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1. 发明授权

US06410342B1 Method and apparatus for controlled photoelution 失效
标题翻译：用于控制光洗净的方法和装置
公开(公告)号：US06410342B1
公开(公告)日：2002-06-25
申请号：US08914861
申请日：1997-08-19
申请人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
发明人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00306 , B01J2219/00308 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , C07K1/04 , C07K1/12 , C40B60/14 , G01N33/54353
摘要： A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.
摘要翻译：公开了一种光可剥离接头连接的化合物的光洗脱方法，以及适用于实施该方法的装置。根据该方法，可光裂解的连接物连接的文库化合物在受控的曝光和受控温度的条件下从固体支持介质中光固化。适用于实施本发明的光洗涤方法的装置包括用于基本均匀地照射可光切割接头的装置，用于控制照明时间和强度的装置，以及用于控制样品温度的装置。

2. 发明授权

US06468787B1 Method and apparatus for controlled photoelution 失效
公开(公告)号：US06468787B1
公开(公告)日：2002-10-22
申请号：US09294169
申请日：1999-04-19
申请人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
发明人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
IPC分类号： C12M100
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00306 , B01J2219/00308 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , C07K1/04 , C07K1/12 , C40B60/14 , G01N33/54353
摘要： A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.

3. 发明授权

US06890491B1 Method and apparatus for universal fluid exchange 失效
标题翻译：通用流体交换方法和装置
公开(公告)号：US06890491B1
公开(公告)日：2005-05-10
申请号：US08872097
申请日：1997-06-10
申请人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling , Peter Kieselbach , Gregory Louis Kirk , Ian Henderson
发明人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling , Peter Kieselbach , Gregory Louis Kirk , Ian Henderson
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： B01L3/565 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00326 , B01J2219/00423 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , C40B60/14 , G01N35/025 , G01N35/10 , G01N2035/00534 , Y10T436/25375 , Y10T436/2575
摘要： A universal fluid exchange device includes upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.
摘要翻译：通用流体交换装置包括上部和下部反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到适当的接收船只。该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

4. 发明授权

US6158146A Rapid drying oven and methods for providing rapid drying of multiple samples 失效
标题翻译：快速干燥炉和多种样品的快速干燥方法
公开(公告)号：US6158146A
公开(公告)日：2000-12-12
申请号：US533877
申请日：2000-03-22
申请人： Peter Kieselbach , Ilya Feygin , Joseph J. Brzezinski , Gregory L. Kirk , Thuc Nguyen , Joseph A. Mollica
发明人： Peter Kieselbach , Ilya Feygin , Joseph J. Brzezinski , Gregory L. Kirk , Thuc Nguyen , Joseph A. Mollica
IPC分类号： F26B5/04 , F26B9/06 , F26B21/00 , F26B21/14
CPC分类号： F26B5/044 , F26B21/004 , F26B21/14
摘要： A dryer for use with chemical compounds employs controlled vacuum, elevated temperature and dry, inert gas to dry the chemical compounds. The dryer includes a vacuum chamber into which trays containing the compounds are placed. The chamber includes heating elements which elevate the temperature of chemical samples placed within the chamber. Supplying and evacuating manifolds, each with a plurality of orifices for supplying and evacuating dry inert gas, provide a substantially laminar flow of dry inert gas just above the trays of chemical compounds which are to be dried. The laminar gas flow removes the unwanted vapor which tends to form above the tray of chemical compound, thus accelerating the drying process.
摘要翻译：与化学化合物一起使用的干燥器采用受控真空，高温和干燥，惰性气体来干燥化学化合物。干燥机包括一个真空室，其中放置含有化合物的托盘。该腔室包括提升放置在腔室内的化学样品的温度的加热元件。供应和排空歧管，每个歧管各具有用于供应和排出干燥惰性气体的多个孔，提供干燥惰性气体的基本层流，正好在要干燥的化合物的塔板上方。层流气流除去易于形成化学化合物塔板上方的不需要的蒸汽，从而加速干燥过程。

5. 发明授权

US6058625A Rapid drying oven and methods for providing rapid drying of multiple samples 失效
公开(公告)号：US6058625A
公开(公告)日：2000-05-09
申请号：US314086
申请日：1999-05-18
申请人： Peter Kieselbach , Ilya Feygin , Joseph J. Brzezinski , Gregory L. Kirk , Thuc Nguyen , Joseph A. Mollica
发明人： Peter Kieselbach , Ilya Feygin , Joseph J. Brzezinski , Gregory L. Kirk , Thuc Nguyen , Joseph A. Mollica
IPC分类号： F26B5/04 , F26B9/06 , F26B21/00 , F26B21/14
CPC分类号： F26B5/044 , F26B21/004 , F26B21/14
摘要： A dryer for use with chemical compounds employs controlled vacuum, elevated temperature and dry, inert gas to dry the chemical compounds. The dryer includes a vacuum chamber into which trays containing the compounds are placed. The chamber includes heating elements which elevate the temperature of chemical samples placed within the chamber. Supplying and evacuating manifolds, each with a plurality of orifices for supplying and evacuating dry inert gas, provide a substantially laminar flow of dry inert gas just above the trays of chemical compounds which are to be dried. The laminar gas flow removes the unwanted vapor which tends to form above the tray of chemical compound, thus accelerating the drying process.

