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1. 发明专利

CA2955172A1 SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172A1
公开(公告)日：2016-01-21
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

2. 发明专利

CA2955172C SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172C
公开(公告)日：2021-07-20
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12M1/34 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

3. 发明专利

AU2016266584A1 Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers 未知
公开(公告)号：AU2016266584A1
公开(公告)日：2017-10-26
申请号：AU2016266584
申请日：2016-03-04
申请人： HINOJOSA CHRISTOPHER DAVID , INGBER DONALD E , JAIN ABHISHEK , LEVNER DANIEL , VAN DER HELM MARINKE , VAN DER MEER ANDRIES , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/00 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

4. 发明专利

CA2978727A1 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 未知
公开(公告)号：CA2978727A1
公开(公告)日：2016-12-01
申请号：CA2978727
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12Q1/00 , C12M1/00 , C12M1/34 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

5. 发明申请

WO2016190939A3 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 审中-公开
标题翻译：用于定量生活组织层的动态渗透性和液压电导率的流体装置
公开(公告)号：WO2016190939A3
公开(公告)日：2017-02-16
申请号：PCT/US2016021025
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , G01N33/00 , G01N33/48 , G01N33/50
CPC分类号： B01L3/502746 , B01L3/502715 , B01L3/50273 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/4833 , G01N33/50 , G01N33/5005 , G01N2015/0065
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
摘要翻译：公开了用于测量与电池层相关的动态水力传导性和磁导率的系统和方法。一些系统包括微流体装置，一个或多个工作流体储存器和一个或多个流体阻力元件。微流体装置包括第一微通道，第二微通道和它们之间的阻挡层。屏障包括附着在其上的电池层。将工作流体输送到微流体装置。流体阻力元件联接到一个或多个流体路径并且提供流体阻力以引起穿过流体阻力元件的压降。在第一微通道和第二微通道之间发生质量转移，其指示与电池相关联的水力传导性和/或动态磁导率。

6. 发明专利

AU2021261826A1 Open-top microfluidic devices and methods for simulating a function of a tissue 未知
公开(公告)号：AU2021261826A1
公开(公告)日：2021-12-02
申请号：AU2021261826
申请日：2021-11-01
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE
发明人： VARONE ANTONIO , WEN NORMAN , LEVNER DANIEL , NOVAK RICHARD , MCPARTLIN LORI , INGBER DONALD E , CHOE YOUNGJAE , LENG LIAN , NGUYEN JUSTIN K
IPC分类号： C12M1/00 , C12M1/34 , C12M1/42 , C12M3/00 , C12M3/04 , C12Q1/02
摘要： Abstract: A device for simulating a function of a issue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing forward the first membrane and a second facing forward the second chamber. The membrane separates the first chamber from the second chamber.

7. 发明公开

EP3083057A4 ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 有权转让
标题翻译：有机气候变化研究与发展研究所维尔文根和赫斯特朗戴蒙
公开(公告)号：EP3083057A4
公开(公告)日：2017-03-08
申请号：EP14885808
申请日：2014-12-19
申请人： HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
发明人： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
IPC分类号： B01L3/00 , C12M3/00
CPC分类号： C12M23/16 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
摘要翻译：有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流动而将机械力施加到细胞。有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。有机模拟装置可以通过分别制造单独的部件来制造，例如，可以随后层压在一起的单独的层。

8. 发明申请

WO2015138032A3 ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
标题翻译：有机装置及其使用和制造方法
公开(公告)号：WO2015138032A3
公开(公告)日：2015-12-03
申请号：PCT/US2014071570
申请日：2014-12-19
申请人： HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
发明人： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
IPC分类号： B01L3/00 , C12M3/00
CPC分类号： C12M23/16 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
摘要翻译：有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流而将机械力施加到细胞。有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。有机模拟装置可以通过单独制造各个组件来制造，例如，作为随后层压在一起的各个层。

9. 发明申请

WO2005031398A3 PROGRAMMABLE OPTICAL GRATING DEVICE AND METHOD 审中-公开
标题翻译：可编程光刻设备及方法
公开(公告)号：WO2005031398A3
公开(公告)日：2005-10-20
申请号：PCT/US2004031345
申请日：2004-09-24
申请人： DIGITAL LIGHT CIRCUITS INC , LEVNER DANIEL , FAY MARTIN F , BLOCH JONATHAN C , WEISS JEFFREY
发明人： LEVNER DANIEL , FAY MARTIN F , BLOCH JONATHAN C , WEISS JEFFREY
IPC分类号： G02B20060101 , G02B6/34
CPC分类号： G02F1/011 , G02B6/124 , G02B6/266 , G02B26/0808 , G02F1/025 , G02F1/0316 , G02F1/035 , G02F2201/307 , G02F2203/055
摘要： An optical waveguide (28) has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator (38) separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. Preferably, the bodies are metal striplines (40), an electro-optical material is disposed between the striplines (40) and the exposed surface, and the actuator (28) is a CMOS chip that imposes a voltage to some or all of the lines. The voltage changes the refractive index at the interface with the surface, changing an index of refraction profile of the waveguide and effectively imposing a grating (20). Alternatively, the bodies are micro-beams and the actuator, also controlled by a CMOS chip, separately moves each micro-beam into and out of proximity to the surface. The grating is programmable via the CMOS chip. The programmable gratings may be used to couple different waves in the same or different waveguides, and may act as Bragg gratings, binary supergratings, or multi-level supergratings.
摘要翻译：光波导（28）具有表面。单独致动体的阵列设置在暴露表面附近，并且致动器（38）分别致动至少一些主体以改变通过波导传播的波的光谱特性。优选地，主体是金属带状线（40），电光材料设置在带状线（40）和暴露表面之间，并且致动器（28）是对一些或全部线路施加电压的CMOS芯片。电压改变与表面的界面处的折射率，改变波导的折射率分布，并有效地施加光栅（20）。或者，主体是微光束，并且也由CMOS芯片控制的致动器将每个微光束分别移动到表面附近和离开表面。光栅可通过CMOS芯片进行编程。可编程光栅可以用于耦合相同或不同波导中的不同波，并且可以用作布拉格光栅，二进制超格或多级超级光栅。

10. 发明专利

CA2382645A1 SYNTHESIS OF SUPERGRATINGS BY FOURIER METHODS 未知
公开(公告)号：CA2382645A1
公开(公告)日：2001-02-15
申请号：CA2382645
申请日：2000-08-04
申请人： LEVNER DANIEL , XU JINGMING , FAY MARTIN
发明人： LEVNER DANIEL , XU JINGMING , FAY MARTIN
IPC分类号： G02B6/124 , G02B5/18 , G02B6/16
摘要： The present invention relates to a method for synthesizing supergratings usi ng Fourier analysis. The method divides the synthesis process into different stages: synthesis of an "analog" grating profile, followed by a quantization step, a standard test using the transfer matrix method and error feedback to improve the grating profile. The latter two steps may be iteractive. The method provides a generalized procedure for analog synthesis by drawing on t he Fourier approximation and on finite-impulse-response (FIR) filter design theory, while it interprets the simple threshold quantization as a "zeroth order" Delta-Sigma Modulator, which it improves. The method of designing a supergrating for a waveguide includes providing a reflectance spectrum, transforming the reflectance spectrum to a Fourier domain representation, computationally synthesizing an analog refractive index profile using Fourie r transform and transforming the analog refractive index profile to a binary o r multi-level refractive index profile.

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