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1. 发明授权

US08000507B2 Viewing system for control of PTCA angiograms 有权
标题翻译：观察PTCA血管造影检查系统
公开(公告)号：US08000507B2
公开(公告)日：2011-08-16
申请号：US11568273
申请日：2005-04-26
申请人： Peter Maria Johannes Rongen , Raoul Florent , Herman Stegehuis
发明人： Peter Maria Johannes Rongen , Raoul Florent , Herman Stegehuis
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61B6/504 , A61B6/12 , A61B6/469 , A61B90/39 , A61B2017/22051 , A61F2/82 , A61F2/958
摘要： A medical viewing system for processing and displaying a sequence of medical angiograms representing a balloon, moving in an artery, this system comprising extracting means for automatically extracting balloon image data in a phase of balloon expansion, and computing means for automatically defining and storing coordinates of a Region of Interest (ROI) based on the expanded balloon image data, located around the expanded balloon; and display means for displaying the images. Contrast agent may be used as agent of balloon expansion. The system may have means to detect and keep track of balloon markers and means to look around those markers for further balloon image data extraction.
摘要翻译：一种用于处理和显示代表在动脉中移动的气球的医疗血管造影图的序列的医疗观察系统，该系统包括用于在气球扩张阶段自动提取气囊图像数据的提取装置，以及用于自动定义和存储坐标的坐标的计算装置基于扩展的气囊图像数据的位于感兴趣区域（ROI）的位置，位于扩展的气囊周围; 以及用于显示图像的显示装置。对比剂可用作气囊膨胀剂。该系统可以具有检测和跟踪气球标记的手段，并且可以查看围绕这些标记的手段以进一步提取气囊图像数据。

2. 发明授权

US07941000B2 Method for producing an image and system for producing an image 有权
标题翻译：用于制作图像的方法和用于产生图像的系统
公开(公告)号：US07941000B2
公开(公告)日：2011-05-10
申请号：US11747394
申请日：2007-05-11
申请人： Peter Maria Johannes Rongen , Nicolaas Hylke Bakker , Herman Stegehuis , Peter Willem van den Houten , Raoul Florent
发明人： Peter Maria Johannes Rongen , Nicolaas Hylke Bakker , Herman Stegehuis , Peter Willem van den Houten , Raoul Florent
IPC分类号： G06K9/36 , G06K9/00 , G01N23/04 , H05G1/64
CPC分类号： G06K9/3216 , A61B6/12 , A61B6/5235 , G06K2209/05 , Y10S128/922
摘要： An image of a physical object is produced by receiving a plurality of raw images, dividing the plurality of raw images into a first subset of primary images and a second subset of secondary images according to a predetermined criterion. From the first subset of primary images an intermediate image is determined while from the second subset of secondary images a mask image is determined. Afterwards a registration of the intermediate image and the mask image is performed by using direct registration of predetermined features present in the intermediate image and the mask image. A fused image of the physical object is generated out of the mask image and the intermediate image.
摘要翻译：通过接收多个原始图像来生成物理对象的图像，根据预定标准将多个原始图像划分为主图像的第一子集和次图像的第二子集。从原始图像的第一子集中确定中间图像，同时从次要图像的第二子集确定掩模图像。之后，通过使用中间图像和掩模图像中存在的预定特征的直接配准来执行中间图像和掩模图像的登记。从掩模图像和中间图像生成物理对象的融合图像。

3. 发明申请

US20080279476A1 METHOD FOR PRODUCING AN IMAGE AND SYSTEM FOR PRODUCING AN IMAGE 有权
标题翻译：用于生成图像的方法和用于生成图像的系统
公开(公告)号：US20080279476A1
公开(公告)日：2008-11-13
申请号：US11747394
申请日：2007-05-11
申请人： Peter Maria Johannes RONGEN , Nicolaas Hylke BAKKER , Herman STEGEHUIS , Peter Willem van den HOUTEN , Raoul FLORENT
发明人： Peter Maria Johannes RONGEN , Nicolaas Hylke BAKKER , Herman STEGEHUIS , Peter Willem van den HOUTEN , Raoul FLORENT
IPC分类号： G06K9/36
CPC分类号： G06K9/3216 , A61B6/12 , A61B6/5235 , G06K2209/05 , Y10S128/922
摘要： According to an exemplary embodiment a method for producing an image of a physical object comprises receiving a plurality of raw images, dividing the plurality of raw images into a first subset of primary images and a second subset of secondary images according to a predetermined criterion. From the first subset of primary images an intermediate image is determined while from the second subset of secondary images a mask image is determined. Afterwards a registration of the intermediate image and the mask image is performed by using direct registration of predetermined features present in the intermediate image and the mask image and fused image of the physical object is generated out of the mask image and the intermediate image.
摘要翻译：根据示例性实施例，用于产生物理对象的图像的方法包括：接收多个原始图像，根据预定标准将所述多个原始图像划分为主图像的第一子集和次要图像的第二子集。从原始图像的第一子集中确定中间图像，同时从次要图像的第二子集确定掩模图像。之后，通过使用中间图像中存在的预定特征的直接登记和掩模图像来执行中间图像和掩模图像的登记，并且从掩模图像和中间图像生成物理对象的融合图像。

