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1. 发明授权

US5972217A Blood cell separation devices having a membrane with particular coating 失效
标题翻译：具有具有特定涂层的膜的血细胞分离装置
公开(公告)号：US5972217A
公开(公告)日：1999-10-26
申请号：US971887
申请日：1997-11-17
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： B01D39/16 , B01D61/18
CPC分类号： B01D39/1692
摘要： Blood filtration devices and methods of filtering are disclosed. In part, a blood filtration device is provided comprising a housing defining an interior periphery. The device includes a rotating structure mounted within the interior periphery and defining with the housing an annular gap within the interior periphery, an inlet fluid path for allowing a blood product to flow into the annular gap, and the rotating structure including an exterior surface that includes a filter membrane. The filter membrane has a coating thereon comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight bifunctional diamino-polyoxyalkylene oxide derivative.
摘要翻译：公开了血液过滤装置和过滤方法。部分地，提供血液过滤装置，其包括限定内周的壳体。该装置包括旋转结构，该旋转结构安装在内部周边内并且在壳体内限定内部周边内的环形间隙，用于允许血液制品流入环形间隙的入口流体路径，以及包括外部表面的旋转结构，滤膜。过滤膜在其上具有包含第一亲电活性的高分子量聚环氧烷和第二高分子量双官能二氨基 - 聚氧化亚烷基氧化物衍生物的原位缩合产物的涂层。

2. 发明授权

US06746482B2 Method for producing medical devices and devices so produced 失效
标题翻译：生产医疗器械和器械的方法
公开(公告)号：US06746482B2
公开(公告)日：2004-06-08
申请号：US09991298
申请日：2001-11-09
申请人： Neng S. Ung-Chhun
发明人： Neng S. Ung-Chhun
IPC分类号： A61F206
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61L33/0041 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising a polyalkylene oxide and a functional group, preferably heparin, magainin, or chlorhexidine.
摘要翻译：提供医疗装置及其制造方法。医疗装置包括主体构件和至少一部分主体构件上的涂层，其包含聚环氧烷和官能团，优选肝素，马卡宁或氯己定。

3. 发明授权

US06648922B2 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06648922B2
公开(公告)日：2003-11-18
申请号：US09790395
申请日：2001-02-21
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F236
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

4. 发明授权

US06306454B1 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06306454B1
公开(公告)日：2001-10-23
申请号：US09388913
申请日：1999-09-01
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunahan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunahan
IPC分类号： A61L5103
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

5. 发明授权

US6045701A Method of filtering a fluid suspension with a membrane having a particular coating 失效
标题翻译：用具有特定涂层的膜过滤流体悬浮液的方法
公开(公告)号：US6045701A
公开(公告)日：2000-04-04
申请号：US073490
申请日：1998-05-06
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： A61M1/36 , B01D61/00 , B01D61/14
CPC分类号： A61M1/3679 , A61M1/262 , A61M1/265 , A61M2202/0439
摘要： Novel blood cell fractionation devices are provided. The device utilizes filters coated with high molecular weight polyethylene oxide derivatives cross-linked to prevent leaching from filter surfaces. These filters have a special efficacy in preventing protein adsorption and cellular adhesion to the membrane filter.
摘要翻译：提供新型血细胞分馏装置。该装置使用涂覆有交联的高分子量聚环氧乙烷衍生物的过滤器以防止从过滤表面浸出。这些过滤器在防止蛋白质吸附和细胞粘附到膜过滤器上具有特殊的功效。

6. 发明授权

US5795483A Method of separating leukocytes from blood cells using a leukodepletion filter 失效
标题翻译：使用白血病过滤器从白细胞分离白细胞的方法
公开(公告)号：US5795483A
公开(公告)日：1998-08-18
申请号：US810751
申请日：1997-03-04
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： A61M1/34 , A61K35/14 , A61M1/02 , A61M1/36 , B01D35/02 , B01D39/16 , B01D37/00 , B01D39/02
CPC分类号： A61M1/3679 , B01D39/1623 , A61M2202/0439 , Y10T428/2915 , Y10T436/25375 , Y10T436/255
摘要： Novel blood cell fractionation means utilizes conventional filters coated with high molecular weight polyethylene oxide derivatives crosslinked to prevent leaching from filter surfaces. These fractionation means have a special efficacy in binding white blood cells from whole blood while simultaneously allowing red cells and platelets to pass in the effluent phase.
摘要翻译：新型血细胞分馏方法是利用传统的过滤器，其涂覆有交联的高分子量聚环氧乙烷衍生物以防止从过滤表面浸出。这些分离装置在结合来自全血的白血球中具有特殊功效，同时使红细胞和血小板通过流出相。

7. 发明授权

US5647985A Whole blood leukodepletion and platelet filter 失效
标题翻译：全血白血病和血小板过滤
公开(公告)号：US5647985A
公开(公告)日：1997-07-15
申请号：US323559
申请日：1994-10-17
申请人： Neng S. Ung-Chhun , Richard J. Johnson
发明人： Neng S. Ung-Chhun , Richard J. Johnson
IPC分类号： A61M1/34 , A61K35/14 , A61M1/02 , A61M1/36 , B01D35/02 , B01D39/16 , B01D39/02 , C08J7/04 , C09D171/02
CPC分类号： A61M1/3679 , B01D39/1623 , A61M2202/0439 , Y10T428/2915 , Y10T436/25375 , Y10T436/255
摘要： Novel blood cell fractionation means utilizes conventional filters coated with high molecular weight polyethylene oxide derivatives crosslinked to prevent leaching from filter surfaces. These fractionation means have a special efficacy in binding white blood cells from whole blood while simultaneously allowing red cells and platelets to pass in the effluent phase.
摘要翻译：新型血细胞分馏方法是利用传统的过滤器，其涂覆有交联的高分子量聚环氧乙烷衍生物，以防止从过滤表面浸出。这些分离装置在结合来自全血的白血球中具有特殊功效，同时使红细胞和血小板通过流出相。

8. 发明授权

US07422606B2 Medical devices and products having coatings applied thereto 失效
标题翻译：带有涂层的医疗器械和产品
公开(公告)号：US07422606B2
公开(公告)日：2008-09-09
申请号：US10678875
申请日：2003-10-03
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F2/02
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

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