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1. 发明申请

WO2007038172A3 GUANIDIUM CARRIERS 审中-公开
标题翻译：手持机
公开(公告)号：WO2007038172A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036746
申请日：2006-09-21
申请人： NITTO DENKO CORP , ZHAO GANG , YU LEI , LIU JIAN , KITAURA CHIEKO , WANG XINGHE , SONG YUCHENG , CASTELLO CHRIS
发明人： ZHAO GANG , YU LEI , LIU JIAN , KITAURA CHIEKO , WANG XINGHE , SONG YUCHENG , CASTELLO CHRIS
IPC分类号： C07K7/06 , A61K47/48 , C07K7/02
CPC分类号： C07K5/0215 , A61K31/555 , A61K47/641 , A61K47/645 , A61K49/085 , A61K49/146 , C07K7/02
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
摘要翻译：本文公开了含有胍基的跨膜转运体化合物。本文还公开了使用跨膜转运体化合物在生物膜上输送生物活性部分的方法。特别地，本发明提供了一种在诸如内皮组织之类的膜的生物膜上递送生物活性部分的方法。

2. 发明申请

WO2008141107A2 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
标题翻译：包含疏水化合物和聚氨基酸共混物的组合物
公开(公告)号：WO2008141107A2
公开(公告)日：2008-11-20
申请号：PCT/US2008063114
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
发明人： VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译：制备包括疏水化合物和聚氨基酸缀合物的各种组合物。本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。

3. 发明申请

WO2008141107A3 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
标题翻译：包含疏水化合物和聚氨基酸共混物的组合物
公开(公告)号：WO2008141107A3
公开(公告)日：2009-04-23
申请号：PCT/US2008063114
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
发明人： VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications. The inventors have discovered novel compositions that include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. In some embodiments, the polymers and the resulting conjugates preferentially accumulate in certain tissues (e.g. tumor tissues) and/or certain receptors, and thus are useful for delivering drugs (e.g., anticancer drugs) and/or imaging agents to specific parts of the body (e.g., tumors). In some embodiments, the polymers described herein and the resulting conjugates can form nanoparticles that effectively solubilize the drug in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the drug.
摘要翻译：制备包括疏水化合物和聚氨基酸缀合物的各种组合物。本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。发明人已经发现了包括聚合物缀合物，第一疏水性药物和第二疏水性药物的新型组合物。本文所述组合物的聚合物缀合物能够与许多试剂（例如成像剂，靶向剂，稳定剂和/或药物）共轭。在一些实施方案中，聚合物和所得的缀合物优先积聚在某些组织（例如肿瘤组织）和/或某些受体中，因此可用于将药物（例如抗癌药物）和/或成像剂递送至身体的特定部位（例如肿瘤）。在一些实施方案中，本文所述的聚合物和所得的共轭物可以形成纳米颗粒，其通过将其分散在分子水平上来有效地将药物溶解在水性体系中，从而增加药物的功能性和/或生物利用度。

4. 发明申请

WO2007038171A3 PEPTIDE NUCLEIC ACID BASED GUANIDINIUM COMPOUNDS 审中-公开
标题翻译：肽核酸基胍化合物
公开(公告)号：WO2007038171A3
公开(公告)日：2007-12-13
申请号：PCT/US2006036745
申请日：2006-09-21
申请人： NITTO DENKO CORP , ZHAO GANG , KITAURA CHIEKO , LIU JIAN , DAS SANJIB KUMAR , YU LEI
发明人： ZHAO GANG , KITAURA CHIEKO , LIU JIAN , DAS SANJIB KUMAR , YU LEI
IPC分类号： A61K47/48 , A61P35/00 , C07K14/00
CPC分类号： C07K14/003 , A61K47/62 , A61K47/645
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.
摘要翻译：本文公开了含有胍基团的跨膜转运蛋白化合物以增强聚合物骨架穿过生物膜的运输。治疗和其他生物活性部分可以连接到化合物上。聚合物主链可以包括肽核酸单体单元。

5. 发明申请

WO2009036368A2 DRUG CARRIERS 审中-公开
标题翻译：药物载体
公开(公告)号：WO2009036368A2
公开(公告)日：2009-03-19
申请号：PCT/US2008076287
申请日：2008-09-12
申请人： NITTO DENKO CORP , YU LEI , LIU JIAN , ZHAO GANG , MA NIANCHUN , VAN SANG
发明人： YU LEI , LIU JIAN , ZHAO GANG , MA NIANCHUN , VAN SANG
CPC分类号： A61K31/337 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K47/6455
摘要： Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：本文公开了可包含阳离子聚合物载体，靶向剂和治疗剂的组合物。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

