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1. 发明专利

CA2978727A1 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 未知
公开(公告)号：CA2978727A1
公开(公告)日：2016-12-01
申请号：CA2978727
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12Q1/00 , C12M1/00 , C12M1/34 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

2. 发明专利

AU2016266584A1 Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers 未知
公开(公告)号：AU2016266584A1
公开(公告)日：2017-10-26
申请号：AU2016266584
申请日：2016-03-04
申请人： HINOJOSA CHRISTOPHER DAVID , INGBER DONALD E , JAIN ABHISHEK , LEVNER DANIEL , VAN DER HELM MARINKE , VAN DER MEER ANDRIES , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/00 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

3. 发明申请

WO2016190939A3 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 审中-公开
标题翻译：用于定量生活组织层的动态渗透性和液压电导率的流体装置
公开(公告)号：WO2016190939A3
公开(公告)日：2017-02-16
申请号：PCT/US2016021025
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , G01N33/00 , G01N33/48 , G01N33/50
CPC分类号： B01L3/502746 , B01L3/502715 , B01L3/50273 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/4833 , G01N33/50 , G01N33/5005 , G01N2015/0065
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
摘要翻译：公开了用于测量与电池层相关的动态水力传导性和磁导率的系统和方法。一些系统包括微流体装置，一个或多个工作流体储存器和一个或多个流体阻力元件。微流体装置包括第一微通道，第二微通道和它们之间的阻挡层。屏障包括附着在其上的电池层。将工作流体输送到微流体装置。流体阻力元件联接到一个或多个流体路径并且提供流体阻力以引起穿过流体阻力元件的压降。在第一微通道和第二微通道之间发生质量转移，其指示与电池相关联的水力传导性和/或动态磁导率。

4. 发明专利

CA2955172A1 SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172A1
公开(公告)日：2016-01-21
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

5. 发明专利

CA2955172C SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172C
公开(公告)日：2021-07-20
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12M1/34 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

6. 发明申请

WO2005031398A3 PROGRAMMABLE OPTICAL GRATING DEVICE AND METHOD 审中-公开
标题翻译：可编程光刻设备及方法
公开(公告)号：WO2005031398A3
公开(公告)日：2005-10-20
申请号：PCT/US2004031345
申请日：2004-09-24
申请人： DIGITAL LIGHT CIRCUITS INC , LEVNER DANIEL , FAY MARTIN F , BLOCH JONATHAN C , WEISS JEFFREY
发明人： LEVNER DANIEL , FAY MARTIN F , BLOCH JONATHAN C , WEISS JEFFREY
IPC分类号： G02B20060101 , G02B6/34
CPC分类号： G02F1/011 , G02B6/124 , G02B6/266 , G02B26/0808 , G02F1/025 , G02F1/0316 , G02F1/035 , G02F2201/307 , G02F2203/055
摘要： An optical waveguide (28) has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator (38) separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. Preferably, the bodies are metal striplines (40), an electro-optical material is disposed between the striplines (40) and the exposed surface, and the actuator (28) is a CMOS chip that imposes a voltage to some or all of the lines. The voltage changes the refractive index at the interface with the surface, changing an index of refraction profile of the waveguide and effectively imposing a grating (20). Alternatively, the bodies are micro-beams and the actuator, also controlled by a CMOS chip, separately moves each micro-beam into and out of proximity to the surface. The grating is programmable via the CMOS chip. The programmable gratings may be used to couple different waves in the same or different waveguides, and may act as Bragg gratings, binary supergratings, or multi-level supergratings.
摘要翻译：光波导（28）具有表面。单独致动体的阵列设置在暴露表面附近，并且致动器（38）分别致动至少一些主体以改变通过波导传播的波的光谱特性。优选地，主体是金属带状线（40），电光材料设置在带状线（40）和暴露表面之间，并且致动器（28）是对一些或全部线路施加电压的CMOS芯片。电压改变与表面的界面处的折射率，改变波导的折射率分布，并有效地施加光栅（20）。或者，主体是微光束，并且也由CMOS芯片控制的致动器将每个微光束分别移动到表面附近和离开表面。光栅可通过CMOS芯片进行编程。可编程光栅可以用于耦合相同或不同波导中的不同波，并且可以用作布拉格光栅，二进制超格或多级超级光栅。

7. 发明专利

CA2382645A1 SYNTHESIS OF SUPERGRATINGS BY FOURIER METHODS 未知
公开(公告)号：CA2382645A1
公开(公告)日：2001-02-15
申请号：CA2382645
申请日：2000-08-04
申请人： LEVNER DANIEL , XU JINGMING , FAY MARTIN
发明人： LEVNER DANIEL , XU JINGMING , FAY MARTIN
IPC分类号： G02B6/124 , G02B5/18 , G02B6/16
摘要： The present invention relates to a method for synthesizing supergratings usi ng Fourier analysis. The method divides the synthesis process into different stages: synthesis of an "analog" grating profile, followed by a quantization step, a standard test using the transfer matrix method and error feedback to improve the grating profile. The latter two steps may be iteractive. The method provides a generalized procedure for analog synthesis by drawing on t he Fourier approximation and on finite-impulse-response (FIR) filter design theory, while it interprets the simple threshold quantization as a "zeroth order" Delta-Sigma Modulator, which it improves. The method of designing a supergrating for a waveguide includes providing a reflectance spectrum, transforming the reflectance spectrum to a Fourier domain representation, computationally synthesizing an analog refractive index profile using Fourie r transform and transforming the analog refractive index profile to a binary o r multi-level refractive index profile.

