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1. 发明专利

JP2011140511A Protease inhibitor 有权
标题翻译： PROTEASE抑制剂
公开(公告)号：JP2011140511A
公开(公告)日：2011-07-21
申请号：JP2011068521
申请日：2011-03-25
申请人： Redox Bioscience Inc , レドックス・バイオサイエンス株式会社
发明人： YODOI JUNJI , NAKAMURA HAJIME , HOSHINO TOMOAKI , AIZAWA HISAMICHI
IPC分类号： A61K38/44 , A01K67/027 , A61K38/00 , A61K38/55 , A61K45/00 , A61K45/06 , A61K48/00 , A61P9/00 , A61P9/02 , A61P11/00 , A61P43/00 , C07K14/54 , C12N9/64 , C12N9/99 , C12N15/09 , G01N33/15 , G01N33/50
CPC分类号： A61K38/57 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K45/06 , C07K14/54 , C12N9/6475
摘要： PROBLEM TO BE SOLVED: To provide a new protease inhibitor, and to provide a definite-curative remedy and a therapeutic method for chronic obstructive pulmonary diseases, immunodeficiency syndrome, pulmonary alveolar proteinosis and circulatory diseases. SOLUTION: The protease inhibitor includes at least one or more selected from among (1) thioredoxin (TRX); (2) a protein composed of an amino acid sequence in which one or several amino acids in the amino acid sequence of the TRX are deleted, replaced or added, and having an activity similar to that of the TRX; (3) a gene encoding (1); and (4) a gene encoding (2), as active ingredients, and has inhibitory actions on caspase-1. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供新的蛋白酶抑制剂，并为慢性阻塞性肺疾病，免疫缺陷综合征，肺泡蛋白沉积和循环系统疾病提供一定的疗效和治疗方法。解决方案：蛋白酶抑制剂包括选自（1）硫氧还蛋白（TRX）中的至少一种或多种; （2）由TRX的氨基酸序列中的一个或几个氨基酸缺失，替换或添加并具有与TRX类似的活性的氨基酸序列组成的蛋白质; （3）编码（1）的基因; 和（4）编码（2）的基因作为活性成分，对胱天蛋白酶-1具有抑制作用。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011001269A External preparation for preventing or treating ultraviolet-induced dermatitis or primary irritant dermatitis 审中-公开
标题翻译：用于预防或治疗超紫外线诱发剂或主要刺激物的外用制剂
公开(公告)号：JP2011001269A
公开(公告)日：2011-01-06
申请号：JP2009142868
申请日：2009-06-16
申请人： Yuma Hoshino , Chikako Nishigori , Redox Bioscience Inc , Theravalues Corp , Junji Yodoi , レドックス・バイオサイエンス株式会社 , 勇馬星野 , 株式会社セラバリューズ , 淳司淀井 , 千佳子錦織
发明人： NISHIGORI CHIKAKO , HOSHINO YUMA , YODOI JUNJI , FUKUNAGA ATSUSHI , ONO RYUSUKE
IPC分类号： A61K38/44 , A61K31/728 , A61P17/16 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a topically administrable prophylactic and therapeutic agent for ultraviolet-induced dermatitis or primary irritant dermatitis.SOLUTION: The external preparation for preventing or treating ultraviolet-induced dermatitis or primary irritant dermatitis includes a polypeptide belonging to the thioredoxin super family as an effective ingredient.
摘要翻译：要解决的问题：提供一种用于紫外线诱发的皮炎或原发性刺激性皮炎的局部施用的预防和治疗剂。解决方案：用于预防或治疗紫外线诱发的皮炎或原发性刺激性皮炎的外用制剂包括属于硫氧还蛋白超家族的多肽作为有效成分。

