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1. 发明专利

JP2008231000A Thioredoxin-containing extract and method for producing the same 审中-公开
标题翻译：含硫三环素的提取物及其生产方法
公开(公告)号：JP2008231000A
公开(公告)日：2008-10-02
申请号：JP2007070869
申请日：2007-03-19
申请人： Kizakura Co Ltd , Kyoto Univ , Redox Bioscience Inc , レドックス・バイオサイエンス株式会社 , 国立大学法人京都大学 , 黄桜株式会社
发明人： YODOI JIYUNJI , INOUE YOSHIHARU , WAKAI YOSHINORI , KIYOKAWA YOSHIFUMI , KITAOKA ATSUSHI , MURATA KAZUO , KATO NORIKO
IPC分类号： C07K14/395 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an extract containing thioredoxin derived from yeasts in high purity by a simple and effective means.
SOLUTION: This method for producing the thioredoxin-containing extract containing the thioredoxin in high purity is provided by separating fractions having ≥10,000 Da molecular weight from yeast alcohol fermented products such as sake, fermented seasoning, beer, low-malt beer, etc.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种以简单有效的方式生产含有高纯度酵母的硫氧还蛋白的提取物的方法。解决方案：通过从酵母醇发酵产物如酒，发酵调味料，啤酒，低麦芽啤酒中分离具有≥1000Da分子量的级分，提供含有高纯度硫氧还蛋白的含硫氧还蛋白的提取物的方法，版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2009178087A Method for producing liquors or fermented seasoning 审中-公开
标题翻译：生产液体或发酵季节的方法
公开(公告)号：JP2009178087A
公开(公告)日：2009-08-13
申请号：JP2008019636
申请日：2008-01-30
申请人： Kizakura Co Ltd , Kyoto Univ , Redox Bioscience Inc , レドックス・バイオサイエンス株式会社 , 国立大学法人京都大学 , 黄桜株式会社
发明人： YODOI JUNJI , INOUE YOSHIHARU , WAKAI YOSHINORI , KIYOKAWA YOSHIFUMI , KITAOKA ATSUSHI , KATO NORIKO
IPC分类号： C12G3/02 , A23L27/24 , A23L33/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing liquors such as Sake containing thioredoxin produced with a yeast at a high concentration, other brewed liquors, sparkling liquors, or mixed liquors, or a fermented seasoning by adding an improvement to a conventional brewing process using the yeast.
SOLUTION: Unrefined Sake preparation is carried out by setting preparation conditions so as to have a yeast death rate before filtration of 5% or more, preferably 10% or more in a step of brewing the Sake, the other brewed liquors, the sparkling liquors, or the mixed liquors, or the fermented seasoning using the yeast. The yeast used, a change in material temperature, an alcohol concentration during fermentation, and a fermentation period are included in the preparation conditions. The unrefined Sake is passed through by applying a thermal stress and an alcohol stress to the yeast at a material temperature slightly higher than usual temperature and a high alcohol concentration of 17% or more. Thereby, the thioredoxin in yeast fungal bodies can be released to the outside of the fungal bodies to produce the liquors such as the Sake with a high thioredoxin content and the fermented seasoning.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产含有高浓度酵母生产的硫氧还蛋白的酒精的液体的方法，其他酿造的酒，起泡酒或混合液，或发酵调味料的添加方法常规酿造工艺使用酵母。解决方案：通过制备制备条件进行未精制的清酒制备，以在过滤之前的酵母死亡率为5％以上，优选为10％以上，在酿造酒，其他酿造液，起泡酒或混合液，或使用酵母的发酵调味料。在制备条件中包括使用的酵母，物质温度的变化，发酵过程中的酒精浓度和发酵时间。通过在比通常温度稍高的酒精浓度和17％以上的高酒精浓度的物质温度下对酵母施加热应激和酒精应激来通过未精制的Sake。因此，酵母真菌体中的硫氧还蛋白可以释放到真菌体的外部，以产生具有高硫氧还蛋白含量的酒和发酵调味料的液体。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2009207398A Vector for transforming chloroplast of compositae family plant, human thioredoxin-producing transformed plant and production method thereof as well as composition containing human thioredoxin 审中-公开
