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1. 发明授权

US08795633B2 Multiphoton in vivo flow cytometry method and device 有权
标题翻译：多光子体内流式细胞术方法及装置
公开(公告)号：US08795633B2
公开(公告)日：2014-08-05
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： A61B5/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译：本发明涉及用于诊断致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式Ab-X的缀合物或复合物的组合物，其中组Ab包含与致病细胞和组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。

2. 发明申请

US20080254499A1 Multiphoton in Vivo Flow Cytometry Method and Device 有权
标题翻译：多光子体内流式细胞术方法和装置
公开(公告)号：US20080254499A1
公开(公告)日：2008-10-16
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译：本发明涉及一种用于诊断由致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式“π-in-line-formula description =”的共轭物或复合物的组合物公式“end =”lead“？> Ab-X <？in-line-formula description =”In-line Formulas“end =”tail“？>其中A组包括配体结合致病细胞，组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。

3. 发明申请

US20100055735A1 EX VIVO FLOW CYTOMETRY METHOD AND DEVICE 有权
标题翻译： EX VIVO FLOW CYTOMETRY方法和设备
公开(公告)号：US20100055735A1
公开(公告)日：2010-03-04
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A. Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A. Kularatne
IPC分类号： C12Q1/06
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译：本发明涉及诊断由致病细胞介导的疾病状态的方法。该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及使用流式细胞术检测表达配体受体的致病细胞。

4. 发明授权

US08685752B2 Ex vivo flow cytometry method and device 有权
标题翻译：离体流式细胞术方法及装置
公开(公告)号：US08685752B2
公开(公告)日：2014-04-01
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A Kularatne
IPC分类号： G01N33/82 , G01N31/22 , A61K38/00
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X, wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译：本发明涉及诊断由致病细胞介导的疾病状态的方法。该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，并使用流式细胞术检测表达配体受体的致病细胞。

5. 发明申请

US20160351371A1 SCANNING TRANSMISSION ELECTRON MICROSCOPE WITH VARIABLE AXIS OBJECTIVE LENS AND DETECTIVE SYSTEM 有权
标题翻译：扫描传输电子显微镜与可变轴目标镜头和检测系统
公开(公告)号：US20160351371A1
公开(公告)日：2016-12-01
申请号：US14940102
申请日：2015-11-12
申请人： Shuai Li , Wei He , Zhongwei Chen
发明人： Shuai Li , Wei He , Zhongwei Chen
IPC分类号： H01J37/145 , H01J37/28 , H01J37/21 , H01J37/147
CPC分类号： H01J37/145 , H01J37/1477 , H01J37/21 , H01J37/28 , H01J2237/0473 , H01J2237/2802
摘要： The present invention provides a scanning transmission electron microscope (STEM). In the STEM, a specimen is sandwiched between a variable axis objective lens and a variable axis collection lens. The axis of the collection lens varies along with the variation of the objective lens axis in a coordinated manner. The STEM of the invention exhibits technical merits such as large scanning field, high image resolution across the entire scanning field, and high throughput, among others.
摘要翻译：本发明提供扫描透射电子显微镜（STEM）。在STEM中，将样本夹在可变轴物镜和可变轴收集透镜之间。收集透镜的轴线随着物镜轴的协调变化而变化。本发明的STEM具有如扫描场大，整个扫描场的高图像分辨率，高通量等技术优点。

6. 发明申请

US20150335046A1 Methods for improving rice nutrition via manipulation of starch crystalline structure and nutrient penetration treatment 审中-公开
标题翻译：通过操作淀粉结晶结构和营养渗透处理改善水稻营养的方法
公开(公告)号：US20150335046A1
公开(公告)日：2015-11-26
申请号：US14544853
申请日：2015-02-23
申请人： Zhaohua Peng , Vivian Peng , Wei He
发明人： Zhaohua Peng , Vivian Peng , Wei He
IPC分类号： A23L1/182
CPC分类号： A21D13/047 , A21D13/04 , A21D13/06 , A23L7/101 , A23L7/143 , A23L7/196
摘要： The methods of the invention provide improved rice grain nutrition by manipulation of the rice starch crystalline structure leading to easier penetration of nutrients into the rice grain and enhancement of rice grains with nutrients, thereby creating enhanced rice grain products. In addition, methods of direct delivery of nutrients into rice grains are also presented.
摘要翻译：本发明的方法通过操作大米淀粉结晶结构提供改善的稻谷营养，导致营养物质进入米粒更容易渗透，并增加米粒营养，从而产生增强的米粒产品。此外，还提出了将营养物质直接输送到稻谷中的方法。

