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1. 发明授权

US08515817B2 Systems and methods of matching purchase requests with consummated sales 有权
标题翻译：将购买请求与完成销售相匹配的系统和方法
公开(公告)号：US08515817B2
公开(公告)日：2013-08-20
申请号：US11968137
申请日：2007-12-31
申请人： Oded Noy , Jason McBride , James Berger , Rosa Welton , Scott Painter
发明人： Oded Noy , Jason McBride , James Berger , Rosa Welton , Scott Painter
IPC分类号： G06Q30/00
CPC分类号： G06Q40/12 , G06Q30/02 , G06Q30/0241 , G06Q30/0601 , G06Q40/10
摘要： A sales matching system which may match sales of products or services with consummated sales by collecting selected leads from a group of lead suppliers, collecting a plurality of sales records from multiple sales sources, and matching at least some of the sales records to selected leads. The matches may be assigned a matching confidence, and may reach a threshold level of confidence to be considered a matched sale. The system may also generate invoices to selected sellers identifying invoice-able sales for which compensation may be obtained in exchange for providing leads giving rise thereto.
摘要翻译：一种销售配对系统，其可以通过从一组主要供应商的集合中收集选定的潜在客户，从多个销售来源收集多个销售记录，并且将至少一些销售记录与选定的销售线匹配来匹配产品或服务的销售与完成的销售。匹配可以被分配匹配的置信度，并且可以达到被认为是匹配销售的置信度阈值水平。该系统还可以向选择的卖家生成发票，以识别可以获得补偿的交易，以换取提供引起的潜在客户的潜在销售。

2. 发明申请

US20090171761A1 Systems and Methods of Matching Purchase Requests with Consummated Sales 有权
标题翻译：将采购申请与消费销售相匹配的系统和方法
公开(公告)号：US20090171761A1
公开(公告)日：2009-07-02
申请号：US11968137
申请日：2007-12-31
申请人： Oded Noy , Jason McBride , James Berger , Rosa Welton , Scott Painter
发明人： Oded Noy , Jason McBride , James Berger , Rosa Welton , Scott Painter
IPC分类号： G06Q30/00
CPC分类号： G06Q40/12 , G06Q30/02 , G06Q30/0241 , G06Q30/0601 , G06Q40/10
摘要： A sales matching system which may match sales of products or services with consummated sales by collecting selected leads from a group of lead suppliers, collecting a plurality of sales records from multiple sales sources, and matching at least some of the sales records to selected leads. The matches may be assigned a matching confidence, and may reach a threshold level of confidence to be considered a matched sale. The system may also generate invoices to selected sellers identifying invoice-able sales for which compensation may be obtained in exchange for providing leads giving rise thereto.
摘要翻译：一种销售配对系统，其可以通过从一组主要供应商的集合中收集选定的潜在客户，从多个销售来源收集多个销售记录，并且将至少一些销售记录与选定的销售线匹配来匹配产品或服务的销售与完成的销售。匹配可以被分配匹配的置信度，并且可以达到被认为是匹配销售的置信度阈值水平。该系统还可以向选择的卖家生成发票，以识别可以获得补偿的交易，以换取提供引起的潜在客户的潜在销售。

3. 发明申请

US20060196409A1 High throughput screening of crystallization materials 有权
公开(公告)号：US20060196409A1
公开(公告)日：2006-09-07
申请号：US11415672
申请日：2006-05-01
申请人： Stephen Quake , Carl Hansen , James Berger
发明人： Stephen Quake , Carl Hansen , James Berger
IPC分类号： C30B15/14
CPC分类号： C30B29/00 , B01D9/00 , B01D9/0072 , B01D9/0077 , B01J19/0046 , B01J2219/00274 , B01J2219/00286 , B01J2219/00317 , B01J2219/00389 , B01J2219/00418 , B01J2219/00432 , B01J2219/00585 , B01J2219/00756 , B01J2219/00891 , B01J2219/00907 , B01J2219/00952 , B01L3/06 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/051 , B81B2201/054 , B81B2203/0127 , B81B2203/0315 , B81C1/00119 , B81C99/0065 , C30B7/14 , C30B29/54 , C30B29/58 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