4. 发明申请

US20100074504A1 METHOD AND APPARATUS FOR ACQUIRING FUSION X-RAY IMAGES 审中-公开
标题翻译：用于获取融合X射线图像的方法和装置
公开(公告)号：US20100074504A1
公开(公告)日：2010-03-25
申请号：US12532459
申请日：2008-03-14
申请人： Antonius J.C. Bruijns , Ronaldus P.J. Hermans , Peter M.J. Rongen , Jarl J.P. Blijd , Herman Stegehuis , Joerg Bredno
发明人： Antonius J.C. Bruijns , Ronaldus P.J. Hermans , Peter M.J. Rongen , Jarl J.P. Blijd , Herman Stegehuis , Joerg Bredno
IPC分类号： G06K9/00 , G01N23/04
CPC分类号： A61B6/504 , A61B6/481 , A61B6/482 , A61B6/503 , A61B6/5235 , A61B6/541
摘要： A method for acquiring fusion images of a periodically moving body organ and an apparatus adapted to implement such method is described. In a preferred embodiment of the method, X-rays are irradiated to the body organ and a multiplicity of mask images is acquired by X-ray detection at a high image acquisition rate of at least 60 frames per second. Then, contrast medium is injected into vessels of the body organ and subsequently at least one contrast image of the body organ with the contrast medium included in the vessels is acquired by X-ray detection. A matching image from the multiplicity of mask images is determined which has been acquired at substantially the same stage of the movement of the body organ as the contrast image. By calculating the difference between the matching mask image and the at least one contrast image a subtraction image of the body organ can be obtained and displayed. Using different image acquisition rates during mask image acquisition and contrast image acquisition high quality subtraction images can be achieved while at the same time reducing the overall X-ray exposure dose.
摘要翻译：描述了一种用于获取定期移动的身体器官的融合图像的方法和适于实现这种方法的装置。在该方法的优选实施例中，将X射线照射到身体器官，并且通过以至少60帧/秒的高图像采集率的X射线检测获取多个掩模图像。然后，将造影剂注射到身体器官的血管中，随后通过X射线检测获得体内器官与包含在血管中的造影剂的至少一个对比图像。确定来自多个掩模图像的匹配图像，其在与对比图像的身体器官的移动的基本相同的阶段已被获取。通过计算匹配掩模图像和至少一个对比图像之间的差异，可以获得并显示身体器官的减影图像。在掩模图像采集和对比度图像采集期间使用不同的图像采集率可以实现高质量的减影图像，同时减少整个X射线曝光剂量。

5. 发明申请

US20090147911A1 SCATTER COMPENSATION IN AN X-RAY SYSTEM 失效
标题翻译： X射线系统中的散射体补偿
公开(公告)号：US20090147911A1
公开(公告)日：2009-06-11
申请号：US11719555
申请日：2005-11-17
申请人： Johannes Henricus Maria Joosten , Niels Noordhoek , Herman Stegehuis
发明人： Johannes Henricus Maria Joosten , Niels Noordhoek , Herman Stegehuis
IPC分类号： H05G1/60
CPC分类号： G01T1/1644 , A61B6/06 , A61B6/5282 , A61B6/542 , A61B6/544 , Y10S378/901
摘要： Scatter compensation is achieved in an X-ray imaging system by providing collimation means in the form of shutters (12) to collimate the primary X-ray beam (1) such that the radiation (8) transmitted through a subject (4) to be imaged is incident substantially centrally on the active part (14) of an image detector (3), so as to define an active border (14b), in respect of which scatter levels can be measured. An electrical signal (104) representative of the scatter level is subtracted from the electrical signal (7) representative of the radiation (8) transmitted through the subject, to obtain a scatter-compensated image signal (106).
摘要翻译：通过提供以快门（12）的形式的准直装置来准直主X射线束（1），使得通过被摄物体（4）传播的辐射（8）成为X射线成像系统，实现散射补偿成像的图像基本上集中在图像检测器（3）的有源部分（14）上，以便限定可以测量散射水平的活动边界（14b）。从代表通过被摄体发射的辐射（8）的电信号（7）中减去代表散射电平的电信号（104），以获得散射补偿图像信号（106）。

