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1. 发明申请

US20070231894A1 FLEA ULTRASPIRACLE NUCLEIC ACID MOLECULES 失效
标题翻译： FLEA ULTRASPIRACLE核酸分子
公开(公告)号：US20070231894A1
公开(公告)日：2007-10-04
申请号：US11697551
申请日：2007-04-06
申请人： Nancy Wisnewski , Anna Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna Becher , Eric Jarvis
IPC分类号： C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.
摘要翻译：本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

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