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1. 发明专利

JP2014005225A Agent for suppressing appetite improvement and body weight gain 有权
标题翻译：用于抑制可见改善和体重增重的代理
公开(公告)号：JP2014005225A
公开(公告)日：2014-01-16
申请号：JP2012141283
申请日：2012-06-22
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , Sapporo Breweries Ltd , サッポロビール株式会社 , Sapporo Holdings Ltd , サッポロホールディングス株式会社
发明人： OISHI KATSUTAKA , YAMAMOTO YUKIORI , ITO NANAKO , MIYAZAKI REKI , NAKAKITA YASUICHI , KANEDA HIROTAKA
IPC分类号： A61K35/74 , A23L1/30 , A61P1/14 , A61P3/04
摘要： PROBLEM TO BE SOLVED: To provide a novel use of a Lactobacillus brevis SBC8803 strain.SOLUTION: The agent for suppressing appetite improvement and body weight gain contains a bacterial cell or a processed bacterial cell of a SBC8803 (accession number: FERM BP-10632) strain belonging to Lactobacillus brevis.
摘要翻译：要解决的问题：提供短乳杆菌SBC8803菌株的新用途。解决方案：用于抑制食欲改善和体重增加的药物含有SBC8803的细菌细胞或加工细菌细胞（登录号：FERM BP-10632）属于短乳杆菌的菌株。

2. 发明专利

JP2015000851A 体温上昇剤审中-公开
标题翻译：身体温度升高剂
公开(公告)号：JP2015000851A
公开(公告)日：2015-01-05
申请号：JP2013124849
申请日：2013-06-13
申请人：独立行政法人産業技術総合研究所 , National Institute Of Advanced Industrial & Technology , サッポロビール株式会社 , Sapporo Breweries Ltd , サッポロホールディングス株式会社 , Sapporo Holdings Ltd
发明人： OISHI KATSUTAKA , YAMAMOTO YUKIORI , ITO NANAKO , MIYAZAKI REKI , NAKAKITA YASUICHI , KANEDA HIROTAKA
IPC分类号： A61K35/74 , A23L1/30 , A61P3/00
CPC分类号： A61K35/747 , A23K10/18 , A23K50/50 , A23L33/135
摘要：【課題】適度な体温上昇効果を有する新規の体温上昇剤を提供すること。【解決手段】ラクトバチラス・ブレビス(Lactobacillus brevis)に属するSBC8803(受託番号:FERM BP−10632)菌株の菌体又はその処理物を有効成分として含有する体温上昇剤。【選択図】なし
摘要翻译：要解决的问题：提供具有适当体温升高效果的新型体温升高剂。解决方案：本发明提供一种体温升高剂，其包含作为活性成分的菌株SBC8803（保藏号：FERM BP-10632）或其处理产物。

3. 发明专利

JP2014033661A Small animal breeding device 有权
标题翻译：小动物育种装置
公开(公告)号：JP2014033661A
公开(公告)日：2014-02-24
申请号：JP2012178079
申请日：2012-08-10
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , Melquest:Kk , 有限会社メルクエスト
发明人： MIYAZAKI REKI , OISHI KATSUTAKA , YAMAMOTO TOSHIYUKI
IPC分类号： A01K1/03 , A01K1/035
摘要： PROBLEM TO BE SOLVED: To provide a small animal breeding device capable of creating a model animal suitable for research related to a chronic stressful sleep disorder.SOLUTION: A small animal breeding device includes a running wheel 14 having: a turning wheel 22 having one end face closed by a closing plate 24; and a support member journaling the turning wheel 22 sideways. The turning wheel 22 turns by walking of a small animal inside the turning wheel 22 on a peripheral face 28. The small animal breeding device includes a cage 16 that is a housing set with the running wheel 14 thereinside and has a closing face 34 closing the other end part of the turning wheel 22. A feed window 40 and a water window 42 through which the small animal cannot pass are opened in the closing face 34. The small animal breeding device includes a feeder 18 having a feed storage part 50 and a feeding port 52. The small animal breeding device includes a waterer 20 having a water storage part 58 and a nozzle 60. The small animal inserts the head into the feeding port 52 through the feed window 40 to eat feed, and can ingest water from the nozzle 60 through the water window 42.
摘要翻译：要解决的问题：提供能够创建适合于与慢性压力性睡眠障碍相关的研究的模型动物的小型动物育种装置。解决方案：小型动物育种装置包括行进轮14，其具有：具有一端的转向轮22 由封闭板24封闭的面; 以及将转向轮22侧向对准的支撑部件。转动轮22通过在转动轮22内的周边面28上的小动物的行走而转动。小型动物饲养装置包括保持架16，该保持架16是具有行走轮14的壳体，其具有封闭面34 转动轮22的另一端部。小动物饲养装置包括具有饲料储存部分50和饲料储存部分50的进料器18，小动物不能通过的进料口40和水窗42。小动物饲养装置包括具有储水部分58和喷嘴60的饮水器20.小动物通过进料窗40将头部进入进料口52以进食，并且可以从喷嘴60通过水窗42。

