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1. 发明授权

US5834204A Apparatus for reducing solvent luminescence background emissions 失效
标题翻译：减少溶剂发光背景辐射的装置
公开(公告)号：US5834204A
公开(公告)日：1998-11-10
申请号：US989509
申请日：1997-12-12
申请人： Rhett L. Affleck , W. Patrick Ambrose , James N. Demas , Peter M. Goodwin , Mitchell E. Johnson , Richard A. Keller , Jeffrey T. Petty , Jay A. Schecker , Ming Wu
发明人： Rhett L. Affleck , W. Patrick Ambrose , James N. Demas , Peter M. Goodwin , Mitchell E. Johnson , Richard A. Keller , Jeffrey T. Petty , Jay A. Schecker , Ming Wu
IPC分类号： G01N21/64 , G01N33/52 , G01N33/58 , C12Q1/68 , C12M1/40
CPC分类号： G01N21/6428 , G01N21/01 , G01N21/645 , G01N33/52 , G01N33/582
摘要： The detectability of luminescent molecules in solution is enhanced by reducing the background luminescence due to impurity species also present in the solution. A light source that illuminates the solution acts to photolyze the impurities so that the impurities do not luminesce in the fluorescence band of the molecule of interest. Molecules of interest may be carried through the photolysis region in the solution or may be introduced into the solution after the photolysis region.
摘要翻译：通过降低由于溶液中也存在的杂质物质引起的背景发光，增强了溶液中发光分子的可检测性。照亮溶液的光源用于使杂质光解，使得杂质不会在感兴趣的分子的荧光带中发光。感兴趣的分子可以通过溶液中的光解区域进行，或者可以在光解区域之后引入溶液中。

2. 发明授权

US5827663A Method and apparatus for reducing solvent luminescence background emissions 失效
标题翻译：降低溶剂发光背景辐射的方法和装置
公开(公告)号：US5827663A
公开(公告)日：1998-10-27
申请号：US727841
申请日：1996-10-04
申请人： Rhett L. Affleck , W. Patrick Ambrose , James N. Demas , Peter M. Goodwin , Mitchell E. Johnson , Richard A. Keller , Jeffrey T. Petty , Jay A. Schecker , Ming Wu
发明人： Rhett L. Affleck , W. Patrick Ambrose , James N. Demas , Peter M. Goodwin , Mitchell E. Johnson , Richard A. Keller , Jeffrey T. Petty , Jay A. Schecker , Ming Wu
IPC分类号： G01N21/64 , G01N33/52 , G01N33/58 , C12Q1/68 , C12N15/00 , C12Q1/37
CPC分类号： G01N21/6428 , G01N21/01 , G01N21/645 , G01N33/52 , G01N33/582
摘要： The detectability of luminescent molecules in solution is enhanced by reducing the background luminescence due to impurity species also present in the solution. A light source that illuminates the solution acts to photolyze the impurities so that the impurities do not luminesce in the fluorescence band of the molecule of interest. Molecules of interest may be carried through the photolysis region in the solution or may be introduced into the solution after the photolysis region.
摘要翻译：通过降低由于溶液中也存在的杂质物质引起的背景发光，增强了溶液中发光分子的可检测性。照亮溶液的光源用于使杂质光解，使得杂质不会在感兴趣的分子的荧光带中发光。感兴趣的分子可以通过溶液中的光解区域进行，或者可以在光解区域之后引入溶液中。

3. 发明授权

US5799682A Reduction of diffusional defocusing in hydrodynamically focused flows 失效
标题翻译：减少流体动力学聚焦流中的扩散散焦
公开(公告)号：US5799682A
公开(公告)日：1998-09-01
申请号：US758738
申请日：1996-12-06
申请人： Rhett L. Affleck , James N. Demas , Peter M. Goodwin , Richard Keller , Ming Wu
发明人： Rhett L. Affleck , James N. Demas , Peter M. Goodwin , Richard Keller , Ming Wu
IPC分类号： G01N15/14 , F15C1/20
CPC分类号： G01N15/1404 , Y10T137/0396 , Y10T137/2076 , Y10T137/2196
摘要： An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream.
摘要翻译：具有相对较低分子量和相应的高扩散系数的具有第一分子的分析物流体流减少了分析物流体流的扩散散焦。第一分子的分析物流体流与具有相对低的扩散系数的第二分子和具有与第一分子缔合有关的结合常数的第二分子缔合。维持聚焦的分析物流体流，因为相关联的第一和第二分子的组合分子量有效地使第一分子离开分析物流体流的扩散最小化。

