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1. 发明公开

EP3348177A8 CHRISTMAS ORNAMENT STRUCTURE 审中-公开
公开(公告)号：EP3348177A8
公开(公告)日：2019-02-20
申请号：EP17151572.9
申请日：2017-01-16
申请人： Lin, Min-Lu
发明人： Lin, Min-Lu
IPC分类号： A47G33/08 , A47G33/10
摘要： A Christmas ornament structure comprises a glass ball (3) and a ceramic cap (4), wherein the glass ball (3) is a hollow object, and a blow orifice part (31) upwardly extends from an end of the surface and includes a hole (32); in addition, the ceramic cap (4) is a modeled body (42), a circle ring (43) is connected on the top of the modeled body (42), a hollow structure (413) is inwardly formed by a connection inner wall (412) on the interior surface of the ceramic cap (4), and such a hollow structure (413) is connected in communication with the interior of the glass ball (3); moreover, the bottom of the ceramic cap (4) includes an opening (411) which allows the blow orifice part (31) of the glass ball (3) to enter, the perimeter of the opening (411) includes a connection inner wall (412) having an arc-shaped face closely fitting to the surface of the glass ball (3) and fixedly bonded to the glass ball (3) thus resulting in an in-out thoroughly connected Christmas ornament model of integral formation.

2. 发明公开

EP3348177A1 CHRISTMAS ORNAMENT STRUCTURE 审中-公开
公开(公告)号：EP3348177A1
公开(公告)日：2018-07-18
申请号：EP17151572.9
申请日：2017-01-16
申请人： Liu, Min-Lu
发明人： Liu, Min-Lu
IPC分类号： A47G33/08 , A47G33/10
摘要： A Christmas ornament structure comprises a glass ball (3) and a ceramic cap (4), wherein the glass ball (3) is a hollow object, and a blow orifice part (31) upwardly extends from an end of the surface and includes a hole (32); in addition, the ceramic cap (4) is a modeled body (42), a circle ring (43) is connected on the top of the modeled body (42), a hollow structure (413) is inwardly formed by a connection inner wall (412) on the interior surface of the ceramic cap (4), and such a hollow structure (413) is connected in communication with the interior of the glass ball (3); moreover, the bottom of the ceramic cap (4) includes an opening (411) which allows the blow orifice part (31) of the glass ball (3) to enter, the perimeter of the opening (411) includes a connection inner wall (412) having an arc-shaped face closely fitting to the surface of the glass ball (3) and fixedly bonded to the glass ball (3) thus resulting in an in-out thoroughly connected Christmas ornament model of integral formation.

3. 发明授权

EP3348177B1 CHRISTMAS ORNAMENT STRUCTURE 有权
公开(公告)号：EP3348177B1
公开(公告)日：2019-11-13
申请号：EP17151572.9
申请日：2017-01-16
申请人： Lin, Min-Lu
发明人： Lin, Min-Lu
IPC分类号： A47G33/08 , A47G33/10

5. 发明专利

GB2188261A Manufacture of a bead chain 未知
公开(公告)号：GB2188261A
公开(公告)日：1987-09-30
申请号：GB8607503
申请日：1986-03-26
申请人： WONG MIN LU
发明人： WONG MIN-LU
IPC分类号： B21L11/12
摘要： In the method (a) at each of equidistant consecutive first segments of a first tube 301 two adjoined flanges 302 connected by a weakened joint are formed by dies 33; (b) the tube 301 is inserted into a second hollow tube 304 of larger diameter; (c) and the tube 304 is pressed by dies 36 to form a series of consecutive second segments constituted of alternate enlarged portions 366 and narrow portions 367, with each narrow portion 367 located between the flanges 302 of a first segment; and (d) each pair of said adjoined flange portions 302 is separated by tapping by a rod 37 along the weakened joint. The tube 301 is bent in a hollow tube- forming member 32, and the second tube is bent in a hollow tube-forming member 35. The resultant chain has beads connected by hollow members.

6. 发明授权

US11685761B2 Cyclic di-nucleotide compounds as sting agonists 有权
公开(公告)号：US11685761B2
公开(公告)日：2023-06-27
申请号：US16771814
申请日：2018-12-17
申请人： Merck Sharp & Dohme Corp. , Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
发明人： Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
IPC分类号： C07H21/00 , A61P37/04 , C07H21/02 , A61K31/7084 , C07H21/04
CPC分类号： C07H21/00 , A61K31/7084 , A61P37/04 , C07H21/02 , C07H21/04 , C07B2200/07
摘要： A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

