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1. 发明授权

US08730237B2 Coupling the viewing direction of a blood vessel's CPR view with the viewing angle on the 3D tubular structure's rendered voxel volume and/or with the C-arm geometry of a 3D rotational angiography device's C-arm system 有权
标题翻译：将血管CPR视图的观察方向与3D管状结构的再现的体素体积上的视角和/或3D旋转血管造影装置的C臂系统的C形臂几何结合
公开(公告)号：US08730237B2
公开(公告)日：2014-05-20
申请号：US12670866
申请日：2008-07-31
申请人： Daniel Simon Anna Ruijters , Nicolaas Hylke Bakker , Robert Johannes Frederik Homan
发明人： Daniel Simon Anna Ruijters , Nicolaas Hylke Bakker , Robert Johannes Frederik Homan
IPC分类号： G06T15/08 , G06T19/00
CPC分类号： G06T15/08 , G06T19/00 , G06T2210/41 , G06T2215/06
摘要： The present invention describes a method for rendering and displaying a curved planar reformat (CPR) view (7′) of a blood vessel's 3D tubular structure (1), wherein the viewing direction of the curved planar reformat view (7′) is coupled to the viewing angle on a segmented or raw representation of the 3D tubular structure's rendered voxel volume to be visualized or, alternatively, to the C-arm geometry of a 3D rotational angiography device's C-arm system (6). The proposed method thus enables measurements on the X-ray image which do not suffer from spatial foreshortening and do not need to be calibrated. Thereby, said coupling can be performed bidirectional. According to a first aspect of the proposed method, this means that the viewing direction of the aforementioned curved planar reformat view (7′) follows the viewing angle on a segmented or raw representation of the 3D tubular structure's rendered voxel volume to be visualized, or vice versa. According to another aspect of the proposed method, this means that the viewing direction of the curved planar reformat view (7′) is set depending on the C-arm geometry given by the roll (θx), pitch (θy) and yaw angle (θz) of a 3D rotational angiography device's C-arm system (6), or vice versa.
摘要翻译：本发明描述了一种用于渲染和显示血管3D管状结构（1）的弯曲平面重新格栅（CPR）视图（7'）的方法，其中弯曲平面重新格式视图（7'）的观察方向被耦合到 3D管状结构的渲染体素的分段或原始表示的视角要被可视化，或者替代地对于3D旋转血管造影装置的C臂系统（6）的C形臂几何形状。因此，所提出的方法能够对不具有空间缩短的X射线图像进行测量，并且不需要校准。由此，可以双向执行所述耦合。根据所提出的方法的第一方面，这意味着上述弯曲平面重新格式化视图（7'）的观察方向遵循3D管状结构的呈现的体素体积的分段或原始表示的视角，以被可视化，或反之亦然。根据所提出的方法的另一方面，这意味着弯曲平面重新格式化视图（7'）的观察方向根据由辊（＆amp; x），间距（＆amp; y; y）给出的C形臂几何来设定，和3D旋转血管造影装置的C臂系统（6）的偏航角（＆amp; t; z），反之亦然。