4. 发明专利

JP2014139166A Improvement agent for abnormal glucose tolerance 有权
标题翻译：异丙醇耐量改良剂
公开(公告)号：JP2014139166A
公开(公告)日：2014-07-31
申请号：JP2013261692
申请日：2013-12-18
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , Nisshin Seifun Group Inc , 株式会社日清製粉グループ本社 , Oriental Yeast Co Ltd , オリエンタル酵母工業株式会社
发明人： OISHI KATSUTAKA , ITO NANAKO , YAMAMOTO YUKIORI , FUKUTOME SHINICHI , KIKUCHI YOSUKE , OKITA KIMIKO
IPC分类号： A61K36/899 , A23K1/16 , A23L1/30 , A61K31/05 , A61P3/10
摘要： PROBLEM TO BE SOLVED: To provide an improvement agent for abnormal glucose tolerance capable of effectively preventing and treating abnormal glucose tolerance of humans or animals which develop diabetes or are incipient diabetics.SOLUTION: The improvement agent for abnormal glucose tolerance comprises a peak component of partition chromatography of an alcohol extract from a gramineous plant seed as an active ingredient. The peak component preferably comprises a mixture of a plurality of kinds of alkylresorcinol (AR). The mixture comprises AR in which Rin general formula (I) is a saturated or unsaturated alkyl group having 15C, AR in which Ris a saturated or unsaturated alkyl group having 17C, AR in which Ris a saturated or unsaturated alkyl group having 19C, AR in which Ris a saturated or unsaturated alkyl group having 21C, AR in which Ris a saturated or unsaturated alkyl group having 23C, and AR in which Ris a saturated or unsaturated alkyl group having 25C, by a specified amount.
摘要翻译：要解决的问题：提供能够有效预防和治疗发生糖尿病或初期糖尿病的人或动物异常葡萄糖耐量异常的葡萄糖耐量改善剂。解决方案：葡萄糖耐量异常的改善剂包括分配的峰分量从禾本科植物种子的醇提取物的色谱法作为活性成分。峰组分优选包含多种烷基间苯二酚（AR）的混合物。该混合物包含其中Rin通式（I）是具有15C的饱和或不饱和烷基的AR，其中R是具有17C的饱和或不饱和烷基的AR，其中R是具有19C的饱和或不饱和烷基，AR在其中R是具有21C的饱和或不饱和烷基，其中R是具有23℃的饱和或不饱和烷基的AR，其中R是具有25℃的饱和或不饱和烷基的AR，具有规定量。