7. 发明申请

US20220259188A1 1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权
公开(公告)号：US20220259188A1
公开(公告)日：2022-08-18
申请号：US17614732
申请日：2020-06-01
申请人： Hua ZHOU , John J. ACTON, III , Michael J. ARDOLINO , Yi-Heng CHEN , Peter H. FULLER , Anmol GULATI , Rebecca Elizabeth JOHNSON , William P. KAPLAN , Solomon D. KATTAR , Mitchell H. KEYLOR , Derun LI , Kaitlyn Marie LOGAN , Min LU , Gregori J. MORRIELLO , Santhosh F. NEELAMKAVIL , Barbara PIO , Nunzio SCIAMMETTA , Vladimir SIMOV , Jing SU , Luis TORRES , Xin YAN , Merck Sharp & Dohme Corp.
发明人： Hua Zhou , John J. Acton, III , Michael J. Ardolino , Yi-Heng Chen , Peter H. Fuller , Anmol Gulati , Rebecca Elizabeth Johnson , William P. Kaplan , Solomon D. Kattar , Mitchell H. Keylor , Derun Li , Kaitlyn Marie Logan , Min Lu , Gregori J. Morriello , Santhosh F. Neelamkavil , Barbara Pio , Nunzio Sciammetta , Vladimir Simov , Jing Su , Luis Torres , Xin Yan
IPC分类号： C07D405/14 , C07D487/08 , C07D409/14 , C07D403/04 , C07D403/14 , C07D498/04 , C07D498/08 , C07D487/10 , C07D401/14 , C07D471/10 , C07D491/107 , C07D471/04 , C07D487/04 , A61P25/16
摘要： The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

8. 发明授权

US09589009B2 Long-lived data transactions 有权
标题翻译：长期的数据交易
公开(公告)号：US09589009B2
公开(公告)日：2017-03-07
申请号：US13365442
申请日：2012-02-03
申请人： Kanchan Shringi , Min Lu , Xiaopei (Joyce) Zhang , Siemel Naran , Rahim Yaseen , Jon Rexford Degenhardt
发明人： Kanchan Shringi , Min Lu , Xiaopei (Joyce) Zhang , Siemel Naran , Rahim Yaseen , Jon Rexford Degenhardt
IPC分类号： G06F17/30
CPC分类号： G06F17/30371
摘要： In one embodiment, a method includes accessing a mapping that represents a correspondence between a column in a source database and a column in a temporary storage table, in response to receiving a data operation request to execute a data operation on a column of the source database. The method further includes changing the temporary storage table by executing the data operation on the temporary storage table and performing a reconstruction operation using data from the temporary storage table and the source database.
摘要翻译：在一个实施例中，一种方法包括访问表示源数据库中的列与临时存储表中的列之间的对应关系的映射，响应于接收到对源数据库的列执行数据操作的数据操作请求。该方法还包括通过对临时存储表执行数据操作来改变临时存储表，并使用来自临时存储表和源数据库的数据执行重建操作。

9. 发明授权

US08709806B2 EpCAM as a reprogramming factor for non-pluripotent cells 有权
标题翻译： EpCAM作为非多能细胞的重编程因子
公开(公告)号：US08709806B2
公开(公告)日：2014-04-29
申请号：US12930154
申请日：2010-12-28
申请人： Han-Chung Wu , Tung-Ying Lu , Cheng-Fu Kao , John Yu , Ruei-Min Lu , Mei-Ying Liao , Hung-Chih Kuo
发明人： Han-Chung Wu , Tung-Ying Lu , Cheng-Fu Kao , John Yu , Ruei-Min Lu , Mei-Ying Liao , Hung-Chih Kuo
IPC分类号： C12N15/00 , C12N15/02
CPC分类号： G01N33/5073 , C12N5/0696 , C12N2501/58 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00
摘要： Methods are provided for inducing non-pluripotent cells to become pluripotent. Methods also include identifying and isolating induced pluripotent (iPS) cells and uses thereof. Compositions and kits for carrying out the subject methods are also provided.
摘要翻译：提供用于诱导非多能细胞变为多能的方法。方法还包括鉴定和分离诱导多能（iPS）细胞及其用途。还提供了用于实施主题方法的组合物和试剂盒。

10. 发明授权

US08669066B2 Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays 有权
标题翻译：用于鉴定人和非人灵长类动物味道特异性基因的理由，方法和测定及其在味觉调节剂和治疗性筛选测定中的用途
公开(公告)号：US08669066B2
公开(公告)日：2014-03-11
申请号：US13090335
申请日：2011-04-20
申请人： Bryan Moyer , Albert Zlotnik , Peter Hevezi , Hortensia Soto , Dalia Kalabat , Min Lu , Na Gao , Evan Carl White
发明人： Bryan Moyer , Albert Zlotnik , Peter Hevezi , Hortensia Soto , Dalia Kalabat , Min Lu , Na Gao , Evan Carl White
IPC分类号： G01N33/567 , C12Q1/68 , C07K14/705
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5005 , G01N33/5044 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.
摘要翻译：本发明涉及用于鉴定人类和灵长类动物特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感觉的基因以及基因参与其他味觉细胞或味觉受体相关活性，如消化功能和消化相关疾病，味觉细胞周转，口服和消化道的免疫调节，以及代谢调节，如糖尿病和肥胖症，使用这些方法鉴定的基因和测定用于鉴定使用这些基因的味觉调节剂（增强子或阻断剂）和潜在的治疗剂。这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。此外，本发明涉及用于鉴定可用作哺乳动物中不同味道细胞类型（包括甜味，苦味，鲜味，酸味，咸味和其他味觉细胞）的标记的味道特异性基因的新方法，以及测量在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染。特别地，本文鉴定的基因和其抗体或寡核苷酸可以用作标识物，以通过使用FACS或磁珠细胞选择或其他已知的细胞纯化和分离程序来鉴定和/或纯化特定味细胞，例如来自味细胞悬浮液。

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