2. 发明申请

US20100239140A1 COUPLING THE VIEWING DIRECTION OF A BLOOD VESSEL'S CPR VIEW WITH THE VIEWING ANGLE ON THE 3D TUBULAR STRUCTURE'S RENDERED VOXEL VOLUME AND/OR WITH THE C-ARM GEOMETRY OF A 3D ROTATIONAL ANGIOGRAPHY DEVICE'S C-ARM SYSTEM 有权
标题翻译：联合3D血管血管造影检查方向的观察方向与3D管状结构的变形体积和/或三维旋转血管成像装置的C-ARM系统的C-ARM几何的观察角度
公开(公告)号：US20100239140A1
公开(公告)日：2010-09-23
申请号：US12670866
申请日：2008-07-31
申请人： Daniel Simon Anna Ruijters , Nicolaas Hylke Bakker , Robert Johannes Frederik Homan
发明人： Daniel Simon Anna Ruijters , Nicolaas Hylke Bakker , Robert Johannes Frederik Homan
IPC分类号： G06K9/00 , G06T17/00
CPC分类号： G06T15/08 , G06T19/00 , G06T2210/41 , G06T2215/06
摘要： The present invention describes a method for rendering and displaying a curved planar reformat (CPR) view (7′) of a blood vessel's 3D tubular structure (1), wherein the viewing direction of the curved planar reformat view (7′) is coupled to the viewing angle on a segmented or raw representation of the 3D tubular structure's rendered voxel volume to be visualized or, alternatively, to the C-arm geometry of a 3D rotational angiography device's C-arm system (6). The proposed method thus enables measurements on the X-ray image which do not suffer from spatial foreshortening and do not need to be calibrated. Thereby, said coupling can be performed bidirectional. According to a first aspect of the proposed method, this means that the viewing direction of the aforementioned curved planar reformat view (7′) follows the viewing angle on a segmented or raw representation of the 3D tubular structure's rendered voxel volume to be visualized, or vice versa. According to another aspect of the proposed method, this means that the viewing direction of the curved planar reformat view (7′) is set depending on the C-arm geometry given by the roll (θx), pitch (θy) and yaw angle (θz) of a 3D rotational angiography device's C-arm system (6), or vice versa.
摘要翻译：本发明描述了一种用于渲染和显示血管3D管状结构（1）的弯曲平面重新格栅（CPR）视图（7'）的方法，其中弯曲平面重新格式视图（7'）的观察方向被耦合到 3D管状结构的渲染体素的分段或原始表示的视角要被可视化，或者替代地对于3D旋转血管造影装置的C臂系统（6）的C形臂几何形状。因此，所提出的方法能够对不具有空间缩短的X射线图像进行测量，并且不需要校准。由此，可以双向执行所述耦合。根据所提出的方法的第一方面，这意味着上述弯曲平面重新格式化视图（7'）的观察方向遵循3D管状结构的呈现的体素体积的分段或原始表示的视角，以被可视化，或反之亦然。根据所提出的方法的另一方面，这意味着弯曲平面重新格式化视图（7'）的观察方向根据由辊（＆amp; x），间距（＆amp; y; y）给出的C形臂几何来设定，和3D旋转血管造影装置的C臂系统（6）的偏航角（＆amp; t; z），反之亦然。

3. 发明申请

US20120183122A1 AUTOMATIC C-ARM VIEWING ANGLES FOR STRUCTURAL HEART DISEASE TREATMENT 有权
标题翻译：用于结构性心脏疾病治疗的自动C-臂观察角度
公开(公告)号：US20120183122A1
公开(公告)日：2012-07-19
申请号：US13388214
申请日：2010-09-28
申请人： Daniel Simon Anna Ruijters , Sander Denissen , Nicolaas Hylke Bakker
发明人： Daniel Simon Anna Ruijters , Sander Denissen , Nicolaas Hylke Bakker
IPC分类号： A61B6/02
CPC分类号： A61B6/504 , A61B6/503 , A61B6/547
摘要： In a method for positioning an X-ray image acquisition device a straight reference plane (30) intersecting a three-dimensional representation of the object, a center point (34) within the intersection of the object, a normal vector (38) to the reference plane and at least one tangential vector (40) within the reference plane are created. Thereafter, the reference plane, the object's frame of reference and the X-ray image acquisition's frame of reference are registered. At least one viewing direction derived from the normal vector (38) and/or at least one tangential vector (40) is defined, wherein the X-ray image acquisition device is adjusted to the geometrical parameters of the X-ray image acquisition device. Thereby, planned and stored optimal viewing directions may be made available by a single push of a button, leading to automatically positioning of the X-ray image acquisition device and a much faster adjustment of the live guidance image, thus resulting in less exposure of radiation as well as a less cumbersome adjustment procedure. Furthermore a more optimal deployment of the interventional devices can be reached, since they can be more accurately positioned.
摘要翻译：在用于将X射线图像采集装置定位为与物体的三维表示相交的直线参考平面（30）的方法中，在物体的交叉点内的中心点（34），法线向量（38）到参考平面和参考平面内的至少一个切向矢量（40）。此后，登记参考平面，物体的参照系和X射线图像获取的参照系。定义从法向量（38）和/或至少一个切向矢量（40）导出的至少一个观察方向，其中将X射线图像采集装置调整到X射线图像采集装置的几何参数。因此，可以通过单次按压按钮使计划和存储的最佳观看方向可用，导致X射线图像采集装置的自动定位和实时指导图像的更快调整，从而导致较少的辐射暴露以及较不麻烦的调整程序。此外，可以达到更好的部署介入装置，因为它们可以更准确地定位。

