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1. 发明授权

US10646184B2 Automatic road mapping for heart valve replacement 有权
公开(公告)号：US10646184B2
公开(公告)日：2020-05-12
申请号：US13133693
申请日：2009-12-07
申请人： Raoul Florent , Nicolaas Hylke Bakker
发明人： Raoul Florent , Nicolaas Hylke Bakker
IPC分类号： A61B6/00 , A61B6/12 , G06T7/00 , A61B17/00 , A61F2/24 , A61B90/00 , A61B34/10
摘要： The present invention relates to a method for automatic road mapping for heart valve replacement and an examination apparatus for automatic road mapping for heart valve replacement. In order to provide the cardiologist or surgeon with better information during PHV implantation, an examination apparatus for automatic roadmapping for heart valve replacement is provided, that comprises at least one X-ray image acquisition device (10), a calculation unit (18) and a display device (20). The image acquisition device is adapted to acquire (32) at least one X-ray image of a vessel root region of a heart with injected contrast agent and to acquire (46) at least one current fluoroscopy image of the vessel root region with a replacement valve inserted into the vessel. The calculation unit is adapted to identify (34) vessel information data within the at least one acquired image, to model (36) vessel root representation using the vessel information data and to generate (44) a composite image by a combination of the model of the vessel root representation with the at least one fluoroscopy image. The display unit is adapted to display (48) the composite image.

2. 发明申请

US20110249794A1 AUTOMATIC ROAD MAPPING FOR HEART VALVE REPLACEMENT 审中-公开
标题翻译：用于心瓣置换的自动路径绘图
公开(公告)号：US20110249794A1
公开(公告)日：2011-10-13
申请号：US13133693
申请日：2009-12-07
申请人： Raoul Florent , Nicolaas Hylke Bakker
发明人： Raoul Florent , Nicolaas Hylke Bakker
IPC分类号： G01N23/04
CPC分类号： A61B6/504 , A61B6/12 , A61B6/463 , A61B6/481 , A61B6/503 , A61B6/5235 , A61B2017/00243 , A61B2034/105 , A61B2090/376 , A61F2/24 , G06T7/0012 , G06T2207/10116 , G06T2207/10121 , G06T2207/20212 , G06T2207/30048 , G06T2207/30101
摘要： The present invention relates to a method for automatic road mapping for heart valve replacement and an examination apparatus for automatic road mapping for heart valve replacement. In order to provide the cardiologist or surgeon with better information during PHV implantation, an examination apparatus for automatic roadmapping for heart valve replacement is provided, that comprises at least one X-ray image acquisition device (10), a calculation unit (18) and a display device (20). The image acquisition device is adapted to acquire (32) at least one X-ray image of a vessel root region of a heart with injected contrast agent and to acquire (46) at least one current fluoroscopy image of the vessel root region with a replacement valve inserted into the vessel. The calculation unit is adapted to identify (34) vessel information data within the at least one acquired image, to model (36) vessel root representation using the vessel information data and to generate (44) a composite image by a combination of the model of the vessel root representation with the at least one fluoroscopy image. The display unit is adapted to display (48) the composite image.
摘要翻译：本发明涉及用于心脏瓣膜置换的自动道路绘图方法和用于心脏瓣膜置换的自动道路测绘的检查装置。为了在PHV植入期间为心脏病专家或外科医生提供更好的信息，提供了一种用于心脏瓣膜置换的自动路线图检查装置，其包括至少一个X射线图像采集装置（10），计算单元（18）和显示装置（20）。所述图像采集装置适于获取（32）具有注入的造影剂的心脏的血管根区域的至少一个X射线图像，并获取（46）至少一个当前的血管根部区域的透视图像，阀插入容器。所述计算单元适于识别（34）所述至少一个获取的图像内的血管信息数据，使用所述血管信息数据来模拟（36）血管根表示，并通过所述模型的组合来生成（44）合成图像血管根表示与至少一个荧光透视图像。显示单元适于显示（48）合成图像。