4. 发明申请

US20120156731A1 Improved Methods for Rapid Gene Synthesis 审中-公开
标题翻译：改进的快速基因合成方法
公开(公告)号：US20120156731A1
公开(公告)日：2012-06-21
申请号：US12052156
申请日：2008-03-20
申请人： Yanyi Huang , James Berger , Stephen Quake
发明人： Yanyi Huang , James Berger , Stephen Quake
IPC分类号： C12P19/34 , C07H21/04 , C12M1/00 , C12N9/00
CPC分类号： C12Y605/01001 , C12P19/34 , C12Y605/01002
摘要： Disclosed are methods and materials for assembling long polynucleotides from synthetic oligonucleotides. The use of synthetic oligonucleotides permits non-natural design of sequences. The oligonucleotides used for construction may be relatively short, according to practicalities of nucleotide synthesis. They are assembled using a ligase which is operative over a range of temperatures, i.e., is thermostable. The method and oligonucleotides are designed such that the melting temperature of the strands to be hybridized is set at a number of selected specific temperatures for each group of oligonucleotides to be hybridized and ligated. Hybridization and ligation take place at or near the melting temperature, so that each succeeding ligation is governed by a temperature that will prevent hybridization if any mismatches are present.
摘要翻译：公开了用于从合成寡核苷酸组装长多核苷酸的方法和材料。合成寡核苷酸的使用允许序列的非自然设计。根据核苷酸合成的实用性，用于构建的寡核苷酸可能相对较短。它们使用在一定温度范围内操作的连接酶组装，即是耐热的。设计该方法和寡核苷酸使待杂交的链的解链温度被设定为要混合并连接的每组寡核苷酸的选定的特定温度的数目。杂交和连接在熔融温度或接近熔化温度下进行，因此每次后续连接都由温度控制，如果存在任何错配，将会阻止杂交。

5. 发明申请

US20050053917A1 Core structure of gp41 from the HIV envelope glycoprotein 失效
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US20050053917A1
公开(公告)日：2005-03-10
申请号：US10680853
申请日：2003-10-07
申请人： David Chan , Deborah Fass , Min Lu , James Berger , Peter Kim
发明人： David Chan , Deborah Fass , Min Lu , James Berger , Peter Kim
IPC分类号： A61K38/00 , C07K14/16 , C12Q1/70 , A61K38/06 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

6. 发明申请

US20070209572A1 HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION MATERIALS 有权
标题翻译：结晶材料的高通量筛选
公开(公告)号：US20070209572A1
公开(公告)日：2007-09-13
申请号：US11668263
申请日：2007-01-29
申请人： Carl Hansen , Stephen Quake , James Berger
发明人： Carl Hansen , Stephen Quake , James Berger
IPC分类号： C30B7/10 , F17D1/08
CPC分类号： C30B7/08 , B01J2219/00274 , B01L3/06 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2300/1827 , B01L2400/0481 , B01L2400/049 , B01L2400/0638 , B01L2400/0655 , B01L2400/0688 , C12Q1/6874 , C30B7/14 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0034 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T117/1004 , Y10T117/1008 , Y10T137/0318 , Y10T137/0396 , C12Q2535/125
摘要： High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
摘要翻译：目标材料的结晶化的高通量筛选是通过将目标材料的溶液同时引入微细加工的流体装置的多个室来实现的。然后对微制造的流体装置进行操作以改变室中的溶液状态，从而同时提供大量的结晶环境。改变的溶液条件的控制可以由各种技术产生，包括但不限于通过体积排阻将结晶剂计量到室中的体积，通过捕获通过微结构结构的尺寸确定的结晶剂的体积，将样品和结晶剂通道注入由相交的正交流动通道限定的连接阵列。

7. 发明申请

US20050229839A1 High throughput screening of crystallization of materials 有权
标题翻译：高通量筛选材料结晶
公开(公告)号：US20050229839A1
公开(公告)日：2005-10-20
申请号：US11135923
申请日：2005-05-23
申请人： Stephen Quake , Carl Hansen , James Berger
发明人： Stephen Quake , Carl Hansen , James Berger
IPC分类号： B01D9/00 , B01J19/00 , B01L3/00 , B01L3/06 , B01L7/00 , B01L9/00 , B81B3/00 , B81C1/00 , C30B1/00 , F04B43/04 , F15C5/00 , F16K99/00
CPC分类号： C30B29/00 , B01D9/00 , B01D9/0072 , B01D9/0077 , B01J19/0046 , B01J2219/00274 , B01J2219/00286 , B01J2219/00317 , B01J2219/00389 , B01J2219/00418 , B01J2219/00432 , B01J2219/00585 , B01J2219/00756 , B01J2219/00891 , B01J2219/00907 , B01J2219/00952 , B01L3/06 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/051 , B81B2201/054 , B81B2203/0127 , B81B2203/0315 , B81C1/00119 , B81C99/0065 , C30B7/14 , C30B29/54 , C30B29/58 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
摘要翻译：目标材料的结晶化的高通量筛选是通过将目标材料的溶液同时引入微细加工的流体装置的多个室来实现的。然后对微制造的流体装置进行操作以改变室中的溶液状态，从而同时提供大量的结晶环境。改变的溶液条件的控制可以由各种技术产生，包括但不限于通过体积排阻将结晶剂计量到室中的体积，通过捕获通过微结构结构的尺寸确定的结晶剂体积，将样品和结晶剂通道注入由相交的正交流动通道限定的连接阵列。