4. 发明授权

US08681935B2 Automatic C-arm viewing angles for structural heart disease treatment 有权
标题翻译：用于结构性心脏病治疗的自动C-臂视角
公开(公告)号：US08681935B2
公开(公告)日：2014-03-25
申请号：US13388214
申请日：2010-09-28
申请人： Daniel Simon Anna Ruijters , Sander Denissen , Nicolaas Hylke Bakker
发明人： Daniel Simon Anna Ruijters , Sander Denissen , Nicolaas Hylke Bakker
IPC分类号： G01N23/04
CPC分类号： A61B6/504 , A61B6/503 , A61B6/547
摘要： In a method for positioning an X-ray image acquisition device a straight reference plane (30) intersecting a three-dimensional representation of the object, a center point (34) within the intersection of the object, a normal vector (38) to the reference plane and at least one tangential vector (40) within the reference plane are created. Thereafter, the reference plane, the object's frame of reference and the X-ray image acquisition's frame of reference are registered. At least one viewing direction derived from the normal vector (38) and/or at least one tangential vector (40) is defined, wherein the X-ray image acquisition device is adjusted to the geometrical parameters of the X-ray image acquisition device. Thereby, planned and stored optimal viewing directions may be made available by a single push of a button, leading to automatically positioning of the X-ray image acquisition device and a much faster adjustment of the live guidance image, thus resulting in less exposure of radiation as well as a less cumbersome adjustment procedure. Furthermore a more optimal deployment of the interventional devices can be reached, since they can be more accurately positioned.
摘要翻译：在用于将X射线图像采集装置定位为与物体的三维表示相交的直线参考平面（30）的方法中，在物体的交叉点内的中心点（34），法线向量（38）到参考平面和参考平面内的至少一个切向矢量（40）。此后，登记参考平面，物体的参照系和X射线图像获取的参照系。定义从法向量（38）和/或至少一个切向矢量（40）导出的至少一个观察方向，其中将X射线图像采集装置调整到X射线图像采集装置的几何参数。因此，可以通过单次按压按钮使计划和存储的最佳观看方向可用，导致X射线图像采集装置的自动定位和实时指导图像的更快调整，从而导致较少的辐射暴露以及较不麻烦的调整程序。此外，可以达到更好的部署介入装置，因为它们可以更准确地定位。

5. 发明授权

US09262830B2 2D/3D image registration 有权
标题翻译： 2D / 3D图像配准
公开(公告)号：US09262830B2
公开(公告)日：2016-02-16
申请号：US14002375
申请日：2012-02-27
申请人： Nicolaas Hylke Bakker , Sandar Hans Denissen , Wilhelmus Henrica Gerarda Maria Van Den Boomen , Daniel Simon Anna Ruijters , Pieter Maria Mielekamp
发明人： Nicolaas Hylke Bakker , Sandar Hans Denissen , Wilhelmus Henrica Gerarda Maria Van Den Boomen , Daniel Simon Anna Ruijters , Pieter Maria Mielekamp
IPC分类号： G06T7/00
CPC分类号： G06T7/0024 , G06T7/30 , G06T7/33 , G06T2207/10121 , G06T2207/20092 , G06T2207/20212 , G06T2207/30101 , G06T2211/404
摘要： 2D images are registered with 3D volume data. In order to provide 2D/3D registration with a facilitated workflow 3D volume data (112) of an object, having a frame of reference is received. A transformation plane (116) is defined in relation to the 3D volume data. A 2D image of the object with an image plane is received. The transformation plane is projected on the image plane. The frame of reference is aligned with the 2D image. At least one alignment interaction value (128) is projected (130) on the transformation plane to determine (134) at least one transformed interaction value (132). The frame of reference is translated with the at least one transformed interaction value.
摘要翻译： 2D图像使用3D体积数据进行注册。为了提供具有简化的工作流的2D / 3D注册，接收具有参考系的对象的3D体数据（112）。相对于3D体积数据定义变换平面（116）。接收具有图像平面的对象的2D图像。变换平面投影在图像平面上。参考框架与2D图像对齐。在变换平面上投影（130）至少一个对准交互值（128）以确定（134）至少一个变换的相互作用值（132）。用至少一个变换的相互作用值翻译参考系。

