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    • 8. 发明专利
    • Biomarker for predicting disturbance of circadian rhythm
    • 用于预测CIRCADIAN RHYTHM的干扰的生物标记
    • JP2013255481A
    • 2013-12-26
    • JP2012144660
    • 2012-06-27
    • National Institute Of Advanced Industrial Science & Technology独立行政法人産業技術総合研究所
    • OISHI KATSUTAKAMIYAZAKI REKIITO NANAKOYAMAMOTO YUKIORI
    • C12Q1/68C12N15/09G01N33/15G01N33/50G01N33/53G01N33/68
    • PROBLEM TO BE SOLVED: To provide a method for predicting a circadian rhythm sleep disorder or circadian rhythm disturbance, particularly a marker for accurately and easily diagnosing the circadian rhythm sleep disorder.SOLUTION: A marker for diagnosing a circadian rhythm sleep disorder includes HSPA1a protein or an HSPA1a gene. Specifically, a method is provided for diagnosing the circadian rhythm sleep disorder or circadian rhythm disturbance by measuring the increase amount of the expression amount of the HSPA1a or its gene in a subject's blood, and a method is provided for screening a substance for improving the circadian rhythm sleep disorder or circadian rhythm disturbance by measuring the increase control amount of the expression amount of the HSPA1a or its gene in the blood of a circadian rhythm sleep disorder model mouse or a stress sleep disorder mouse dosed with a test substance.
    • 要解决的问题:提供一种用于预测昼夜节律睡眠障碍或昼夜节律紊乱的方法,特别是用于准确和容易地诊断昼夜节律睡眠障碍的标记。解决方案:用于诊断昼夜节律睡眠障碍的标记包括HSPA1a蛋白或 HSPA1a基因。 具体而言,提供了通过测量受试者血液中HSPA1a或其基因的表达量的增加量来诊断昼夜节律睡眠障碍或昼夜节律紊乱的方法,并且提供了用于筛选用于改善昼夜节律的物质的方法 通过测量伴随测试物质的昼夜节律睡眠障碍模型小鼠或应激性睡眠障碍小鼠血液中HSPA1a或其基因的表达量的增加控制量,来调节节律性睡眠障碍或昼夜节律紊乱。