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1. 发明申请

US20070231894A1 FLEA ULTRASPIRACLE NUCLEIC ACID MOLECULES 失效
标题翻译： FLEA ULTRASPIRACLE核酸分子
公开(公告)号：US20070231894A1
公开(公告)日：2007-10-04
申请号：US11697551
申请日：2007-04-06
申请人： Nancy Wisnewski , Anna Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna Becher , Eric Jarvis
IPC分类号： C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.
摘要翻译：本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

2. 发明授权

US07208589B2 Flea ultraspiracle nucleic acid molecules and uses thereof 有权
标题翻译：跳蚤超急性核酸分子及其用途
公开(公告)号：US07208589B2
公开(公告)日：2007-04-24
申请号：US10855541
申请日：2004-05-27
申请人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
IPC分类号： C07H21/02 , C12N15/09 , A61K38/00
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： We claim a flea ultraspiracle nucleic acid molecule encoding an ultraspiracle protein, and a composition comprising the isolated nucleic acid molecule. Also, we claim a method of recombinantly producing the ultraspiracle protein thereof.
摘要翻译：我们要求编码超尖锐蛋白的跳蚤超尖锐核酸分子和包含分离的核酸分子的组合物。此外，我们要求重组产生其超蛋白质蛋白的方法。

3. 发明授权

US06489140B1 Flea ecdysone and ultraspiracle nucleic acid molecules, proteins and uses thereof 有权
标题翻译：跳蚤蜕皮激素和超尖锐核酸分子，蛋白质及其用途
公开(公告)号：US06489140B1
公开(公告)日：2002-12-03
申请号：US09435019
申请日：1999-11-05
申请人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
IPC分类号： C12P2106
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.
摘要翻译：本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

4. 发明授权

US07667019B2 Flea ultraspiracle nucleic acid molecules 失效
标题翻译：跳蚤超尖锐核酸分子
公开(公告)号：US07667019B2
公开(公告)日：2010-02-23
申请号：US11697551
申请日：2007-04-06
申请人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
IPC分类号： C07H21/04 , A61K38/00
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.
摘要翻译：本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

5. 发明授权

US06767721B2 Flea ecdysone nucleic acid molecules and uses thereof 失效
标题翻译：跳蚤蜕皮激素核酸分子及其用途
公开(公告)号：US06767721B2
公开(公告)日：2004-07-27
申请号：US10065200
申请日：2002-09-25
申请人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
IPC分类号： C12P2106
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.
摘要翻译：本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

6. 发明授权

US06506784B1 Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides 失效
标题翻译：使用1,3-取代的吡唑-5-基磺酸盐作为农药
公开(公告)号：US06506784B1
公开(公告)日：2003-01-14
申请号：US09606986
申请日：2000-06-29
申请人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Dimitris Agrafiotis , Nancy Wisnewski , Gary M. Silver , Dan T. Stinchcomb , R. Lee Seward
发明人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Dimitris Agrafiotis , Nancy Wisnewski , Gary M. Silver , Dan T. Stinchcomb , R. Lee Seward
IPC分类号： A01N4356
CPC分类号： A01N43/56
摘要： The present invention is directed to inhibiting pest GABA receptors by contacting said receptors with a compound of Formula I: The invention is also directed to methods of controlling pests, especially insects and arachnids such as fleas and ticks, and to novel compounds within the scope of Formula I.
摘要翻译：本发明涉及通过使所述受体与式I化合物接触来抑制病虫害GABA受体：本发明还涉及防治害虫，特别是昆虫和蜘蛛如跳蚤和蜱的方法，以及在本发明范围内的新化合物一级方程式

7. 发明授权

US06207158B1 Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof 失效
标题翻译：寄生虫蠕虫巨噬细胞迁移抑制因子蛋白质，核酸分子及其用途
公开(公告)号：US06207158B1
公开(公告)日：2001-03-27
申请号：US08906480
申请日：1997-08-05
申请人： Cynthia Ann Tripp , Kevin S. Brandt , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Kevin S. Brandt , Nancy Wisnewski
IPC分类号： A61K3900
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子，针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

8. 发明授权

US5789194A Parasitic helminth venom allergen antigen 5-like genes and proteins 失效
标题翻译：寄生蠕虫毒液变应原抗原5样基因和蛋白质
公开(公告)号：US5789194A
公开(公告)日：1998-08-04
申请号：US450944
申请日：1995-05-23
申请人： Cynthia Ann Tripp , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Nancy Wisnewski
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P33/00 , C07K14/435 , C07K14/44 , C07K16/18 , C07K16/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/00 , C12P21/02 , C12P21/00 , C07H21/04 , C07K1/00
CPC分类号： C07K16/18 , C07K14/4354 , A61K38/00 , A61K39/00
摘要： The present invention relates to parasitic helminth venom allergen antigen 5-like proteins; to parasitic helminth venom allergen antigen 5-like nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules and/or antibodies, as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫毒液变应原抗原5样蛋白; 对寄生蠕虫毒素变应原抗原5样核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。本发明还包括获得这些蛋白质，核酸分子和抗体的方法。本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

9. 发明授权

US08088903B2 Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 有权
标题翻译：跳蚤头，神经线，后肠和恶臭小管核酸分子，蛋白质及其用途
公开(公告)号：US08088903B2
公开(公告)日：2012-01-03
申请号：US11565729
申请日：2006-12-01
申请人： Kevin S. Brandt , Patrick J. Gaines , Dan T. Stinchcomb , Nancy Wisnewski
发明人： Kevin S. Brandt , Patrick J. Gaines , Dan T. Stinchcomb , Nancy Wisnewski
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C07K14/4359
摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
摘要翻译：本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子，抗体或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

10. 发明授权

US06638744B2 Canine cox-2 nucleic acid molecules and uses thereof 有权
标题翻译：犬cox-2核酸分子及其用途
公开(公告)号：US06638744B2
公开(公告)日：2003-10-28
申请号：US09919060
申请日：2001-07-31
申请人： Nancy Wisnewski , Kevin S. Brandt
发明人： Nancy Wisnewski , Kevin S. Brandt
IPC分类号： C12N902
CPC分类号： A61K31/7088 , C12N9/90
摘要： The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals.
摘要翻译：本发明涉及犬COX-1和COX-2蛋白; 涉及犬COX-1和COX-2核酸分子，包括分别编码这种COX-1和COX-2蛋白的那些; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这种抑制性化合物，特别是特异性抑制COX-2活性的抑制性化合物的治疗组合物，以及这些治疗组合物用于治疗动物的用途。

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