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1. 发明授权

US08795633B2 Multiphoton in vivo flow cytometry method and device 有权
标题翻译：多光子体内流式细胞术方法及装置
公开(公告)号：US08795633B2
公开(公告)日：2014-08-05
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： A61B5/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译：本发明涉及用于诊断致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式Ab-X的缀合物或复合物的组合物，其中组Ab包含与致病细胞和组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。

2. 发明申请

US20080254499A1 Multiphoton in Vivo Flow Cytometry Method and Device 有权
标题翻译：多光子体内流式细胞术方法和装置
公开(公告)号：US20080254499A1
公开(公告)日：2008-10-16
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译：本发明涉及一种用于诊断由致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式“π-in-line-formula description =”的共轭物或复合物的组合物公式“end =”lead“？> Ab-X <？in-line-formula description =”In-line Formulas“end =”tail“？>其中A组包括配体结合致病细胞，组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。

3. 发明申请

US20130158383A1 BOND-SELECTIVE VIBRATIONAL PHOTOACOUSTIC IMAGING SYSTEM AND METHOD 审中-公开
标题翻译： BOND选择性振动摄影成像系统及方法
公开(公告)号：US20130158383A1
公开(公告)日：2013-06-20
申请号：US13818075
申请日：2011-08-22
申请人： Ji-Xin Cheng , Han-Wei Wang , Michael Sturek
发明人： Ji-Xin Cheng , Han-Wei Wang , Michael Sturek
IPC分类号： A61B5/00
CPC分类号： A61B5/0095
摘要： An imaging system, including a radiation source configured to output a signal that can non-invasively and selectively cause overtone excitation of molecules based on a predetermined chemical bond, and an ultrasound detector configured to non-invasively detect an acoustic signal generated by vibrational energy caused by the selective overtone excitation of the molecules and further configured to convert the acoustic signal into an image.
摘要翻译：一种成像系统，包括被配置为输出基于预定化学键可以非侵入地选择性地引起分子泛音激励的信号的辐射源，以及被配置为非侵入性地检测由振动能产生的声信号的超声波检测器通过分子的选择性泛音激励，并且还被配置为将声信号转换为图像。

4. 发明申请

US20140200434A1 VIBRATIONAL PHOTOACOUSTIC TOMOGRAPHY USING RAMAN LASER 有权
标题翻译：使用拉曼激光的振动光电图像
公开(公告)号：US20140200434A1
公开(公告)日：2014-07-17
申请号：US14156946
申请日：2014-01-16
申请人： Ji-Xin Cheng
发明人： Ji-Xin Cheng
IPC分类号： A61B5/00
CPC分类号： A61B5/0095
摘要： A method of noninvasively imaging tissue within a body includes irradiating the tissue using an imaging laser including a Raman-based laser tuner, the radiation including a plurality of laser pulses, each having energy greater than 100 mJ; receiving an acoustic signal generated by vibrational energy in the tissue, wherein the vibrational energy is a result of selective overtone excitation of molecules in the tissue by the radiation; and automatically converting the acoustic signal to an image representative of the tissue using a processor. An imaging system includes an imaging laser configured to irradiate tissue with a plurality of laser pulses using a Raman-based laser tuner. An ultrasonic transducer receives an acoustic signal generated by vibrational energy in the tissue due to overtone excitation by the radiation. A processor is configured to automatically produce an image representative of the tissue using the received acoustic signal.
摘要翻译：一种在体内非侵入性地成像组织的方法包括使用包括基于拉曼的激光调谐器的成像激光器照射组织，该辐射包括多个激光脉冲，每个激光脉冲具有大于100mJ的能量; 接收由所述组织中的振动能产生的声信号，其中所述振动能是由所述辐射对所述组织中的分子的选择性泛音激励的结果; 并使用处理器自动地将声信号转换成代表组织的图像。一种成像系统包括：成像激光器，被配置为使用基于拉曼的激光调谐器来照射具有多个激光脉冲的组织。超声换能器由于辐射的泛音激励而接收由组织中的振动能产生的声信号。处理器被配置为使用所接收的声信号自动产生代表组织的图像。

