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1. 发明授权

US07941000B2 Method for producing an image and system for producing an image 有权
标题翻译：用于制作图像的方法和用于产生图像的系统
公开(公告)号：US07941000B2
公开(公告)日：2011-05-10
申请号：US11747394
申请日：2007-05-11
申请人： Peter Maria Johannes Rongen , Nicolaas Hylke Bakker , Herman Stegehuis , Peter Willem van den Houten , Raoul Florent
发明人： Peter Maria Johannes Rongen , Nicolaas Hylke Bakker , Herman Stegehuis , Peter Willem van den Houten , Raoul Florent
IPC分类号： G06K9/36 , G06K9/00 , G01N23/04 , H05G1/64
CPC分类号： G06K9/3216 , A61B6/12 , A61B6/5235 , G06K2209/05 , Y10S128/922
摘要： An image of a physical object is produced by receiving a plurality of raw images, dividing the plurality of raw images into a first subset of primary images and a second subset of secondary images according to a predetermined criterion. From the first subset of primary images an intermediate image is determined while from the second subset of secondary images a mask image is determined. Afterwards a registration of the intermediate image and the mask image is performed by using direct registration of predetermined features present in the intermediate image and the mask image. A fused image of the physical object is generated out of the mask image and the intermediate image.
摘要翻译：通过接收多个原始图像来生成物理对象的图像，根据预定标准将多个原始图像划分为主图像的第一子集和次图像的第二子集。从原始图像的第一子集中确定中间图像，同时从次要图像的第二子集确定掩模图像。之后，通过使用中间图像和掩模图像中存在的预定特征的直接配准来执行中间图像和掩模图像的登记。从掩模图像和中间图像生成物理对象的融合图像。

2. 发明授权

US08000507B2 Viewing system for control of PTCA angiograms 有权
标题翻译：观察PTCA血管造影检查系统
公开(公告)号：US08000507B2
公开(公告)日：2011-08-16
申请号：US11568273
申请日：2005-04-26
申请人： Peter Maria Johannes Rongen , Raoul Florent , Herman Stegehuis
发明人： Peter Maria Johannes Rongen , Raoul Florent , Herman Stegehuis
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61B6/504 , A61B6/12 , A61B6/469 , A61B90/39 , A61B2017/22051 , A61F2/82 , A61F2/958
摘要： A medical viewing system for processing and displaying a sequence of medical angiograms representing a balloon, moving in an artery, this system comprising extracting means for automatically extracting balloon image data in a phase of balloon expansion, and computing means for automatically defining and storing coordinates of a Region of Interest (ROI) based on the expanded balloon image data, located around the expanded balloon; and display means for displaying the images. Contrast agent may be used as agent of balloon expansion. The system may have means to detect and keep track of balloon markers and means to look around those markers for further balloon image data extraction.
摘要翻译：一种用于处理和显示代表在动脉中移动的气球的医疗血管造影图的序列的医疗观察系统，该系统包括用于在气球扩张阶段自动提取气囊图像数据的提取装置，以及用于自动定义和存储坐标的坐标的计算装置基于扩展的气囊图像数据的位于感兴趣区域（ROI）的位置，位于扩展的气囊周围; 以及用于显示图像的显示装置。对比剂可用作气囊膨胀剂。该系统可以具有检测和跟踪气球标记的手段，并且可以查看围绕这些标记的手段以进一步提取气囊图像数据。

3. 发明授权

US07551758B2 Medical viewing system and method for detecting borders of an object of interest in noisy images 有权
标题翻译：用于检测嘈杂图像中感兴趣对象的边界的医学观察系统和方法
公开(公告)号：US07551758B2
公开(公告)日：2009-06-23
申请号：US10537208
申请日：2003-11-26
申请人： Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
发明人： Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T7/73 , G06T2207/10016 , G06T2207/10121 , G06T2207/20101 , G06T2207/30021 , G06T2207/30204
摘要： The invention relates to a viewing system and a method for detecting an object of interest in a sequence of images (IS). Said object of interest is detected by first locating localizers related to said object of interest and by locating borders (BL) related to said object of interest using the location (LI, LZ) of said localizers. The viewing system according to the invention is able to produce a sequence of enhanced images in which the object of interest is enhanced, to measure some characteristics and to build a three dimensional representation of said object of interest. The viewing system is also able to register and combine said sequence of enhanced images with a sequence of reference images.
摘要翻译：本发明涉及一种用于检测图像序列（IS）中的感兴趣对象的观看系统和方法。通过首先定位与所述感兴趣对象相关的定位器以及通过使用所述定位器的位置（LI，LZ）定位与所述感兴趣对象相关的边界（BL）来检测所述感兴趣的对象。根据本发明的观看系统能够产生增强图像的序列，其中感兴趣的对象被增强，以测量一些特征并构建所述感兴趣对象的三维表示。观看系统还能够将所述增强图像序列与参考图像序列进行注册和组合。

