专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA2955172A1 SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172A1
公开(公告)日：2016-01-21
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

2. 发明专利

CA2955172C SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172C
公开(公告)日：2021-07-20
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12M1/34 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

3. 发明专利

AU2016266584A1 Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers 未知
公开(公告)号：AU2016266584A1
公开(公告)日：2017-10-26
申请号：AU2016266584
申请日：2016-03-04
申请人： HINOJOSA CHRISTOPHER DAVID , INGBER DONALD E , JAIN ABHISHEK , LEVNER DANIEL , VAN DER HELM MARINKE , VAN DER MEER ANDRIES , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/00 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

4. 发明专利

CA2978727A1 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 未知
公开(公告)号：CA2978727A1
公开(公告)日：2016-12-01
申请号：CA2978727
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12Q1/00 , C12M1/00 , C12M1/34 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

5. 发明申请

WO2016190939A3 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 审中-公开
标题翻译：用于定量生活组织层的动态渗透性和液压电导率的流体装置
公开(公告)号：WO2016190939A3
公开(公告)日：2017-02-16
申请号：PCT/US2016021025
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , G01N33/00 , G01N33/48 , G01N33/50
CPC分类号： B01L3/502746 , B01L3/502715 , B01L3/50273 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/4833 , G01N33/50 , G01N33/5005 , G01N2015/0065
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
摘要翻译：公开了用于测量与电池层相关的动态水力传导性和磁导率的系统和方法。一些系统包括微流体装置，一个或多个工作流体储存器和一个或多个流体阻力元件。微流体装置包括第一微通道，第二微通道和它们之间的阻挡层。屏障包括附着在其上的电池层。将工作流体输送到微流体装置。流体阻力元件联接到一个或多个流体路径并且提供流体阻力以引起穿过流体阻力元件的压降。在第一微通道和第二微通道之间发生质量转移，其指示与电池相关联的水力传导性和/或动态磁导率。

6. 发明专利

AU2021261826A1 Open-top microfluidic devices and methods for simulating a function of a tissue 未知
公开(公告)号：AU2021261826A1
公开(公告)日：2021-12-02
申请号：AU2021261826
申请日：2021-11-01
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE
发明人： VARONE ANTONIO , WEN NORMAN , LEVNER DANIEL , NOVAK RICHARD , MCPARTLIN LORI , INGBER DONALD E , CHOE YOUNGJAE , LENG LIAN , NGUYEN JUSTIN K
IPC分类号： C12M1/00 , C12M1/34 , C12M1/42 , C12M3/00 , C12M3/04 , C12Q1/02
摘要： Abstract: A device for simulating a function of a issue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing forward the first membrane and a second facing forward the second chamber. The membrane separates the first chamber from the second chamber.

7. 发明公开

EP3083057A4 ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 有权转让
标题翻译：有机气候变化研究与发展研究所维尔文根和赫斯特朗戴蒙
公开(公告)号：EP3083057A4
公开(公告)日：2017-03-08
申请号：EP14885808
申请日：2014-12-19
申请人： HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
发明人： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
IPC分类号： B01L3/00 , C12M3/00
CPC分类号： C12M23/16 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
摘要翻译：有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流动而将机械力施加到细胞。有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。有机模拟装置可以通过分别制造单独的部件来制造，例如，可以随后层压在一起的单独的层。

8. 发明申请

WO2015138032A3 ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
标题翻译：有机装置及其使用和制造方法
公开(公告)号：WO2015138032A3
公开(公告)日：2015-12-03
申请号：PCT/US2014071570
申请日：2014-12-19
申请人： HARVARD COLLEGE , FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD
发明人： FERNANDEZ-ALCON JOSE , WEN NORMAN , NOVAK RICHARD , INGBER DONALD E , HAMILTON GERALDINE A , HINOJOSA CHRISTOPHER , DOMANSKY KAREL , LEVNER DANIEL , THOMPSON II GUY , HAJIPOURAN BENAM KAMBEZ , VILLENAVE REMI , UMUNDUM THOMAS , PARIS ALFRED , BAUER GEORG
IPC分类号： B01L3/00 , C12M3/00
CPC分类号： C12M23/16 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
摘要翻译：有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流而将机械力施加到细胞。有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。有机模拟装置可以通过单独制造各个组件来制造，例如，作为随后层压在一起的各个层。

9. 发明申请

WO2012118956A3 THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
标题翻译：透明媒体的热管理
公开(公告)号：WO2012118956A3
公开(公告)日：2012-11-08
申请号：PCT/US2012027253
申请日：2012-03-01
申请人： HARVARD COLLEGE , INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
发明人： INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
IPC分类号： H05B3/84
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24J2/0433 , F24J2/20 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译：可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗户。热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。流体可用于加热或冷却窗户面板的表面，以控制跨过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。流体可以使用建筑物中的环境空气进行加热或冷却。可以调节流体的折射率以改变窗口的光学透明性。在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。在其他实施例中，窗口可以着色，阻挡或散射入射光。

10. 发明申请

WO0189788A2 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A2
公开(公告)日：2001-11-29
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B29C
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以为拓扑复杂和改进的微流体系统提供方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式