8. 发明申请

WO0111401A8 SYNTHESIS OF SUPERGRATINGS BY FOURIER METHODS 审中-公开
标题翻译：通过FOURIER方法合成超声波
公开(公告)号：WO0111401A8
公开(公告)日：2001-06-14
申请号：PCT/CA0000900
申请日：2000-08-04
申请人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
发明人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
IPC分类号： G02B6/124 , G02B6/16
CPC分类号： G02B6/02085 , G02B6/124 , G02B2006/02166
摘要： The present invention relates to a method for synthesizing supergratings using Fourier analysis. The method divides the synthesis process into different stages: synthesis of an "analog" grating profile, followed by a quantization step, a standard test using the transfer matrix method and error feedback to improve the grating profile. The latter two steps may be iteractive. The method provides a generalized procedure for analog synthesis by drawing on the Fourier approximation and on finite-impulse-response (FIR) filter design theory, while it interprets the simple threshold quantization as a "zeroth order" Delta-Sigma Modulator, which it improves. The method of designing a supergrating for a waveguide includes providing a reflectance spectrum, transforming the reflectance spectrum to a Fourier domain representation, computationally synthesizing an analog refractive index profile using Fourier transform and transforming the analog refractive index profile to a binary or multi-level refractive index profile.
摘要翻译：本发明涉及一种使用傅立叶分析合成超级光栅的方法。该方法将合成过程分为不同阶段：合成“模拟”光栅轮廓，随后进行量化步骤，使用传递矩阵法的标准测试和误差反馈以改善光栅轮廓。后两步可能是迭代的。该方法通过利用傅里叶近似和有限脉冲响应（FIR）滤波器设计理论提供了模拟合成的一般化过程，同时将简单的阈值量化解释为“零阶”Δ-Σ调制器，其改进。设计用于波导的超级光栅的方法包括提供反射光谱，将反射光谱转换成傅立叶域表示，使用傅里叶变换计算合成模拟折射率分布，并将模拟折射率分布变换为二进制或多电平折射指数资料。

9. 发明专利

AT300057T 未知
公开(公告)号：AT300057T
公开(公告)日：2005-08-15
申请号：AT00952814
申请日：2000-08-04
申请人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
发明人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
IPC分类号： G02B6/124 , G02B6/16
摘要： The present invention relates to a method for synthesizing supergratings using Fourier analysis. The method divides the synthesis process into two stages: synthesis of an "analog" grating profile, followed by a quantization step. The method provides a generalized procedure for analog synthesis by drawing on the Fourier approximation and on finite-inpulse-response (FIR) filter design theory, while it interprets the simple threshold quantization as a "zeroth order" Delta-Sigma Modulator, which it improves. The method of designing a supergrating for a waveguide includes providing a reflectance spectrum in at least one spectral band to be produced by a supergrating in a waveguide, the reflectance spectrum having specified reflectance features, transforming the reflectance spectrum to a Fourier domain representation having Fourier-domain features, computationally synthesizing an analog refractive index profile corresponding to the Fourier-domain representation and transforming the analog refractive index profile to a binary or multi-level refractive index profile representation in such a way as to conserve Fourier-domain information within the spectral band.

10. 发明专利

DE60021391D1 未知
公开(公告)号：DE60021391D1
公开(公告)日：2005-08-25
申请号：DE60021391
申请日：2000-08-04
申请人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
发明人： LEVNER DANIEL , FAY MARTIN F , XU JINGMING
IPC分类号： G02B6/124 , G02B6/16
摘要： The present invention relates to a method for synthesizing supergratings using Fourier analysis. The method divides the synthesis process into two stages: synthesis of an "analog" grating profile, followed by a quantization step. The method provides a generalized procedure for analog synthesis by drawing on the Fourier approximation and on finite-inpulse-response (FIR) filter design theory, while it interprets the simple threshold quantization as a "zeroth order" Delta-Sigma Modulator, which it improves. The method of designing a supergrating for a waveguide includes providing a reflectance spectrum in at least one spectral band to be produced by a supergrating in a waveguide, the reflectance spectrum having specified reflectance features, transforming the reflectance spectrum to a Fourier domain representation having Fourier-domain features, computationally synthesizing an analog refractive index profile corresponding to the Fourier-domain representation and transforming the analog refractive index profile to a binary or multi-level refractive index profile representation in such a way as to conserve Fourier-domain information within the spectral band.

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