6. 发明授权

US5937536A Rapid drying oven for providing rapid drying of multiple samples 失效
标题翻译：快速干燥炉，用于快速干燥多个样品
公开(公告)号：US5937536A
公开(公告)日：1999-08-17
申请号：US944860
申请日：1997-10-06
申请人： Peter Kieselbach , Ilya Feygin , Joseph J. Brzezinski , Gregory L. Kirk , Thuc Nguyen , Joseph A. Mollica
发明人： Peter Kieselbach , Ilya Feygin , Joseph J. Brzezinski , Gregory L. Kirk , Thuc Nguyen , Joseph A. Mollica
IPC分类号： F26B5/04 , F26B9/06 , F26B21/00 , F26B21/14 , F26B13/30
CPC分类号： F26B5/044 , F26B21/004 , F26B21/14
摘要： A dryer for use with chemical compounds employs controlled vacuum, elevated temperature and dry, inert gas to dry the chemical compounds. The dryer includes a vacuum chamber into which trays containing the compounds are placed. The chamber includes heating elements which elevate the temperature of chemical samples placed within the chamber. Supplying and evacuating manifolds, each with a plurality of orifices for supplying and evacuating dry inert gas, provide a substantially laminar flow of dry inert gas just above the trays of chemical compounds which are to be dried. The laminar gas flow removes the unwanted vapor which tends to form above the tray of chemical compound, thus accelerating the drying process.
摘要翻译：与化学化合物一起使用的干燥器采用受控真空，高温和干燥，惰性气体来干燥化学化合物。干燥机包括一个真空室，其中放置含有化合物的托盘。该腔室包括提升放置在腔室内的化学样品的温度的加热元件。供应和排空歧管，每个歧管各具有用于供应和排出干燥惰性气体的多个孔，提供干燥惰性气体的基本层流，正好在要干燥的化合物的塔板上方。层流气流除去易于形成化学化合物塔板上方的不需要的蒸汽，从而加速干燥过程。

7. 发明授权

US06497155B1 Article comprising a particle retrieval device 失效
标题翻译：文章包括一个粒子检索装置
公开(公告)号：US06497155B1
公开(公告)日：2002-12-24
申请号：US09247722
申请日：1999-02-09
申请人： Ilya Feygin , Rhett L. Affleck , Aleksandr Grinberg , Thuc H. Nguyen
发明人： Ilya Feygin , Rhett L. Affleck , Aleksandr Grinberg , Thuc H. Nguyen
IPC分类号： G01N3510
CPC分类号： G01N35/10 , B01J2219/00376 , B01J2219/00414 , B01J2219/00468 , C40B60/14 , G01N15/0272 , G01N35/1074 , G01N2015/1486 , G01N2015/149 , G01N2035/00237 , G01N2035/00574 , G01N2035/1039 , Y10T436/114998 , Y10T436/119163
摘要： In one embodiment, a particle-retrieval device in accordance with the present teachings includes a receiver tube, vacuum-flow providing means and particle-disengaging means. The receiver tube is in fluid communication with the vacuum-flow providing means such that when flow is introduced into the vacuum-flow providing means, a suction or vacuum flow is developed at an end of the receiver tube. The suction causes a particle to adhere to the end of the receiver. A particle is disengaged by discontinuing the suction and, advantageously, by wetting the engaged particle.
摘要翻译：在一个实施例中，根据本教导的颗粒检索装置包括接收管，真空流提供装置和颗粒分离装置。接收管与真空流提供装置流体连通，使得当流入真空流提供装置时，吸收管或真空流在接收管的一端形成。吸力使颗粒粘附到接收器的末端。通过中断吸力并有利地通过润湿接合的颗粒来分离颗粒。