6. 发明申请

WO2008151150A3 PEG-PEI COPOLYMERS FOR NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于核酸交付的PEG-PEI共聚物
公开(公告)号：WO2008151150A3
公开(公告)日：2009-07-30
申请号：PCT/US2008065564
申请日：2008-06-02
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , MA NIANCHUN , ZHAO XIN , LU JIAN , TANAKA YASUNOBU
发明人： YU LEI , ZHAO GANG , MA NIANCHUN , ZHAO XIN , LU JIAN , TANAKA YASUNOBU
IPC分类号： A61K47/48 , C12N15/11
CPC分类号： C12M35/02 , A61K47/59 , A61K47/60 , C12M23/12 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Compositions for siRNA delivery are described which include water soluble degradable crosslinked cationic polymers having a water soluble polyethylene glycol component, a cationic polyethyleneimine component and a degradable unit component. The composition may be used to deliver siRNA to cells, particularly cancer cells. The composition may be applied to a solid surface such as a multiwell plate so that the delivery of siRNA may be carried out on the solid surface.
摘要翻译：描述了用于siRNA递送的组合物，其包括具有水溶性聚乙二醇组分的水溶性可降解交联阳离子聚合物，阳离子聚乙烯亚胺组分和可降解单元组分。该组合物可用于将siRNA递送至细胞，特别是癌细胞。可以将组合物施用于固体表面，例如多孔板，使得可以在固体表面上进行siRNA的递送。

7. 发明申请

WO2008124735A3 MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS 审中-公开
标题翻译：多官能聚氨基甲酸酯药物载体
公开(公告)号：WO2008124735A3
公开(公告)日：2009-05-14
申请号：PCT/US2008059677
申请日：2008-04-08
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , VAN SANG
发明人： YU LEI , ZHAO GANG , VAN SANG
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/14 , A61P35/00
CPC分类号： A61K49/146 , A61K47/60 , A61K47/62 , A61K47/645 , A61K49/0002 , A61K49/085
摘要： Various biodegradable polyglutamate polymer conjugates that can include recurring units of the general formulae (I) and (II) are described herein. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：本文描述了可包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸酯聚合物缀合物。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

8. 发明申请

WO2008141110A3 POLYGLUTAMATE CONJUGATES AND POLYGLUTAMATE-AMINO ACID CONJUGATES HAVING A PLURALITY OF DRUGS 审中-公开
标题翻译：聚氨基酸结合物和具有多种药物的聚谷氨酸 - 氨基酸结合物
公开(公告)号：WO2008141110A3
公开(公告)日：2009-06-04
申请号：PCT/US2008063126
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , YU LEI , ZHAO GANG
发明人： VAN SANG , YU LEI , ZHAO GANG
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/12 , A61P35/00
CPC分类号： A61K49/146 , A61K47/645 , A61K49/0056 , A61K49/085
摘要： Various biodegradable polyglutamate conjugates comprising recurring units of the general formulae (I), (II), (III), (IV), (V), and/or (VI) are prepared. The polymers are conjugated with a plurality of drugs. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I），（II），（III），（IV），（V）和/或（VI）的重复单元的各种可生物降解的聚谷氨酸共轭物。聚合物与多种药物缀合。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

9. 发明申请

WO2008094834A2 MULTI-FUNCTIONAL DRUG CARRIERS 审中-公开
标题翻译：多功能药物载体
公开(公告)号：WO2008094834A2
公开(公告)日：2008-08-07
申请号：PCT/US2008052094
申请日：2008-01-25
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , CHEN FU , JIN YI , FU XIAOLI
发明人： YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , CHEN FU , JIN YI , FU XIAOLI
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这样的聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。

10. 发明申请

WO2010045370A2 METHOD OF PREPARING POLYGLUTAMATE CONJUGATES 审中-公开
标题翻译：制备聚谷氨酸盐结合物的方法
公开(公告)号：WO2010045370A2
公开(公告)日：2010-04-22
申请号：PCT/US2009060694
申请日：2009-10-14
申请人： NITTO DENKO CORP , VAN SANG , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
发明人： VAN SANG , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
IPC分类号： A61K47/48
CPC分类号： A61K47/645
摘要： Methods for preparing and isolating polymer conjugates that include a recurring unit of Formulae (I) and (Ia) are described herein. The polymer conjugates can include an anti¬ cancer drug.
摘要翻译：本文描述了制备和分离包含式（I）和（Ia）的重复单元的聚合物缀合物的方法。聚合物缀合物可以包括抗癌药物。

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