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1. 发明申请

WO2007038171A3 PEPTIDE NUCLEIC ACID BASED GUANIDINIUM COMPOUNDS 审中-公开
标题翻译：肽核酸基胍化合物
公开(公告)号：WO2007038171A3
公开(公告)日：2007-12-13
申请号：PCT/US2006036745
申请日：2006-09-21
申请人： NITTO DENKO CORP , ZHAO GANG , KITAURA CHIEKO , LIU JIAN , DAS SANJIB KUMAR , YU LEI
发明人： ZHAO GANG , KITAURA CHIEKO , LIU JIAN , DAS SANJIB KUMAR , YU LEI
IPC分类号： A61K47/48 , A61P35/00 , C07K14/00
CPC分类号： C07K14/003 , A61K47/62 , A61K47/645
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.
摘要翻译：本文公开了含有胍基团的跨膜转运蛋白化合物以增强聚合物骨架穿过生物膜的运输。治疗和其他生物活性部分可以连接到化合物上。聚合物主链可以包括肽核酸单体单元。

2. 发明申请

WO2007038172A3 GUANIDIUM CARRIERS 审中-公开
标题翻译：手持机
公开(公告)号：WO2007038172A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036746
申请日：2006-09-21
申请人： NITTO DENKO CORP , ZHAO GANG , YU LEI , LIU JIAN , KITAURA CHIEKO , WANG XINGHE , SONG YUCHENG , CASTELLO CHRIS
发明人： ZHAO GANG , YU LEI , LIU JIAN , KITAURA CHIEKO , WANG XINGHE , SONG YUCHENG , CASTELLO CHRIS
IPC分类号： C07K7/06 , A61K47/48 , C07K7/02
CPC分类号： C07K5/0215 , A61K31/555 , A61K47/641 , A61K47/645 , A61K49/085 , A61K49/146 , C07K7/02
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
摘要翻译：本文公开了含有胍基的跨膜转运体化合物。本文还公开了使用跨膜转运体化合物在生物膜上输送生物活性部分的方法。特别地，本发明提供了一种在诸如内皮组织之类的膜的生物膜上递送生物活性部分的方法。

3. 发明申请

WO2006044063A2 TRANSEPITHELIAL DELIVERY OF PEPTIDES WITH INCRETIN HORMONE ACTIVITIES 审中-公开
标题翻译：通过增加激素活性来递送肽
公开(公告)号：WO2006044063A2
公开(公告)日：2006-04-27
申请号：PCT/US2005032636
申请日：2005-09-14
申请人： NITTO DENKO CORP , KITAURA CHIEKO , MINOMI KENJIRO , OKUBO KATSUYUKI , OKADA KEISAKU , KAGEHISA NATSUKO , KAMIYAMA MASASHI , HOU ZHENG , LIU JIAN , SONG YUCHENG , YU LEI
发明人： KITAURA CHIEKO , MINOMI KENJIRO , OKUBO KATSUYUKI , OKADA KEISAKU , KAGEHISA NATSUKO , KAMIYAMA MASASHI , HOU ZHENG , LIU JIAN , SONG YUCHENG , YU LEI
IPC分类号： A61K47/48
CPC分类号： C07K14/605 , A61K9/0014 , A61K38/00 , A61K47/62 , A61K47/645 , C07K14/57563
摘要： Compositions and methods are disclosed for the treatment of diabetes and related diseases using peptides with incretin hormone activity. Preferably, the peptide with incretin hormone activity is GLP-1, exendin or an analog of GLP-1 or exendin. The peptides with incretin hormone activity are administered transepithelially using a transepithelial carrier peptide. The transepithelial peptide contains sufficient amino, guanidine or amidino groups to stimulate transepithelial delivery. In some embodiments, the transepithelial carrier and the peptide with incretin hormone activity are embedded in a pressure sensitive adhesive layer of a plaster or patch.
摘要翻译：公开了使用具有肠降血糖素激素活性的肽治疗糖尿病和相关疾病的组合物和方法。优选地，具有肠降血糖素激素活性的肽是GLP-1，毒蜥外泌肽或GLP-1或毒蜥外泌肽类似物。具有肠过氧化物激素活性的肽通过经上皮载体肽经上皮内给药。跨上皮肽含有足够的氨基，胍或脒基以刺激跨上皮递送。在一些实施方案中，将经上皮载体和具有肠降血糖素激素活性的肽嵌入膏药或贴剂的压敏粘合剂层中。

