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1. 发明授权

US06648922B2 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06648922B2
公开(公告)日：2003-11-18
申请号：US09790395
申请日：2001-02-21
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F236
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

2. 发明授权

US5686527A Polymeric compositions for medical packaging and devices 失效
标题翻译：用于医疗包装和装置的聚合物组合物
公开(公告)号：US5686527A
公开(公告)日：1997-11-11
申请号：US461050
申请日：1995-06-05
申请人： Dean Laurin , Angeles Lillian Buan , Lecon Woo , Michael T. K. Ling , Yuan Pang Samuel Ding , William Anderson , Larry A. Rosenbaum , Denise S. Hayward , Joseph P. Hoppesch , Gregg Nebgen , Stanley Westphal
发明人： Dean Laurin , Angeles Lillian Buan , Lecon Woo , Michael T. K. Ling , Yuan Pang Samuel Ding , William Anderson , Larry A. Rosenbaum , Denise S. Hayward , Joseph P. Hoppesch , Gregg Nebgen , Stanley Westphal
IPC分类号： A61L27/00 , A61L31/00 , C08L23/02 , C08L23/06 , C08L23/08 , C08L23/10 , C08L23/16 , C08L23/20 , C08L23/26 , C08L29/04 , C08L31/04 , C08L51/06 , C08L53/00 , C08L53/02 , C08L67/00 , C08L75/00 , C08L77/00 , C08L101/00 , C08L101/12
CPC分类号： C08L23/02 , C08L101/00 , C08L23/10 , C08L2203/02 , C08L2205/08 , C08L23/0815 , C08L23/0846 , C08L23/0853 , C08L23/0869 , C08L51/06 , C08L53/00 , C08L53/02 , C08L77/00
摘要： Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ("RF") susceptible polymer; a compatibilizing polymer; the composition having physical properties within the range a =70%; c 1.0; e =0.05; h
摘要翻译：用于制造成物品的多组分聚合物组合物。特别地，包含耐热聚合物的聚合物组合物; 射频（“RF”）敏感聚合物; 相容聚合物; 所述组合物具有在<40,000psi范围内的物理性质; b> = 70％; c <30％; d> 1.0; e <0.1％; f <0.1％; g> = 0.05; h <= 60％; i = 0; 其中：a是根据ASTM D-882测量的组合物的机械模量; b是初始20％变形后组合物的长度恢复百分比; c根据ASTM D-1003，组合物的光学雾度为9密耳厚度; d是在熔体处理温度下测量的组合物在1Hz下的损耗角正切; e是组合物重量的元素卤素含量; f是组合物的低分子量水溶性级分; g是组合物在1至60MHz之间的介电损耗和25至250℃的高温; 在121℃下测量在27psi负载下组合物的1英寸条带的样品蠕变; 并且，i表示组合物在以约20英寸（50cm）/分钟的中等速度应变至约100％伸长率（原始长度的两倍）和应变增白（由1表示）或缺乏的应变之后不显示应变增白（由0表示）。

3. 发明授权

US4677143A Antimicrobial compositions 失效
标题翻译：抗微生物组合物
公开(公告)号：US4677143A
公开(公告)日：1987-06-30
申请号：US802555
申请日：1985-11-27
申请人： Dean Laurin , James Stupar
发明人： Dean Laurin , James Stupar
IPC分类号： A01N25/10 , A01N59/16 , A61L29/08 , A61L29/16 , C08K3/00 , A61M25/00
CPC分类号： C08K3/005 , A01N25/10 , A01N59/16 , A61L29/085 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404
摘要： Antimicrobial compositions finding particular utility for coating access systems, lead devices including shunts, cannulae, catheters, catheter adapters, wires and other solid or hollow tubular devices used for a variety of medical purposes is provided. The composition comprises a material selected from the group consisting of acrylonitrile-butadiene-styrene copolymers, polyvinyl chloride, mixtures thereof, polyesters, polyurethanes, styrene-block copolymers, natural and synthetic rubbers, polycarbonates, nylon and silicone rubber mixed with an oligodynamic material consisting essentially of compounds of physiological, antimicrobial metals.
摘要翻译：提供了用于涂覆进入系统，包括分流器，套管，导管，导管适配器，电线以及用于各种医疗目的的其它固体或中空管状装置的引线装置的特别实用的抗微生物组合物。该组合物包括选自丙烯腈 - 丁二烯 - 苯乙烯共聚物，聚氯乙烯，其混合物，聚酯，聚氨酯，苯乙烯嵌段共聚物，天然和合成橡胶，聚碳酸酯，尼龙和硅橡胶的材料，所述低聚物包含基本上是生理，抗微生物金属的化合物。