3. 发明申请

US20120177277A1 LIVE REGISTRATION FOR VESSEL TREATMENT 有权
标题翻译：船舶处理的实际注册
公开(公告)号：US20120177277A1
公开(公告)日：2012-07-12
申请号：US13387234
申请日：2010-09-22
申请人： Raoul Florent , Nicolaas Hylke Bakker
发明人： Raoul Florent , Nicolaas Hylke Bakker
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B5/02007 , A61B6/12 , A61B6/4441 , A61B6/463 , A61B6/466 , A61B6/481 , A61B6/5247 , A61B90/36 , A61B2090/364 , A61B2090/376 , G06T7/33 , G06T2207/10121 , G06T2207/30101
摘要： The present invention relates to accurate positioning for vessel intervention procedures, particularly to a method for accurate positioning for vessel intervention procedures, a medical imaging system for accurate positioning for vessel intervention procedures and a catheterization laboratory system for accurate positioning for vessel intervention procedures. First, at least one X-ray image of a vessel region of interest is acquired (24) with injected contrast agent. Further, vessel information data is identified (26) within the at least one acquired image. Then, first calcification features of the vessel in the vessel region of interest in the at least one acquired image are detected (28). Further, vessel representation is generated (30) using the vessel information data and the detected calcification features. Further, at least one current fluoroscopic image of the vessel region of interest is acquired (32). Then, second calcification features of the vessel in the vessel region of interest in the at least one current fluoroscopy image are detected (34), wherein the second calcification features are according to the first calcification features. Further, the vessel representation is registered (36) with the fluoroscopy image, wherein the calcification features are used for the registration. Then, a composite image is generated (38) by combining the vessel representation with the at least one fluoroscopy image. Further, a composite image is displayed (40).
摘要翻译：本发明涉及用于血管干预程序的精确定位，特别涉及用于容器干预程序的精确定位的方法，用于血管介入程序的精确定位的医学成像系统和用于血管干预程序的精确定位的导管实验室系统。首先，用注入的造影剂获取感兴趣的血管区域的至少一个X射线图像（24）。此外，在至少一个获取的图像内识别（26）船只信息数据。然后，检测在所述至少一个获取图像中的感兴趣的血管区域中的血管的第一钙化特征（28）。此外，使用血管信息数据和检测到的钙化特征产生（30）血管表示。此外，获取感兴趣血管区域的至少一个当前荧光透视图像（32）。然后，检测在所述至少一个当前荧光透视图像中的所述血管区域中的血管的第二钙化特征（34），其中所述第二钙化特征根据所述第一钙化特征。此外，用荧光透视图像记录（36）血管表示，其中钙化特征用于登记。然后，通过组合血管表示与至少一个荧光透视图来产生合成图像（38）。此外，显示合成图像（40）。

4. 发明授权

US07941000B2 Method for producing an image and system for producing an image 有权
标题翻译：用于制作图像的方法和用于产生图像的系统
公开(公告)号：US07941000B2
公开(公告)日：2011-05-10
申请号：US11747394
申请日：2007-05-11
申请人： Peter Maria Johannes Rongen , Nicolaas Hylke Bakker , Herman Stegehuis , Peter Willem van den Houten , Raoul Florent
发明人： Peter Maria Johannes Rongen , Nicolaas Hylke Bakker , Herman Stegehuis , Peter Willem van den Houten , Raoul Florent
IPC分类号： G06K9/36 , G06K9/00 , G01N23/04 , H05G1/64
CPC分类号： G06K9/3216 , A61B6/12 , A61B6/5235 , G06K2209/05 , Y10S128/922
摘要： An image of a physical object is produced by receiving a plurality of raw images, dividing the plurality of raw images into a first subset of primary images and a second subset of secondary images according to a predetermined criterion. From the first subset of primary images an intermediate image is determined while from the second subset of secondary images a mask image is determined. Afterwards a registration of the intermediate image and the mask image is performed by using direct registration of predetermined features present in the intermediate image and the mask image. A fused image of the physical object is generated out of the mask image and the intermediate image.
摘要翻译：通过接收多个原始图像来生成物理对象的图像，根据预定标准将多个原始图像划分为主图像的第一子集和次图像的第二子集。从原始图像的第一子集中确定中间图像，同时从次要图像的第二子集确定掩模图像。之后，通过使用中间图像和掩模图像中存在的预定特征的直接配准来执行中间图像和掩模图像的登记。从掩模图像和中间图像生成物理对象的融合图像。

