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1. 发明专利

JP2013256486A Circadian rhythm regulator 有权
标题翻译： CIRCADIAN RHYTHM调节器
公开(公告)号：JP2013256486A
公开(公告)日：2013-12-26
申请号：JP2012241533
申请日：2012-11-01
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所 , Nisshin Seifun Group Inc , 株式会社日清製粉グループ本社 , Oriental Yeast Co Ltd , オリエンタル酵母工業株式会社
发明人： OISHI KATSUTAKA , MIYAZAKI REKI , ONISHI YOSHIAKI , TOMITA TATSUNOSUKE , ITO NANAKO , FUKUTOME SHINICHI , TANAKA KEIKO , KIKUCHI YOSUKE , KASUYA KENJI
IPC分类号： A61K31/05 , A61K36/18 , A61K36/899 , A61P25/02 , A61P25/20
CPC分类号： A61K31/05 , A61K36/185 , A61K2236/33 , C07C39/08
摘要： PROBLEM TO BE SOLVED: To provide a food-derived circadian rhythm regulator which is secure and safe even when it is taken for a long time.SOLUTION: A circadian rhythm regulator containing an alkylresorcinol represented by formula (I) as an effective component and a circadian rhythm regulator that contains, as an effective component, an alkylresorcinol-containing extract extracted from cereal or nuts containing the alkylresorcinol represented by formula (I) are provided. In formula (I), Ris a saturated or unsaturated alkyl group and R2 is a hydrogen atom or a methyl group. Further, in formula (I), Rand Rare preferably bonded in a para position and Ris preferably a 15-27C saturated or unsaturated alkyl group.
摘要翻译：要解决的问题：提供即使长时间服用也是安全和安全的食源性昼夜节律调节剂。解决方案：含有由式（I）表示的烷基间苯二酚作为有效成分的昼夜节律调节剂和提供了含有由含有由式（I）表示的烷基间苯二酚的谷物或坚果提取的含烷基间苯二酚的提取物作为有效成分的昼夜节律调节剂。在式（I）中，R是饱和或不饱和的烷基，R 2是氢原子或甲基。此外，在式（I）中，兰德Rare优选键合在对位，R 1优选为15-27℃饱和或不饱和烷基。

