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1. 发明专利

JP2013165725A Process for producing thioredoxin 审中-公开
标题翻译：生产噻二酮的方法
公开(公告)号：JP2013165725A
公开(公告)日：2013-08-29
申请号：JP2013080461
申请日：2013-04-08
申请人： Kyoto Univ , 国立大学法人京都大学 , Redox Bioscience Inc , レドックス・バイオサイエンス株式会社 , Kizakura Co Ltd , 黄桜株式会社
发明人： YODOI JUNJI , INOUE YOSHIHARU , IZAWA SHINGO , MASUTANI HIROSHI , MURATA KAZUO , TAMASU SHOGO
IPC分类号： C12P21/02
CPC分类号： C12P21/02 , C12N9/0036
摘要： PROBLEM TO BE SOLVED: To provide a process for conveniently and efficiently producing high-purity thioredoxin from yeast.SOLUTION: In the production of thioredoxin using yeast, thioredoxin is produced through the following steps (1) to (3): (1) culturing the yeast; (2) stressing the yeast obtained in the step (1) to cause a release of thioredoxin from a cell of the yeast; and (3) collecting the thioredoxin released from the yeast cell.
摘要翻译：要解决的问题：提供从酵母中方便有效地生产高纯度硫氧还蛋白的方法。解决方案：在使用酵母生产硫氧还蛋白的过程中，硫氧还蛋白通过以下步骤（1）至（3）产生：（1）培养酵母（2）强调在步骤（1）中获得的酵母，以使酵母中的硫氧还蛋白释放出来; 和（3）收集从酵母细胞释放的硫氧还蛋白。