4. 发明授权

US06760401B2 Apparatus and method for processing of digital images 失效
标题翻译：数字图像处理装置及方法
公开(公告)号：US06760401B2
公开(公告)日：2004-07-06
申请号：US10215692
申请日：2002-08-09
申请人： Georg Schmitz , Til Aach , Peter Maria Johannes Rongen , Herman Stegehuis
发明人： Georg Schmitz , Til Aach , Peter Maria Johannes Rongen , Herman Stegehuis
IPC分类号： G01N23083
CPC分类号： G06T5/50 , G06T7/0012 , G06T2207/30101
摘要： This invention relates to an apparatus and method for improved display of small dark structures such as in particular coronary blood vessels in digital X-ray images. A live image (S) is initially subjected to multiscale decomposition in which firstly multiple uses of low pass filtering with subsequent resolution reduction (RED), and secondly resolution increases using subsequent low pass filtration (EXP), give detailed images (D1, D2, D3, D4) of different resolution. In accordance with the first variant of the method, a mask (M) representative of the uninteresting image background is subtracted from the detailed image (D4) having the lowest degree of resolution. This ensures that the subtraction will only comprise correspondingly coarse structures with dimensions greater than the expected image motion. A further improvement can be achieved by applying a motion estimation (MOT EST) and motion compensation (MOT COMP) to the mask (M) and to the detailed image (D4) of the lowest degree of resolution. The detailed images (D1-D4) may be multiplied by factors (c2) before they are combined to form the overall image (G). For this purpose, asymmetrical intensification functions are preferably used, so that negative contrast values corresponding to small dark structures can be intensified and positive contrast values can be suppressed.
摘要翻译：本发明涉及一种用于改进数字X射线图像中特别是冠状血管的小黑暗结构的显示的装置和方法。实时图像（S）最初经受多尺度分解，其中首先多次使用低通滤波，随后进行分辨率降低（RED），其次分辨率随后的低通滤波（EXP）增加，给出详细图像（D1，D2， D3，D4）不同分辨率。根据该方法的第一变型，从具有最低分辨率的详细图像（D4）中减去代表不感兴趣的图像背景的掩码（M）。这确保了减法将仅包括具有大于预期图像运动的尺寸的对应粗略结构。另外，通过将运动估计（MOT EST）和运动补偿（MOT COMP）应用于最低分辨率的掩模（M）和详细图像（D4）可以实现进一步的改进。详细图像（D1-D4）可以在它们组合之前乘以因子（c2）以形成整体图像（G）。为此，优选使用非对称增强功能，从而可以增强对应于小暗结构的负对比度值，并且可以抑制正对比度值。

5. 发明授权

US07233689B2 Method of processing images for digital subtraction angiography 失效
标题翻译：数字减影血管造影图像处理方法
公开(公告)号：US07233689B2
公开(公告)日：2007-06-19
申请号：US10234798
申请日：2002-09-04
申请人： Sylvain Justin Georges André Haupert , Peter Maria Johannes Rongen , Herman Stegehuis
发明人： Sylvain Justin Georges André Haupert , Peter Maria Johannes Rongen , Herman Stegehuis
IPC分类号： G06K9/00
CPC分类号： H04N5/325 , G06T5/50
摘要： The invention relates to the field of digital subtraction angiography. An image processing method is applied to a digitized mask (100) and to a sequence of digitized opacified images (101). A logarithmic function (105) is applied to the values of the pixels of the digitized mask and to the values of the pixels of the sequence of digitized opacified images, and then a subtraction (108) is made of the logarithmic value of each pixel of a digitized opacified image from the logarithmic value of the corresponding pixel in the digitized mask. In order to improve the quality of the images processed, a processing step (102) able to decrease certain pixel values of the digitized mask and of the digitized opacified images is applied before applying the logarithmic function.
摘要翻译：本发明涉及数字减影血管造影术领域。图像处理方法应用于数字化掩模（100）和数字化不透明图像序列（101）。将对数函数（105）应用于数字化掩模的像素的值和数字化不透明图像序列的像素的值，然后减法（108）由每个像素的像素的对数值来自数字化掩模中对应像素的对数值的数字化不透明图像。为了提高处理的图像的质量，在应用对数函数之前应用能够减小数字化掩模和数字化不透明图像的某些像素值的处理步骤（102）。