6. 发明申请

US20130336565A1 2D/3D IMAGE REGISTRATION 有权
标题翻译： 2D / 3D图像注册
公开(公告)号：US20130336565A1
公开(公告)日：2013-12-19
申请号：US14002375
申请日：2012-02-27
申请人： Nicolaas Hylke Bakker , Sandar Hans Denissen , Wilhelmus Henrica Gerarda Maria Van Den Boomen , Daniel Simon Anna Ruijters , Pieter Maria Mielekamp
发明人： Nicolaas Hylke Bakker , Sandar Hans Denissen , Wilhelmus Henrica Gerarda Maria Van Den Boomen , Daniel Simon Anna Ruijters , Pieter Maria Mielekamp
IPC分类号： G06T7/00
CPC分类号： G06T7/0024 , G06T7/30 , G06T7/33 , G06T2207/10121 , G06T2207/20092 , G06T2207/20212 , G06T2207/30101 , G06T2211/404
摘要： The present invention relates to interactive registration of 2D images with 3D volume data, and in particular relates to the registration of two 2D images with 3D volume data. In order to provide 2D/3D registration with a facilitated workflow for the user, an example of a method is provided comprising the steps of providing (110) 3D volume data (112) of an object, comprising a frame of reference; defining (114) a transformation plane (116) in relation to the 3D volume data perpendicular to the image plane of the first image; aligning the frame of reference with the second 2D image, wherein at least one alignment interaction value (128) is projected (130) on the transformation plane to determine (134) at least one transformed interaction value (132); and translating (136) the frame of reference with the at least one
摘要翻译：本发明涉及2D图像与3D体积数据的交互注册，具体涉及两维2D图像与3D体积数据的配准。为了向用户提供方便的工作流程的2D / 3D注册，提供了一种方法的示例，其包括以下步骤：提供（110）对象的3D体积数据（112），其包括参考系; 相对于垂直于第一图像的图像平面的3D体积数据定义（114）变换平面（116）; 将所述参考系对准所述第二2D图像，其中在所述变换平面上投影（130）至少一个对准相互作用值（130）以确定（134）至少一个变换的相互作用值（132）; 以及用所述至少一个翻译（136）所述参考系

7. 发明申请

US20090281418A1 DETERMINING TISSUE SURROUNDING AN OBJECT BEING INSERTED INTO A PATIENT 审中-公开
标题翻译：确定一个被包含在患者身上的物体的组织
公开(公告)号：US20090281418A1
公开(公告)日：2009-11-12
申请号：US12295754
申请日：2007-03-15
申请人： Daniel Simon Anna Ruijters , Drazenko Babic , Robert Johannes Frederik Homan , Pieter Maria Mielenkamp
发明人： Daniel Simon Anna Ruijters , Drazenko Babic , Robert Johannes Frederik Homan , Pieter Maria Mielenkamp
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5235 , A61B6/5247 , A61B34/20 , A61B90/36 , A61B2034/2051 , A61B2034/2065 , A61B2090/364 , G06T7/33 , G06T7/38 , G06T2207/10081 , G06T2207/10121 , G06T2207/30021 , G06T2207/30101
摘要： It is described a method for determining and assessing the tissue surrounding an object being inserted into a patient. The method comprises acquiring a first dataset representing a first 3D image of the patient, acquiring a second dataset representing a second 3D image of the blood vessel structure of the patient and acquiring a third dataset representing a 2D image of the patient including the object. The method further comprises recognizing the object within the 2D image, registering two of the three datasets with each other, whereby the object is back-projected in the blood vessel structure, in order to generate a first combined dataset, and registering the first combined dataset with the remaining dataset in order to generate a second combined dataset representing a further image surrounding the object. The method allows for combining diagnostic scanning such as CT, 3D RA and real-time 2D fluoroscopy. Thereby, it is possible to generate an image perpendicular to a catheter tip representing the object being inserted into the patient. Since the 3D-RA displays the lumen and the diagnostic scanning displays soft-tissue, it is possible to assess the tissue at the catheter tip position.
摘要翻译：描述了一种用于确定和评估被插入患者体内的物体周围的组织的方法。该方法包括获取表示患者的第一3D图像的第一数据集，获取表示患者的血管结构的第二3D图像的第二数据集，并获取表示包括对象的患者的2D图像的第三数据集。该方法还包括识别2D图像内的对象，将三个数据集中的两个相互注册，从而将对象反投影在血管结构中，以便生成第一组合数据集，以及登记第一组合数据集与剩余的数据集合，以便生成表示对象周围的另一图像的第二组合数据集。该方法允许组合诊断扫描，如CT，3D RA和实时2D荧光透视。由此，可以产生垂直于代表被插入患者体内的导管尖端的图像。由于3D-RA显示管腔，诊断扫描显示软组织，因此可以评估导管尖端位置处的组织。