3. 发明专利

JP2010090055A Medicine for administration to pregnant woman 有权
标题翻译：用于管理孕妇的药物
公开(公告)号：JP2010090055A
公开(公告)日：2010-04-22
申请号：JP2008261081
申请日：2008-10-07
申请人： Redox Bioscience Inc , レドックス・バイオサイエンス株式会社
发明人： YODOI JUNJI , MIURA MIKIKO , YANAGIHARA ITARU , NANBA FUMIHIKO , NAKAHIRA KUMIKO
IPC分类号： A61K38/00 , A61K9/06 , A61K9/08 , A61P11/00 , A61P15/06 , A61P29/00 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide a medicine for administration to a pregnant woman not only having a premature delivery-preventing effect but also inhibiting the lung inflammation of a fetus, frequently developing as a complication to the premature delivery and also having less adverse effects. SOLUTION: This medicine for administration to the pregnant woman is provided by containing ≥1 kind of a polypeptide of a thioredoxin family and/or its inducing agent as an active ingredient, and having the preventive effect of the premature delivery and an anti-inflammatory effect to the lung of the fetus. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了向孕妇提供一种药物，其不仅具有过早的预防交叉作用，而且抑制胎儿的肺部炎症，经常发展为早产的并发症，并且具有较少的不利影响。该药用于对孕妇进行给药，是通过含有≥1种硫氧还蛋白家族的多肽和/或其诱导剂作为活性成分而提供的，具有预防性输送的预防作用，对胎儿肺的炎症作用。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009178087A Method for producing liquors or fermented seasoning 审中-公开
标题翻译：生产液体或发酵季节的方法
公开(公告)号：JP2009178087A
公开(公告)日：2009-08-13
申请号：JP2008019636
申请日：2008-01-30
申请人： Kizakura Co Ltd , Kyoto Univ , Redox Bioscience Inc , レドックス・バイオサイエンス株式会社 , 国立大学法人京都大学 , 黄桜株式会社
发明人： YODOI JUNJI , INOUE YOSHIHARU , WAKAI YOSHINORI , KIYOKAWA YOSHIFUMI , KITAOKA ATSUSHI , KATO NORIKO
IPC分类号： C12G3/02 , A23L27/24 , A23L33/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing liquors such as Sake containing thioredoxin produced with a yeast at a high concentration, other brewed liquors, sparkling liquors, or mixed liquors, or a fermented seasoning by adding an improvement to a conventional brewing process using the yeast.
SOLUTION: Unrefined Sake preparation is carried out by setting preparation conditions so as to have a yeast death rate before filtration of 5% or more, preferably 10% or more in a step of brewing the Sake, the other brewed liquors, the sparkling liquors, or the mixed liquors, or the fermented seasoning using the yeast. The yeast used, a change in material temperature, an alcohol concentration during fermentation, and a fermentation period are included in the preparation conditions. The unrefined Sake is passed through by applying a thermal stress and an alcohol stress to the yeast at a material temperature slightly higher than usual temperature and a high alcohol concentration of 17% or more. Thereby, the thioredoxin in yeast fungal bodies can be released to the outside of the fungal bodies to produce the liquors such as the Sake with a high thioredoxin content and the fermented seasoning.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产含有高浓度酵母生产的硫氧还蛋白的酒精的液体的方法，其他酿造的酒，起泡酒或混合液，或发酵调味料的添加方法常规酿造工艺使用酵母。解决方案：通过制备制备条件进行未精制的清酒制备，以在过滤之前的酵母死亡率为5％以上，优选为10％以上，在酿造酒，其他酿造液，起泡酒或混合液，或使用酵母的发酵调味料。在制备条件中包括使用的酵母，物质温度的变化，发酵过程中的酒精浓度和发酵时间。通过在比通常温度稍高的酒精浓度和17％以上的高酒精浓度的物质温度下对酵母施加热应激和酒精应激来通过未精制的Sake。因此，酵母真菌体中的硫氧还蛋白可以释放到真菌体的外部，以产生具有高硫氧还蛋白含量的酒和发酵调味料的液体。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2013165725A Process for producing thioredoxin 审中-公开
标题翻译：生产噻二酮的方法
公开(公告)号：JP2013165725A
公开(公告)日：2013-08-29
申请号：JP2013080461
申请日：2013-04-08
申请人： Kyoto Univ , 国立大学法人京都大学 , Redox Bioscience Inc , レドックス・バイオサイエンス株式会社 , Kizakura Co Ltd , 黄桜株式会社
发明人： YODOI JUNJI , INOUE YOSHIHARU , IZAWA SHINGO , MASUTANI HIROSHI , MURATA KAZUO , TAMASU SHOGO
IPC分类号： C12P21/02
CPC分类号： C12P21/02 , C12N9/0036
摘要： PROBLEM TO BE SOLVED: To provide a process for conveniently and efficiently producing high-purity thioredoxin from yeast.SOLUTION: In the production of thioredoxin using yeast, thioredoxin is produced through the following steps (1) to (3): (1) culturing the yeast; (2) stressing the yeast obtained in the step (1) to cause a release of thioredoxin from a cell of the yeast; and (3) collecting the thioredoxin released from the yeast cell.
摘要翻译：要解决的问题：提供从酵母中方便有效地生产高纯度硫氧还蛋白的方法。解决方案：在使用酵母生产硫氧还蛋白的过程中，硫氧还蛋白通过以下步骤（1）至（3）产生：（1）培养酵母（2）强调在步骤（1）中获得的酵母，以使酵母中的硫氧还蛋白释放出来; 和（3）收集从酵母细胞释放的硫氧还蛋白。