2. 发明专利

JP2013099360A Control agent for biological rhythm 有权
标题翻译：生物RHYTHM控制剂
公开(公告)号：JP2013099360A
公开(公告)日：2013-05-23
申请号：JP2013029057
申请日：2013-02-18
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所
发明人： OISHI KATSUTAKA , ONISHI YOSHIAKI
IPC分类号： C12Q1/02 , A61K31/404 , A61K45/00 , A61P25/20 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for treating a circadian rhythm disorder by adjusting a circadian rhythm cycle, a fundamental therapy for a disease caused by the circadian rhythm disorder, and an established cell line suitable for screening substance that can adjust the circadian rhythm cycle.SOLUTION: An agent for improving circadian rhythm disorder, or a medical composition for preventing and treating a disease caused by the circadian rhythm disorder, contains a substance acting as an activating agent or an inhibitor of protein kinase C. A kit for screening the substance that can adjust the circadian rhythm cycle includes established recombinant NIH3T3 cells that stably hold a luciferase gene transfer-adjusted by a Bmal1 promoter.
摘要翻译：要解决的问题：提供一种通过调节昼夜节律循环来治疗昼夜节律紊乱的方法，由昼夜节律紊乱引起的疾病的基础治疗，以及适用于筛选能够调节的物质的已建立的细胞系昼夜节律循环。解决方案：用于改善昼夜节律紊乱的药剂或用于预防和治疗由昼夜节律紊乱引起的疾病的医药组合物含有作为活化剂或蛋白激酶C抑制剂的物质。用于筛选的试剂盒可以调节昼夜节律循环的物质包括稳定保持通过Bmal1启动子调节的荧光素酶基因的已建立的重组NIH3T3细胞。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2011026270A Regulating agent of biological rhythm 有权
标题翻译：生物RHYTHM的调节剂
公开(公告)号：JP2011026270A
公开(公告)日：2011-02-10
申请号：JP2009175576
申请日：2009-07-28
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所
发明人： OISHI KATSUTAKA , ONISHI YOSHIAKI
IPC分类号： A61K45/00 , A61P25/20 , A61P25/24 , A61P43/00 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for treating circadian rhythm disorders by regulating circadian rhythm periods, and a fundamental treating method of diseases caused by the circadian rhythm disorders, and also an established cell line suitable for the screening of a substance capable of regulating such the circadian rhythm periods.
SOLUTION: This circadian rhythm disorder-improving agent or the preventing or treating agent of the diseases caused by the circadian rhythm disorders is characterized by containing a substance acting as an activating agent or inhibitor of protein kinase C. The kit for screening the substance capable of regulating the circadian rhythm periods is provided by containing an established recombinant NIH3T3 cell stably holding luciferase gene transcribed and controlled by Bmal1 promotor.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过调节昼夜节律周期来治疗昼夜节律紊乱的方法，以及由昼夜节律紊乱引起的疾病的基本治疗方法，以及适用于筛选物质的已建立的细胞系能够调节这种昼夜节律周期。解决方案：昼夜节律障碍改善剂或由昼夜节律紊乱引起的疾病的预防或治疗剂的特征在于含有作为蛋白激酶C的活化剂或抑制剂的物质。用于筛选能够调节昼夜节律周期的物质通过含有稳定保持由Bmal1启动子转录和控制的荧光素酶基因的建立的重组NIH3T3细胞来提供。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2013255481A Biomarker for predicting disturbance of circadian rhythm 有权
标题翻译：用于预测CIRCADIAN RHYTHM的干扰的生物标记
公开(公告)号：JP2013255481A
公开(公告)日：2013-12-26
申请号：JP2012144660
申请日：2012-06-27
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所
发明人： OISHI KATSUTAKA , MIYAZAKI REKI , ITO NANAKO , YAMAMOTO YUKIORI
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting a circadian rhythm sleep disorder or circadian rhythm disturbance, particularly a marker for accurately and easily diagnosing the circadian rhythm sleep disorder.SOLUTION: A marker for diagnosing a circadian rhythm sleep disorder includes HSPA1a protein or an HSPA1a gene. Specifically, a method is provided for diagnosing the circadian rhythm sleep disorder or circadian rhythm disturbance by measuring the increase amount of the expression amount of the HSPA1a or its gene in a subject's blood, and a method is provided for screening a substance for improving the circadian rhythm sleep disorder or circadian rhythm disturbance by measuring the increase control amount of the expression amount of the HSPA1a or its gene in the blood of a circadian rhythm sleep disorder model mouse or a stress sleep disorder mouse dosed with a test substance.
摘要翻译：要解决的问题：提供一种用于预测昼夜节律睡眠障碍或昼夜节律紊乱的方法，特别是用于准确和容易地诊断昼夜节律睡眠障碍的标记。解决方案：用于诊断昼夜节律睡眠障碍的标记包括HSPA1a蛋白或 HSPA1a基因。具体而言，提供了通过测量受试者血液中HSPA1a或其基因的表达量的增加量来诊断昼夜节律睡眠障碍或昼夜节律紊乱的方法，并且提供了用于筛选用于改善昼夜节律的物质的方法通过测量伴随测试物质的昼夜节律睡眠障碍模型小鼠或应激性睡眠障碍小鼠血液中HSPA1a或其基因的表达量的增加控制量，来调节节律性睡眠障碍或昼夜节律紊乱。

5. 发明专利

JP2013181005A Circadian rhythm improving medicine 有权
标题翻译： CIRCADIAN RHYTHM改进药物
公开(公告)号：JP2013181005A
公开(公告)日：2013-09-12
申请号：JP2012046806
申请日：2012-03-02
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所 , Sapporo Breweries Ltd , サッポロビール株式会社 , Sapporo Holdings Ltd , サッポロホールディングス株式会社
发明人： OISHI KATSUTAKA , MIYAZAKI REKI , ITO NANAKO , YAMAMOTO YUKIORI , NAKAKITA YASUICHI , KANEDA HIROTAKA
IPC分类号： A61K35/74 , A23L1/30 , A23L2/52 , A61P25/00 , A61P25/20
CPC分类号： A61K35/74 , A23L2/382 , A23L2/52 , A23L33/135 , A23V2002/00 , A23Y2220/13 , A61K35/744
摘要： PROBLEM TO BE SOLVED: To provide a new circadian rhythm improving medicine.SOLUTION: Provided is a circadian rhythm improving medicine containing the bacterial cell of lactobacillus or processed product thereof as an active constituent.
摘要翻译：要解决的问题：提供新的昼夜节律改善药物。解决方案：提供一种含有乳酸杆菌的细菌细胞或其加工产物作为活性成分的昼夜节律改善药物。

