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1. 发明授权

US06410342B1 Method and apparatus for controlled photoelution 失效
标题翻译：用于控制光洗净的方法和装置
公开(公告)号：US06410342B1
公开(公告)日：2002-06-25
申请号：US08914861
申请日：1997-08-19
申请人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
发明人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00306 , B01J2219/00308 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , C07K1/04 , C07K1/12 , C40B60/14 , G01N33/54353
摘要： A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.
摘要翻译：公开了一种光可剥离接头连接的化合物的光洗脱方法，以及适用于实施该方法的装置。根据该方法，可光裂解的连接物连接的文库化合物在受控的曝光和受控温度的条件下从固体支持介质中光固化。适用于实施本发明的光洗涤方法的装置包括用于基本均匀地照射可光切割接头的装置，用于控制照明时间和强度的装置，以及用于控制样品温度的装置。

2. 发明授权

US06468787B1 Method and apparatus for controlled photoelution 失效
公开(公告)号：US06468787B1
公开(公告)日：2002-10-22
申请号：US09294169
申请日：1999-04-19
申请人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
发明人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
IPC分类号： C12M100
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00306 , B01J2219/00308 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , C07K1/04 , C07K1/12 , C40B60/14 , G01N33/54353
摘要： A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.

3. 发明授权

US06890491B1 Method and apparatus for universal fluid exchange 失效
标题翻译：通用流体交换方法和装置
公开(公告)号：US06890491B1
公开(公告)日：2005-05-10
申请号：US08872097
申请日：1997-06-10
申请人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling , Peter Kieselbach , Gregory Louis Kirk , Ian Henderson
发明人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling , Peter Kieselbach , Gregory Louis Kirk , Ian Henderson
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： B01L3/565 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00326 , B01J2219/00423 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , C40B60/14 , G01N35/025 , G01N35/10 , G01N2035/00534 , Y10T436/25375 , Y10T436/2575
摘要： A universal fluid exchange device includes upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.
摘要翻译：通用流体交换装置包括上部和下部反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到适当的接收船只。该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

4. 发明授权

US06497155B1 Article comprising a particle retrieval device 失效
标题翻译：文章包括一个粒子检索装置
公开(公告)号：US06497155B1
公开(公告)日：2002-12-24
申请号：US09247722
申请日：1999-02-09
申请人： Ilya Feygin , Rhett L. Affleck , Aleksandr Grinberg , Thuc H. Nguyen
发明人： Ilya Feygin , Rhett L. Affleck , Aleksandr Grinberg , Thuc H. Nguyen
IPC分类号： G01N3510
CPC分类号： G01N35/10 , B01J2219/00376 , B01J2219/00414 , B01J2219/00468 , C40B60/14 , G01N15/0272 , G01N35/1074 , G01N2015/1486 , G01N2015/149 , G01N2035/00237 , G01N2035/00574 , G01N2035/1039 , Y10T436/114998 , Y10T436/119163
摘要： In one embodiment, a particle-retrieval device in accordance with the present teachings includes a receiver tube, vacuum-flow providing means and particle-disengaging means. The receiver tube is in fluid communication with the vacuum-flow providing means such that when flow is introduced into the vacuum-flow providing means, a suction or vacuum flow is developed at an end of the receiver tube. The suction causes a particle to adhere to the end of the receiver. A particle is disengaged by discontinuing the suction and, advantageously, by wetting the engaged particle.
摘要翻译：在一个实施例中，根据本教导的颗粒检索装置包括接收管，真空流提供装置和颗粒分离装置。接收管与真空流提供装置流体连通，使得当流入真空流提供装置时，吸收管或真空流在接收管的一端形成。吸力使颗粒粘附到接收器的末端。通过中断吸力并有利地通过润湿接合的颗粒来分离颗粒。

