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1. 发明申请

US20080274155A1 Chimeric Cannulae Proteins, Nucleic Acids Encoding Them And Methods For Making And Using Them 审中-公开
标题翻译：嵌合插管蛋白，编码它们的核酸和制造和使用它们的方法
公开(公告)号：US20080274155A1
公开(公告)日：2008-11-06
申请号：US10593846
申请日：2005-03-24
申请人： Nelson R. Barton , Eileen O'Donoghue , Ryan Short , Gerhard Frey , David Weiner , Dan E. Robertson , Steven Briggs , Paul Zorner
发明人： Nelson R. Barton , Eileen O'Donoghue , Ryan Short , Gerhard Frey , David Weiner , Dan E. Robertson , Steven Briggs , Paul Zorner
IPC分类号： A61F2/00 , C07K14/195 , C12N9/00 , C12N9/40 , C12N9/10 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/19 , C12N1/15 , A01K67/027 , A01H5/00 , C12P1/00 , A61K38/16 , A01K1/015 , B32B9/04 , A61K39/00 , A61K39/395 , A61K31/70 , C12N5/06 , A61K35/12
CPC分类号： C07K14/195 , C07K2319/00 , Y10T428/249921
摘要： The invention provides chimeric cannulae polypeptides and nanotubules and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one aspect, the invention provides compositions and methods for making and using nanotubules. In one aspect, the invention provides compositions and methods for the selection and purification of chiral compositions from racemic mixtures. In one aspect, the chimeric proteins and polymers (e.g., nanotubules, tubules, bundles, balls, fibers, filaments, sheets, threads, textiles) of the invention comprise a detectable moiety, e.g., a fluorescent protein. In one aspect, the invention provides a flame retardant or heat resistant device comprising a sheeting, a covering, a coating or an adhesive comprising a chimeric protein of the invention.
摘要翻译：本发明提供了嵌合插管多肽和纳米管，以及制备和使用它们的方法。一方面，本发明提供用于鉴定，分离或合成蛋白质或配体的组合物和方法。一方面，本发明提供了制备和使用纳米管的组合物和方法。一方面，本发明提供了用于从外消旋混合物中选择和纯化手性组合物的组合物和方法。在一个方面，本发明的嵌合蛋白质和聚合物（例如纳米管，小管，束，球，纤维，丝，片，丝，纺织品）包含可检测部分，例如荧光蛋白。一方面，本发明提供一种阻燃或耐热装置，其包含片剂，覆盖物，包衣或包含本发明的嵌合蛋白质的粘合剂。

2. 发明授权

US07432097B2 Phytases, nucleic acids encoding them and methods of making and using them 有权
标题翻译：植酸酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US07432097B2
公开(公告)日：2008-10-07
申请号：US10933115
申请日：2004-09-01
申请人： Jay M. Short , Keith A. Kretz , Kevin A. Gray , Nelson Robert Barton , James B. Garrett , Eileen O'Donoghue , William Baum , Dan E. Robertson , Paul Zorner
发明人： Jay M. Short , Keith A. Kretz , Kevin A. Gray , Nelson Robert Barton , James B. Garrett , Eileen O'Donoghue , William Baum , Dan E. Robertson , Paul Zorner
IPC分类号： C12N11/00 , C12N9/16 , A61K38/46 , C07K14/00 , C12N15/00 , C12N1/21 , C12N5/10 , C12P21/00 , C12Q1/44 , C07H21/00
CPC分类号： C12N9/16 , A01K2217/05 , A21D8/042 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K33/00 , A61K36/00 , A61K38/00 , A61K45/06 , C12Y301/03008 , C12Y301/03026 , Y02P60/877 , A23V2300/21
摘要： In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
摘要翻译：一方面，本发明提供了来自大肠杆菌K12 appA植酸酶的纯化和修饰的植酸酶。与野生型酶相比，该酶具有植酸酶活性和改善的耐热性。此外，该酶在低pH下具有改善的蛋白酶稳定性。修饰的植酸酶的糖基化提供了具有改善的热耐受性和蛋白酶稳定性的进一步改进的酶。该酶可以由天然或重组宿主细胞产生，并且可以用于有助于在需要时消化植酸盐。一方面，本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。