6. 发明专利

JP2011195560A Biological rhythm controlling agent 有权
标题翻译：生物RHYTHM控制剂
公开(公告)号：JP2011195560A
公开(公告)日：2011-10-06
申请号：JP2010241712
申请日：2010-10-28
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所
发明人： ONISHI YOSHIAKI , YAMAZAKI YUKINAE , KONO YASUHIRO , OISHI KATSUTAKA
IPC分类号： A61K31/437 , A61P25/20
摘要： PROBLEM TO BE SOLVED: To provide a method for the treatment of circadian dysrhythmia by modifying the circadian rhythm cycle and a circadian rhythm improving agent for the treatment.SOLUTION: The circadian rhythm improving agent includes a harmala alkaloid such as harmine or a pharmacologically acceptable salt of the same as an effective ingredient.
摘要翻译：要解决的问题：提供一种通过改变昼夜节律循环和昼夜节律改善剂治疗昼夜节律性心律失常的方法。解决方案：昼夜节律改善剂包括一种危害生物碱，例如毒素或药理学上可接受的盐与有效成分相同。

7. 发明专利

JP2011037755A Regulator of biological rhythm 有权
标题翻译：生物RHYTHM的调节器
公开(公告)号：JP2011037755A
公开(公告)日：2011-02-24
申请号：JP2009186257
申请日：2009-08-11
申请人： National Institute Of Advanced Industrial Science & Technology , 独立行政法人産業技術総合研究所
发明人： ONISHI YOSHIAKI , OISHI KATSUTAKA , MARUYAMA SUSUMU , YAMAZAKI YUKINAE , KONO YASUHIRO
IPC分类号： A61K31/4355 , A61K31/437 , C07D491/056 , C07D491/16 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for treating circadian rhythm failure by regulating circadian rhythm cycle, and to provide a fundamental therapeutic method of a disease caused by the circadian rhythm failure. SOLUTION: The circadian rhythm failure-ameliorating agent contains lycorins or lycoricidinols of alkaloids of Amaryllidaceae family, or a pharmacologically acceptable salts thereof as an active ingredient. The medicinal composition for the prevention or therapy of the disease caused by the circadian rhythm failure is also provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供通过调节昼夜节律循环来治疗昼夜节律失败的方法，并提供由昼夜节律失败引起的疾病的基本治疗方法。解决方案：昼夜节律失调改善剂含有芳香id科家族的生物碱的lycorins或抗坏血酸，或其药理学上可接受的盐作为活性成分。还提供了用于预防或治疗由昼夜节律失败引起的疾病的药物组合物。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2014005225A Agent for suppressing appetite improvement and body weight gain 有权
标题翻译：用于抑制可见改善和体重增重的代理
公开(公告)号：JP2014005225A
公开(公告)日：2014-01-16
申请号：JP2012141283
申请日：2012-06-22
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , Sapporo Breweries Ltd , サッポロビール株式会社 , Sapporo Holdings Ltd , サッポロホールディングス株式会社
发明人： OISHI KATSUTAKA , YAMAMOTO YUKIORI , ITO NANAKO , MIYAZAKI REKI , NAKAKITA YASUICHI , KANEDA HIROTAKA
IPC分类号： A61K35/74 , A23L1/30 , A61P1/14 , A61P3/04
摘要： PROBLEM TO BE SOLVED: To provide a novel use of a Lactobacillus brevis SBC8803 strain.SOLUTION: The agent for suppressing appetite improvement and body weight gain contains a bacterial cell or a processed bacterial cell of a SBC8803 (accession number: FERM BP-10632) strain belonging to Lactobacillus brevis.
摘要翻译：要解决的问题：提供短乳杆菌SBC8803菌株的新用途。解决方案：用于抑制食欲改善和体重增加的药物含有SBC8803的细菌细胞或加工细菌细胞（登录号：FERM BP-10632）属于短乳杆菌的菌株。