5. 发明授权

US5952240A Discrete matrix plate positioner 失效
标题翻译：离散矩阵板定位器
公开(公告)号：US5952240A
公开(公告)日：1999-09-14
申请号：US926389
申请日：1997-09-09
申请人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling
发明人： Ilya Feygin , Rhett L. Affleck , Leslie A. Walling
IPC分类号： G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： G01N35/028 , B01L2300/0893 , G01N2035/042 , G01N2035/0491 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/2575
摘要： A positive displacement positioner employs rigid stops and actuators to position a work piece, such as a microtiter plate, in any one of at least three positions. Positioner platforms, each of which is capable of moving a work piece between at least two distinct positions, are nested in order to multiply the number of positions available. For example, a two-position rigid stop positioner platform nested in a four-position rigid stop positioner platform, or a four-position rigid stop positioner platform nested in a two-position rigid stop positioner platform would permit the movement of a work piece to any one of eight distinct positions. A four-position platform nested inside a four-position platform yields sixteen positions, and so on. Each positioner platform preferably has a symmetrical polygonal outline and nested platforms provide displacement along each of the polygon's axes of symmetry. Consequently, a positioner will preferably provide displacement to any one of a number of positions.
摘要翻译：正位移定位器使用刚性止动件和致动器来将诸如微量滴定板的工件定位在至少三个位置中的任一个中。定位器平台（每个平台能够在至少两个不同的位置之间移动工件）被嵌套，以便乘以可用位置的数量。例如，嵌套在四位刚性停止定位器平台中的两位刚性停止定位器平台或嵌在两位置刚性停止定位器平台中的四位刚性停止定位器平台将允许工件移动到八个不同位置中的任何一个。嵌在四位平台中的四位平台产生十六个位置，依此类推。每个定位器平台优选地具有对称的多边形轮廓，并且嵌套平台沿着多边形的对称轴线提供位移。因此，定位器将优选地向多个位置中的任何一个提供位移。

6. 发明申请

US20120163945A1 DRIVE ASSEMBLY FOR ROBOTIC CONVEYOR SYSTEM 审中-公开
标题翻译：用于机器人输送系统的驱动装置
公开(公告)号：US20120163945A1
公开(公告)日：2012-06-28
申请号：US13334619
申请日：2011-12-22
申请人： Robert K. Neeper , Rhett L. Affleck , John E. Lillig
发明人： Robert K. Neeper , Rhett L. Affleck , John E. Lillig
IPC分类号： B65G1/06
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： A storage and retrieval system is provided. The storage and retrieval system having a frame and a shuttle movable within the frame, the shuttle having a carriage extending at least partially between a top and bottom of the frame. At least one tension member extends between a first and second ends of the frame and is coupled to the shuttle. At least one drive member extends between the first and second ends of the frame and is coupled to the shuttle. The at least one drive member and the at least one tension member project from opposite sides of the shuttle towards respective first and second ends of the frame and effect stabilization of the carriage against at least rotation relative to the frame. The at least one tension member crosses the at least one drive member and the at least one drive member effects movement of the shuttle.
摘要翻译：提供存储和检索系统。存储和取回系统具有框架和可在框架内移动的梭子，梭子具有至少部分地在框架的顶部和底部之间延伸的托架。至少一个张紧构件在框架的第一和第二端之间延伸并且联接到梭子。至少一个驱动构件在框架的第一和第二端之间延伸并且联接到梭子。所述至少一个驱动构件和所述至少一个张紧构件从所述梭子的相对侧朝向所述框架的相应的第一和第二端突出，并且相对于所述框架至少使所述托架抵抗至少旋转。所述至少一个张紧构件穿过所述至少一个驱动构件，并且所述至少一个驱动构件影响所述梭的运动。

7. 外观设计

USD480815S1 Card carrying an array of compounds 失效
标题翻译：携带一系列化合物的卡
公开(公告)号：USD480815S1
公开(公告)日：2003-10-14
申请号：US29165712
申请日：2002-08-13
申请人： William R. Ewing , Robert K. Neeper , Rhett L. Affleck , Gordon W. Hudson , John F. Bridwell , John E. Lillig
设计人： William R. Ewing , Robert K. Neeper , Rhett L. Affleck , Gordon W. Hudson , John F. Bridwell , John E. Lillig