8. 发明申请

US20070209574A1 MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY TECHNIQUES 有权
标题翻译：微流感蛋白晶体学技术
公开(公告)号：US20070209574A1
公开(公告)日：2007-09-13
申请号：US11748838
申请日：2007-05-15
申请人： Carl Hansen , Stephen Quake , James Berger
发明人： Carl Hansen , Stephen Quake , James Berger
IPC分类号： C30B7/00
CPC分类号： C30B29/54 , B01D9/00 , B01J19/0046 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/00599 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L3/5025 , B01L3/502738 , B01L3/502753 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/123 , B01L2400/0472 , B01L2400/0481 , B01L2400/0655 , B01L2400/084 , C30B7/00 , C30B7/14 , C30B29/58 , C30B35/00 , C40B60/14 , G01N1/08 , Y10T117/1024
摘要： The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
摘要翻译：本发明涉及促进结晶物质如蛋白质生长和分析的微流体装置和方法。根据一个实施例，晶体生长结构由具有大得多体积的相邻阱的可渗透膜分离。该孔可以被配置成包含具有与晶体生长中使用的溶剂和结晶剂相似的特性和浓度的流体，并且通过膜的扩散稳定了该过程。或者，孔可以被配置为包含具有计算以影响结晶过程的同一性的流体。根据另一个实施方案，所述孔可以被配置为容纳诸如冷冻保护剂的材料，其可用于在形成后保护结晶材料。

9. 发明申请

US20070169686A1 Systems and methods for mixing reactants 审中-公开
标题翻译：用于混合反应物的系统和方法
公开(公告)号：US20070169686A1
公开(公告)日：2007-07-26
申请号：US11689302
申请日：2007-03-21
申请人： Stephen Quake , Carl Hansen , James Berger
发明人： Stephen Quake , Carl Hansen , James Berger
IPC分类号： C30B15/00 , C30B23/00
CPC分类号： C30B29/00 , B01D9/00 , B01D9/0072 , B01D9/0077 , B01J19/0046 , B01J2219/00274 , B01J2219/00286 , B01J2219/00317 , B01J2219/00389 , B01J2219/00418 , B01J2219/00432 , B01J2219/00585 , B01J2219/00756 , B01J2219/00891 , B01J2219/00907 , B01J2219/00952 , B01L3/06 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/051 , B81B2201/054 , B81B2203/0127 , B81B2203/0315 , B81C1/00119 , B81C99/0065 , C30B7/14 , C30B29/54 , C30B29/58 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
摘要翻译：目标材料的结晶化的高通量筛选是通过将目标材料的溶液同时引入微细加工的流体装置的多个室来实现的。然后对微制造的流体装置进行操作以改变室中的溶液状态，从而同时提供大量的结晶环境。改变的溶液条件的控制可以由各种技术产生，包括但不限于通过体积排阻将结晶剂计量到室中的体积，通过捕获通过微结构结构的尺寸确定的结晶剂的体积，将样品和结晶剂通道注入由相交的正交流动通道限定的连接阵列。

10. 发明申请

US20050062196A1 Microfluidic protein crystallography techniques 有权
标题翻译：微流体蛋白晶体学技术
公开(公告)号：US20050062196A1
公开(公告)日：2005-03-24
申请号：US10810350
申请日：2004-03-26
申请人： Carl Hansen , Stephen Quake , James Berger
发明人： Carl Hansen , Stephen Quake , James Berger
IPC分类号： B29C33/40 , C12Q20060101
CPC分类号： C30B29/16 , B01F5/10 , B01F5/108 , B01F13/0059 , B01L3/06 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , C30B7/00 , C30B7/14 , C30B29/58
摘要： The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
摘要翻译：本发明涉及促进结晶物质如蛋白质生长和分析的微流体装置和方法。根据一个实施例，晶体生长结构由具有大得多体积的相邻阱的可渗透膜分离。该孔可以被配置成包含具有与晶体生长中使用的溶剂和结晶剂相似的特性和浓度的流体，并且通过膜的扩散稳定了该过程。或者，孔可以被配置为包含具有计算以影响结晶过程的同一性的流体。根据另一个实施方案，所述孔可以被配置为容纳诸如冷冻保护剂的材料，其可用于在形成后保护结晶材料。

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