6. 发明专利

JP2012167121A Preventive or therapeutic agent for inflammatory ocular-surface disease 有权
标题翻译：用于炎症性表面疾病的预防或治疗药物
公开(公告)号：JP2012167121A
公开(公告)日：2012-09-06
申请号：JP2012116025
申请日：2012-05-21
申请人： Redox Bioscience Inc , レドックス・バイオサイエンス株式会社
发明人： YODOI JUNJI , NAKAMURA HAJIME , KINOSHITA SHIGERU , SOTOZONO CHIE
IPC分类号： A61K38/44 , A61K9/06 , A61K9/08 , A61P27/02 , A61P29/00 , C07K14/52 , C12N15/09
CPC分类号： A61K9/0048 , A61K38/07 , A61K38/44 , C12Y108/01008
摘要： PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent for inflammatory ocular-surface diseases.SOLUTION: The invention provides a preventive or therapeutic agent for inflammatory ocular-surface diseases, which comprises polypeptides of thioredoxin superfamily as an active ingredient.
摘要翻译：待解决的问题：提供用于炎症性眼表面疾病的预防或治疗剂。解决方案：本发明提供了一种炎症性眼表疾病的预防或治疗剂，其包含硫氧还蛋白超家族的多肽作为活性成分。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2012025776A Function restoration agent for retina neurocyte 有权
标题翻译：功能恢复剂RETINA神经网络
公开(公告)号：JP2012025776A
公开(公告)日：2012-02-09
申请号：JP2011229233
申请日：2011-10-18
申请人： Redox Bioscience Inc , レドックス・バイオサイエンス株式会社
发明人： YODOI JUNJI , NAKAMURA HAJIME , MASUTANI HIROSHI , TANIDO MASAKI , HAKU KIYOSHI
IPC分类号： A61K38/00 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a function restoration agent for a retina neurocyte.SOLUTION: This function restoration agent for the retina neurocyte contains, as effective components, one kind, two kinds or more of polypeptides belonging to a family having a sequence of Cys-Gly-Pro-Cys, Cys-Pro-Tyr-Cys, Cys-Pro-His-Cys or Cys-Pro-Pro-Cys, and having thioredoxin activity.
摘要翻译：要解决的问题：提供视网膜神经细胞的功能恢复剂。解决方案：视网膜神经细胞的功能恢复剂含有属于具有Cys-Gly-Pro-Cys，Cys-Pro-Tyr-Cys序列的家族的一种，两种以上的多肽作为有效成分， Cys，Cys-Pro-His-Cys或Cys-Pro-Pro-Cys，并具有硫氧还蛋白活性。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2009143818A Preventive or therapeutic agent containing anti-thioredoxin antibody polypeptide as active ingredient for disorder 审中-公开
标题翻译：含抗坏血酸抗体多肽作为主要成分的预防或治疗药物
公开(公告)号：JP2009143818A
公开(公告)日：2009-07-02
申请号：JP2007320233
申请日：2007-12-11
申请人： Redox Bioscience Inc , Junji Yodoi , レドックス・バイオサイエンス株式会社 , 淳司淀井
发明人： YODOI JUNJI , SON YASUO , KONDO NORIHIKO , NAKAMURA HAJIME , HARA TOMIJIRO , KATO NORIKO
IPC分类号： A61K39/395 , A23L1/305 , A61K38/00 , A61P1/04 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P11/06 , A61P11/16 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/08 , A61P43/00 , C07K16/18
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/77
摘要： PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent exhibiting high effects against disorders induced by an MIF (macrophage migration inhibitory factor) and vascular system disorders, and having fewer side effects. SOLUTION: The preventive or therapeutic agent containing a polypeptide of an anti-thioredoxin antibody is effective for the disorders induced by the macrophage migration inhibitory factor and the vascular system disorders. In particular, the anti-thioredoxin antibody inhibits a cell internalization of the macrophage migration inhibitory factor, and inhibits the adherence of leukocyte to vascular endothelial cell. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供对MIF（巨噬细胞迁移抑制因子）和血管系统疾病诱导的病症表现出高效果并且具有较少副作用的预防或治疗剂。解决方案：含有抗硫氧还蛋白抗体多肽的预防或治疗剂对于由巨噬细胞迁移抑制因子和血管系统疾病诱导的病症是有效的。特别地，抗硫氧还蛋白抗体抑制巨噬细胞迁移抑制因子的细胞内化，并抑制白血球对血管内皮细胞的粘附。版权所有（C）2009，JPO＆INPIT