4. 发明申请

US20120163945A1 DRIVE ASSEMBLY FOR ROBOTIC CONVEYOR SYSTEM 审中-公开
标题翻译：用于机器人输送系统的驱动装置
公开(公告)号：US20120163945A1
公开(公告)日：2012-06-28
申请号：US13334619
申请日：2011-12-22
申请人： Robert K. Neeper , Rhett L. Affleck , John E. Lillig
发明人： Robert K. Neeper , Rhett L. Affleck , John E. Lillig
IPC分类号： B65G1/06
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： A storage and retrieval system is provided. The storage and retrieval system having a frame and a shuttle movable within the frame, the shuttle having a carriage extending at least partially between a top and bottom of the frame. At least one tension member extends between a first and second ends of the frame and is coupled to the shuttle. At least one drive member extends between the first and second ends of the frame and is coupled to the shuttle. The at least one drive member and the at least one tension member project from opposite sides of the shuttle towards respective first and second ends of the frame and effect stabilization of the carriage against at least rotation relative to the frame. The at least one tension member crosses the at least one drive member and the at least one drive member effects movement of the shuttle.
摘要翻译：提供存储和检索系统。存储和取回系统具有框架和可在框架内移动的梭子，梭子具有至少部分地在框架的顶部和底部之间延伸的托架。至少一个张紧构件在框架的第一和第二端之间延伸并且联接到梭子。至少一个驱动构件在框架的第一和第二端之间延伸并且联接到梭子。所述至少一个驱动构件和所述至少一个张紧构件从所述梭子的相对侧朝向所述框架的相应的第一和第二端突出，并且相对于所述框架至少使所述托架抵抗至少旋转。所述至少一个张紧构件穿过所述至少一个驱动构件，并且所述至少一个驱动构件影响所述梭的运动。

5. 外观设计

USD480815S1 Card carrying an array of compounds 失效
标题翻译：携带一系列化合物的卡
公开(公告)号：USD480815S1
公开(公告)日：2003-10-14
申请号：US29165712
申请日：2002-08-13
申请人： William R. Ewing , Robert K. Neeper , Rhett L. Affleck , Gordon W. Hudson , John F. Bridwell , John E. Lillig
设计人： William R. Ewing , Robert K. Neeper , Rhett L. Affleck , Gordon W. Hudson , John F. Bridwell , John E. Lillig

6. 发明授权

US06410342B1 Method and apparatus for controlled photoelution 失效
标题翻译：用于控制光洗净的方法和装置
公开(公告)号：US06410342B1
公开(公告)日：2002-06-25
申请号：US08914861
申请日：1997-08-19
申请人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
发明人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00306 , B01J2219/00308 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , C07K1/04 , C07K1/12 , C40B60/14 , G01N33/54353
摘要： A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.
摘要翻译：公开了一种光可剥离接头连接的化合物的光洗脱方法，以及适用于实施该方法的装置。根据该方法，可光裂解的连接物连接的文库化合物在受控的曝光和受控温度的条件下从固体支持介质中光固化。适用于实施本发明的光洗涤方法的装置包括用于基本均匀地照射可光切割接头的装置，用于控制照明时间和强度的装置，以及用于控制样品温度的装置。

7. 发明申请

US20120103501A1 DEVICE AND METHOD FOR REMOVING A PEELABLE SEAL 有权
标题翻译：用于去除可剥离密封件的装置和方法
公开(公告)号：US20120103501A1
公开(公告)日：2012-05-03
申请号：US13284437
申请日：2011-10-28
申请人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
发明人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
IPC分类号： B32B38/10
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
摘要翻译：用可剥离密封件密封的容器或容器阵列通过输送机沿着处理路径被输送到一个吸引站，在该站处，具有基本上等于或大于密封件的宽度的宽度的粘合剂表面被压紧可剥离密封件的上表面。收集杆在粘合剂表面上施加向下的压力，当压板随着输送机移动时，将其压靠在密封件上并将容器或容器阵列保持在输送机上的适当位置。当密封的前缘通过收集杆时，粘合剂表面向上滚动，远离密封件的平面，在密封件的前缘上拉起，以将其与容器或容器阵列分开，同时容器或容器阵列被滚筒压住。然后将去除的密封件丢弃。

