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1. 发明申请

WO2008094834A2 MULTI-FUNCTIONAL DRUG CARRIERS 审中-公开
标题翻译：多功能药物载体
公开(公告)号：WO2008094834A2
公开(公告)日：2008-08-07
申请号：PCT/US2008052094
申请日：2008-01-25
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , CHEN FU , JIN YI , FU XIAOLI
发明人： YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , CHEN FU , JIN YI , FU XIAOLI
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这样的聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。

2. 发明申请

WO2010045370A2 METHOD OF PREPARING POLYGLUTAMATE CONJUGATES 审中-公开
标题翻译：制备聚谷氨酸盐结合物的方法
公开(公告)号：WO2010045370A2
公开(公告)日：2010-04-22
申请号：PCT/US2009060694
申请日：2009-10-14
申请人： NITTO DENKO CORP , VAN SANG , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
发明人： VAN SANG , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
IPC分类号： A61K47/48
CPC分类号： A61K47/645
摘要： Methods for preparing and isolating polymer conjugates that include a recurring unit of Formulae (I) and (Ia) are described herein. The polymer conjugates can include an anti¬ cancer drug.
摘要翻译：本文描述了制备和分离包含式（I）和（Ia）的重复单元的聚合物缀合物的方法。聚合物缀合物可以包括抗癌药物。

3. 发明申请

WO2007038171A3 PEPTIDE NUCLEIC ACID BASED GUANIDINIUM COMPOUNDS 审中-公开
标题翻译：肽核酸基胍化合物
公开(公告)号：WO2007038171A3
公开(公告)日：2007-12-13
申请号：PCT/US2006036745
申请日：2006-09-21
申请人： NITTO DENKO CORP , ZHAO GANG , KITAURA CHIEKO , LIU JIAN , DAS SANJIB KUMAR , YU LEI
发明人： ZHAO GANG , KITAURA CHIEKO , LIU JIAN , DAS SANJIB KUMAR , YU LEI
IPC分类号： A61K47/48 , A61P35/00 , C07K14/00
CPC分类号： C07K14/003 , A61K47/62 , A61K47/645
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may include peptide nucleic acid monomer units.
摘要翻译：本文公开了含有胍基团的跨膜转运蛋白化合物以增强聚合物骨架穿过生物膜的运输。治疗和其他生物活性部分可以连接到化合物上。聚合物主链可以包括肽核酸单体单元。

4. 发明专利

AU2021103279A4 A PROCESS FOR ISOLATION AND YIELD INCREASE OF FLAVONOID COMPOUND/QUERCETIN FROM PLANT HOUTTUYNIA CORDATA THUNB BY UV-B EXPOSURE 未知
公开(公告)号：AU2021103279A4
公开(公告)日：2021-07-29
申请号：AU2021103279
申请日：2021-06-10
申请人： HUI PALLABI KALITA , TAG HUI , DUTTA DEBJIT , DAS SANJIB KUMAR
发明人： HUI PALLABI KALITA , TAG HUI , DUTTA DEBJIT , DAS SANJIB KUMAR
IPC分类号： C07D311/62 , A01N35/06 , A01N65/08 , A61K36/78
摘要： Present invention provides a process of extraction, isolation of bioactive compound "quercetin" from the UV-B irradiated methanolic extract of plant source (Houttuynia cordata) and subsequent characterization for the first time. The quercetin isolated from the said methanolic extract of UV-B irradiated plant material shows an improved yield of 70.2% which is significantly higher than that when compared with the conventional process involving non UV irradiated plant material. Selective UV-B radiation exposure for short duration of 6 hrs to 24 hrs in an enclosed UV-B closed chamber is critical. For Non UV Irradiation For UV Irradiation Powdered Sample PowderedSample Preparation of UV irradiation of powdered sample Methanolic Extract Isolation of quercetin 612hr 18hr Preparation Preparation Preparation of Methanolic of Methanolic of Methanolic Extract Extract Extract Yield of Preparation quercetin _of Methanolic Isolation of quercetin Extract Isolation of quercetin Isolation of quercetin Isolation of quercetin Yieldof Yieldof Yieldof Yield of quercetin quercetin quercetin quercetin