6. 发明授权

US07822241B2 Device and method for combining two images 有权
标题翻译：用于组合两个图像的装置和方法
公开(公告)号：US07822241B2
公开(公告)日：2010-10-26
申请号：US10568479
申请日：2004-08-11
申请人： Kai Eck , Jörg Bredno , Paul Antoon Cyriel Desmedt , Peter Maria Johannes Rongen , Herman Stegehuis , Geert Gijsbers
发明人： Kai Eck , Jörg Bredno , Paul Antoon Cyriel Desmedt , Peter Maria Johannes Rongen , Herman Stegehuis , Geert Gijsbers
IPC分类号： G06K9/00 , G06K9/32
CPC分类号： G06T3/4053 , A61B5/7289 , A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5235 , A61B6/5247 , G06F19/00 , G06T7/30 , G06T2207/10116 , G06T2207/30101
摘要： Images of static vascular maps (B), which were taken at different phases of the cardiac cycle and/or the respiratory cycle and were archived in a memory (6), are superimposed on a current image (A) of a catheter (2, 8) in the vascular system (9). In the method, a defined section of a map image (B) around the estimated actual position of the catheter is selected and is displayed superimposed on the current image (A) on a monitor (10). The map image (B) used for this is preferably selected by an electrocardiogram to match the particular cardiac cycle. The position of the catheter relative to the map image (B) is estimated using a distance image (D).
摘要翻译：在心脏周期和/或呼吸周期的不同阶段拍摄并存储在记忆体（6）中的静态血管图（B）的图像叠加在导管（2）的当前图像（A）上， 8）在血管系统（9）中。在该方法中，选择围绕估计的导管的实际位置的地图图像（B）的限定部分，并将其叠加显示在监视器（10）上的当前图像（A）上。用于此的地图图像（B）优选地通过心电图来选择以匹配特定心动周期。使用距离图像（D）估计导管相对于地图图像（B）的位置。

7. 发明授权

US09393079B2 Processing of images of interventional instruments with markers 有权
标题翻译：用标记处理介入仪器的图像
公开(公告)号：US09393079B2
公开(公告)日：2016-07-19
申请号：US11573292
申请日：2005-07-21
申请人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
发明人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
IPC分类号： A61B5/05 , A61B19/00
CPC分类号： A61B34/20 , A61B90/39 , A61B90/90 , A61B2034/2065 , A61B2090/392
摘要： A method and an image processing system for the evaluation of projection images generated by an X-ray imaging system, wherein the images may show different instruments of a given set of interventional instruments like catheters or guide wires. The instruments are equipped with markers such that their configuration is characteristic of the corresponding instrument. Preferably three markers are arranged on a straight line, the ratio of the distances between them being characteristic for the corresponding instrument. The image processing system may then identify the instruments present in a given projection and provide functionalities for a user that correspond to said instruments. Moreover, the system may be used to locate an instrument of interest in a projection image if the marker configuration of that instrument is known a priori.
摘要翻译：一种用于评估由X射线成像系统产生的投影图像的方法和图像处理系统，其中所述图像可以显示给定的一组介入装置如导管或导丝的不同仪器。这些仪器配有标记，使得它们的配置是相应仪器的特征。优选地，三个标记布置在直线上，它们之间的距离比对于相应的仪器是特征的。然后，图像处理系统可以识别给定投影中存在的工具，并为与用户对应的功能提供功能。此外，如果该仪器的标记配置是先验已知的，则该系统可用于在投影图像中定位感兴趣的仪器。

8. 发明申请

US20110135064A1 DYNAMICAL VISUALIZATION OF CORONARY VESSELS AND MYOCARDIAL PERFUSION INFORMATION 有权
标题翻译：冠状动脉和心肌灌注信息的动态可视化
公开(公告)号：US20110135064A1
公开(公告)日：2011-06-09
申请号：US13057772
申请日：2009-08-06
申请人： Antonius Johannes Cornelius Buijns , Peter Maria Johannes Rongen , Vincent Maurice Andre Auvray , Odile Bonnefous , Raoul Florent
发明人： Antonius Johannes Cornelius Buijns , Peter Maria Johannes Rongen , Vincent Maurice Andre Auvray , Odile Bonnefous , Raoul Florent
IPC分类号： H05G1/64
CPC分类号： A61B6/504 , A61B6/463 , A61B6/464 , A61B6/481 , A61B6/503 , A61B6/507 , A61B6/5217 , A61B6/5235 , A61B6/5264 , A61B6/541
摘要： A method for dynamically visualizing coronary information and an apparatus adapted to implement such method is described. In a preferred embodiment of the method, first dynamic cardiac data is acquired during a first cardiac stage and second dynamic cardiac data is acquired during a second cardiac stage. Then, the two data sets are visualized continuously the in a superimposed presentation, wherein the first cardiac data and the second cardiac data corresponding to a same phase within the cardiac cycle are visualized simultaneously. In this way for example information about the vessel geometry may be immediately linked with information about the muscle irrigation or perfusion. Furthermore, this useful information may be displayed in a high-contrasted and low-noise presentation.
摘要翻译：描述了用于动态可视化冠状动脉信息的方法和适于实现这种方法的装置。在该方法的优选实施例中，在第一心脏阶段期间获取第一动态心脏数据，并且在第二心脏阶段期间获取第二动态心脏数据。然后，以叠加的呈现连续显示两个数据集，其中与心脏周期内的相同相位相对应的第一心脏数据和第二心脏数据被同时显现。以这种方式，例如关于血管几何的信息可以立即与关于肌肉灌注或灌注的信息相关联。此外，该有用信息可以以高对比度和低噪声的呈现来显示。