标题翻译：用于改变组合物家族植物氯化物的生物转化植物和生产方法以及作为包含人硫酸素的组合物的生产方法
公开(公告)号：JP2009207398A
公开(公告)日：2009-09-17
申请号：JP2008052709
申请日：2008-03-03
申请人： Kyoto Univ , Nara Institute Of Science & Technology , 国立大学法人奈良先端科学技術大学院大学 , 国立大学法人京都大学
发明人： YOKOTA AKIO , ASHIDA HIROKI , YODOI JUNJI , MASUTANI HIROSHI , KATO NORIKO
IPC分类号： C12N15/09 , A01H1/00 , A01H5/00 , A61K38/00 , A61P3/00 , A61P3/10 , A61P9/10 , A61P11/00
摘要： PROBLEM TO BE SOLVED: To provide a low-cost and convenient method for producing human thioredoxin by which human thioredoxin free from microorganism-derived endotoxin can be produced. SOLUTION: Disclosed are: a vector for transforming chloroplast of Compositae family plant; chloroplast-transformed chrysanthemum plant expressing human thioredoxin by transforming the chloroplast of chrysanthemum plant; a production method thereof; and a human thioredoxin-containing composition containing human thioredoxin extracted from the transformed Compositae family plant. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产人硫氧还蛋白的低成本和方便的方法，通过该方法可以生产不含微生物的内毒素的人硫氧还蛋白。解决方案：公开了用于转化菊科植物叶绿体的载体; 叶绿体转化的菊花植物，通过转化菊花植物的叶绿体表达人硫氧还蛋白; 其制造方法; 和含有硫氧还蛋白的组合物，其含有从转化的菊科植物提取的人硫氧还蛋白。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2009143818A Preventive or therapeutic agent containing anti-thioredoxin antibody polypeptide as active ingredient for disorder 审中-公开
标题翻译：含抗坏血酸抗体多肽作为主要成分的预防或治疗药物
公开(公告)号：JP2009143818A
公开(公告)日：2009-07-02
申请号：JP2007320233
申请日：2007-12-11
申请人： Redox Bioscience Inc , Junji Yodoi , レドックス・バイオサイエンス株式会社 , 淳司淀井
发明人： YODOI JUNJI , SON YASUO , KONDO NORIHIKO , NAKAMURA HAJIME , HARA TOMIJIRO , KATO NORIKO
IPC分类号： A61K39/395 , A23L1/305 , A61K38/00 , A61P1/04 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P11/06 , A61P11/16 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P37/00 , A61P37/08 , A61P43/00 , C07K16/18
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/77
摘要： PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent exhibiting high effects against disorders induced by an MIF (macrophage migration inhibitory factor) and vascular system disorders, and having fewer side effects. SOLUTION: The preventive or therapeutic agent containing a polypeptide of an anti-thioredoxin antibody is effective for the disorders induced by the macrophage migration inhibitory factor and the vascular system disorders. In particular, the anti-thioredoxin antibody inhibits a cell internalization of the macrophage migration inhibitory factor, and inhibits the adherence of leukocyte to vascular endothelial cell. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供对MIF（巨噬细胞迁移抑制因子）和血管系统疾病诱导的病症表现出高效果并且具有较少副作用的预防或治疗剂。解决方案：含有抗硫氧还蛋白抗体多肽的预防或治疗剂对于由巨噬细胞迁移抑制因子和血管系统疾病诱导的病症是有效的。特别地，抗硫氧还蛋白抗体抑制巨噬细胞迁移抑制因子的细胞内化，并抑制白血球对血管内皮细胞的粘附。版权所有（C）2009，JPO＆INPIT

5. 发明公开

EP2363475A4 SCREENING METHOD, COMPOSITION CONTAINING SUBSTANCE SELECTED BY THE SCREENING METHOD, AND BINDING SUBSTANCE 审中-公开
标题翻译：检查方法，成分与程序选择的材料的筛选和结合物质
公开(公告)号：EP2363475A4
公开(公告)日：2012-07-18
申请号：EP09829147
申请日：2009-11-26
申请人： REDOX BIOSCIENCE INC
发明人： YODOI JUNJI , KONDO NORIHIKO , SON AOI , KATO NORIKO , HARA TOMIJIRO , HORIBE TOMOHISA
IPC分类号： C12N15/09 , C07D307/935 , C07K5/037 , C07K14/47 , G01N21/27 , G01N33/53
CPC分类号： C12Y108/01008 , C07D307/935 , C12N9/0036 , C12N15/1055 , G01N2500/00

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