7. 发明申请

US20150155846A1 APPARATUS AND METHODS FOR WIRELESS COMMUNICATION 审中-公开
标题翻译：无线通信的装置和方法
公开(公告)号：US20150155846A1
公开(公告)日：2015-06-04
申请号：US14400655
申请日：2012-05-22
申请人： Wei He , Wenliang Qiao , Qingyu Guo
发明人： Wei He , Wenliang Qiao , Qingyu Guo
IPC分类号： H03H7/38 , H01Q5/335 , H04W88/06
CPC分类号： H03H7/38 , H01Q5/335 , H03H2007/386 , H04B1/0458 , H04B1/18 , H04W88/06 , Y10T29/49016
摘要： An apparatus comprising: a first resonant circuit configured to have an impedance at a first operational frequency band to impedance match a first radiator to radio circuitry, and to have an impedance at a second operational frequency band to impedance match a second radiator to the radio circuitry; a second resonant circuit configured to have an impedance at the first operational frequency band to impedance match the first radiator to the radio circuitry, and to have an impedance at the second operational frequency band to impedance match the second radiator to the radio circuitry; and a third resonant circuit configured to have an impedance at the first operational frequency band to impedance match the first radiator to the radio circuitry, and to have an impedance at the second operational frequency band to impedance match the second radiator to the radio circuitry.
摘要翻译：一种装置，包括：第一谐振电路，其被配置为具有在第一工作频带处的阻抗以阻抗匹配第一辐射器与无线电电路，并且具有在第二工作频带处的阻抗以将第二辐射器阻抗匹配到所述无线电电路 ; 第二谐振电路，其被配置为具有在所述第一工作频带处的阻抗以使所述第一辐射器与所述无线电电路匹配，并且具有在所述第二工作频带处的阻抗以使所述第二辐射器与所述无线电电路匹配; 以及第三谐振电路，其被配置为具有在所述第一工作频带处的阻抗以使所述第一辐射器与所述无线电电路匹配，并且具有在所述第二操作频带处的阻抗以使所述第二辐射器与所述无线电电路匹配。

8. 发明授权

US09027686B2 Truck fairing 有权
标题翻译：卡车整流罩
公开(公告)号：US09027686B2
公开(公告)日：2015-05-12
申请号：US14348096
申请日：2011-10-12
申请人： Wei He , Mathew Frederick Heinecke
发明人： Wei He , Mathew Frederick Heinecke
IPC分类号： B62D35/02
CPC分类号： B62D35/02 , B62D35/001 , B62D37/02 , Y02T10/88
摘要： A truck includes a frame, an operator cab on the frame and a drive axle having a differential. The differential can be connected to a drive shaft. A fairing for directing air flow around the differential is attached to the frame forward of the drive axle and forward of the differential. The fairing can have a non-deflected position and a deflected position.
摘要翻译：卡车包括框架，框架上的操作驾驶室和具有差速器的驱动桥。差速器可以连接到驱动轴。用于将气流引导到差速器周围的整流罩附接到驱动轴前方的框架和差速器的前方。整流罩可以具有非偏转位置和偏转位置。

9. 发明授权

US08829451B2 High efficiency scintillator detector for charged particle detection 有权
标题翻译：用于带电粒子检测的高效闪烁体检测器
公开(公告)号：US08829451B2
公开(公告)日：2014-09-09
申请号：US13495102
申请日：2012-06-13
申请人： Zhibin Wang , Wei He , Fumin He
发明人： Zhibin Wang , Wei He , Fumin He
IPC分类号： G01T1/20
CPC分类号： G01T1/2002 , H01J37/244 , H01J37/28 , H01J2237/2443
摘要： An assembly for a charged particle detection device of high detection efficiency is described. The assembly comprising a metal grid for applying attractive potential to lure charged particles; a scintillator disc to absorb the energy from impinging charged particle and reemit the energy in form of light or photons; a light guide to transmit light or photons; and a photomultiplier tube (PMT) cohere with the end of light guide to receive light or photons from light guide and convert it into current signal. A light guide with a bullet-head-shaped front portion ensures total reflection of light propagating within the light guide. A frustum-cone-shaped scintillator disc releases the light that originally trapped in the scintillator disc due to the shape of scintillator.
摘要翻译：描述了一种检测效率高的带电粒子检测装置的组件。所述组件包括金属网格，用于施加诱发电位以诱使带电粒子; 闪烁体盘，以吸收来自撞击带电粒子的能量并以光或光子的形式再次产生能量; 用于传输光或光子的光导; 和光电倍增管（PMT）与光导的端部相连，以从光导中接收光或光子并将其转换为电流信号。具有子弹头前部的光导确保了在光导内传播的光的全反射。锥形锥形闪烁体盘由于闪烁体的形状而释放原先被俘获在闪烁体盘中的光。

10. 发明申请

US20140038968A1 AMINO-HETEROARYL-CONTAINING PROKINETICIN 1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：含有氨基酸的化合物1受体拮抗剂
公开(公告)号：US20140038968A1
公开(公告)日：2014-02-06
申请号：US13653452
申请日：2012-10-17
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC分类号： C07D251/38 , C07D403/12
CPC分类号： C07D251/38 , C07D401/12 , C07D403/12 , C07D405/14
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
摘要翻译：本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。

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