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1. 发明授权

US06506784B1 Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides 失效
标题翻译：使用1,3-取代的吡唑-5-基磺酸盐作为农药
公开(公告)号：US06506784B1
公开(公告)日：2003-01-14
申请号：US09606986
申请日：2000-06-29
申请人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Dimitris Agrafiotis , Nancy Wisnewski , Gary M. Silver , Dan T. Stinchcomb , R. Lee Seward
发明人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Dimitris Agrafiotis , Nancy Wisnewski , Gary M. Silver , Dan T. Stinchcomb , R. Lee Seward
IPC分类号： A01N4356
CPC分类号： A01N43/56
摘要： The present invention is directed to inhibiting pest GABA receptors by contacting said receptors with a compound of Formula I: The invention is also directed to methods of controlling pests, especially insects and arachnids such as fleas and ticks, and to novel compounds within the scope of Formula I.
摘要翻译：本发明涉及通过使所述受体与式I化合物接触来抑制病虫害GABA受体：本发明还涉及防治害虫，特别是昆虫和蜘蛛如跳蚤和蜱的方法，以及在本发明范围内的新化合物一级方程式

2. 发明授权

US06518266B1 1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides 有权
标题翻译： 1-芳基-3-硫烷基吡唑，其合成及其作为杀虫剂的用途
公开(公告)号：US06518266B1
公开(公告)日：2003-02-11
申请号：US09621456
申请日：2000-07-21
申请人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Nancy Wisnewski , Gary Silver , Dan T. Stinchcomb , R. Lee Seward , Dimitris Agrafiotis , Deyou Sha
发明人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Nancy Wisnewski , Gary Silver , Dan T. Stinchcomb , R. Lee Seward , Dimitris Agrafiotis , Deyou Sha
IPC分类号： C07D23124
CPC分类号： C07D403/04 , A01N43/56 , A01N43/82 , A01N55/00 , C07D231/18 , C07D231/20 , C07D231/44 , C07D231/52 , C07D409/04 , C07D413/04
摘要： The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R1 represents R5O, R5SO2, R5SO or R5S in which R5 is as defined herein; X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond; R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; and R3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.
摘要翻译：本发明涉及新颖的吡唑衍生物及其作为杀虫剂的用途。吡唑衍生物具有式I或其盐，其中R 1表示其中R 5如本文所定义的R5O，R5SO2，R5SO或R5S; X为卤素，氰基，C1-6烷氧基羰基，C2-6炔基，任选取代的C6-14 芳基或通过碳 - 碳键与噻唑连接的任选取代的5至7元杂芳环; R 2是氢，氨基，氯，溴，碘，氰基，C 1-6烷氧基，C 1-6烷基或C 6-10 芳基; 和R 3 -R 7各自表示氢，卤素，直链或支链C 1-4烷基或C 1-4烷氧基，其中任一个是未取代的或被一个或多个卤素原子，直链或支链C 1-4烷硫基或任选被一个或多个卤素原子取代的C 1-4烷基亚磺酰基，未被取代或被一个或多个卤素原子取代的硝基，氰基或直链或支链C 1-4烷基磺酰基。

3. 发明授权

US08088903B2 Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 有权
标题翻译：跳蚤头，神经线，后肠和恶臭小管核酸分子，蛋白质及其用途
公开(公告)号：US08088903B2
公开(公告)日：2012-01-03
申请号：US11565729
申请日：2006-12-01
申请人： Kevin S. Brandt , Patrick J. Gaines , Dan T. Stinchcomb , Nancy Wisnewski
发明人： Kevin S. Brandt , Patrick J. Gaines , Dan T. Stinchcomb , Nancy Wisnewski
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C07K14/4359
摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
摘要翻译：本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子，抗体或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