8. 发明授权

US07596251B2 Automated sample analysis system and method 有权
标题翻译：自动样本分析系统和方法
公开(公告)号：US07596251B2
公开(公告)日：2009-09-29
申请号：US10769462
申请日：2004-01-30
申请人： Rhett L. Affleck , Mike Bodnar , Robert K. Levin , John E. Lillig , Robert K. Neeper
发明人： Rhett L. Affleck , Mike Bodnar , Robert K. Levin , John E. Lillig , Robert K. Neeper
IPC分类号： G06K9/00 , A61B19/02 , A61C19/02 , B01L9/02 , A47B88/06
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An automated biological sample analysis system and method for use in incubating and analyzing multiple samples for protein crystallization. A temperature controlled cabinet houses sample storage, sample transport, and sample imaging systems. The operation of the system is automated and can be controlled by software, which can be reconfigured remotely. An array of storage shelves includes multiple shelf columns arranged around a core. Multiple banks of removable shelves arranged as magazines are accessed through a door on the cabinet. Each shelf stores a multi-well plate and different sizes can be stored in different shelves. The core houses a sample transport system that includes a multi-axis robot that rotates about a vertical axis to access the shelves in the shelf array. The transport system retrieves and replaces the multi-well plates in the shelves and can move plates from the shelves to an imaging system where each sample can be automatically imaged.
摘要翻译：一种用于孵化和分析多个样品进行蛋白质结晶的自动化生物样品分析系统和方法。温度控制柜包含样品储存，样品运输和样品成像系统。系统的操作是自动化的，可以通过软件进行控制，可以远程重新配置。一组存储架包括围绕一个核心布置的多个搁架列。可以通过柜子上的门访问多个排列成杂志的可移动货架。每个货架存储多孔板，不同的尺寸可以存放在不同的货架上。核心包含一个样品输送系统，其中包括一个绕垂直轴旋转的多轴机器人，以便进入架子阵列中的货架。运输系统检索和取代货架中的多孔板，并可将板从搁板移动到成像系统，每个样品可自动成像。

9. 发明申请

US20080216955A1 DEVICE AND METHOD FOR REMOVING A PEELABLE SEAL 有权
标题翻译：用于去除可剥离密封件的装置和方法
公开(公告)号：US20080216955A1
公开(公告)日：2008-09-11
申请号：US12045644
申请日：2008-03-10
申请人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
发明人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
IPC分类号： B32B38/10
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
摘要翻译：用可剥离密封件密封的容器或容器阵列通过输送机沿着处理路径被输送到一个吸引站，在该站处，具有基本上等于或大于密封件的宽度的宽度的粘合剂表面被压紧可剥离密封件的上表面。收集杆在粘合剂表面上施加向下的压力，当压板随着输送机移动时，将其压靠在密封件上并将容器或容器阵列保持在输送机上的适当位置。当密封的前缘通过收集杆时，粘合剂表面向上滚动，远离密封件的平面，在密封件的前缘上拉起，以将其与容器或容器阵列分开，同时容器或容器阵列被滚筒压住。然后将去除的密封件丢弃。

10. 发明申请

US20070172396A1 AUTOMATED SYSTEM FOR STORING, RETRIEVING AND MANAGING SAMPLE 有权
标题翻译：用于存储，检索和管理样品的自动化系统
公开(公告)号：US20070172396A1
公开(公告)日：2007-07-26
申请号：US11626359
申请日：2007-01-23
申请人： Robert K. Neeper , Rhett L. Affleck , John E. Lillig
发明人： Robert K. Neeper , Rhett L. Affleck , John E. Lillig
IPC分类号： B01L9/00
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
摘要翻译：用于将大量样品储存在托盘中的自动存储系统包括储存室，在一侧邻接储藏室的托盘穿梭隔室和另一侧上的多个独立模块。模块执行通过托盘穿梭从储存室取出的样品的处理，包括从检索的源托盘提取所选样品并将所选样品转移到单独的目的地托盘中，所述目的托盘可以进一步处理或从系统中移除使用。模块的独立操作允许不同模块同时执行处理和处理，而托盘穿梭器访问存储隔间内的附加样品。在一个实施例中，垂直转盘用于将期望的托盘垂直地对准托盘梭，而托盘梭在水平面内运行。

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