4. 发明专利

CA2729764A1 PHARMACEUTICAL COMPOSITION CONTAINING SURFACE-COATED MICROPARTICLES 未知
公开(公告)号：CA2729764A1
公开(公告)日：2010-01-07
申请号：CA2729764
申请日：2009-07-01
申请人： NITTO DENKO CORP
发明人： OKUBO KATSUYUKI , KITAURA CHIEKO , MINOMI KENJIRO , PEARSON ELIZABETH , ROBERTS CLIVE J , DAVIES MARTYN C , STOLNIK-TRENKIC SNJEZANA , ILLUM LISBETH
IPC分类号： A61K9/16 , A61K31/137 , A61K31/4045 , A61K31/715 , A61K38/00 , A61K38/28 , A61K39/00 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/36 , A61K47/42 , A61K48/00 , A61P3/10 , A61P11/10 , A61P25/06
摘要： Disclosed is a pharmaceutical composition which can be used for the administration of a low-molecular-weight substance or a high-molecular-weight substance such as a peptide and a protein by a means other than injection with high efficiency. Also disclosed is a method for producing the composition. Specifically disclosed is a pharmaceutical composition for transmucosal administration, which comprises (a) a substance which can carry a positive or negative electrical charge at a given pH value, (b) pharmaceutically acceptable microparticles, and (c) a pharmaceutically acceptable surface-coating polymer which can be electrically charged at the above-mentioned pH value. In the composition, the surface-coating polymer coats the surfaces of the microparticles, and the substance is immobilized on the surfaces of the microparticles through the surface-coating polymer. In the composition, the microparticles interact non-covalently with the surface-coating polymer and, at the same time, the surface-coating polymer interacts electrostatically with the substance, thereby forming a complex.

5. 发明专利

RU2508093C2 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ МИКРОЧАСТИЦЫ С ПОВЕРХНОСТНЫМ ПОКРЫТИЕМ 未知
公开(公告)号：RU2508093C2
公开(公告)日：2014-02-27
申请号：RU2011103437
申请日：2009-07-01
申请人： NITTO DENKO CORP
发明人： OKUBO KATSUJUKI , KITAURA CHIEKO , MINOMI KENZIRO , PIRSON EHLIZABET , ROBERTS KLAJV DZH , DEHVIS MARTIN K , STOL NIK-TRENKICH SNEZHANA , ILLUM LISBET
IPC分类号： A61K9/16 , A61K38/00 , A61K38/28 , A61K47/30
摘要： Группаизобретенийотноситсяк фармацевтикеи заключаетсяв обеспечениифармацевтическойкомпозиции, которуюможноиспользоватьдляэффективноговведениянизкомолекулярныхлекарственныхвеществи полимерныхсоединений, такихкакпептидыи белки, способом, отличнымотинъекции, испособапроизводстваданнойкомпозиции. Фармацевтическаякомпозициядлячресслизистоговведениявключает (a) лекарственноевещество, имеющееположительныйилиотрицательныйзарядпри pH композициипослеполучения, (b) фармацевтическиприемлемуюмалуючастицуразмеромнеменее 1 нми неболее 50 мкми (c) фармацевтическиприемлемыйполимерповерхностногопокрытия, имеющийзарядсознаком, противоположнымзарядулекарственноговеществаприуказанном pH, приэтомповерхностьчастицыпокрытаполимеромповерхностногопокрытия, лекарственноевеществозафиксированонаповерхностиданнойчастицыс помощьюполимераповерхностногопокрытияи комплексобразованв результатенековалентноговзаимодействиямеждуданноймалойчастицейи полимеромповерхностногопокрытияи конкурирующегоэлектростатическоговзаимодействиямеждуполимеромповерхностногопокрытияи лекарственнымвеществом. Группаизобретенийобеспечиваетболеевысокуюстабильность, атакжеконтрольчресслизистоговсасыванияданноголекарственноговещества. 4 н. и 13 з.п. ф-лы, 8 пр., 13 табл., 10 ил.