4. 发明授权

US09028809B2 Compositions, methods and uses for expression of enterobacterium-associated peptides 有权
标题翻译：用于表达肠杆菌相关肽的组合物，方法和用途
公开(公告)号：US09028809B2
公开(公告)日：2015-05-12
申请号：US13511652
申请日：2010-11-24
申请人： Dan T. Stinchcomb , Jorge E. Osorio , Timothy D. Powell , Joseph N. Brewoo
发明人： Dan T. Stinchcomb , Jorge E. Osorio , Timothy D. Powell , Joseph N. Brewoo
IPC分类号： A01N63/00 , A61K39/275 , A61K39/00 , A61K39/02
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译：本发明的实施方案通常公开了用于产生和表达肠细菌相关肽的方法，组合物和用途。在一些实施方案中，肠细菌相关肽包括但不限于瘟疫相关肽。在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于表达肠细菌相关肽的减毒或修饰的痘苗病毒载体。在其它实施方案中，报告了在受试者中使用的疫苗组合物。

5. 发明授权

US09011874B2 Compositions, methods and uses for poxvirus elements in vaccine constructs 有权
标题翻译：疫苗结构中痘病毒成分的组成，方法和用途
公开(公告)号：US09011874B2
公开(公告)日：2015-04-21
申请号：US13510601
申请日：2010-11-22
申请人： Dan T. Stinchcomb , Jorge E. Osorio , Timothy D. Powell , Jeremy Jones
发明人： Dan T. Stinchcomb , Jorge E. Osorio , Timothy D. Powell , Jeremy Jones
IPC分类号： A61K49/00 , A61K39/38 , A61K39/295 , A61K39/145 , A61K39/245 , C12Q1/70 , C12N15/863 , A61K39/12 , A61K39/00 , C07K14/005
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24134 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译：本发明的实施方案通常公开了用于产生和表达痘病毒构建体的方法，组合物和用途。在一些实施方案中，构建体可以含有流感病毒基因区段。在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于痘病毒疫苗组合物。在其它实施方案中，报告了在受试者中使用的疫苗组合物。

6. 发明授权

US09005632B2 Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains 有权
标题翻译：针对流感病毒亚型或株系的疫苗结构中痘病毒元件的组成，方法和用途
公开(公告)号：US09005632B2
公开(公告)日：2015-04-14
申请号：US13555026
申请日：2012-07-20
申请人： Dan T. Stinchcomb , Jorge E. Osorio , Timothy D. Powell , Jeremy C. Jones , Joseph N. Brewoo
发明人： Dan T. Stinchcomb , Jorge E. Osorio , Timothy D. Powell , Jeremy C. Jones , Joseph N. Brewoo
IPC分类号： A61K49/00 , A61K39/38 , A61K39/295 , A61K39/145 , A61K39/245 , C12Q1/70 , C12N15/863 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions having two or more influenza gene segments. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译：本发明的实施方案通常公开了用于产生和表达痘病毒构建体的方法，组合物和用途。在一些实施方案中，构建体可以含有流感病毒基因区段。在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于具有两个或更多个流感基因片段的痘病毒疫苗组合物。在其它实施方案中，报告了在受试者中使用的疫苗组合物。

7. 发明授权

US08029776B2 Cationic lipid-mediated enhancement of nucleic acid immunization of cats 有权
标题翻译：阳离子脂质介导的猫的核酸免疫增强
公开(公告)号：US08029776B2
公开(公告)日：2011-10-04
申请号：US11866558
申请日：2007-10-03
申请人： Joel R. Haynes , Ramani S. Wonderling , Dan T. Stinchcomb
发明人： Joel R. Haynes , Ramani S. Wonderling , Dan T. Stinchcomb
IPC分类号： A61K39/21 , C07H23/00 , A61K48/00
CPC分类号： A61K39/205 , A61K39/0005 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/6018 , C12N2760/20134
摘要： The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of administering to the felid, by a parenteral route, a nucleic acid-cationic lipid complex to elicit and/or enhance an immune response. In one embodiment, this method enhances the immune response in a felid compared to a method in which a naked DNA vaccine is administered to a felid. Also provided is a method to deliver a nucleic acid to a felid. This method comprises parenterally administering to the felid a composition that includes a nucleic acid molecule complexed with a cationic lipid.
摘要翻译：本发明涉及通过施用核酸 - 阳离子脂质复合物组合物将核酸分子引入纤毛蛋白的方法。该方法包括通过肠胃外途径向核蛋白施用核酸 - 阳离子脂质复合物以引发和/或增强免疫应答的步骤。在一个实施方案中，与将裸DNA疫苗施用于felid的方法相比，该方法增强了felid中的免疫应答。还提供了将核酸递送至felid的方法。该方法包括肠胃外施用包含与阳离子脂质复合的核酸分子的组合物。