2. 发明专利

JP2009108009A Antioxidative enzyme inducer 有权
标题翻译：抗氧化酶诱导剂
公开(公告)号：JP2009108009A
公开(公告)日：2009-05-21
申请号：JP2007284529
申请日：2007-10-31
申请人： Kyoto Univ , Rock Field Co Ltd , 国立大学法人京都大学 , 株式会社ロック・フィールド
发明人： YODOI JUNJI , MASUTANI HIROSHI , YAMAGUCHI YOSHIMI , OTSUKI RYOKO , TAKENAKA MASAHIRO , KUNIMOTO YUJI , KANO YUKIE
IPC分类号： A61K31/11 , A23L1/30 , A61K8/35 , A61P1/04 , A61P1/16 , A61P17/18 , A61P39/06 , A61Q19/00 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a superior antioxidative enzyme inducer inducing the expression of an antioxidative enzyme, a medicinal composition using it and a screening method of the antioxidative substance.
SOLUTION: The antioxidative enzyme inducer contains a compound having an α, β-unsaturated bond as expressed by general formula (1). The medicinal composition and the screening method of the antioxidative substance are presented. In the formula, R
1 represents a hydrogen atom, a 1-8C alkyl group, 3-8C cycloalkyl group, a 1-8C alkenyl group or an aryl group each optionally substituted by a hydroxy group; R
2 represents a hydrogen atom or a 1-8C alkyl group; R
1 may bond to C
x in place of the hydrogen atom directly bonded to C
x to form a cyclohexene ring or a cyclohexadiene ring; at least one group selected from among the group consisting of 1-8C alkyl groups and 1-8C alkenyl groups may be substituted on the cyclohexene ring or the cyclohexadiene ring.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供诱导抗氧化酶表达的优良抗氧化酶诱导剂，使用它的药物组合物和抗氧化物质的筛选方法。解决方案：抗氧化酶诱导剂含有通式（1）表示的具有α，β-不饱和键的化合物。介绍了抗氧化物质的药物组成和筛选方法。在该式中，R 1表示氢原子，1-8C烷基，3-8C环烷基，1-8C烯基或任选被羟基取代的芳基; R SB 2表示氢原子或1-8C烷基; R 1 可以键合到C X 而不是直接键合到C 上的氢原子以形成环己烯环或环己二烯环; 选自1-8C烷基和1-8C烯基的至少一个基团可以在环己烯环或环己二烯环上被取代。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2009207398A Vector for transforming chloroplast of compositae family plant, human thioredoxin-producing transformed plant and production method thereof as well as composition containing human thioredoxin 审中-公开
标题翻译：用于改变组合物家族植物氯化物的生物转化植物和生产方法以及作为包含人硫酸素的组合物的生产方法
公开(公告)号：JP2009207398A
公开(公告)日：2009-09-17
申请号：JP2008052709
申请日：2008-03-03
申请人： Kyoto Univ , Nara Institute Of Science & Technology , 国立大学法人奈良先端科学技術大学院大学 , 国立大学法人京都大学
发明人： YOKOTA AKIO , ASHIDA HIROKI , YODOI JUNJI , MASUTANI HIROSHI , KATO NORIKO
IPC分类号： C12N15/09 , A01H1/00 , A01H5/00 , A61K38/00 , A61P3/00 , A61P3/10 , A61P9/10 , A61P11/00
摘要： PROBLEM TO BE SOLVED: To provide a low-cost and convenient method for producing human thioredoxin by which human thioredoxin free from microorganism-derived endotoxin can be produced. SOLUTION: Disclosed are: a vector for transforming chloroplast of Compositae family plant; chloroplast-transformed chrysanthemum plant expressing human thioredoxin by transforming the chloroplast of chrysanthemum plant; a production method thereof; and a human thioredoxin-containing composition containing human thioredoxin extracted from the transformed Compositae family plant. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产人硫氧还蛋白的低成本和方便的方法，通过该方法可以生产不含微生物的内毒素的人硫氧还蛋白。解决方案：公开了用于转化菊科植物叶绿体的载体; 叶绿体转化的菊花植物，通过转化菊花植物的叶绿体表达人硫氧还蛋白; 其制造方法; 和含有硫氧还蛋白的组合物，其含有从转化的菊科植物提取的人硫氧还蛋白。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2006109754A Food inducing expression of thioredoxin 审中-公开
标题翻译：食物诱导表达THIOREDOXIN
公开(公告)号：JP2006109754A
公开(公告)日：2006-04-27
申请号：JP2004300282
申请日：2004-10-14
申请人： Redox Bioscience Inc , Rock Field Co Ltd , レドックス・バイオサイエンス株式会社 , 株式会社ロック・フィールド
发明人： YODOI JIYUNJI , MASUTANI HIROSHI , NAKAMURA HAJIME , TANIDO MASAKI , KUNIMOTO YUJI , KANO YUKIE , HARA TOMIJIRO , FUJIKURA MAI
IPC分类号： A23L1/30 , A61K36/00 , A61K36/18 , A61P39/06 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide food inducing expression of thioredoxin comprising safe drink and food inducing expression of thioredoxin, specifically, softening influence caused by oxidation stress. SOLUTION: The drink and food contains sulforaphane comprising extract from crucifers. The extract contains 0.01-50 mg/g of the sulforaphane. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供诱导表达硫氧还蛋白的食物，其包括安全饮料和诱导硫氧还蛋白表达的食物，具体地，由氧化应激引起的软化影响。
解决方案：饮料和食物含有包含十字花科植物提取物的萝卜硫素。提取物含有0.01-50mg / g的萝卜硫素。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2012025776A Function restoration agent for retina neurocyte 有权
标题翻译：功能恢复剂RETINA神经网络
公开(公告)号：JP2012025776A
公开(公告)日：2012-02-09
申请号：JP2011229233
申请日：2011-10-18
申请人： Redox Bioscience Inc , レドックス・バイオサイエンス株式会社
发明人： YODOI JUNJI , NAKAMURA HAJIME , MASUTANI HIROSHI , TANIDO MASAKI , HAKU KIYOSHI
IPC分类号： A61K38/00 , A61P27/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a function restoration agent for a retina neurocyte.SOLUTION: This function restoration agent for the retina neurocyte contains, as effective components, one kind, two kinds or more of polypeptides belonging to a family having a sequence of Cys-Gly-Pro-Cys, Cys-Pro-Tyr-Cys, Cys-Pro-His-Cys or Cys-Pro-Pro-Cys, and having thioredoxin activity.
摘要翻译：要解决的问题：提供视网膜神经细胞的功能恢复剂。解决方案：视网膜神经细胞的功能恢复剂含有属于具有Cys-Gly-Pro-Cys，Cys-Pro-Tyr-Cys序列的家族的一种，两种以上的多肽作为有效成分， Cys，Cys-Pro-His-Cys或Cys-Pro-Pro-Cys，并具有硫氧还蛋白活性。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2004010574A NERVE REGENERATION FACTOR 审中-公开
公开(公告)号：JP2004010574A
公开(公告)日：2004-01-15
申请号：JP2002169204
申请日：2002-06-10
申请人： REDOX BIOSCIENCE INC , YODOI JIYUNJI , NAKAMURA HAJIME , MASUTANI HIROSHI , TANIDO MASAKI , HAKU KIYOSHI
发明人： YODOI JIYUNJI , NAKAMURA HAJIME , MASUTANI HIROSHI , TANIDO MASAKI , HAKU KIYOSHI
IPC分类号： A61K38/22 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P43/00 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide an agent for the treatment of diseases treatable by the regeneration of nerve such as Alzheimer's disease, Parkinson's disease and blindness. SOLUTION: The nerve regeneration agent contains one or more substances selected from polypeptides belonging to a family having thioredoxin activity. The polypeptide belonging to the family having thioredoxin activity is widely extended from oligopeptides to polypeptides (protein) provided that the substance has thioredoxin activity. Especially preferable polypeptides are human thioredoxin and yeast thioredoxin. COPYRIGHT: (C)2004,JPO

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