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1. 发明申请

US20110112291A1 STABILIZATION OF CONJUGATES COMPRISING A THIOUREA LINKER 审中-公开
标题翻译：包含一个连接器的连接器的稳定性
公开(公告)号：US20110112291A1
公开(公告)日：2011-05-12
申请号：US12323942
申请日：2008-11-26
申请人： Eva Hoess , Rene Blind , Gerhard Fink , Hans-Joachim Kytzia
发明人： Eva Hoess , Rene Blind , Gerhard Fink , Hans-Joachim Kytzia
IPC分类号： C07D223/18
CPC分类号： G01N33/532 , A61K47/55
摘要： The present invention discloses a composition containing a conjugate comprising two moieties covalently linked by a thiourea linker and thiourea or a derivative thereof in free form. It also relates to a method for stabilizing a conjugate comprising two moieties covalently linked by a thiourea linker is described the method comprising the steps of providing the conjugate, adding thereto thiourea or a derivative thereof in free form and thereby stabilizing the conjugate and to the use of a composition containing a conjugate comprising two moieties covalently linked by a thiourea linker and thiourea or a derivative thereof in free form.
摘要翻译：本发明公开了一种含有共轭物的组合物，其包含由硫脲接头和硫脲或其衍生物以游离形式共价连接的两个部分。本发明还涉及一种用于稳定缀合物的方法，其包含由硫脲连接体共价连接的两个部分，所述方法包括以下步骤：提供缀合物，向其中加入游离形式的硫脲或其衍生物，从而稳定缀合物和使用包含共轭物的组合物，其包含由硫脲接头和硫脲或其衍生物以游离形式共价连接的两个部分。

2. 发明申请

US20070178546A1 STABILIZED CHOLINESTERASE SUBSTRATE SOLUTION 审中-公开
标题翻译：稳定的胆碱酯底物溶液
公开(公告)号：US20070178546A1
公开(公告)日：2007-08-02
申请号：US11566788
申请日：2006-12-05
申请人： Friederike Weber , Norbert Gottschalk , Hans-Joachim Kytzia , Matthias Muecke , Rolf Nagel
发明人： Friederike Weber , Norbert Gottschalk , Hans-Joachim Kytzia , Matthias Muecke , Rolf Nagel
IPC分类号： C12Q1/34
CPC分类号： C12Q1/46
摘要： The present invention relates to the use of a polar organic solvent for the stabilization of a cholinesterase substrate solution, wherein at least one substrate is stabilized by at least one species of a polar organic solvent in a buffered solution, and to the use of said solution for determining the activity of cholinesterase in a sample. Also within the scope of the present invention is a stabilized cholinesterase substrate solution for determining the activity of a cholinesterase in a sample, wherein at least one substrate is stabilized by at least one species of a polar organic solvent. Furthermore, the invention relates to a method for determining the activity of a cholinesterase in a sample, as well as a kit for determining the activity of a cholinesterase in a sample and a kit for conducting a method for determining the activity of a cholinesterase in a sample.
摘要翻译：本发明涉及极性有机溶剂用于稳定胆碱酯酶底物溶液的用途，其中至少一种底物由缓冲溶液中的至少一种极性有机溶剂稳定，并且使用所述溶液用于确定样品中胆碱酯酶的活性。在本发明的范围内也是用于测定样品中胆碱酯酶活性的稳定化胆碱酯酶底物溶液，其中至少一种底物由至少一种极性有机溶剂稳定。此外，本发明涉及一种用于测定样品中胆碱酯酶的活性的方法，以及用于测定样品中胆碱酯酶的活性的试剂盒和用于进行确定胆碱酯酶活性的方法的试剂盒样品。

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