8. 发明授权

US5877022A Ribozymes targeted to APO(a) RNA 失效
标题翻译：针对APO（a）RNA的核酶
公开(公告)号：US5877022A
公开(公告)日：1999-03-02
申请号：US774310
申请日：1996-12-26
申请人： Dan T. Stinchcomb , James McSwiggen , Roger S. Newton , Randy Ramharack
发明人： Dan T. Stinchcomb , James McSwiggen , Roger S. Newton , Randy Ramharack
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , C12N5/10 , C12N9/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122
摘要： Enzymatic RNA molecules which cleave apo(a) mRNA.
摘要翻译：切割apo（a）mRNA的酶RNA分子。

9. 发明授权

US08968996B2 Compositions and methods for rapid immunization against dengue virus 有权
标题翻译：用于快速免疫登革热病毒的组合物和方法
公开(公告)号：US08968996B2
公开(公告)日：2015-03-03
申请号：US13492884
申请日：2012-06-10
申请人： Dan T. Stinchcomb , Jorge E. Osorio , Charalambos D. Partidos , Joseph N. Brewoo
发明人： Dan T. Stinchcomb , Jorge E. Osorio , Charalambos D. Partidos , Joseph N. Brewoo
IPC分类号： C12Q1/70 , A61K39/295 , A61K39/12 , A61K45/06 , A61K39/00
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject against all dengue virus serotypes. In some embodiments, multiple vaccine compositions may be administered to a subject in different anatomical locations in order to induce a rapid response to all dengue virus serotypes. In certain embodiments, administration of two or more vaccine compositions to a subject against all dengue virus serotypes may include two or more routes of administration.
摘要翻译：本发明的实施方案报道了针对所有登革热病毒血清型疫苗接种受试者的组合物和方法。在一些实施方案中，可以将多种疫苗组合物施用于不同解剖位置的受试者，以便诱导对所有登革热病毒血清型的快速反应。在某些实施方案中，将两种或更多种疫苗组合物施用于所有登革热病毒血清型的受试者可包括两种或更多种施用途径。

10. 发明申请

US20090060948A1 CATIONIC LIPID-MEDIATED ENHANCEMENT OF NUCLEIC ACID IMMUNIZATION OF CATS 有权
标题翻译：阳离子脂质介导的CATS核酸免疫增强
公开(公告)号：US20090060948A1
公开(公告)日：2009-03-05
申请号：US11866558
申请日：2007-10-03
申请人： Joel R. Haynes , Ramani S. Wonderling , Dan T. Stinchcomb
发明人： Joel R. Haynes , Ramani S. Wonderling , Dan T. Stinchcomb
IPC分类号： A61K39/00 , A61K31/7088 , A61P31/00
CPC分类号： A61K39/205 , A61K39/0005 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/6018 , C12N2760/20134
摘要： The present invention relates to a method to introduce a nucleic acid molecule into a fetid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of administering to the felid, by a parenteral route, a nucleic acid-cationic lipid complex to elicit and/or enhance an immune response. In one embodiment, this method enhances the immune response in a fetid compared to a method in which a naked DNA vaccine is administered to a felid. Also provided is a method to deliver a nucleic acid to a felid. This method comprises parenterally administering to the fetid a composition that includes a nucleic acid molecule complexed with a cationic lipid.
摘要翻译：本发明涉及通过施用核酸 - 阳离子脂质复合物组合物将核酸分子引入胎儿的方法。该方法包括通过肠胃外途径向核蛋白施用核酸 - 阳离子脂质复合物以引发和/或增强免疫应答的步骤。在一个实施方案中，与将裸DNA疫苗施用于felid的方法相比，该方法增强了胎儿中的免疫应答。还提供了将核酸递送至felid的方法。该方法包括向胎儿肠胃外施用包含与阳离子脂质复合的核酸分子的组合物。

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