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1. 发明授权

US09540702B2 Stabilization of enzymes with stable coenzymes 有权
标题翻译：用稳定的辅酶稳定酶
公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/04
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

2. 发明申请

US20120276565A1 STABILIZATION OF ENZYMES WITH STABLE COENZYMES 有权
标题翻译：用稳定的聚苯乙烯稳定酶
公开(公告)号：US20120276565A1
公开(公告)日：2012-11-01
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/96 , G01N27/26 , G01N21/76 , C12Q1/32 , C12Q1/26
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

3. 发明授权

US08580949B2 Enzymatic synthesis of carba-NAD 有权
标题翻译：碳酰化酶的酶合成
公开(公告)号：US08580949B2
公开(公告)日：2013-11-12
申请号：US13358146
申请日：2012-01-25
申请人： Hartmut Duefel , Dieter Heindl , Carina Horn , Thomas Meier , Rainer Schmuck
发明人： Hartmut Duefel , Dieter Heindl , Carina Horn , Thomas Meier , Rainer Schmuck
IPC分类号： C07H19/207
CPC分类号： C07H19/207 , C12P19/32
摘要： The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.
摘要翻译：本公开内容涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含碳环糖代替核糖。

4. 发明申请

US20120130062A1 ENZYMATIC SYNTHESIS OF CARBA-NAD 有权
标题翻译： CARBA-NAD的酶促合成
公开(公告)号：US20120130062A1
公开(公告)日：2012-05-24
申请号：US13358146
申请日：2012-01-25
申请人： Hartmut Duefel , Dieter Heindl , Carina Horn , Thomas Meier , Rainer Schmuck
发明人： Hartmut Duefel , Dieter Heindl , Carina Horn , Thomas Meier , Rainer Schmuck
IPC分类号： C07H19/207 , C12P19/32
CPC分类号： C07H19/207 , C12P19/32
摘要： The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.
摘要翻译：本公开内容涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含碳环糖代替核糖。

5. 发明授权

US09359634B2 Fast reaction kinetics of enzymes having low activity in dry chemistry layers 有权
标题翻译：在干化学层中具有低活性的酶的快速反应动力学
公开(公告)号：US09359634B2
公开(公告)日：2016-06-07
申请号：US13210564
申请日：2011-08-16
申请人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
发明人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
IPC分类号： C12Q1/54 , C12N11/00 , C12N11/02 , C12N11/14 , C12N9/04 , C12Q1/32
CPC分类号： C12Q1/54 , C12N9/0006 , C12N11/00 , C12N11/02 , C12N11/14 , C12Q1/32
摘要： The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
摘要翻译：本发明涉及一种用于确定分析物的方法以及因此合适的诊断元件。在一种具体形式中，用于确定分析物的方法包括使含有分析物的样品与包含干试剂层的诊断元件接触。干试剂层含有对分析物和人工辅酶特异的突变脱氢酶。该方法还包括确定分析物存在和分析物的量中的至少一种。

6. 发明申请

US20140322737A1 FAST REACTION KINETICS OF ENZYMES HAVING LOW ACTIVITY IN DRY CHEMISTRY LAYERS 有权
标题翻译：在干燥化学物质层中具有低活性的酶的快速反应动力学
公开(公告)号：US20140322737A1
公开(公告)日：2014-10-30
申请号：US13210564
申请日：2011-08-16
申请人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
发明人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
IPC分类号： C12Q1/54 , C12Q1/32
CPC分类号： C12Q1/54 , C12N9/0006 , C12N11/00 , C12N11/02 , C12N11/14 , C12Q1/32
摘要： The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
摘要翻译：本发明涉及一种用于确定分析物的方法以及因此合适的诊断元件。在一种具体形式中，用于确定分析物的方法包括使含有分析物的样品与包含干试剂层的诊断元件接触。干试剂层含有对分析物和人工辅酶特异的突变脱氢酶。该方法还包括确定分析物存在和分析物的量中的至少一种。