4. 发明授权

US4485064A Antibacterial seal 失效
标题翻译：抗菌密封
公开(公告)号：US4485064A
公开(公告)日：1984-11-27
申请号：US366022
申请日：1982-04-06
申请人： Dean Laurin
发明人： Dean Laurin
IPC分类号： A61J1/00 , A61J1/14 , B29D3/00 , B65D81/24
CPC分类号： A61J1/1443 , A61J1/1468
摘要： Containers used for storing and dispensing liquids for medical applications include a closure, and medical connection device include cooperating connector members. An article of manufacture and a method are provided where a plastic outer closure is applied over container closures or over connection devices. The application of the plastic outer closure exerts an antibacterial effect in the juncture area defined by the interface of the outer closure and the container inner closure and neck, or defined by the interface of the outer closure and the connection site of the connector members. The outer closure is of a type of plastic that releases an antibacterial agent, which exerts an antibacterial effect in the juncture area.
摘要翻译：用于存储和分配用于医疗应用的液体的容器包括封闭件，医疗连接装置包括配合的连接器构件。提供了一种制造物品和方法，其中塑料外部封闭件应用于容器封闭件或连接装置上。塑料外壳的应用在由外部封闭件和容器内部封闭件和颈部的界面限定的接合区域中产生抗菌作用，或者由外部封闭件和连接器构件的连接部位的界面限定。外壳是一种释放抗菌剂的塑料，其在接合区域发挥抗菌作用。

5. 发明授权

US07422606B2 Medical devices and products having coatings applied thereto 失效
标题翻译：带有涂层的医疗器械和产品
公开(公告)号：US07422606B2
公开(公告)日：2008-09-09
申请号：US10678875
申请日：2003-10-03
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F2/02
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

6. 发明授权

US5849843A Polymeric compositions for medical packaging and devices 失效
标题翻译：用于医疗包装和装置的聚合物组合物
公开(公告)号：US5849843A
公开(公告)日：1998-12-15
申请号：US153823
申请日：1993-11-16
申请人： Dean Laurin , Angeles Lillian Buan , Lecon Woo , Michael T. K. Ling , Yuan Pang Samuel Ding , William Anderson , Larry A. Rosenbaum , Denise S. Hayward , Joseph P. Hoppesch , Gregg Nebgen , Stanley Westphal
发明人： Dean Laurin , Angeles Lillian Buan , Lecon Woo , Michael T. K. Ling , Yuan Pang Samuel Ding , William Anderson , Larry A. Rosenbaum , Denise S. Hayward , Joseph P. Hoppesch , Gregg Nebgen , Stanley Westphal
IPC分类号： A61L27/00 , A61L31/00 , C08L23/02 , C08L23/06 , C08L23/08 , C08L23/10 , C08L23/16 , C08L23/20 , C08L23/26 , C08L29/04 , C08L31/04 , C08L51/06 , C08L53/00 , C08L53/02 , C08L67/00 , C08L75/00 , C08L77/00 , C08L101/00 , C08L101/12
CPC分类号： C08L23/02 , C08L101/00 , C08L23/10 , C08L2203/02 , C08L2205/08 , C08L23/0815 , C08L23/0846 , C08L23/0853 , C08L23/0869 , C08L51/06 , C08L53/00 , C08L53/02 , C08L77/00
摘要： Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ("RF") susceptible polymer; a compatibilizing polymer; the composition having physical properties within the range a =70%; c 1.0; e =0.05; h
摘要翻译：用于制造成物品的多组分聚合物组合物。特别地，包含耐热聚合物的聚合物组合物; 射频（“RF”）敏感聚合物; 相容聚合物; 所述组合物具有在<40,000psi范围内的物理性质; b> = 70％; c <30％; d> 1.0; e <0.1％; f <0.1％; g> = 0.05; h <= 60％; i = 0; 其中：a是根据ASTM D-882测量的组合物的机械模量; b是初始20％变形后组合物的长度恢复百分比; c根据ASTM D-1003，组合物的光学雾度为9密耳厚度; d是在熔体处理温度下测量的组合物在1Hz下的损耗角正切; e是组合物重量的元素卤素含量; f是组合物的低分子量水溶性级分; g是组合物在1至60MHz之间的介电损耗和25至250℃的高温; 在121℃下测量在27psi负载下组合物的1英寸条带的样品蠕变; 并且，i表示组合物在以约20英寸（50cm）/分钟的中等速度应变至约100％伸长率（原始长度的两倍）和应变增白（由1表示）或缺乏的应变之后不显示应变增白（由0表示）。

