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1. 发明授权

US06306454B1 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06306454B1
公开(公告)日：2001-10-23
申请号：US09388913
申请日：1999-09-01
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunahan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunahan
IPC分类号： A61L5103
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

2. 发明授权

US06648922B2 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06648922B2
公开(公告)日：2003-11-18
申请号：US09790395
申请日：2001-02-21
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F236
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

3. 发明授权

US07422606B2 Medical devices and products having coatings applied thereto 失效
标题翻译：带有涂层的医疗器械和产品
公开(公告)号：US07422606B2
公开(公告)日：2008-09-09
申请号：US10678875
申请日：2003-10-03
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F2/02
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

4. 发明授权

US5972217A Blood cell separation devices having a membrane with particular coating 失效
标题翻译：具有具有特定涂层的膜的血细胞分离装置
公开(公告)号：US5972217A
公开(公告)日：1999-10-26
申请号：US971887
申请日：1997-11-17
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： B01D39/16 , B01D61/18
CPC分类号： B01D39/1692
摘要： Blood filtration devices and methods of filtering are disclosed. In part, a blood filtration device is provided comprising a housing defining an interior periphery. The device includes a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery, an inlet fluid path for allowing a blood product to flow into the annular gap, and the rotating structure including an exterior surface that includes a filter membrane. The filter membrane has a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene oxide derivative.
摘要翻译：公开了血液过滤装置和过滤方法。部分地，提供血液过滤装置，其包括限定内周的壳体。该装置包括旋转结构，该旋转结构安装在内部周边内并且在壳体内限定内部周边内的环形间隙，用于允许血液制品流入环形间隙的入口流体路径，以及包括外部表面的旋转结构，滤膜。过滤膜在其上具有包含第一亲电活性的高分子量聚环氧烷和第二高分子量双官能二氨基 - 聚氧化亚烷基氧化物衍生物的原位缩合产物的涂层。

5. 发明授权

US6045701A Method of filtering a fluid suspension with a membrane having a particular coating 失效
标题翻译：用具有特定涂层的膜过滤流体悬浮液的方法
公开(公告)号：US6045701A
公开(公告)日：2000-04-04
申请号：US073490
申请日：1998-05-06
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： A61M1/36 , B01D61/00 , B01D61/14
CPC分类号： A61M1/3679 , A61M1/262 , A61M1/265 , A61M2202/0439
摘要： Novel blood cell fractionation devices are provided. The device utilizes filters coated with high molecular weight polyethylene oxide derivatives cross-linked to prevent leaching from filter surfaces. These filters have a special efficacy in preventing protein adsorption and cellular adhesion to the membrane filter.
摘要翻译：提供新型血细胞分馏装置。该装置使用涂覆有交联的高分子量聚环氧乙烷衍生物的过滤器以防止从过滤表面浸出。这些过滤器在防止蛋白质吸附和细胞粘附到膜过滤器上具有特殊的功效。

6. 发明授权

US5795483A Method of separating leukocytes from blood cells using a leukodepletion filter 失效
标题翻译：使用白血病过滤器从白细胞分离白细胞的方法
公开(公告)号：US5795483A
公开(公告)日：1998-08-18
申请号：US810751
申请日：1997-03-04
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： A61M1/34 , A61K35/14 , A61M1/02 , A61M1/36 , B01D35/02 , B01D39/16 , B01D37/00 , B01D39/02
CPC分类号： A61M1/3679 , B01D39/1623 , A61M2202/0439 , Y10T428/2915 , Y10T436/25375 , Y10T436/255
摘要： Novel blood cell fractionation means utilizes conventional filters coated with high molecular weight polyethylene oxide derivatives crosslinked to prevent leaching from filter surfaces. These fractionation means have a special efficacy in binding white blood cells from whole blood while simultaneously allowing red cells and platelets to pass in the effluent phase.
摘要翻译：新型血细胞分馏方法是利用传统的过滤器，其涂覆有交联的高分子量聚环氧乙烷衍生物以防止从过滤表面浸出。这些分离装置在结合来自全血的白血球中具有特殊功效，同时使红细胞和血小板通过流出相。

7. 发明授权

US5647985A Whole blood leukodepletion and platelet filter 失效
标题翻译：全血白血病和血小板过滤
公开(公告)号：US5647985A
公开(公告)日：1997-07-15
申请号：US323559
申请日：1994-10-17
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： A61M1/34 , A61K35/14 , A61M1/02 , A61M1/36 , B01D35/02 , B01D39/16 , B01D39/02 , C08J7/04 , C09D171/02
CPC分类号： A61M1/3679 , B01D39/1623 , A61M2202/0439 , Y10T428/2915 , Y10T436/25375 , Y10T436/255
摘要： Novel blood cell fractionation means utilizes conventional filters coated with high molecular weight polyethylene oxide derivatives crosslinked to prevent leaching from filter surfaces. These fractionation means have a special efficacy in binding white blood cells from whole blood while simultaneously allowing red cells and platelets to pass in the effluent phase.
摘要翻译：新型血细胞分馏方法是利用传统的过滤器，其涂覆有交联的高分子量聚环氧乙烷衍生物，以防止从过滤表面浸出。这些分离装置在结合来自全血的白血球中具有特殊功效，同时使红细胞和血小板通过流出相。