5. 发明专利

JP2003070376A Animal having diurnal rhythm exhibiting night type 有权
标题翻译：动物DIY RHYTHM展览夜类型
公开(公告)号：JP2003070376A
公开(公告)日：2003-03-11
申请号：JP2001270451
申请日：2001-09-06
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： ISHIDA MARIO , OISHI KATSUTAKA , MORITA YUSUKE , SEI HIROYOSHI
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a model animal useful for elucidating a mechanism of sleep-wake abnormality in human.
SOLUTION: The animal in which diurnal rhythm exhibits night type and clock gene has variation, a fertilized egg obtained by crossing animals, a method for preparing the mouse in which diurnal rhythm exhibits night type, characterized by backcrossing a mouse in which clock gene has variation and which has genetic background other than Jcl:ICR line with a mouse having a genetic background of Jcl:ICR line and a method for screening a compound having an influence on stability of a Clock protein or a Clock mRNA isolated from the animal of the present invention by using the Clock protein or the Clock mRNA are provided.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种用于阐明人类睡眠 - 苏醒异常机制的模型动物。解决方案：昼夜节律表现为夜型和时钟基因的动物具有变异性，通过交叉动物获得的受精卵，制备昼夜节律显示夜型的小鼠的方法，其特征在于回交时钟基因具有变异性的小鼠具有Jcl：ICR系的遗传背景的小鼠的JCL：ICR系以及从本发明的动物分离的Clock蛋白或Clock mRNA的稳定性有影响的化合物的方法。提供了使用Clock蛋白或Clock mRNA的发明。

6. 发明专利

JP2015004688A 生体リズムの制御剤有权
标题翻译：生物RHYTHM控制剂
公开(公告)号：JP2015004688A
公开(公告)日：2015-01-08
申请号：JP2014194023
申请日：2014-09-24
申请人：独立行政法人産業技術総合研究所 , National Institute Of Advanced Industrial & Technology
发明人： ONISHI YOSHIAKI , YAMAZAKI YUKINAE , KONO YASUHIRO , OISHI KATSUTAKA
IPC分类号： G01N33/50 , G01N33/15 , G01N33/68
摘要：【課題】本発明は、概日リズム周期を調節することで概日リズム障害を治療する方法、及びそのための概日リズム周期改善剤を提供することにある。【解決手段】本発明においては、ハルミンなどのハルマラアルカロイド、又はその薬理学的に許容しうる塩を有効成分として含む、概日リズム周期改善剤を提供する。【選択図】なし
摘要翻译：要解决的问题：提供一种通过调节昼夜节律循环来治疗昼夜节律紊乱的方法及其昼夜节律循环改善剂。解决方案：昼夜节律循环改善剂包括危害生物碱如胡麻或药理学上可接受的盐与有效成分相同。

7. 发明专利

JP2014085214A Biomarker for predicting circadian rhythm disturbance 有权
标题翻译：用于预测CIRCADIAN RHYTHM干扰的生物标记
公开(公告)号：JP2014085214A
公开(公告)日：2014-05-12
申请号：JP2012234036
申请日：2012-10-23
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： NEMOTO NAO , OISHI KATSUTAKA , MIYAZAKI REKI , NAGAI YUKA
IPC分类号： G01N33/68 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting a sleep disorder or circadian rhythm disturbance, and a marker for accurately and simply diagnosing a circadian rhythm sleep disorder and performing risk evaluation.SOLUTION: There are provided a method for measuring and evaluating a sleep disorder caused by stress, and a marker used therefor.
摘要翻译：要解决的问题：提供一种预测睡眠障碍或昼夜节律紊乱的方法，以及用于准确和简单地诊断昼夜节律睡眠障碍并执行风险评估的标记。解决方案：提供了一种用于测量和评估睡眠的方法由应激引起的障碍，以及用于其的标记物。