5. 发明申请

US20130337075A1 NANOMEDICINES FOR EARLY NERVE REPAIR 审中-公开
标题翻译：用于早期神经修复的纳米酮
公开(公告)号：US20130337075A1
公开(公告)日：2013-12-19
申请号：US14001189
申请日：2012-02-24
申请人： Ji-Xin Cheng
发明人： Ji-Xin Cheng
IPC分类号： A61K47/48 , A61K45/06
CPC分类号： A61K47/48923 , A61K9/0019 , A61K9/19 , A61K9/5153 , A61K31/573 , A61K36/9066 , A61K45/06 , A61K47/542 , A61K47/61 , A61K47/6939 , Y10T428/2982
摘要： The present disclosure describes hydrophobically modified nanoparticles and polymeric nanostructures that can be utilized to for the treatment of neuronal injury or neuronal disease in an affected patient, along with methods of forming and using the nanoparticles and nanostructures. Furthermore, the nanoparticles and nanostructures are designed as “dual action” compositions to treat neuronal injury and neuronal disease via repair of damaged membrane and suppression of intracellular inflammation.
摘要翻译：本公开内容描述了可用于治疗受影响患者的神经元损伤或神经元疾病的疏水改性的纳米颗粒和聚合物纳米结构，以及形成和使用纳米颗粒和纳米结构的方法。此外，纳米颗粒和纳米结构被设计为“双作用”组合物，通过修复受损膜并抑制细胞内炎症来治疗神经元损伤和神经元疾病。

6. 发明授权

US06809814B2 System and method for epi-detected coherent anti-stokes raman scattering microscopy 有权
标题翻译：用于epi检测的相干反火箭拉曼散射显微镜的系统和方法
公开(公告)号：US06809814B2
公开(公告)日：2004-10-26
申请号：US10345677
申请日：2003-01-16
申请人： Xiaoling Sunney Xie , Ji-Xin Cheng , Andreas Volkmer
发明人： Xiaoling Sunney Xie , Ji-Xin Cheng , Andreas Volkmer
IPC分类号： G01J344
CPC分类号： G01N21/65 , G01J3/44 , G01N15/1434 , G01N15/1475 , G01N2015/1006 , G01N2021/653
摘要： Systems and methods are disclosed for detecting a coherent anti-Stokes Raman scattering (CARS) signal from a microscopic sample in an epi-direction. In an embodiment, the system includes at least two sources having a pump source for generating a pump field at the pump frequency, a Stoke source for generating a Stoke field at the Stoke frequency that is different from the pump frequency, optics (64) for directing the pump and Stoke beams (60) in a collinear fashion through a focusing lens (66) toward a common focal spot in a sample (70), and detector optics that images the CARS in epi-direction, which is generated by the interaction of the pump and Stoke fields (60) with the sample (70) and is collected by the same focusing lens (66), towards an epi-detector (78).
摘要翻译：公开了用于从表面方向检测来自微观样品的相干反斯托克斯拉曼散射（CARS）信号的系统和方法。在一个实施例中，该系统包括至少两个源，其具有用于产生泵频率的泵浦场的泵浦源，用于产生Stoke频率不同于泵浦频率的Stoke场的Stoke源，用于将泵和Stoke梁（60）以共线的方式通过聚焦透镜（66）朝向样品（70）中的公共焦斑引导，以及检测器光学器件，其通过相互作用产生的外延方向成像CARS 的泵和Stoke磁场（60）与样品（70）并且被相同的聚焦透镜（66）收集到外部探测器（78）。

7. 发明申请

US20140218726A1 SYSTEM AND METHOD FOR MULTIPLEX SPECTROSCOPIC IMAGING 有权
标题翻译：多光谱成像系统与方法
公开(公告)号：US20140218726A1
公开(公告)日：2014-08-07
申请号：US14171052
申请日：2014-02-03
申请人： Ji-Xin Cheng , Mikhail N. Slipchenko , Robert A. Oglesbee
发明人： Ji-Xin Cheng , Mikhail N. Slipchenko , Robert A. Oglesbee
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/2803
摘要： A system for measuring an sample includes an illumination source providing electromagnetic radiation pulses at a selected temporal frequency. A microscope focuses the radiation to interact with the sample and produce resultant electromagnetic radiation. A disperser disperses wavelengths of the resultant radiation onto optical sensors, and respective resonant amplifiers amplify signals having the selected temporal frequency. Optical detection apparatus includes the optical sensors, resonant amplifiers, and disperser. The resonant amplifiers amplify portion(s) of their inputs having a selected temporal frequency and attenuate other portion(s). A method of analyzing constituents of a sample includes contemporaneously irradiating the sample with narrowband light and broadband light, the optical power of either modulated at a selected temporal frequency; dispersing wavelengths of resultant light across the optical detectors; and filtering respective signals from the optical detectors to provide spectrum data including signals corresponding to the selected temporal frequency.
摘要翻译：用于测量样本的系统包括以选定的时间频率提供电磁辐射脉冲的照明源。显微镜将放射线与样品相互作用并产生电磁辐射。分散器将所得辐射的波长分散到光学传感器上，并且相应的谐振放大器放大具有所选择的时间频率的信号。光学检测装置包括光学传感器，谐振放大器和分散器。谐振放大器放大其输入的具有选定时间频率的部分，并衰减其它部分。分析样品成分的方法包括同时以窄带光和宽带光照射样品，以选定的时间频率调制的光功率; 将所得光的波长分散在光学检测器上; 并且对来自光学检测器的各个信号进行滤波以提供包括对应于选定的时间频率的信号的频谱数据