8. 发明授权

US5952240A Discrete matrix plate positioner 失效
标题翻译：离散矩阵板定位器
公开(公告)号：US5952240A
公开(公告)日：1999-09-14
申请号：US926389
申请日：1997-09-09
申请人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling
发明人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling
IPC分类号： G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： G01N35/028 , B01L2300/0893 , G01N2035/042 , G01N2035/0491 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/2575
摘要： A positive displacement positioner employs rigid stops and actuators to position a work piece, such as a microtiter plate, in any one of at least three positions. Positioner platforms, each of which is capable of moving a work piece between at least two distinct positions, are nested in order to multiply the number of positions available. For example, a two-position rigid stop positioner platform nested in a four-position rigid stop positioner platform, or a four-position rigid stop positioner platform nested in a two-position rigid stop positioner platform would permit the movement of a work piece to any one of eight distinct positions. A four-position platform nested inside a four-position platform yields sixteen positions, and so on. Each positioner platform preferably has a symmetrical polygonal outline and nested platforms provide displacement along each of the polygon's axes of symmetry. Consequently, a positioner will preferably provide displacement to any one of a number of positions.
摘要翻译：正位移定位器使用刚性止动件和致动器来将诸如微量滴定板的工件定位在至少三个位置中的任一个中。定位器平台（每个平台能够在至少两个不同的位置之间移动工件）被嵌套，以便乘以可用位置的数量。例如，嵌套在四位刚性停止定位器平台中的两位刚性停止定位器平台或嵌在两位置刚性停止定位器平台中的四位刚性停止定位器平台将允许工件移动到八个不同位置中的任何一个。嵌在四位平台中的四位平台产生十六个位置，依此类推。每个定位器平台优选地具有对称的多边形轮廓，并且嵌套平台沿着多边形的对称轴线提供位移。因此，定位器将优选地向多个位置中的任何一个提供位移。

9. 发明授权

US07179637B2 Apparatus and method for using intestinal segments or their substitutes in high-throughput analysis of compound absorption 失效
标题翻译：在化合物吸收的高通量分析中使用肠段或其替代物的装置和方法
公开(公告)号：US07179637B2
公开(公告)日：2007-02-20
申请号：US10225057
申请日：2002-08-21
申请人： Ilya Feygin , Rafail Kushak
发明人： Ilya Feygin , Rafail Kushak
IPC分类号： C12M3/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00423 , B01J2219/00585 , B01J2219/00599 , B01J2219/00756 , Y10S623/915 , Y10S623/917
摘要： An apparatus for high-throughput analysis of compound absorption in a controlled environment that closely resembles in-vivo conditions. The apparatus includes at least one tissue-receiving enclosure that is capable of interfacing (e.g., via transfer of fluids, electronically, etc.) with a variety of preparative devices and analytical instrumentation. In some variations, the tissue-receiving enclosure is formed from two housings, which, when engaged, have a capsular shape. The enclosure receives a tissue sample in the form of an un-everted or everted intestinal segment or tubular artificial membrane. The tissue sample is coupled to a generally cylindrical tissue support. The tissue support and the enclosure are axially aligned, and openings at the ends of the enclosure align with openings at the ends of the tissue support. Two feed fittings, one for each end of the enclosure, forcefully mate with the aligned openings in the housing and the tissue support. The feed fitting seals against the ends of the tissue support, forming “outer” and “inner” chambers within the enclosure, with the intestinal tissue being the interface between the chambers. It is across this interface that absorption occurs.
摘要翻译：用于在与体内条件非常相似的受控环境中高通量分析化合物吸收的装置。该装置包括至少一个能够与各种制备装置和分析仪器进行接口（例如通过流体，电子传递等）接触的组织接收外壳。在一些变型中，组织接收外壳由两个外壳形成，当外壳接合时，其具有荚膜形状。外壳接收非直肠或直肠肠段或管状人造膜形式的组织样本。组织样本联接到大致圆柱形的组织支撑。组织支撑件和外壳被轴向对齐，并且外壳端部处的开口与组织支撑件端部处的开口对齐。两个进给配件，一个用于外壳的每一端，与壳体和组织支撑件中对齐的开口强制配合。进料配件密封组织支撑件的端部，在外壳内形成“外”和“内”腔，肠组织是腔室之间的界面。在这个界面上，吸收发生。

10. 发明授权

US06644364B1 Article comprising a multi-channel dispensing head 失效
标题翻译：包括多通道分配头的物品
公开(公告)号：US06644364B1
公开(公告)日：2003-11-11
申请号：US10088150
申请日：2002-03-13
申请人： Ilya Feygin
发明人： Ilya Feygin
IPC分类号： B65B105
CPC分类号： B01L3/0265 , B01J3/002 , B01J3/03 , B01J4/02 , B01J2219/00274 , B01J2219/00315 , B01J2219/00317 , B01J2219/0036 , B01J2219/00369 , B01J2219/00585 , B01L2200/025 , B01L2200/146 , B01L2400/0633 , B01L2400/082 , C40B60/14 , G01N35/1065 , G01N2035/1041 , G01N2035/1044
摘要： A multi-channel fluid dispenser includes a reservoir (106) with multiple internal chambers (844) with ports (850) to fill each chamber (844), a multi-channel liquid dispensing head, a plurality of fluid-delivery conduits, and support and positioning elements.
摘要翻译：多通道流体分配器包括具有多个内室（844）的储存器（106），其具有用于填充每个室（844）的端口（850），多通道液体分配头，多个流体输送管道和支撑件和定位元件。

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