5. 发明授权

US08774363B2 Medical viewing system for displaying a region of interest on medical images 有权
标题翻译：用于在医学图像上显示感兴趣区域的医疗观察系统
公开(公告)号：US08774363B2
公开(公告)日：2014-07-08
申请号：US13203266
申请日：2010-03-01
申请人： Peter Van Den Houten , Nicolaas Hylke Bakker , Raoul Florent , Vincent Maurice Andre Auvray
发明人： Peter Van Den Houten , Nicolaas Hylke Bakker , Raoul Florent , Vincent Maurice Andre Auvray
IPC分类号： H05G1/64
CPC分类号： A61B6/504 , A61B6/469 , A61B6/481 , G06T7/33 , G06T2207/10116 , G06T2207/30101
摘要： A medical viewing system with an X-ray image acquisition device for acquiring angiograms and interventional live images of vessels is adapted for generating a region of interest border into which an object referenced by an object-based registration process must extend in order to achieve an accurate registration of vessel trees extracted from the angiogram and the live images. The region of interest border is then overlaid onto the vessel tree images and the live images. The medical viewing system reminds the person accomplishing the intervention of the importance of pushing the object far enough into the image, while being discrete enough to be ignored if preferred, thus yielding in a reliable and precise road mapping processing.
摘要翻译：具有用于获取血管造影和血管介入实时图像的X射线图像获取装置的医学观察系统适于生成感兴趣区域边界，基于对象的注册过程所引用的对象必须延伸到该区域中以便实现准确注册从血管造影图像提取的血管树和实时图像。然后将兴趣区边界覆盖在船只树图像和实时图像上。医疗观察系统提醒人们完成对物体足够强的重要性的干预，同时足够离散以至于被忽视，如果是优选的，从而产生可靠和精确的道路测绘处理。

6. 发明申请

US20100209012A1 METHOD OF ENHANCEMENT OF MOVING STRUCTURE USING DOUBLE-WARPING 审中-公开
标题翻译：使用双重保护措施提高移动结构的方法
公开(公告)号：US20100209012A1
公开(公告)日：2010-08-19
申请号：US12679329
申请日：2008-09-16
申请人： Raoul Florent , Nicolaas Hylke Bakker
发明人： Raoul Florent , Nicolaas Hylke Bakker
IPC分类号： G06K9/40
CPC分类号： G06T5/002 , G06T5/003 , G06T5/50 , G06T7/0016 , G06T7/10 , G06T7/20 , G06T2207/10016 , G06T2207/10121 , G06T2207/20012 , G06T2207/20182 , G06T2207/20192 , G06T2207/30021
摘要： A method for enhancing a moving structure of interest in a sequence of images is described, wherein images of the sequence are captured at different times and defined by a matrix of discrete pixels. The method comprises the steps of warping the data representative of pixels defining the images I(t) by using the data representative of the displacements V(t→to) to obtain data representative of pixels defining a second sequence of images A (t), applying an enhancement operation to images of the second sequence A (t) to obtain data representative of pixels defining a third sequence of images B(t), selecting data representative if pixels defining one image B(s) from the third sequence of images B(t), generating data representative of a reverse displacement V(to→O for pixels of the selected structure of interest between the image I(to) captured at reference time to and each image I(t) of the sequence of images captured at time t, and warping of the image B(s) using the data representative of the reverse displacement V(to→t) to obtain data representative of pixels defining a fourth sequence of images E(t).
摘要翻译：描述了用于增强图像序列中感兴趣的移动结构的方法，其中在不同时间捕获序列的图像并且由离散像素的矩阵定义。该方法包括以下步骤：通过使用表示位移V（t→to）的数据来代表定义图像I（t）的像素的数据，以获得表示定义第二图像序列A（t）的像素的数据，对第二序列A（t）的图像应用增强操作以获得表示定义第三图像序列B（t）的像素的数据，选择代表从第三图像序列B（s）定义一个图像B的像素的数据（t），产生表示在参考时刻捕获的图像I（至）与所捕获的图像序列的每个图像I（t）之间的所选择的结构的像素的反向位移V（至→0）的数据。时间t和使用表示反向位移V（to→t）的数据的图像B（s）的翘曲以获得表示定义第四图像序列E（t）的像素的数据。