6. 发明申请

US20090052615A1 IMAGING APPARATUS USING DISTRIBUTED X-RAY SOUCES AND METHOD THEREOF 有权
标题翻译：使用分布式X射线摄像机的成像装置及其方法
公开(公告)号：US20090052615A1
公开(公告)日：2009-02-26
申请号：US12162692
申请日：2007-01-23
申请人： Carolina Ribbing , Peter Klaus Bachmann , Matthijs Adriaansz , Han Kroon , Herman Stegehuis , Hans Nikol
发明人： Carolina Ribbing , Peter Klaus Bachmann , Matthijs Adriaansz , Han Kroon , Herman Stegehuis , Hans Nikol
IPC分类号： A61B6/00
CPC分类号： A61B6/405 , A61B6/032 , A61B6/4007 , A61B6/4241 , A61B6/4266 , A61B6/482 , G01N23/046 , G01N2223/419
摘要： An imaging apparatus is disclosed. The imaging apparatus comprises a multidimensional assembly that further comprises a plurality of x-ray sources that are individually addressable. The plurality of x-ray sources is further configurable to simultaneously emit x-ray spectra at different mean energies. Furthermore, the multi-dimensional assembly further comprises a plurality of x-ray detectors that are arranged to detect at least a part of the x-rays that are emitted from at least one of the x-ray sources.
摘要翻译：公开了一种成像装置。成像设备包括多维组件，其进一步包括可单独寻址的多个x射线源。多个x射线源还可配置成以不同的平均能量同时发射X射线光谱。此外，多维组件还包括多个x射线检测器，其被布置成检测从至少一个x射线源发射的X射线的至少一部分。

7. 发明授权

US06760401B2 Apparatus and method for processing of digital images 失效
标题翻译：数字图像处理装置及方法
公开(公告)号：US06760401B2
公开(公告)日：2004-07-06
申请号：US10215692
申请日：2002-08-09
申请人： Georg Schmitz , Til Aach , Peter Maria Johannes Rongen , Herman Stegehuis
发明人： Georg Schmitz , Til Aach , Peter Maria Johannes Rongen , Herman Stegehuis
IPC分类号： G01N23083
CPC分类号： G06T5/50 , G06T7/0012 , G06T2207/30101
摘要： This invention relates to an apparatus and method for improved display of small dark structures such as in particular coronary blood vessels in digital X-ray images. A live image (S) is initially subjected to multiscale decomposition in which firstly multiple uses of low pass filtering with subsequent resolution reduction (RED), and secondly resolution increases using subsequent low pass filtration (EXP), give detailed images (D1, D2, D3, D4) of different resolution. In accordance with the first variant of the method, a mask (M) representative of the uninteresting image background is subtracted from the detailed image (D4) having the lowest degree of resolution. This ensures that the subtraction will only comprise correspondingly coarse structures with dimensions greater than the expected image motion. A further improvement can be achieved by applying a motion estimation (MOT EST) and motion compensation (MOT COMP) to the mask (M) and to the detailed image (D4) of the lowest degree of resolution. The detailed images (D1-D4) may be multiplied by factors (c2) before they are combined to form the overall image (G). For this purpose, asymmetrical intensification functions are preferably used, so that negative contrast values corresponding to small dark structures can be intensified and positive contrast values can be suppressed.
摘要翻译：本发明涉及一种用于改进数字X射线图像中特别是冠状血管的小黑暗结构的显示的装置和方法。实时图像（S）最初经受多尺度分解，其中首先多次使用低通滤波，随后进行分辨率降低（RED），其次分辨率随后的低通滤波（EXP）增加，给出详细图像（D1，D2， D3，D4）不同分辨率。根据该方法的第一变型，从具有最低分辨率的详细图像（D4）中减去代表不感兴趣的图像背景的掩码（M）。这确保了减法将仅包括具有大于预期图像运动的尺寸的对应粗略结构。另外，通过将运动估计（MOT EST）和运动补偿（MOT COMP）应用于最低分辨率的掩模（M）和详细图像（D4）可以实现进一步的改进。详细图像（D1-D4）可以在它们组合之前乘以因子（c2）以形成整体图像（G）。为此，优选使用非对称增强功能，从而可以增强对应于小暗结构的负对比度值，并且可以抑制正对比度值。