7. 发明授权

US5645904A Method and compositions that render materials RF responsive 失效
标题翻译：使材料RF响应的方法和组成
公开(公告)号：US5645904A
公开(公告)日：1997-07-08
申请号：US805218
申请日：1991-12-11
申请人： Lecon Woo , Ying Lo , Michael T. K. Ling , Dean Laurin , Byron Gleason , Lillian A. Buan , William D. Johnston
发明人： Lecon Woo , Ying Lo , Michael T. K. Ling , Dean Laurin , Byron Gleason , Lillian A. Buan , William D. Johnston
IPC分类号： A61J1/10 , B29C65/00 , B29C65/04 , B29C65/52 , B29L9/00 , B29L22/00 , B32B7/02 , B65D65/42 , B65D75/30 , B32B1/08
CPC分类号： B29C65/04 , B29C65/4815 , B29C65/52 , B29C66/0044 , B29C66/1122 , B29C66/43 , B29C66/472 , B29C66/53262 , B29C66/723 , B29C66/73143 , B29C66/81457 , B29C66/8322 , B65D75/30 , B29C65/522 , B29C65/525 , B29C65/526 , B29C65/528 , B29C66/24 , B29C66/71 , B29C66/73774 , B29C66/7392 , B29C66/73921 , B29C66/73941 , B29C66/81871 , B29K2027/06 , B29L2031/7148 , Y10T156/1089 , Y10T29/49803 , Y10T428/1341 , Y10T428/1352 , Y10T428/31551 , Y10T428/31573 , Y10T428/31576 , Y10T428/31587 , Y10T428/31736 , Y10T428/31743 , Y10T428/31797 , Y10T428/3192
摘要： The coating of a RF active material on a non-RF active substrate material of typical thickness for packaging purposes, can generate sufficient thermal energy to effect strong bonding of the substrate materials. The RF active material may be deposited on less than the entire inner surface area of the substrate material, preferably, at or near the portion of the substrate surface which represents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing process. Flexible medical containers capable of containing a product which is maintained and removed under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.
摘要翻译：在用于包装目的的典型厚度的非RF有源衬底材料上的RF活性材料的涂层可以产生足够的热能来实现衬底材料的强烈结合。 RF活性材料可以沉积在基板材料的小于整个内表面区域上，优选地沉积在表示热封界面的基板表面的部分处或附近。以这种施加方式，可以在不影响热封过程的情况下实现在基板表面上的其它物质的附加涂覆或印刷。能够容纳在无菌条件下保持和去除的产品的灵活的医疗容器可以在这些涂覆的非RF活性基底材料的商业生产机器上构建。