8. 发明授权

US08488910B2 Image provision for registration 有权
标题翻译：图像提供注册
公开(公告)号：US08488910B2
公开(公告)日：2013-07-16
申请号：US13130601
申请日：2009-11-19
申请人： Daniel Simon Anna Ruijters
发明人： Daniel Simon Anna Ruijters
IPC分类号： G06K9/32
CPC分类号： A61B6/541 , A61B5/055 , A61B5/7292 , G06T3/0068 , G06T7/38 , G06T2207/10081 , G06T2207/10121 , G06T2207/30048
摘要： The invention relates to a device and a method for providing a basis for registering a three-dimensional model of an anatomical region with two-dimensional projection images, by deriving a three-dimensional model of an anatomical region at a phase of a periodic signal; deriving two-dimensional projection images of a region which overlaps with the anatomical region re-constructed as the three-dimensional model; pre-5 selecting a subset of projection images out of the derived two-dimensional projection images, which are closest to the phase; and selecting a reference image for the registration from the subset of pre-selected projection images by choosing the projection image with the most contrast.
摘要翻译：本发明涉及一种通过在周期性信号的相位导出解剖区域的三维模型来提供用于通过二维投影图像登记解剖区域的三维模型的基础的装置和方法; 导出与重构为三维模型的解剖区域重叠的区域的二维投影图像; 在5之前从最接近相位的导出的二维投影图像中选择投影图像的子集; 以及通过选择具有最大对比度的投影图像，从预选投影图像的子集中选择用于注册的参考图像。

9. 发明申请

US20110235890A1 IMAGE PROVISION FOR REGISTRATION 有权
标题翻译：图像规定注册
公开(公告)号：US20110235890A1
公开(公告)日：2011-09-29
申请号：US13130601
申请日：2009-11-19
申请人： Daniel Simon Anna Ruijters
发明人： Daniel Simon Anna Ruijters
IPC分类号： G06K9/00
CPC分类号： A61B6/541 , A61B5/055 , A61B5/7292 , G06T3/0068 , G06T7/38 , G06T2207/10081 , G06T2207/10121 , G06T2207/30048
摘要： The invention relates to a device and a method for providing a basis for registering a three-dimensional model of an anatomical region with two-dimensional projection images, by deriving a three-dimensional model of an anatomical region at a phase of a periodic signal; deriving two-dimensional projection images of a region which overlaps with the anatomical region re-constructed as the three-dimensional model; pre-5 selecting a subset of projection images out of the derived two-dimensional projection images, which are closest to the phase; and selecting a reference image for the registration from the subset of pre-selected projection images by choosing the projection image with the most contrast.
摘要翻译：本发明涉及一种通过在周期性信号的相位导出解剖区域的三维模型来提供用于通过二维投影图像登记解剖区域的三维模型的基础的装置和方法; 导出与重构为三维模型的解剖区域重叠的区域的二维投影图像; 在5之前从最接近相位的导出的二维投影图像中选择投影图像的子集; 以及通过选择具有最大对比度的投影图像，从预选投影图像的子集中选择用于注册的参考图像。

10. 发明授权

US09795348B2 Medical viewing system and method for generating an angulated view of an object of interest 有权
公开(公告)号：US09795348B2
公开(公告)日：2017-10-24
申请号：US13695641
申请日：2011-04-27
申请人： Daniel Simon Anna Ruijters
发明人： Daniel Simon Anna Ruijters
IPC分类号： G06K9/00 , A61B6/00 , A61B6/12 , A61B90/00 , A61B34/10
CPC分类号： A61B6/463 , A61B6/12 , A61B6/4441 , A61B2034/107 , A61B2090/365 , A61B2090/367 , A61B2090/376 , A61B2090/3762
摘要： In a medical viewing system having an X-ray image acquisition device a data processing unit is adapted for generating two different views on a three-dimensional image set, wherein a first view is corresponding to the viewing direction of the X-ray image acquisition device and a second view has a rotational offset to the first viewing direction. The first view may include live X-ray images, e.g. for monitoring a stent placement. The second view 10 supports a clinician to unambiguously judge whether ostia connection points may be blocked that are not clearly visible in anterior-posterior images.

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