9. 发明授权

US07877132B2 Medical viewing system and method for detecting and enhancing static structures in noisy images using motion of the image acquisition means 有权
标题翻译：医疗观察系统和方法，用于利用图像采集装置的运动来检测和增强噪声图像中的静态结构
公开(公告)号：US07877132B2
公开(公告)日：2011-01-25
申请号：US11912313
申请日：2006-04-13
申请人： Peter Maria Johannes Rongen , Raoul Florent , Pierre Lelong
发明人： Peter Maria Johannes Rongen , Raoul Florent , Pierre Lelong
IPC分类号： A61B5/05
CPC分类号： A61B6/12 , A61B90/39 , A61B2090/376 , G06T7/579 , G06T2207/30101
摘要： A method for use in a medical viewing system for processing for display a sequence of images of a medical intervention comprising manipulating a tool such as a stent (25) within an artery. Two markers (21, 22) are provided on the tool support (10) and the method includes extracting these markers (21, 22) to yield marker location information, from which tool location information can be derived. The image of the tool within the sequence of images is then enhanced relative to the background. The background can be additionally blurred by simulating or effecting relative movement of the image detector and the stent (25) by, for example, zooming in on the stent (25) or rotating the detector relative thereto, during acquisition of the sequence of images.
摘要翻译：一种用于医疗观察系统中用于显示医疗干预图像序列的处理的方法，包括操纵诸如动脉内的支架（25）的工具。两个标记（21,22）设置在工具支撑件（10）上，并且该方法包括提取这些标记（21,22）以产生标记位置信息，从中可以导出工具位置信息。然后，相对于背景，图像序列内的工具的图像被增强。通过在获取图像序列期间，例如通过放大支架（25）或相对于其旋转检测器，模拟或影响图像检测器和支架（25）的相对运动，背景可以另外模糊。

10. 发明申请

US20090216111A1 PROCESSING OF IMAGES OF INTERVENTIONAL INSTRUMENTS WITH MARKERS 有权
标题翻译：传统仪器与标记的图像处理
公开(公告)号：US20090216111A1
公开(公告)日：2009-08-27
申请号：US11573292
申请日：2005-07-21
申请人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
发明人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
IPC分类号： A61B6/12 , A61B19/00
CPC分类号： A61B34/20 , A61B90/39 , A61B90/90 , A61B2034/2065 , A61B2090/392
摘要： The invention relates to a method and an image processing system (20) for the evaluation of projection images (25) generated by an X-ray imaging system (10), wherein the images (25) may show different instruments (51, 52) of a given set of interventional instruments like catheters or guide wires. The instruments are equipped with markers such that their configuration is characteristic of the corresponding instrument (51, 52). Preferably three markers are arranged on a straight line, the ratio of the distances between them being characteristic for the corresponding instrument. The image processing system (20) may then identify the instruments (51, 52) present in a given projection (25) and provide functionalities for a user that correspond to said instruments. Moreover, the system may be used to locate an instrument (51, 52) of interest in a projection image (25) if the marker configuration of that instrument (51, 52) is known a priori.
摘要翻译：本发明涉及一种用于评估由X射线成像系统（10）产生的投影图像（25）的方法和图像处理系统（20），其中图像（25）可以显示不同的仪器（51,52）一套给定的介入仪器，如导管或导丝。仪器配备有标记，使得它们的配置是相应仪器（51,52）的特征。优选地，三个标记布置在直线上，它们之间的距离比对于相应的仪器是特征的。然后，图像处理系统（20）可以识别存在于给定投影（25）中的仪器（51,52），并为与用户对应的所述仪器提供功能。此外，如果先前已知该仪器（51,52）的标记结构，则该系统可用于在投影图像（25）中定位感兴趣的仪器（51,52）。

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