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1. 发明专利

CA2978727A1 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 未知
公开(公告)号：CA2978727A1
公开(公告)日：2016-12-01
申请号：CA2978727
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12Q1/00 , C12M1/00 , C12M1/34 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

2. 发明专利

AU2016266584A1 Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers 未知
公开(公告)号：AU2016266584A1
公开(公告)日：2017-10-26
申请号：AU2016266584
申请日：2016-03-04
申请人： HINOJOSA CHRISTOPHER DAVID , INGBER DONALD E , JAIN ABHISHEK , LEVNER DANIEL , VAN DER HELM MARINKE , VAN DER MEER ANDRIES , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/00 , G01N33/00 , G01N33/48 , G01N33/50
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.

3. 发明申请

WO2016190939A3 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 审中-公开
标题翻译：用于定量生活组织层的动态渗透性和液压电导率的流体装置
公开(公告)号：WO2016190939A3
公开(公告)日：2017-02-16
申请号：PCT/US2016021025
申请日：2016-03-04
申请人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
发明人： LEVNER DANIEL , HINOJOSA CHRISTOPHER DAVID , VAN DER MEER ANDRIES , VAN DER HELM MARINKE , JAIN ABHISHEK , INGBER DONALD E , ZAMANI MARJON
IPC分类号： C12M1/34 , C12M1/00 , G01N33/00 , G01N33/48 , G01N33/50
CPC分类号： B01L3/502746 , B01L3/502715 , B01L3/50273 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/4833 , G01N33/50 , G01N33/5005 , G01N2015/0065
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
摘要翻译：公开了用于测量与电池层相关的动态水力传导性和磁导率的系统和方法。一些系统包括微流体装置，一个或多个工作流体储存器和一个或多个流体阻力元件。微流体装置包括第一微通道，第二微通道和它们之间的阻挡层。屏障包括附着在其上的电池层。将工作流体输送到微流体装置。流体阻力元件联接到一个或多个流体路径并且提供流体阻力以引起穿过流体阻力元件的压降。在第一微通道和第二微通道之间发生质量转移，其指示与电池相关联的水力传导性和/或动态磁导率。

4. 发明专利

CA2955172A1 SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172A1
公开(公告)日：2016-01-21
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

5. 发明专利

CA2955172C SYSTEMS AND METHODS FOR IMPROVED PERFORMANCE OF FLUIDIC AND MICROFLUIDIC SYSTEMS 未知
公开(公告)号：CA2955172C
公开(公告)日：2021-07-20
申请号：CA2955172
申请日：2015-07-10
申请人： PRESIDENT AND FELLOWS OF HAVARD COLLEGE , HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ ALCON JOSE , INGBER DONALD E
发明人： HINOJOSA CHRISTOPHER DAVID , SLIZ JOSIAH , LEVNER DANIEL , THOMPSON GUY , GEISLER HUBERT , FERNANDEZ-ALCON JOSE , INGBER DONALD E
IPC分类号： B81B7/00 , B81B1/00 , C12M1/00 , C12M1/34 , C12Q1/02
摘要： Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

6. 发明申请

WO2012118956A3 THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
标题翻译：透明媒体的热管理
公开(公告)号：WO2012118956A3
公开(公告)日：2012-11-08
申请号：PCT/US2012027253
申请日：2012-03-01
申请人： HARVARD COLLEGE , INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
发明人： INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
IPC分类号： H05B3/84
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24J2/0433 , F24J2/20 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译：可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗户。热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。流体可用于加热或冷却窗户面板的表面，以控制跨过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。流体可以使用建筑物中的环境空气进行加热或冷却。可以调节流体的折射率以改变窗口的光学透明性。在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。在其他实施例中，窗口可以着色，阻挡或散射入射光。

7. 发明申请

WO0189788A2 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A2
公开(公告)日：2001-11-29
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B29C
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以为拓扑复杂和改进的微流体系统提供方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