5. 发明专利

AT465205T 未知
公开(公告)号：AT465205T
公开(公告)日：2010-05-15
申请号：AT09004686
申请日：2006-12-01
申请人： NITTO DENKO CORP
发明人： YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , FENG ZHONGLING , FU XIAOLI , WANG XINGHE
IPC分类号： C08G69/10
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

6. 发明专利

CA2676912A1 MULTI-FUNCTIONAL DRUG CARRIERS 未知
公开(公告)号：CA2676912A1
公开(公告)日：2008-08-07
申请号：CA2676912
申请日：2008-01-25
申请人： NITTO DENKO CORP
发明人： VAN SANG , FU XIAOLI , JIN YI , CHEN FU , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
摘要： Various biodegradable polyglutamate-amino acids comprising recurring unit s of the general formulae (I) and (II) are prepared. Such polymers are usefu l for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.

7. 发明专利

ES2395461T3 Conjugados de aminoácidos-poliglutamato y métodos 未知
公开(公告)号：ES2395461T3
公开(公告)日：2013-02-12
申请号：ES10004160
申请日：2006-12-01
申请人： NITTO DENKO CORP
发明人： YU LEI , ZHAO GANG , VAN SANG , FENG ZHONGLING , FU XIAOLI , DAS SANJIB KUMAR , WANG XINGHE
IPC分类号： C08G69/10
摘要： Un polímero conjugado que comprende una unidad recurrente de la fórmula (I) y una unidad recurrente dela fórmula (II):en dondecada n es 2,cada A1 es oxígeno o NR5,cada A2 es oxígeno,R1 y R2 son seleccionados cada uno independientemente del grupo que consta de un metal alcalino, unligando polidentado, y un compuesto que comprende un agente;donde el agente es seleccionado entre el grupo constituido por un fármaco anticanceroso, un agente deimagen de resonancia magnética;en donde al menos uno de R1 y R2 es un grupo que comprende un agente;R3 y R4 son seleccionados cada uno independientemente del grupo constituido por hidrógeno, amonio, y unmetal alcalino;donde el polímero conjugado comprende una cantidad del agente en el intervalo de aproximadamente 1 aaproximadamente 50% (peso/peso) basado en la relación de masa del agente al de polímero conjugado;R5 es hidrógeno o alquilo C1-4; ydonde la cantidad del agente, el porcentaje de la unidad recurrente de fórmula (1) y el porcentaje de launidad recurrente de fórmula (II) se seleccionan para proporcionar una solubilidad del polímero conjugadoque es mayor que la de un conjugado de ácido poliglutámico comparable que comprende sustancialmentela misma cantidad del agente, la solubilidad del polímero conjugado es mayor cuando una soluciónanalizada de polímero conjugado, que comprende al menos 5 mg/ml de polímero conjugado en soluciónacuosa 0,9% en peso NaCl a aproximadamente 22ºC, tiene mayor claridad óptica en un intervalo de pHmás amplio que la de una solución analizada de conjugado de ácido poliglutámico .

8. 发明专利

AU2006322254B2 Polyglutamate-amino acid conjugates and methods 未知
公开(公告)号：AU2006322254B2
公开(公告)日：2012-08-02
申请号：AU2006322254
申请日：2006-12-01
申请人： NITTO DENKO CORP
发明人： YU LEI , ZHAO GANG , VAN SANG , FENG ZHONGLING , FU XIAOLI , DAS SANJIB KUMAR , WANG XINGHE
IPC分类号： C08G69/10
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

9. 发明专利

BRPI0619436A2 未知
公开(公告)号：BRPI0619436A2
公开(公告)日：2011-10-04
申请号：BRPI0619436
申请日：2006-12-01
申请人： NITTO DENKO CORP
发明人： YU LEI , ZHAO GANG , VAN SANG , FENG ZHONGLING , FU XIAOLI , DAS SANJIB KUMAR , WANG XINGHE
IPC分类号： C08G69/10
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

10. 发明专利

DK1969031T3 未知
公开(公告)号：DK1969031T3
公开(公告)日：2009-09-14
申请号：DK06838728
申请日：2006-12-01
申请人： NITTO DENKO CORP
发明人： YU LEI , ZHAO GANG , VAN SANG , FENG ZHONGLING , WANG XINGHE , DAS SANJIB KUMAR , FU XIAOLI
IPC分类号： C08G69/10
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

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