电导体（1）通过熔体被拉出，并且在涂覆过程通过校准装置（5）离开涂覆室（12）之后冷却。

9. 发明授权

US5959076A Process for stabilizing the content of glycated protein of a sample on a matrix material 失效
公开(公告)号：US5959076A
公开(公告)日：1999-09-28
申请号：US702972
申请日：1996-08-26
申请人： Rolf Nagel , Jurgen Mistele
发明人： Rolf Nagel , Jurgen Mistele
IPC分类号： G01N33/52 , G01N33/66 , G01N33/68 , G01N33/72 , C07K9/00 , A61K38/14
CPC分类号： G01N33/6842 , G01N33/68 , G01N33/723 , G01N33/726
摘要： The invention concerns a method for stabilizing the content of glycated protein in a sample on a matrix material, which is characterized in that the matrix material is impregnated with boric acid buffer with a pH which is larger or equal to 10.5 or a transition metal salt as well as an appropriate matrix material, an element for collecting, transporting and storing sample material to be analysed with such a matrix material and a system containing such an element and a sealable covering.

10. 发明授权

US5274095A Diarylimidazoles 失效
标题翻译：二芳基咪唑
公开(公告)号：US5274095A
公开(公告)日：1993-12-28
申请号：US928000
申请日：1992-08-11
申请人： Hans-Peter Braun , Ulfert Deneke , Werner Guethlein , Rolf Nagel
发明人： Hans-Peter Braun , Ulfert Deneke , Werner Guethlein , Rolf Nagel
IPC分类号： C07D233/54 , C12Q1/28 , C12Q1/50 , C07D401/04 , C07D233/64
CPC分类号： C07D233/64 , C12Q1/28 , C12Q1/50 , C12Q2326/00
摘要： Diarylimidazoles of the general formula: ##STR1## wherein R.sup.1 is a radical of the general formula: ##STR2## in which R.sup.3 and R.sup.6 are hydrogen atoms, R.sup.4 and R.sup.5, which can be the same or different, are lower alkyl radicals or R.sup.3 /R.sup.4 and /or R.sup.5 /R.sup.6 in each case together represent a lower alkylene radical and R.sup.2 is a lower alkyl radical, and/or of a salt thereof, are useful as redox indicators, particularly in the presence of a SH group-containing substance.
摘要翻译：具有以下通式的二芳基咪唑：其中R 1是具有以下通式的基团：其中R 3和R 6是氢原子，R 4和R 5可以相同或不同，在各种情况下，低级烷基或R 3 / R 4和/或R 5 / R 6一起代表低级亚烷基，R 2为低级烷基，和/或其盐可用作氧化还原指示剂，特别是在含SH组的物质。

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