8. 发明申请

WO2008156904A3 SYSTEMS AND METHODS FOR NANOMAGNETIC ACTUATION OF MOLECULAR CELL SIGNALING 审中-公开
标题翻译：用于分子细胞信号的纳米分解的系统和方法
公开(公告)号：WO2008156904A3
公开(公告)日：2009-03-19
申请号：PCT/US2008059738
申请日：2008-04-09
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , MANNIX ROBERT J , KUMAR SANJAY
发明人： INGBER DONALD E , MANNIX ROBERT J , KUMAR SANJAY
IPC分类号： A61K47/48 , A61N2/02
CPC分类号： A61K41/0052 , A61K47/48507 , A61K47/6835 , A61N2/00 , Y10S977/904
摘要： The present invention relates to signaling mechanisms that transduce magnetic inputs into physiological cellular outputs. More particularly, the present invention relates to systems and methods for non-invasively controlling cellular signaling functions and behaviors by harnessing receptor-mediated and intracellular molecular-mediated signal transduction using nanomagnetic cellular switches.
摘要翻译：本发明涉及将磁输入转换成生理细胞输出的信号传导机制。更具体地，本发明涉及通过利用纳米磁性细胞开关利用受体介导的和细胞内分子介导的信号转导来非侵入性地控制细胞信号传导功能和行为的系统和方法。

9. 发明申请

WO2008127295A2 GUIDED SELF-ASSEMBLY OF MATRICES WITH ORDERD NANO-SCALE STRUCTURE FOR TISSUE ENGINEERING 审中-公开
标题翻译：指导用于组织工程的订单纳米尺度结构的矩阵自组装
公开(公告)号：WO2008127295A2
公开(公告)日：2008-10-23
申请号：PCT/US2007022397
申请日：2007-10-22
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E
发明人： INGBER DONALD E
IPC分类号： H04Q7/22
CPC分类号： C12N5/0075 , C12N2533/56 , C12N2535/10
摘要： Described herein are methods for producing structures useful, for example, for tissue engineering. In their most general form, the methods described herein involve an enzyme activity immobilized on a surface, which is placed in contact with a solution comprising polypeptide monomers. The activity of the enzyme modifies the polypeptide monomers to promote polymerization of the monomers to form polymer structures associated with the surface. Thus, the methods described herein provide a guided self-assembly of polypeptide structures. In preferred embodiments, the self assembly is guided to form regular lattices or other specific structures by specifying the arrangement of the surfaces to which the enzyme, optionally with one or more co-factors, is attached.
摘要翻译：这里描述的是用于产生可用于例如组织工程的结构的方法。在其最一般的形式中，本文描述的方法涉及固定在表面上的酶活性，其被置于与包含多肽单体的溶液接触。酶的活性改变多肽单体以促进单体的聚合以形成与表面相关的聚合物结构。因此，本文所述的方法提供多肽结构的引导自组装。在优选的实施方案中，通过指定酶，任选地与一个或多个辅因子连接的表面的布置，引导自组装形成规则晶格或其它特定结构。

10. 发明申请

WO2007044642A3 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 审中-公开
标题翻译：用于连续流动的材料组合微流化 - 微磁性分离的装置和方法
公开(公告)号：WO2007044642A3
公开(公告)日：2007-11-15
申请号：PCT/US2006039344
申请日：2006-10-06
申请人： HARVARD COLLEGE , INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
发明人： INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
IPC分类号： B01D35/06
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成化的微流体装置通过施加局部磁场梯度将结合到磁性粒子的材料从一个层流路径拉到另一层流路径。该装置不需要任何清洗步骤即可从流动的生物流体中去除微生物和哺乳动物细胞微制造的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入到一个流动路径中时，它们仍然限于该流动路径。当HGMC被磁化时，磁珠从初始流动路径被拉入收集流中，从而清洁流体。微装置允许大量的珠子和材料同时分选，没有容量限制，不会因为颗粒被去除而失去分离效率，并且可用于从血液和其他生物流体中分离细胞。这种片上分离器可以在医院和实验室以外的地方进行细胞分离。

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