8. 发明授权

US09155740B2 Compositions and methods for treatment and prevention of hyperuricemia related health consequences 有权
标题翻译：用于治疗和预防高尿酸血症相关健康后果的组合物和方法
公开(公告)号：US09155740B2
公开(公告)日：2015-10-13
申请号：US13364313
申请日：2012-02-01
申请人： Richard J. Johnson , Takahiko Nakagawa
发明人： Richard J. Johnson , Takahiko Nakagawa
IPC分类号： A01N43/90 , A61K31/519 , A61K31/426 , A61K31/4439
CPC分类号： A61K31/519 , A61K31/426 , A61K31/4439
摘要： Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods that involve administering to a patient susceptible to development of diabetes a composition comprising a uric acid lowering agent in a regimen that maintains serum uric acid levels below at least 5.5 mg/dl, or below at least 5.2 mg/dl.
摘要翻译：本文公开了延迟起效或治疗糖尿病的方法，其包括施用降低尿酸的试剂。本发明人已经发现了显着的发现：升高的尿酸水平不是胰岛素抵抗的必然结果，而是胰岛素抵抗的主要介质。具体举例说明的方法是涉及向患有糖尿病发展的患者施用包含尿酸降低剂的组合物的方法，其维持血清尿酸水平低于至少5.5mg / dl或低于至少5.2mg / dl。

9. 发明申请

US20140377386A1 PLANT-BASED INHIBITORS OF KETOHEXOKINASE FOR THE SUPPORT OF WEIGHT MANAGEMENT 审中-公开
标题翻译：用于支持体重管理的基于植物药物的KETOHEXOKINASE抑制剂
公开(公告)号：US20140377386A1
公开(公告)日：2014-12-25
申请号：US14305876
申请日：2014-06-16
申请人： Jatinder Rana , Russell Keith Randolph , Jeffrey Scholten , MyPhuong Thi Le , Richard J. Johnson , Miguel Angel Lanaspa Garcia
发明人： Jatinder Rana , Russell Keith Randolph , Jeffrey Scholten , MyPhuong Thi Le , Richard J. Johnson , Miguel Angel Lanaspa Garcia
IPC分类号： A61K36/73 , A61K36/38 , A61K36/185 , A61K36/487 , A61K36/539 , A61K36/12 , A61K36/19 , A61K36/62 , A61K36/75 , A61K36/23 , A61K36/605 , A61K36/232 , A61K36/44
CPC分类号： A61K36/73 , A61K36/12 , A61K36/185 , A61K36/19 , A61K36/23 , A61K36/232 , A61K36/38 , A61K36/44 , A61K36/487 , A61K36/539 , A61K36/605 , A61K36/62 , A61K36/75
摘要： A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 μg/mL to about 1000 μg/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may include administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 μg/mL to about 1000 μg/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.
摘要翻译：用于抑制酮基己糖激酶的组合物，例如酮基己糖激酶-C（KHK-C）活性，可以包括至少具有IC 50的植物提取物（即，浓度在约0.1μg/ mL范围内的50％KHK-C抑制约1000μg/ mL，组合物可以是适合于口服摄取的形式，抑制受试者中KHK-C活性的方法可包括给予至少50％KHK-C抑制的植物提取物，浓度为约0.1μg/ mL至约1000μg/ mL，可以进行给药以治疗或预防糖成瘾，肥胖症或代谢综合征中的至少一种。施用可以至少从受试者中提供减少的渴望选自糖，果糖，含果糖的糖，碳水化合物及其组合的组中的一个成员，所述受试者可以是糖尿病前期，糖尿病和/或胰岛素抵抗。

10. 发明授权

US08888043B1 Crew bunk system and method 有权
标题翻译：船员双层系统和方法
公开(公告)号：US08888043B1
公开(公告)日：2014-11-18
申请号：US13610883
申请日：2012-09-12
申请人： Michael J. Olliges , Mark E. King , Marc A. Spane , Paul A. Kinzer , Aaron L. Castillo , Douglas J. Seiersen , Richard J. Johnson , Lee L. Smith
发明人： Michael J. Olliges , Mark E. King , Marc A. Spane , Paul A. Kinzer , Aaron L. Castillo , Douglas J. Seiersen , Richard J. Johnson , Lee L. Smith
IPC分类号： B64D11/06
CPC分类号： B64D11/00 , B64D2011/0076
摘要： A crew bunk system may include a bunk frame assembly and at least two vertically spaced crew berths. Each one of the crew berths may have a lengthwise hinge line dividing the crew berth into a stationary panel and a foldable panel. The stationary panel may be fixedly coupled to the bunk frame assembly. The foldable panel may be hingedly coupled to the stationary panel along the hinge line. The crew bunk system may include at least one connecting member interconnecting the foldable panels such that the foldable panels pivot in unison between a deployed position and a stowed position. The crew bunk system may include a latching mechanism configured to lock the foldable panels in the stowed position.
摘要翻译：船员舱系统可包括双层框架组件和至少两个垂直间隔的船员泊位。船员泊位中的每一个可以具有将船员泊位分成固定板和可折叠板的纵向铰链线。固定面板可以固定地联接到双层框架组件。可折叠面板可以沿铰链线铰接地固定在固定面板上。乘员舱系统可以包括互连可折叠面板的至少一个连接构件，使得可折叠面板在展开位置和收起位置之间一致地枢转。机组双层系统可以包括锁定机构，其构造成将可折叠面板锁定在收起位置。

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