8. 发明专利

JP2013200138A Biomarker for monitoring behavior rhythm 有权
标题翻译：生物标记用于监测行为RHYTHM
公开(公告)号：JP2013200138A
公开(公告)日：2013-10-03
申请号：JP2012067165
申请日：2012-03-23
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： MIYAZAKI REKI , OISHI KATSUTAKA , ITO NANAKO , YOSHIDA KOICHI , SHICHIRI MOTOTADA
IPC分类号： G01N33/92 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a biomarker capable of stably and highly accurately detecting oxidative stress circadian rhythm in a living body, and to provide a method for learning a body time of feeding rhythm that is not interlocked with manifestation of biological clock gene.SOLUTION: Hydroxyoctadecadienoic acids (HODE) in the blood, or 7-hydroxycholesterols (7-OHCh) as well as the HODEs are defines as biomarkers. A method includes: measuring them a plurality of times with age; and observing time-series changes in the measurement values. Thereby, circadian changes in the behavior rhythm such as feeding rhythm can be monitored, and an effective administration time of an oxidative stress-relieving material can be determined.
摘要翻译：要解决的问题：提供能够稳定且高精度地检测生物体中的氧化应激昼夜节律的生物标志物，并且提供一种用于学习与生物钟基因表达不互锁的喂养节奏的身体时间的方法。解决方案：血液中的羟基十八碳二烯酸（HODE）或7-羟基胆固醇（7-OHCh）以及HODE被定义为生物标志物。一种方法包括：随年龄测量多次; 并观察测量值的时间序列变化。因此，可以监测行为节律如进食节律的昼夜变化，并且可以确定氧化应激消除材料的有效施用时间。

9. 发明专利

JP2008247829A Therapeutic agent for rhythm trouble containing ligand of intranuclear receptor 有权
标题翻译：含有内含子受体配体的RHYTHM故障治疗剂
公开(公告)号：JP2008247829A
公开(公告)日：2008-10-16
申请号：JP2007091882
申请日：2007-03-30
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： OISHI KATSUTAKA , SHIRAI HIDENORI , KUDO TAKASHI , SHIBATA SHIGENOBU , ISHIDA MARIO
IPC分类号： A61K31/216 , A61K39/395 , A61P25/20 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a biological clock control agent and a therapeutic or prophylactic agent of the disorder resulting from a trouble of a circadian rhythm.
SOLUTION: The biological clock control agent comprises a ligand of a PPAR (peroxisome proliferator-activated receptor) as an active ingredient.
COPYRIGHT: (C)2009,JPO&INPIT

10. 发明专利

JP2007007135A Transfusion management system using biological clock 有权
标题翻译：使用生物钟的传输管理系统
公开(公告)号：JP2007007135A
公开(公告)日：2007-01-18
申请号：JP2005191337
申请日：2005-06-30
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所
发明人： ISHIDA MARIO , MIYAZAKI REKI , OISHI KATSUTAKA , IWANAGA KEIJI , YANO MASAHIKO , KADOTA MORIHITO
IPC分类号： A61M5/00 , A61G12/00
摘要： PROBLEM TO BE SOLVED: To provide an infusion means which never makes biological clock rhythm out of order. SOLUTION: A transfusion management system using a biological clock comprises: at least four storage containers for housing different transfusion components consisting of an amino acid solution, a sugar solution, a vitamin solution and an inorganic salt solution; an infusion controller; and a pipe for liquid supply. The infusion controller comprises a control means for setting the dropping speeds and dropping time zones of the solutions and controlling a feeding liquid according to the setting; a display means for monitoring the supplying states of the respective solutions; a stoppage means for automatically stopping liquid supply in occurrence of abnormality; four or more entrance means for making the solutions flow in; and one or more exit means for making the solutions flow out. The pipe for liquid supply comprises: pipes for connecting each of the containers and the entrance means of each solution of the infusion controller; and pipes for guiding each solution inside of the infusion controller to the exit means. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供从不使生物钟节奏失调的输液装置。解决方案：使用生物钟的输血管理系统包括：用于容纳由氨基酸溶液，糖溶液，维生素溶液和无机盐溶液组成的不同输液成分的至少四个储存容器; 输液控制器和液体供应管。输液控制器包括用于设定溶液的滴下速度和滴加时间的控制装置，并根据设定控制进料液体; 用于监视各个解决方案的供应状态的显示装置; 用于在异常发生时自动停止液体供给的停止装置; 用于使溶液流入的四个或更多入口装置; 以及用于使溶液流出的一个或多个出口装置。用于液体供应的管道包括：用于连接每个容器的管道和输液控制器的每个溶液的入口装置; 以及用于将输注控制器内部的每个溶液引导到出口装置的管道。版权所有（C）2007，JPO＆INPIT

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