6. 发明专利

DE69912904T2 未知
公开(公告)号：DE69912904T2
公开(公告)日：2004-11-04
申请号：DE69912904
申请日：1999-07-01
申请人： NITTO DENKO CORP
发明人： OKADA KENICHI , TATSUMI MOTOSHIGE , KITAURA CHIEKO , SENDA SHUJI , SAIKA TAKESHI , OKADA KEISAKU
IPC分类号： G01N33/535 , G01N33/543 , G01N33/558 , G01N33/546 , C12Q1/28 , C12Q1/42 , C12Q1/68

7. 发明专利

DE69912904D1 未知
公开(公告)号：DE69912904D1
公开(公告)日：2003-12-24
申请号：DE69912904
申请日：1999-07-01
申请人： NITTO DENKO CORP
发明人： OKADA KENICHI , TATSUMI MOTOSHIGE , KITAURA CHIEKO , SENDA SHUJI , SAIKA TAKESHI , OKADA KEISAKU
IPC分类号： G01N33/535 , G01N33/543 , G01N33/558 , G01N33/546 , C12Q1/28 , C12Q1/42 , C12Q1/68

9. 发明公开

EP2308473A4 PHARMACEUTICAL COMPOSITION CONTAINING SURFACE-COATED MICROPARTICLES 审中-公开
标题翻译：与表面被覆微粒的药物组合物
公开(公告)号：EP2308473A4
公开(公告)日：2013-01-09
申请号：EP09773510
申请日：2009-07-01
申请人： NITTO DENKO CORP
发明人： OKUBO KATSUYUKI , KITAURA CHIEKO , MINOMI KENJIRO , PEARSON ELIZABETH , ROBERTS CLIVE J , DAVIES MARTYN C , STOLNIK-TRENKIC SNJEZANA , ILLUM LISBETH
IPC分类号： A61K9/16 , A61K31/137 , A61K31/4045 , A61K31/715 , A61K38/00 , A61K38/28 , A61K39/00 , A61K45/00 , A61K47/30 , A61K47/32 , A61K47/36 , A61K47/42 , A61K48/00 , A61P3/10 , A61P11/10 , A61P25/06
CPC分类号： A61K9/1676 , A61K9/0043 , A61K9/19 , A61K31/137 , A61K31/195 , A61K31/4045 , A61K31/715 , A61K47/32 , A61K47/34 , A61K47/42

10. 发明专利

JP2011079747A Pharmaceutical composition containing medicament-containing fine particles and method for producing same 有权
标题翻译：含有药物的精细颗粒的药物组合物及其生产方法
公开(公告)号：JP2011079747A
公开(公告)日：2011-04-21
申请号：JP2009231001
申请日：2009-10-02
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： OKUBO KATSUYUKI , OKAZAKI TOSHIHIKO , KITAURA CHIEKO , AJINOMI KENJIRO , PEARSON ELIZABETH , ROBERTS CLIVE J , DAVIES MARTYN C , STOLNIK-TRENKIC SNJEZANA , ILLUM LISBETH
IPC分类号： A61K9/14 , A61K9/19 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K31/715 , A61K38/00 , A61K38/28 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/02 , A61K47/12 , A61K48/00 , A61P3/10
CPC分类号： A61K9/19 , A61K9/146 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K31/715 , A61K33/00 , A61K33/14 , A61K33/30 , A61K38/28 , A61K39/385 , A61K39/39 , A61K45/06 , A61K48/00 , A61K2039/55555 , C12N15/88 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which is used for the purpose of efficiently administering a water-soluble polymer medicament by a means other than injection, and a method for producing the pharmaceutical composition.
SOLUTION: The pharmaceutical composition comprises fine particles that are composed of (a) the water-soluble medicament and (b) a pharmaceutically acceptable ionic crystalline compound that is in a solid state at room temperature. The pharmaceutical composition is characterized in that the ionic crystalline compound is crystallized in the fine particles.
COPYRIGHT: (C)2011,JPO&INPIT

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