7. 发明授权

US08718349B2 Live registration for vessel treatment 有权
标题翻译：血管治疗的实时登记
公开(公告)号：US08718349B2
公开(公告)日：2014-05-06
申请号：US13387234
申请日：2010-09-22
申请人： Raoul Florent , Nicolaas Hylke Bakker
发明人： Raoul Florent , Nicolaas Hylke Bakker
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B5/02007 , A61B6/12 , A61B6/4441 , A61B6/463 , A61B6/466 , A61B6/481 , A61B6/5247 , A61B90/36 , A61B2090/364 , A61B2090/376 , G06T7/33 , G06T2207/10121 , G06T2207/30101
摘要： The present invention relates to accurate positioning for vessel intervention procedures, particularly to a method for accurate positioning for vessel intervention procedures, a medical imaging system for accurate positioning for vessel intervention procedures and a catheterization laboratory system for accurate positioning for vessel intervention procedures. First, at least one X-ray image of a vessel region of interest is acquired (24) with injected contrast agent. Further, vessel information data is identified (26) within the at least one acquired image. Then, first calcification features of the vessel in the vessel region of interest in the at least one acquired image are detected (28). Further, vessel representation is generated (30) using the vessel information data and the detected calcification features. Further, at least one current fluoroscopic image of the vessel region of interest is acquired (32). Then, second calcification features of the vessel in the vessel region of interest in the at least one current fluoroscopy image are detected (34), wherein the second calcification features are according to the first calcification features. Further, the vessel representation is registered (36) with the fluoroscopy image, wherein the calcification features are used for the registration. Then, a composite image is generated (38) by combining the vessel representation with the at least one fluoroscopy image. Further, a composite image is displayed (40).
摘要翻译：本发明涉及用于血管干预程序的精确定位，特别涉及用于容器干预程序的精确定位的方法，用于血管介入程序的精确定位的医学成像系统和用于血管干预程序的精确定位的导管实验室系统。首先，用注入的造影剂获取感兴趣的血管区域的至少一个X射线图像（24）。此外，在至少一个获取的图像内识别（26）船只信息数据。然后，检测在所述至少一个获取图像中的感兴趣的血管区域中的血管的第一钙化特征（28）。此外，使用血管信息数据和检测到的钙化特征产生（30）血管表示。此外，获取感兴趣血管区域的至少一个当前荧光透视图像（32）。然后，检测在所述至少一个当前荧光透视图像中的所述血管区域中的血管的第二钙化特征（34），其中所述第二钙化特征根据所述第一钙化特征。此外，用荧光透视图像记录（36）血管表示，其中钙化特征用于登记。然后，通过组合血管表示与至少一个荧光透视图来产生合成图像（38）。此外，显示合成图像（40）。

8. 发明申请

US20110305322A1 MEDICAL VIEWING SYSTEM FOR DISPLAYING A REGION OF INTEREST ON MEDICAL IMAGES 有权
标题翻译：用于显示医疗图像利益区域的医疗查看系统
公开(公告)号：US20110305322A1
公开(公告)日：2011-12-15
申请号：US13203266
申请日：2010-03-01
申请人： Peter Van Den Houten , Nicolaas Hylke Bakker , Raoul Florent , Vincent Maurice Andre Auvray
发明人： Peter Van Den Houten , Nicolaas Hylke Bakker , Raoul Florent , Vincent Maurice Andre Auvray
IPC分类号： H05G1/64 , G09G5/00
CPC分类号： A61B6/504 , A61B6/469 , A61B6/481 , G06T7/33 , G06T2207/10116 , G06T2207/30101
摘要： A medical viewing system with an X-ray image acquisition device for acquiring angiograms and interventional live images of vessels is adapted for generating a region of interest border into which an object referenced by an object-based registration process must extend in order to achieve an accurate registration of vessel trees extracted from the angiogram and the live images. The region of interest border is then overlaid onto the vessel tree images and the live images. The medical viewing system reminds the person accomplishing the intervention of the importance of pushing the object far enough into the image, while being discrete enough to be ignored if preferred, thus yielding in a reliable and precise road mapping processing.
摘要翻译：具有用于获取血管造影和血管介入实时图像的X射线图像获取装置的医学观察系统适于生成感兴趣区域边界，基于对象的注册过程所引用的对象必须延伸到该区域中以便实现准确注册从血管造影图像提取的血管树和实时图像。然后将兴趣区边界覆盖在船只树图像和实时图像上。医疗观察系统提醒人们完成对物体足够强的重要性的干预，同时足够离散以至于被忽视，如果是优选的，从而产生可靠和精确的道路测绘处理。