8. 发明申请

US20120103501A1 DEVICE AND METHOD FOR REMOVING A PEELABLE SEAL 有权
标题翻译：用于去除可剥离密封件的装置和方法
公开(公告)号：US20120103501A1
公开(公告)日：2012-05-03
申请号：US13284437
申请日：2011-10-28
申请人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
发明人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
IPC分类号： B32B38/10
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
摘要翻译：用可剥离密封件密封的容器或容器阵列通过输送机沿着处理路径被输送到一个吸引站，在该站处，具有基本上等于或大于密封件的宽度的宽度的粘合剂表面被压紧可剥离密封件的上表面。收集杆在粘合剂表面上施加向下的压力，当压板随着输送机移动时，将其压靠在密封件上并将容器或容器阵列保持在输送机上的适当位置。当密封的前缘通过收集杆时，粘合剂表面向上滚动，远离密封件的平面，在密封件的前缘上拉起，以将其与容器或容器阵列分开，同时容器或容器阵列被滚筒压住。然后将去除的密封件丢弃。

9. 发明授权

US07596251B2 Automated sample analysis system and method 有权
标题翻译：自动样本分析系统和方法
公开(公告)号：US07596251B2
公开(公告)日：2009-09-29
申请号：US10769462
申请日：2004-01-30
申请人： Rhett L. Affleck , Mike Bodnar , Robert K. Levin , John E. Lillig , Robert K. Neeper
发明人： Rhett L. Affleck , Mike Bodnar , Robert K. Levin , John E. Lillig , Robert K. Neeper
IPC分类号： G06K9/00 , A61B19/02 , A61C19/02 , B01L9/02 , A47B88/06
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An automated biological sample analysis system and method for use in incubating and analyzing multiple samples for protein crystallization. A temperature controlled cabinet houses sample storage, sample transport, and sample imaging systems. The operation of the system is automated and can be controlled by software, which can be reconfigured remotely. An array of storage shelves includes multiple shelf columns arranged around a core. Multiple banks of removable shelves arranged as magazines are accessed through a door on the cabinet. Each shelf stores a multi-well plate and different sizes can be stored in different shelves. The core houses a sample transport system that includes a multi-axis robot that rotates about a vertical axis to access the shelves in the shelf array. The transport system retrieves and replaces the multi-well plates in the shelves and can move plates from the shelves to an imaging system where each sample can be automatically imaged.
摘要翻译：一种用于孵化和分析多个样品进行蛋白质结晶的自动化生物样品分析系统和方法。温度控制柜包含样品储存，样品运输和样品成像系统。系统的操作是自动化的，可以通过软件进行控制，可以远程重新配置。一组存储架包括围绕一个核心布置的多个搁架列。可以通过柜子上的门访问多个排列成杂志的可移动货架。每个货架存储多孔板，不同的尺寸可以存放在不同的货架上。核心包含一个样品输送系统，其中包括一个绕垂直轴旋转的多轴机器人，以便进入架子阵列中的货架。运输系统检索和取代货架中的多孔板，并可将板从搁板移动到成像系统，每个样品可自动成像。

10. 发明申请

US20080216955A1 DEVICE AND METHOD FOR REMOVING A PEELABLE SEAL 有权
标题翻译：用于去除可剥离密封件的装置和方法
公开(公告)号：US20080216955A1
公开(公告)日：2008-09-11
申请号：US12045644
申请日：2008-03-10
申请人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
发明人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
IPC分类号： B32B38/10
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
摘要翻译：用可剥离密封件密封的容器或容器阵列通过输送机沿着处理路径被输送到一个吸引站，在该站处，具有基本上等于或大于密封件的宽度的宽度的粘合剂表面被压紧可剥离密封件的上表面。收集杆在粘合剂表面上施加向下的压力，当压板随着输送机移动时，将其压靠在密封件上并将容器或容器阵列保持在输送机上的适当位置。当密封的前缘通过收集杆时，粘合剂表面向上滚动，远离密封件的平面，在密封件的前缘上拉起，以将其与容器或容器阵列分开，同时容器或容器阵列被滚筒压住。然后将去除的密封件丢弃。

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