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1. 发明授权

US06809814B2 System and method for epi-detected coherent anti-stokes raman scattering microscopy 有权
标题翻译：用于epi检测的相干反火箭拉曼散射显微镜的系统和方法
公开(公告)号：US06809814B2
公开(公告)日：2004-10-26
申请号：US10345677
申请日：2003-01-16
申请人： Xiaoling Sunney Xie , Ji-Xin Cheng , Andreas Volkmer
发明人： Xiaoling Sunney Xie , Ji-Xin Cheng , Andreas Volkmer
IPC分类号： G01J344
CPC分类号： G01N21/65 , G01J3/44 , G01N15/1434 , G01N15/1475 , G01N2015/1006 , G01N2021/653
摘要： Systems and methods are disclosed for detecting a coherent anti-Stokes Raman scattering (CARS) signal from a microscopic sample in an epi-direction. In an embodiment, the system includes at least two sources having a pump source for generating a pump field at the pump frequency, a Stoke source for generating a Stoke field at the Stoke frequency that is different from the pump frequency, optics (64) for directing the pump and Stoke beams (60) in a collinear fashion through a focusing lens (66) toward a common focal spot in a sample (70), and detector optics that images the CARS in epi-direction, which is generated by the interaction of the pump and Stoke fields (60) with the sample (70) and is collected by the same focusing lens (66), towards an epi-detector (78).
摘要翻译：公开了用于从表面方向检测来自微观样品的相干反斯托克斯拉曼散射（CARS）信号的系统和方法。在一个实施例中，该系统包括至少两个源，其具有用于产生泵频率的泵浦场的泵浦源，用于产生Stoke频率不同于泵浦频率的Stoke场的Stoke源，用于将泵和Stoke梁（60）以共线的方式通过聚焦透镜（66）朝向样品（70）中的公共焦斑引导，以及检测器光学器件，其通过相互作用产生的外延方向成像CARS 的泵和Stoke磁场（60）与样品（70）并且被相同的聚焦透镜（66）收集到外部探测器（78）。

2. 发明授权

US06798507B2 System and method for polarization coherent anti-stokes Raman scattering microscopy 有权
标题翻译：用于偏振相干反斯托克斯拉曼散射显微镜的系统和方法
公开(公告)号：US06798507B2
公开(公告)日：2004-09-28
申请号：US10186104
申请日：2002-06-27
申请人： Xiaoling Sunney Xie , Ji-Xin Cheng
发明人： Xiaoling Sunney Xie , Ji-Xin Cheng
IPC分类号： G01J344
CPC分类号： G01J3/44 , G01N21/65 , G01N2021/653
摘要： Systems and methods are disclosed for detecting a nonlinear coherent field induced in a microscopic sample. The system includes in an embodiment, a first source for generating a first polarized electromagnetic field at a first frequency and a second source for generating a second polarized electromagnetic field at a second frequency that is different from the first frequency. The system further includes optics for combining the first polarized electromagnetic field and the second polarized electromagnetic field in a collinear fashion such that the difference in polarization angles is &phgr; wherein &phgr; is not equal to zero. The optics further direct the combined electromagnetic field toward a common focal volume. The system also includes a polarization sensitive detector for detecting a nonlinear coherent field that is generated responsive to the first and second polarized electromagnetic fields in the focal volume.
摘要翻译：公开了用于检测在微观样品中诱导的非线性相干场的系统和方法。该系统在一个实施例中包括用于产生第一频率的第一极化电磁场的第一源和用于产生与第一频率不同的第二频率的第二极化电磁场的第二源。该系统还包括用于以共线方式组合第一极化电磁场和第二极化电磁场的光学器件，使得偏振角的差是phi，其中phi不等于零。光学器件进一步将组合的电磁场引向公共焦点体积。该系统还包括用于检测响应于焦点体积中的第一和第二极化电磁场产生的非线性相干场的偏振敏感检测器。

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