3. 发明申请

US20050281792A1 Phytases, nucleic acids encoding them and methods of making and using them 有权
标题翻译：植酸酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US20050281792A1
公开(公告)日：2005-12-22
申请号：US10933115
申请日：2004-09-01
申请人： Jay Short , Keith Kretz , Kevin Gray , Nelson Barton , James Garrett , Eileen O'Donoghue , William Baum , Dan Robertson , Paul Zorner
发明人： Jay Short , Keith Kretz , Kevin Gray , Nelson Barton , James Garrett , Eileen O'Donoghue , William Baum , Dan Robertson , Paul Zorner
IPC分类号： A21D8/04 , A23J3/14 , A23K1/14 , A23K1/165 , A23L1/015 , A23L1/03 , A23L1/105 , A23L1/211 , A61K38/00 , C12N1/21 , C12N9/16 , A61K45/00 , A61K38/46
CPC分类号： C12N9/16 , A01K2217/05 , A21D8/042 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K33/00 , A61K36/00 , A61K38/00 , A61K45/06 , C12Y301/03008 , C12Y301/03026 , Y02P60/877 , A23V2300/21
摘要： In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
摘要翻译：一方面，本发明提供了来自大肠杆菌K12 appA植酸酶的纯化和修饰的植酸酶。与野生型酶相比，该酶具有植酸酶活性和改善的耐热性。此外，该酶在低pH下具有改善的蛋白酶稳定性。修饰的植酸酶的糖基化提供了具有改善的热耐受性和蛋白酶稳定性的进一步改进的酶。该酶可以由天然或重组宿主细胞产生，并且可以用于有助于在需要时消化植酸盐。一方面，本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。

4. 发明授权

US4340542A Process and equipment for the continuous manufacture of trioxan 失效
标题翻译：连续生产三恶烷的工艺和设备
公开(公告)号：US4340542A
公开(公告)日：1982-07-20
申请号：US201751
申请日：1980-10-29
申请人： Helmut Bar , Herbert Mader , Karl-Friedrich Muck , Paul Zorner
发明人： Helmut Bar , Herbert Mader , Karl-Friedrich Muck , Paul Zorner
IPC分类号： B01J14/00 , B01J19/24 , C07D323/06
CPC分类号： C07D323/06 , B01J14/00 , B01J19/2435
摘要： The invention relates to a process for the continuous manufacture of trioxan, if appropriate together with cyclic formals, from aqueous formaldehyde solutions in a circulation reactor with an evaporator, wherein the vapor/liquid mixture, before it enters the reactor, is separated into the vapor phase and the liquid phase, and subsequently the two phases are fed separately to the reactor. In particular, high space-time yields can be achieved by the process according to the invention. Moreover, equipment for carrying out this process is a subject of the invention.
摘要翻译：本发明涉及一种在具有蒸发器的循环反应器中连续制备三恶烷（如果合适的话）与循环形式的甲醛水溶液的连续制备方法，其中蒸气/液体混合物在其进入反应器之前被分离成蒸气相和液相，随后两相分别进料到反应器中。特别地，通过根据本发明的方法可以实现高的时空产率。此外，用于执行该过程的设备是本发明的主题。

5. 发明申请

US20050227321A1 Low-cost production of peptides 有权
标题翻译：低成本生产肽
公开(公告)号：US20050227321A1
公开(公告)日：2005-10-13
申请号：US10971444
申请日：2004-10-22
申请人： Joseph Krebs , Paul Zorner , Ian Tomlinson
发明人： Joseph Krebs , Paul Zorner , Ian Tomlinson
IPC分类号： C07H21/04 , C07K5/06 , C07K14/47 , C12N1/21 , C12N9/48 , C12N15/74 , C12P21/04 , C12P21/06
CPC分类号： C07K14/4723 , C07K2319/35 , C07K2319/50
摘要： The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the peptide/AMP as compared to those heretofore known in the art. The subject methods also surprisingly enable the use of Pseudomonas fluorescens to produce AMPs and other peptides. There are several components of the subject invention, which can be used alone or in combination. The subject invention provides for the production of peptides/AMPs in concatemeric precursors. The subject invention also provides novel methods of assembling monomers into multimers, and of cleaving the multimers to yield active monomers. The subject invention also relates to the use of these multimers fused to carrier peptides to produce fusion proteins. Preferably, both the multimers and the fusion proteins (multimers with the carrier polypeptides) lack charge balancing. It has been surprisingly determined that it is not necessary to offset the positive charges of multiple copies of AMPs in multimeric constructs. Thus, the subject invention enables the use of a wider range of multimers and carrier peptides.
摘要翻译：本发明涉及通过使用微生物生产肽（包括抗微生物肽（AMP））的低成本方法。与本领域已知的方法相比，本发明方法能够大大提高肽/ AMP的产率。本发明的方法也令人惊奇地使得能够使用荧光假单胞菌来产生AMP和其他肽。本发明的几个组分可单独使用或组合使用。本发明提供了在并联前体中生产肽/ AMP。本发明还提供了将单体组装成多聚体的新方法，以及裂解多聚体以产生活性单体。本发明还涉及这些与载体肽融合的多聚体产生融合蛋白的用途。优选地，多聚体和融合蛋白（携带多肽的多聚体）都缺乏电荷平衡。已经令人惊讶地确定，不需要在多聚体构建体中抵消多个拷贝的AMP的正电荷。因此，本发明使得能够使用更宽范围的多聚体和载体肽。

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