8. 发明授权

US5854347A Polymeric compositions for medical packaging and devices 失效
公开(公告)号：US5854347A
公开(公告)日：1998-12-29
申请号：US463983
申请日：1995-06-05
申请人： Dean Laurin , Angeles Lillian Buan , Lecon Woo , Michael T. K. Ling , Yuan Pang Samuel Ding , William Anderson , Larry A. Rosenbaum , Denise S. Hayward , Joseph P. Hoppesch , Gregg Nebgen , Stanley Westphal
发明人： Dean Laurin , Angeles Lillian Buan , Lecon Woo , Michael T. K. Ling , Yuan Pang Samuel Ding , William Anderson , Larry A. Rosenbaum , Denise S. Hayward , Joseph P. Hoppesch , Gregg Nebgen , Stanley Westphal
IPC分类号： A61L27/00 , A61L31/00 , C08L23/02 , C08L23/06 , C08L23/08 , C08L23/10 , C08L23/16 , C08L23/20 , C08L23/26 , C08L29/04 , C08L31/04 , C08L51/06 , C08L53/00 , C08L53/02 , C08L67/00 , C08L75/00 , C08L77/00 , C08L101/00 , C08L101/12 , C08L79/08
CPC分类号： C08L23/02 , C08L101/00 , C08L23/10 , C08L2203/02 , C08L2205/08 , C08L23/0815 , C08L23/0846 , C08L23/0853 , C08L23/0869 , C08L51/06 , C08L53/00 , C08L53/02 , C08L77/00
摘要： Multiple component polymer compositions for fabrication into articles. In particular, polymeric compositions comprising a heat resistant polymer; a radio frequency ("RF") susceptible polymer; a compatibilizing polymer; the composition having physical properties within the range a =70%; c 1.0; e =0.05; h

9. 发明授权

US5840146A Method and compositions that render materials RF responsive 失效
标题翻译：使材料RF响应的方法和组成
公开(公告)号：US5840146A
公开(公告)日：1998-11-24
申请号：US466289
申请日：1995-06-06
申请人： Lecon Woo , Ying Lo , Michael T. K. Ling , Dean Laurin , Byron Gleason , Lillian A. Buan , William D. Johnston
发明人： Lecon Woo , Ying Lo , Michael T. K. Ling , Dean Laurin , Byron Gleason , Lillian A. Buan , William D. Johnston
IPC分类号： A61J1/10 , B29C65/00 , B29C65/04 , B29C65/52 , B29L9/00 , B29L22/00 , B32B7/02 , B65D65/42 , B65D75/30 , B32B31/00
CPC分类号： B29C65/04 , B29C65/4815 , B29C65/52 , B29C66/0044 , B29C66/1122 , B29C66/43 , B29C66/472 , B29C66/53262 , B29C66/723 , B29C66/73143 , B29C66/81457 , B29C66/8322 , B65D75/30 , B29C65/522 , B29C65/525 , B29C65/526 , B29C65/528 , B29C66/24 , B29C66/71 , B29C66/73774 , B29C66/7392 , B29C66/73921 , B29C66/73941 , B29C66/81871 , B29K2027/06 , B29L2031/7148 , Y10T156/1089 , Y10T29/49803 , Y10T428/1341 , Y10T428/1352 , Y10T428/31551 , Y10T428/31573 , Y10T428/31576 , Y10T428/31587 , Y10T428/31736 , Y10T428/31743 , Y10T428/31797 , Y10T428/3192
摘要： The coating of a RF active material on a non-RF active substrate material of typical thickness for packaging purposes, can generate sufficient thermal energy to effect strong bonding of the substrate materials. The RF active material may be-deposited on less than the entire inner surface area of the substrate material, preferably, at or near the portion of the substrate surface which represents the heat seal interface. In this manner of application, additional coating or printing of other substances on the substrate surface can be achieved without hampering the heat sealing process. Flexible medical containers capable of containing a product which is maintained and removed under sterile conditions, can be constructed on commercial production machines from these coated non-RF active substrate materials.
摘要翻译：在用于包装目的的典型厚度的非RF有源衬底材料上的RF活性材料的涂层可以产生足够的热能来实现衬底材料的强烈结合。 RF活性材料可以沉积在基底材料的整个内表面区域上，优选地沉积在表示热封界面的基底表面的部分处或附近。以这种施加方式，可以在不影响热封过程的情况下实现在基板表面上的其它物质的附加涂覆或印刷。能够容纳在无菌条件下保持和去除的产品的灵活的医疗容器可以在这些涂覆的非RF活性基底材料的商业生产机器上构建。

10. 发明授权

US06306454B1 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06306454B1
公开(公告)日：2001-10-23
申请号：US09388913
申请日：1999-09-01
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunahan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunahan
IPC分类号： A61L5103
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

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