7. 发明申请

US20130052674A1 DETECTING THE DECOMPOSITION OF ENZYMES IN A TEST ELEMENT BY MEANS OF CONTROLLED RELEASE OF A PROTECTED ANALYTE 审中-公开
标题翻译：通过受保护分析仪的控制释放检测测试单元中酶的分解
公开(公告)号：US20130052674A1
公开(公告)日：2013-02-28
申请号：US13524199
申请日：2012-06-15
申请人： Carina Horn , Dieter Heindl , Hans-Peter Haar , Nelli Steinke
发明人： Carina Horn , Dieter Heindl , Hans-Peter Haar , Nelli Steinke
IPC分类号： C12Q1/32 , G01N21/77 , C12Q1/54
CPC分类号： C12Q1/54
摘要： In one form, a diagnostic element for determining at least one analyte is provided. In a further form, an analytical measuring device includes the diagnostic element. Still, other forms are related to methods for the determination of an analyte, correcting a signal generated by an analyte, and/or checking the detection optics of an analytical measuring device using the diagnostic element. Another form is related to a system for the controlled release of a reagent and the use of such a system as a circuit element. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving diagnostic elements.
摘要翻译：在一种形式中，提供了用于确定至少一种分析物的诊断元件。在另一种形式中，分析测量装置包括诊断元件。仍然，其它形式涉及用于确定分析物的方法，校正由分析物产生的信号和/或使用诊断元件检查分析测量装置的检测光学元件。另一种形式涉及用于控制释放试剂的系统以及使用诸如电路元件的系统。其他方面包括但不限于涉及诊断元件的独特方法，技术，产品，系统和设备。

8. 发明授权

US10260085B2 Detecting the decomposition of enzymes in a test element by means of controlled release of a protected analyte 有权
公开(公告)号：US10260085B2
公开(公告)日：2019-04-16
申请号：US13524199
申请日：2012-06-15
申请人： Carina Horn , Dieter Heindl , Hans-Peter Haar , Nelli Steinke
发明人： Carina Horn , Dieter Heindl , Hans-Peter Haar , Nelli Steinke
IPC分类号： C12Q1/54
摘要： In one form, a diagnostic element for determining at least one analyte is provided. In a further form, an analytical measuring device includes the diagnostic element. Still, other forms are related to methods for the determination of an analyte, correcting a signal generated by an analyte, and/or checking the detection optics of an analytical measuring device using the diagnostic element. Another form is related to a system for the controlled release of a reagent and the use of such a system as a circuit element. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving diagnostic elements.

9. 发明申请

US20130011871A1 STERILIZABLE CHEMISTRY FOR TEST ELEMENTS 有权
标题翻译：测试元素的无菌化学物质
公开(公告)号：US20130011871A1
公开(公告)日：2013-01-10
申请号：US13493251
申请日：2012-06-11
申请人： Carina Horn , Nelli Steinke
发明人： Carina Horn , Nelli Steinke
IPC分类号： C12Q1/32 , G01N27/26 , C07H19/207 , G01N21/75 , A61L2/08 , C12N9/04
CPC分类号： C12Q1/54 , A61L2/081 , A61L2/087 , A61L2/28 , A61L2202/11 , C12Y101/01047 , G01N2333/904
摘要： In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized diagnostic elements and techniques for the production of the same are disclosed. In one embodiment, a sterilized diagnostic element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized diagnostic element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ≧ 80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized diagnostic elements.
摘要翻译：在一个非限制性方面，提供了用于诊断元件的可灭菌的试剂材料。在其它方面，公开了灭菌的诊断元件及其生产技术。在一个实施方案中，消毒的诊断元件包括化学检测试剂，其包括对电离辐射敏感的至少一种成分。灭菌的诊断元件也是无介质的，并且至少一种对电离辐射敏感的组分以功能形式以基于灭菌前诊断元件中各组分的总量的≥80％的比例存在。在某些方面，至少一种对电离辐射敏感的组分包括酶和辅酶中的一种或两种。其他方面包括但不限于独特的方法，技术，产品，系统和涉及可灭菌的试剂材料或灭菌的诊断元件的装置。

10. 发明授权

US09399792B2 Sterilizable chemistry for test elements 有权
标题翻译：测试元素的无菌化学
公开(公告)号：US09399792B2
公开(公告)日：2016-07-26
申请号：US13493251
申请日：2012-06-11
申请人： Carina Horn , Nelli Steinke
发明人： Carina Horn , Nelli Steinke
IPC分类号： C12Q1/32 , C12Q1/54
CPC分类号： C12Q1/54 , A61L2/081 , A61L2/087 , A61L2/28 , A61L2202/11 , C12Y101/01047 , G01N2333/904
摘要： In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized diagnostic elements and techniques for the production of the same are disclosed. In one embodiment, a sterilized diagnostic element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized diagnostic element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ≧80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized diagnostic elements.
摘要翻译：在一个非限制性方面，提供了用于诊断元件的可灭菌的试剂材料。在其它方面，公开了灭菌的诊断元件及其生产技术。在一个实施方案中，消毒的诊断元件包括化学检测试剂，其包括对电离辐射敏感的至少一种成分。灭菌的诊断元件也是无介质的，并且至少一种对电离辐射敏感的组分以功能形式以基于灭菌前诊断元件中各组分的总量的≥80％的比例存在。在某些方面，至少一种对电离辐射敏感的组分包括酶和辅酶中的一种或两种。其他方面包括但不限于独特的方法，技术，产品，系统和涉及可灭菌的试剂材料或灭菌的诊断元件的装置。

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