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1. 发明授权

US09193763B2 PSMA binding ligand-linker conjugates and methods for using 有权
标题翻译： PSMA结合配体 - 接头缀合物和使用方法
公开(公告)号：US09193763B2
公开(公告)日：2015-11-24
申请号：US12673931
申请日：2008-08-15
申请人： Philip Stewart Low , Sumith A. Kularatne
发明人： Philip Stewart Low , Sumith A. Kularatne
IPC分类号： C07K5/08 , C07D207/416 , C07C323/52 , A61K47/48 , A61K49/00 , A61K51/04
CPC分类号： A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译：本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。还描述了制备缀合物和含有它们的组合物的方法。

2. 发明授权

US09192682B2 Folate receptor binding conjugates of antifolates 有权
标题翻译：叶酸受体结合结合抗叶酸酯
公开(公告)号：US09192682B2
公开(公告)日：2015-11-24
申请号：US14010122
申请日：2013-08-26
申请人： Christopher Paul Leamon , Iontcho Radoslavov Vlahov , Philip Stewart Low
发明人： Christopher Paul Leamon , Iontcho Radoslavov Vlahov , Philip Stewart Low
IPC分类号： C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , A61K47/48 , C07D487/04 , A61K31/517
CPC分类号： A61K47/48338 , A61K31/475 , A61K31/517 , A61K47/55 , A61K47/551 , C07D487/04
摘要： Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
摘要翻译：描述了抗叶酸剂，可释放接头和药物的结合物，以及含有它们的药物组合物。缀合物可用于治疗由致病细胞群体引起的疾病。还描述了治疗这些疾病的方法。

3. 发明授权

US08685752B2 Ex vivo flow cytometry method and device 有权
标题翻译：离体流式细胞术方法及装置
公开(公告)号：US08685752B2
公开(公告)日：2014-04-01
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A Kularatne
IPC分类号： G01N33/82 , G01N31/22 , A61K38/00
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X, wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译：本发明涉及诊断由致病细胞介导的疾病状态的方法。该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，并使用流式细胞术检测表达配体受体的致病细胞。

4. 发明申请

US20110189086A1 Diagnostic Method for Atherosclerosis 有权
标题翻译：动脉粥样硬化的诊断方法
公开(公告)号：US20110189086A1
公开(公告)日：2011-08-04
申请号：US13083121
申请日：2011-04-08
申请人： Philip Stewart Low
发明人： Philip Stewart Low
IPC分类号： A61K49/00 , A61K51/04 , A61K51/10
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0052 , A61K49/006 , A61K51/0474 , A61K51/0497 , G01N33/5061 , G01N33/92 , G01N2800/323
摘要： The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.
摘要翻译：本发明涉及鉴定/监测与血管壁相关的活动性动脉粥样硬化斑块的方法，其中斑块包含具有可配位结合位点的活化巨噬细胞。该方法包括以下步骤：向被评估动脉粥样硬化的患者施用有效量的包含配体和能够在预定条件下发光的发色团的缀合物的组合物，允许配体缀合物足够的时间结合活化的巨噬细胞使用基于导管的装置对血管进行预定条件，并且使用基于导管的装置或通过使用外部成像技术检测由发色团发出的光来识别活性斑块。本发明还涉及一种类似的方法，其中能够发射辐射的化学部分与配体缀合。

5. 发明申请

US20080254499A1 Multiphoton in Vivo Flow Cytometry Method and Device 有权
标题翻译：多光子体内流式细胞术方法和装置
公开(公告)号：US20080254499A1
公开(公告)日：2008-10-16
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译：本发明涉及一种用于诊断由致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式“π-in-line-formula description =”的共轭物或复合物的组合物公式“end =”lead“？> Ab-X <？in-line-formula description =”In-line Formulas“end =”tail“？>其中A组包括配体结合致病细胞，组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。