8. 发明授权

US5270925A Method of and device for correcting scattered-radiation effects in X-ray images 失效
标题翻译：用于校正X射线图像中散射辐射效应的方法和装置
公开(公告)号：US5270925A
公开(公告)日：1993-12-14
申请号：US397157
申请日：1989-08-21
申请人： Herman Stegehuis
发明人： Herman Stegehuis
IPC分类号： A61B6/00 , H04N5/32 , H05G1/64 , G06F15/00
CPC分类号： H05G1/64 , H04N5/3205 , Y10S128/922
摘要： Scattered radiation in an X-ray image causes a reduction of contrast. An estimate of the scattered radiation contribution is obtained by means of a version of the original image which is spread-out in space and which is multiplied by a location-dependent weighting factor. By subtracting this scattered radiation image from the X-ray image, a corrected image with enhanced contrast is obtained. The estimate of the scattered radiation image is adapted to the adjustment values for the imaging parameters of the X-ray system.

9. 发明授权

US09700209B2 Medical imaging device for providing an image representation supporting in positioning an intervention device 有权
公开(公告)号：US09700209B2
公开(公告)日：2017-07-11
申请号：US14003486
申请日：2012-03-05
申请人： Raoul Florent , Bart Pierre Antoine Jozef Hoornaert , Herman Stegehuis
发明人： Raoul Florent , Bart Pierre Antoine Jozef Hoornaert , Herman Stegehuis
IPC分类号： G06K9/00 , A61B5/00 , A61B6/06 , A61B6/12 , A61B90/00 , A61B6/00
CPC分类号： A61B5/0037 , A61B6/06 , A61B6/12 , A61B6/4441 , A61B6/481 , A61B6/487 , A61B6/503 , A61B6/504 , A61B6/5229 , A61B6/542 , A61B90/37
摘要： A medical imaging device and a method for providing an image representation supporting positioning of an intervention device such as a wire tip (4) in a region of interest during an intervention is proposed. Therein, the following process steps are to be performed: (S1) acquiring a pre-live anatomy image (1) including a region of interest; (S2) acquiring a live anatomy image using a live image acquisition device comprising an adjustable collimator device; (S3) identifying a location (5) of the intervention device (4) within the live anatomy image; (S4) adjusting settings of the collimator device based on the identified location of the intervention device for subsequently acquiring a further live anatomy image representing the region of interest using the live image acquisition device with the collimator device being in the adjusted settings; and providing (S5) the image representation by merging information from the live anatomy image into the pre-live anatomy image. Thereby, the intervention device may be continuously tracked and the collimator device may restrict a field of view to a location of the intervention device thereby significantly reducing an applied X-ray dose. Background anatomical information may be introduced into the final image representation using the pre-live anatomy image possibly having a higher image contrast than the live anatomy images.

10. 发明授权

US07822241B2 Device and method for combining two images 有权
标题翻译：用于组合两个图像的装置和方法
公开(公告)号：US07822241B2
公开(公告)日：2010-10-26
申请号：US10568479
申请日：2004-08-11
申请人： Kai Eck , Jörg Bredno , Paul Antoon Cyriel Desmedt , Peter Maria Johannes Rongen , Herman Stegehuis , Geert Gijsbers
发明人： Kai Eck , Jörg Bredno , Paul Antoon Cyriel Desmedt , Peter Maria Johannes Rongen , Herman Stegehuis , Geert Gijsbers
IPC分类号： G06K9/00 , G06K9/32
CPC分类号： G06T3/4053 , A61B5/7289 , A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5235 , A61B6/5247 , G06F19/00 , G06T7/30 , G06T2207/10116 , G06T2207/30101
摘要： Images of static vascular maps (B), which were taken at different phases of the cardiac cycle and/or the respiratory cycle and were archived in a memory (6), are superimposed on a current image (A) of a catheter (2, 8) in the vascular system (9). In the method, a defined section of a map image (B) around the estimated actual position of the catheter is selected and is displayed superimposed on the current image (A) on a monitor (10). The map image (B) used for this is preferably selected by an electrocardiogram to match the particular cardiac cycle. The position of the catheter relative to the map image (B) is estimated using a distance image (D).
摘要翻译：在心脏周期和/或呼吸周期的不同阶段拍摄并存储在记忆体（6）中的静态血管图（B）的图像叠加在导管（2）的当前图像（A）上， 8）在血管系统（9）中。在该方法中，选择围绕估计的导管的实际位置的地图图像（B）的限定部分，并将其叠加显示在监视器（10）上的当前图像（A）上。用于此的地图图像（B）优选地通过心电图来选择以匹配特定心动周期。使用距离图像（D）估计导管相对于地图图像（B）的位置。

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