9. 发明公开

EP2363475A4 SCREENING METHOD, COMPOSITION CONTAINING SUBSTANCE SELECTED BY THE SCREENING METHOD, AND BINDING SUBSTANCE 审中-公开
标题翻译：检查方法，成分与程序选择的材料的筛选和结合物质
公开(公告)号：EP2363475A4
公开(公告)日：2012-07-18
申请号：EP09829147
申请日：2009-11-26
申请人： REDOX BIOSCIENCE INC
发明人： YODOI JUNJI , KONDO NORIHIKO , SON AOI , KATO NORIKO , HARA TOMIJIRO , HORIBE TOMOHISA
IPC分类号： C12N15/09 , C07D307/935 , C07K5/037 , C07K14/47 , G01N21/27 , G01N33/53
CPC分类号： C12Y108/01008 , C07D307/935 , C12N9/0036 , C12N15/1055 , G01N2500/00

10. 发明公开

EP1716860A4 PREVENTIVE AND THERAPEUTIC AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：手段防治慢性阻塞性肺疾病
公开(公告)号：EP1716860A4
公开(公告)日：2008-03-05
申请号：EP05710288
申请日：2005-02-09
申请人： REDOX BIOSCIENCE INC
发明人： YODOI JUNJI , SON AOI , NAKAMURA HAJIME
IPC分类号： A61K38/00 , A61K38/44 , A61P11/00
CPC分类号： A61K38/44
摘要： [PROBLEMS] To provide a preventive and therapeutic agent of high efficacy with reduced side effects for chronic obstructive pulmonary disease. [MEANS FOR SOLVING PROBLEMS] There is provided a preventive and therapeutic agent for chronic obstructive pulmonary disease, comprising a thioredoxin superfamily polypeptide as an active ingredient.

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