9. 发明授权

US09262830B2 2D/3D image registration 有权
标题翻译： 2D / 3D图像配准
公开(公告)号：US09262830B2
公开(公告)日：2016-02-16
申请号：US14002375
申请日：2012-02-27
申请人： Nicolaas Hylke Bakker , Sandar Hans Denissen , Wilhelmus Henrica Gerarda Maria Van Den Boomen , Daniel Simon Anna Ruijters , Pieter Maria Mielekamp
发明人： Nicolaas Hylke Bakker , Sandar Hans Denissen , Wilhelmus Henrica Gerarda Maria Van Den Boomen , Daniel Simon Anna Ruijters , Pieter Maria Mielekamp
IPC分类号： G06T7/00
CPC分类号： G06T7/0024 , G06T7/30 , G06T7/33 , G06T2207/10121 , G06T2207/20092 , G06T2207/20212 , G06T2207/30101 , G06T2211/404
摘要： 2D images are registered with 3D volume data. In order to provide 2D/3D registration with a facilitated workflow 3D volume data (112) of an object, having a frame of reference is received. A transformation plane (116) is defined in relation to the 3D volume data. A 2D image of the object with an image plane is received. The transformation plane is projected on the image plane. The frame of reference is aligned with the 2D image. At least one alignment interaction value (128) is projected (130) on the transformation plane to determine (134) at least one transformed interaction value (132). The frame of reference is translated with the at least one transformed interaction value.
摘要翻译： 2D图像使用3D体积数据进行注册。为了提供具有简化的工作流的2D / 3D注册，接收具有参考系的对象的3D体数据（112）。相对于3D体积数据定义变换平面（116）。接收具有图像平面的对象的2D图像。变换平面投影在图像平面上。参考框架与2D图像对齐。在变换平面上投影（130）至少一个对准交互值（128）以确定（134）至少一个变换的相互作用值（132）。用至少一个变换的相互作用值翻译参考系。

10. 发明授权

US08730237B2 Coupling the viewing direction of a blood vessel's CPR view with the viewing angle on the 3D tubular structure's rendered voxel volume and/or with the C-arm geometry of a 3D rotational angiography device's C-arm system 有权
标题翻译：将血管CPR视图的观察方向与3D管状结构的再现的体素体积上的视角和/或3D旋转血管造影装置的C臂系统的C形臂几何结合
公开(公告)号：US08730237B2
公开(公告)日：2014-05-20
申请号：US12670866
申请日：2008-07-31
申请人： Daniel Simon Anna Ruijters , Nicolaas Hylke Bakker , Robert Johannes Frederik Homan
发明人： Daniel Simon Anna Ruijters , Nicolaas Hylke Bakker , Robert Johannes Frederik Homan
IPC分类号： G06T15/08 , G06T19/00
CPC分类号： G06T15/08 , G06T19/00 , G06T2210/41 , G06T2215/06
摘要： The present invention describes a method for rendering and displaying a curved planar reformat (CPR) view (7′) of a blood vessel's 3D tubular structure (1), wherein the viewing direction of the curved planar reformat view (7′) is coupled to the viewing angle on a segmented or raw representation of the 3D tubular structure's rendered voxel volume to be visualized or, alternatively, to the C-arm geometry of a 3D rotational angiography device's C-arm system (6). The proposed method thus enables measurements on the X-ray image which do not suffer from spatial foreshortening and do not need to be calibrated. Thereby, said coupling can be performed bidirectional. According to a first aspect of the proposed method, this means that the viewing direction of the aforementioned curved planar reformat view (7′) follows the viewing angle on a segmented or raw representation of the 3D tubular structure's rendered voxel volume to be visualized, or vice versa. According to another aspect of the proposed method, this means that the viewing direction of the curved planar reformat view (7′) is set depending on the C-arm geometry given by the roll (θx), pitch (θy) and yaw angle (θz) of a 3D rotational angiography device's C-arm system (6), or vice versa.
摘要翻译：本发明描述了一种用于渲染和显示血管3D管状结构（1）的弯曲平面重新格栅（CPR）视图（7'）的方法，其中弯曲平面重新格式视图（7'）的观察方向被耦合到 3D管状结构的渲染体素的分段或原始表示的视角要被可视化，或者替代地对于3D旋转血管造影装置的C臂系统（6）的C形臂几何形状。因此，所提出的方法能够对不具有空间缩短的X射线图像进行测量，并且不需要校准。由此，可以双向执行所述耦合。根据所提出的方法的第一方面，这意味着上述弯曲平面重新格式化视图（7'）的观察方向遵循3D管状结构的呈现的体素体积的分段或原始表示的视角，以被可视化，或反之亦然。根据所提出的方法的另一方面，这意味着弯曲平面重新格式化视图（7'）的观察方向根据由辊（＆amp; x），间距（＆amp; y; y）给出的C形臂几何来设定，和3D旋转血管造影装置的C臂系统（6）的偏航角（＆amp; t; z），反之亦然。

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