8. 发明授权

US06798507B2 System and method for polarization coherent anti-stokes Raman scattering microscopy 有权
标题翻译：用于偏振相干反斯托克斯拉曼散射显微镜的系统和方法
公开(公告)号：US06798507B2
公开(公告)日：2004-09-28
申请号：US10186104
申请日：2002-06-27
申请人： Xiaoling Sunney Xie , Ji-Xin Cheng
发明人： Xiaoling Sunney Xie , Ji-Xin Cheng
IPC分类号： G01J344
CPC分类号： G01J3/44 , G01N21/65 , G01N2021/653
摘要： Systems and methods are disclosed for detecting a nonlinear coherent field induced in a microscopic sample. The system includes in an embodiment, a first source for generating a first polarized electromagnetic field at a first frequency and a second source for generating a second polarized electromagnetic field at a second frequency that is different from the first frequency. The system further includes optics for combining the first polarized electromagnetic field and the second polarized electromagnetic field in a collinear fashion such that the difference in polarization angles is &phgr; wherein &phgr; is not equal to zero. The optics further direct the combined electromagnetic field toward a common focal volume. The system also includes a polarization sensitive detector for detecting a nonlinear coherent field that is generated responsive to the first and second polarized electromagnetic fields in the focal volume.
摘要翻译：公开了用于检测在微观样品中诱导的非线性相干场的系统和方法。该系统在一个实施例中包括用于产生第一频率的第一极化电磁场的第一源和用于产生与第一频率不同的第二频率的第二极化电磁场的第二源。该系统还包括用于以共线方式组合第一极化电磁场和第二极化电磁场的光学器件，使得偏振角的差是phi，其中phi不等于零。光学器件进一步将组合的电磁场引向公共焦点体积。该系统还包括用于检测响应于焦点体积中的第一和第二极化电磁场产生的非线性相干场的偏振敏感检测器。

9. 发明授权

US10928324B2 Stimulated Raman spectroscopic microscope by resonant delay-line tuning 有权
公开(公告)号：US10928324B2
公开(公告)日：2021-02-23
申请号：US16470119
申请日：2017-12-14
申请人： Purdue Research Foundation , Chien-Sheng Liao , Pu Wang , Ji-Xin Cheng
发明人： Chien-Sheng Liao , Pu Wang , Ji-Xin Cheng
IPC分类号： G01J3/44 , G01N21/65 , G01J3/10 , G01J3/433
摘要： A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.

10. 发明授权

US08994932B2 Multimodal platform for nonlinear optical microscopy and microspectroscopy 有权
标题翻译：用于非线性光学显微镜和显微光谱的多模平台
公开(公告)号：US08994932B2
公开(公告)日：2015-03-31
申请号：US13141039
申请日：2009-12-18
申请人： Ji-Xin Cheng , Hongtao Chen , Mikhail Slipchenko , Haifeng Wang
发明人： Ji-Xin Cheng , Hongtao Chen , Mikhail Slipchenko , Haifeng Wang
IPC分类号： G01N21/00 , G01N21/64 , G01J3/44 , G01N21/65 , G02B21/16 , G01N21/63
CPC分类号： G01N21/6486 , G01J3/44 , G01N21/636 , G01N21/6458 , G01N21/65 , G01N2021/653 , G02B21/16
摘要： A method for providing images using a multimodal nonlinear optical microscope is disclosed. The method includes providing a foundation femtosecond laser beam, generating a first femtosecond laser beam and a second femtosecond laser beam corresponding to the foundation femtosecond laser beam, combining the first femtosecond laser beam and the foundation femtosecond laser beam to generate a first combination femtosecond laser beam, and generating a coherent anti-Stokes Raman scattering (CARS) signal based on the first combination femtosecond laser beam. A multimodal nonlinear optical microscopy platform is also disclosed.
摘要翻译：公开了一种使用多模式非线性光学显微镜提供图像的方法。该方法包括提供基础飞秒激光束，产生对应于基础飞秒激光束的第一飞秒激光束和第二飞秒激光束，组合第一飞秒激光束和基础飞秒激光束以产生第一组合飞秒激光束并且基于第一组合飞秒激光束产生相干的反斯托克斯拉曼散射（CARS）信号。还公开了一种多模式非线性光学显微镜平台。

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