9. 发明专利

JP2015000851A 体温上昇剤审中-公开
标题翻译：身体温度升高剂
公开(公告)号：JP2015000851A
公开(公告)日：2015-01-05
申请号：JP2013124849
申请日：2013-06-13
申请人：独立行政法人産業技術総合研究所 , National Institute Of Advanced Industrial & Technology , サッポロビール株式会社 , Sapporo Breweries Ltd , サッポロホールディングス株式会社 , Sapporo Holdings Ltd
发明人： OISHI KATSUTAKA , YAMAMOTO YUKIORI , ITO NANAKO , MIYAZAKI REKI , NAKAKITA YASUICHI , KANEDA HIROTAKA
IPC分类号： A61K35/74 , A23L1/30 , A61P3/00
CPC分类号： A61K35/747 , A23K10/18 , A23K50/50 , A23L33/135
摘要：【課題】適度な体温上昇効果を有する新規の体温上昇剤を提供すること。【解決手段】ラクトバチラス・ブレビス(Lactobacillus brevis)に属するSBC8803(受託番号:FERM BP−10632)菌株の菌体又はその処理物を有効成分として含有する体温上昇剤。【選択図】なし
摘要翻译：要解决的问题：提供具有适当体温升高效果的新型体温升高剂。解决方案：本发明提供一种体温升高剂，其包含作为活性成分的菌株SBC8803（保藏号：FERM BP-10632）或其处理产物。

10. 发明专利

JP2014033661A Small animal breeding device 有权
标题翻译：小动物育种装置
公开(公告)号：JP2014033661A
公开(公告)日：2014-02-24
申请号：JP2012178079
申请日：2012-08-10
申请人： National Institute Of Advanced Industrial & Technology , 独立行政法人産業技術総合研究所 , Melquest:Kk , 有限会社メルクエスト
发明人： MIYAZAKI REKI , OISHI KATSUTAKA , YAMAMOTO TOSHIYUKI
IPC分类号： A01K1/03 , A01K1/035
摘要： PROBLEM TO BE SOLVED: To provide a small animal breeding device capable of creating a model animal suitable for research related to a chronic stressful sleep disorder.SOLUTION: A small animal breeding device includes a running wheel 14 having: a turning wheel 22 having one end face closed by a closing plate 24; and a support member journaling the turning wheel 22 sideways. The turning wheel 22 turns by walking of a small animal inside the turning wheel 22 on a peripheral face 28. The small animal breeding device includes a cage 16 that is a housing set with the running wheel 14 thereinside and has a closing face 34 closing the other end part of the turning wheel 22. A feed window 40 and a water window 42 through which the small animal cannot pass are opened in the closing face 34. The small animal breeding device includes a feeder 18 having a feed storage part 50 and a feeding port 52. The small animal breeding device includes a waterer 20 having a water storage part 58 and a nozzle 60. The small animal inserts the head into the feeding port 52 through the feed window 40 to eat feed, and can ingest water from the nozzle 60 through the water window 42.
摘要翻译：要解决的问题：提供能够创建适合于与慢性压力性睡眠障碍相关的研究的模型动物的小型动物育种装置。解决方案：小型动物育种装置包括行进轮14，其具有：具有一端的转向轮22 由封闭板24封闭的面; 以及将转向轮22侧向对准的支撑部件。转动轮22通过在转动轮22内的周边面28上的小动物的行走而转动。小型动物饲养装置包括保持架16，该保持架16是具有行走轮14的壳体，其具有封闭面34 转动轮22的另一端部。小动物饲养装置包括具有饲料储存部分50和饲料储存部分50的进料器18，小动物不能通过的进料口40和水窗42。小动物饲养装置包括具有储水部分58和喷嘴60的饮水器20.小动物通过进料窗40将头部进入进料口52以进食，并且可以从喷嘴60通过水窗42。

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