6. 发明授权

US07033594B2 Method of treatment using ligand-immunogen conjugates 有权
标题翻译：使用配体 - 免疫原缀合物的治疗方法
公开(公告)号：US07033594B2
公开(公告)日：2006-04-25
申请号：US09822379
申请日：2001-03-30
申请人： Philip Stewart Low , Yingjuan Lu
发明人： Philip Stewart Low , Yingjuan Lu
IPC分类号： A61K39/00 , A61K31/495 , A61K31/445 , A61K31/50 , A61K31/34
CPC分类号： A61K39/39 , A61K39/385 , A61K39/39541 , A61K47/551 , A61K2039/55511 , A61K2039/55522 , A61K2039/55533 , A61K2039/6081 , A61K2300/00
摘要： A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a binding site for a particular ligand. The invention comprises administering the ligand conjugated to an immunogen to a host animal harboring the population of pathogenic cells. Antibodies, preexisting or administered to the host animal to establish a passive immunity, directed against the immunogen bind to the ligand-immunogen conjugate resulting in elimination of the pathogenic cells by the host's immune response. At least one additional therapeutic factor is administered selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent, antimicrobial agent, a cytotoxic immune cell, and a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.
摘要翻译：提供了一种方法和药物组合物，用于增强宿主动物中内源性免疫应答介导的病原体细胞群的消除，其中致病细胞优先表达，独特地表达或过表达特定配体的结合位点。本发明包括将与免疫原缀合的配体施用于携带致病细胞群的宿主动物。预先存在或施用于宿主动物以建立针对免疫原的被动免疫的抗体与配体 - 免疫原缀合物结合，导致宿主免疫应答消除致病细胞。施用至少一种另外的治疗因子，其选自细胞杀伤剂，肿瘤穿透增强剂，化学治疗剂，抗微生物剂，细胞毒性免疫细胞和能够刺激内源性免疫应答的化合物，其中化合物不结合配体 - 免疫原缀合物。

7. 发明申请

US20220105205A1 PSMA-TARGETED NIR DYES AND THEIR USES 有权
公开(公告)号：US20220105205A1
公开(公告)日：2022-04-07
申请号：US17112497
申请日：2020-12-04
申请人： Sumith A. Kularatne , Philip Stewart Low , Sakkarapalayam M. Mahalingam , Pravin Gagare
发明人： Sumith A. Kularatne , Philip Stewart Low , Sakkarapalayam M. Mahalingam , Pravin Gagare
IPC分类号： A61K49/00 , G01N21/64 , C07K5/087 , C07K5/11 , C07K7/06 , C07K5/062 , C07D209/20 , C07K5/083 , G01N33/574 , C07K7/02 , C07K5/072 , C07K5/078 , C07K5/065 , C07K5/09 , G01N33/58
摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

8. 发明授权

US08795633B2 Multiphoton in vivo flow cytometry method and device 有权
标题翻译：多光子体内流式细胞术方法及装置
公开(公告)号：US08795633B2
公开(公告)日：2014-08-05
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： A61B5/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译：本发明涉及用于诊断致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式Ab-X的缀合物或复合物的组合物，其中组Ab包含与致病细胞和组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。

9. 发明申请

US20110172254A1 FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES 有权
标题翻译： FOLATE受体结合抗体结合
公开(公告)号：US20110172254A1
公开(公告)日：2011-07-14
申请号：US13063889
申请日：2009-09-17
申请人： Christopher Paul Leamon , Iontcho Radoslavov Vlahov , Philip Stewart Low
发明人： Christopher Paul Leamon , Iontcho Radoslavov Vlahov , Philip Stewart Low
IPC分类号： A61K31/519 , A61K31/517 , C07D471/04 , C07D239/72 , A61P35/00
CPC分类号： A61K47/48338 , A61K31/475 , A61K31/517 , A61K47/55 , A61K47/551 , C07D487/04
摘要： Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
摘要翻译：描述了抗叶酸剂，可释放接头和药物的结合物，以及含有它们的药物组合物。缀合物可用于治疗由致病细胞群体引起的疾病。还描述了治疗这些疾病的方法。

10. 发明申请

US20100055735A1 EX VIVO FLOW CYTOMETRY METHOD AND DEVICE 有权
标题翻译： EX VIVO FLOW CYTOMETRY方法和设备
公开(公告)号：US20100055735A1
公开(公告)日：2010-03-04
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A. Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A. Kularatne
IPC分类号： C12Q1/06
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译：本发明涉及诊断由致病细胞介导的疾病状态的方法。该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及使用流式细胞术检测表达配体受体的致病细胞。

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