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1. 发明申请

WO2009036368A2 DRUG CARRIERS 审中-公开
标题翻译：药物载体
公开(公告)号：WO2009036368A2
公开(公告)日：2009-03-19
申请号：PCT/US2008076287
申请日：2008-09-12
申请人： NITTO DENKO CORP , YU LEI , LIU JIAN , ZHAO GANG , MA NIANCHUN , VAN SANG
发明人： YU LEI , LIU JIAN , ZHAO GANG , MA NIANCHUN , VAN SANG
CPC分类号： A61K31/337 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K47/6455
摘要： Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：本文公开了可包含阳离子聚合物载体，靶向剂和治疗剂的组合物。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

2. 发明申请

WO2008124735A3 MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS 审中-公开
标题翻译：多官能聚氨基甲酸酯药物载体
公开(公告)号：WO2008124735A3
公开(公告)日：2009-05-14
申请号：PCT/US2008059677
申请日：2008-04-08
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , VAN SANG
发明人： YU LEI , ZHAO GANG , VAN SANG
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/14 , A61P35/00
CPC分类号： A61K49/146 , A61K47/60 , A61K47/62 , A61K47/645 , A61K49/0002 , A61K49/085
摘要： Various biodegradable polyglutamate polymer conjugates that can include recurring units of the general formulae (I) and (II) are described herein. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：本文描述了可包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸酯聚合物缀合物。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

3. 发明申请

WO2008141107A2 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
标题翻译：包含疏水化合物和聚氨基酸共混物的组合物
公开(公告)号：WO2008141107A2
公开(公告)日：2008-11-20
申请号：PCT/US2008063114
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
发明人： VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译：制备包括疏水化合物和聚氨基酸缀合物的各种组合物。本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。

4. 发明申请

WO2010045370A2 METHOD OF PREPARING POLYGLUTAMATE CONJUGATES 审中-公开
标题翻译：制备聚谷氨酸盐结合物的方法
公开(公告)号：WO2010045370A2
公开(公告)日：2010-04-22
申请号：PCT/US2009060694
申请日：2009-10-14
申请人： NITTO DENKO CORP , VAN SANG , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
发明人： VAN SANG , DAS SANJIB KUMAR , ZHAO GANG , YU LEI
IPC分类号： A61K47/48
CPC分类号： A61K47/645
摘要： Methods for preparing and isolating polymer conjugates that include a recurring unit of Formulae (I) and (Ia) are described herein. The polymer conjugates can include an anti¬ cancer drug.
摘要翻译：本文描述了制备和分离包含式（I）和（Ia）的重复单元的聚合物缀合物的方法。聚合物缀合物可以包括抗癌药物。

5. 发明申请

WO2008141107A3 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
标题翻译：包含疏水化合物和聚氨基酸共混物的组合物
公开(公告)号：WO2008141107A3
公开(公告)日：2009-04-23
申请号：PCT/US2008063114
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
发明人： VAN SANG , SONG YUCHENG , WANG XINGHE , HOU ZHENG , FENG ZHONGLING , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications. The inventors have discovered novel compositions that include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. In some embodiments, the polymers and the resulting conjugates preferentially accumulate in certain tissues (e.g. tumor tissues) and/or certain receptors, and thus are useful for delivering drugs (e.g., anticancer drugs) and/or imaging agents to specific parts of the body (e.g., tumors). In some embodiments, the polymers described herein and the resulting conjugates can form nanoparticles that effectively solubilize the drug in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the drug.
摘要翻译：制备包括疏水化合物和聚氨基酸缀合物的各种组合物。本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。发明人已经发现了包括聚合物缀合物，第一疏水性药物和第二疏水性药物的新型组合物。本文所述组合物的聚合物缀合物能够与许多试剂（例如成像剂，靶向剂，稳定剂和/或药物）共轭。在一些实施方案中，聚合物和所得的缀合物优先积聚在某些组织（例如肿瘤组织）和/或某些受体中，因此可用于将药物（例如抗癌药物）和/或成像剂递送至身体的特定部位（例如肿瘤）。在一些实施方案中，本文所述的聚合物和所得的共轭物可以形成纳米颗粒，其通过将其分散在分子水平上来有效地将药物溶解在水性体系中，从而增加药物的功能性和/或生物利用度。

6. 发明申请

WO2008141111A2 POLYMERS CONJUGATED WITH PLATINUM DRUGS 审中-公开
标题翻译：聚合物与白蛋白混合
公开(公告)号：WO2008141111A2
公开(公告)日：2008-11-20
申请号：PCT/US2008063128
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , ZHAO GANG , YU LEI
发明人： VAN SANG , ZHAO GANG , YU LEI
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/0056 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biocompatible polymers having platinum compounds conjugated thereto are prepared. Such polymers are useful for a variety of drug, biomolecule, and imaging agent delivery applications. Also disclosed are methods of using the polymers to treat, diagnose, and/or image a subject.
摘要翻译：制备了具有与其结合的铂化合物的各种生物相容性聚合物。这样的聚合物可用于各种药物，生物分子和成像剂递送应用。还公开了使用聚合物来治疗，诊断和/或成像受试者的方法。

7. 发明申请

WO2008141110A3 POLYGLUTAMATE CONJUGATES AND POLYGLUTAMATE-AMINO ACID CONJUGATES HAVING A PLURALITY OF DRUGS 审中-公开
标题翻译：聚氨基酸结合物和具有多种药物的聚谷氨酸 - 氨基酸结合物
公开(公告)号：WO2008141110A3
公开(公告)日：2009-06-04
申请号：PCT/US2008063126
申请日：2008-05-08
申请人： NITTO DENKO CORP , VAN SANG , YU LEI , ZHAO GANG
发明人： VAN SANG , YU LEI , ZHAO GANG
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/12 , A61P35/00
CPC分类号： A61K49/146 , A61K47/645 , A61K49/0056 , A61K49/085
摘要： Various biodegradable polyglutamate conjugates comprising recurring units of the general formulae (I), (II), (III), (IV), (V), and/or (VI) are prepared. The polymers are conjugated with a plurality of drugs. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I），（II），（III），（IV），（V）和/或（VI）的重复单元的各种可生物降解的聚谷氨酸共轭物。聚合物与多种药物缀合。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

8. 发明申请

WO2008094834A2 MULTI-FUNCTIONAL DRUG CARRIERS 审中-公开
标题翻译：多功能药物载体
公开(公告)号：WO2008094834A2
公开(公告)日：2008-08-07
申请号：PCT/US2008052094
申请日：2008-01-25
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , CHEN FU , JIN YI , FU XIAOLI
发明人： YU LEI , ZHAO GANG , VAN SANG , DAS SANJIB KUMAR , CHEN FU , JIN YI , FU XIAOLI
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这样的聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。

9. 发明申请

WO2005085458A2 COMPOSITIONS AND METHODS FOR BIODEGRADABLE POLYMER-PEPTIDE MEDIATED TRANSFECTION 审中-公开
标题翻译：可生物降解聚合物介导转运的组合物和方法
公开(公告)号：WO2005085458A2
公开(公告)日：2005-09-15
申请号：PCT/US2005005858
申请日：2005-02-24
申请人： NITTO DENKO CORP , VAN SANG , VIROONCHATAPAN NITNARA , JI SHOUPING , MATSUMOTO KENJI , YU LEI
发明人： VAN SANG , VIROONCHATAPAN NITNARA , JI SHOUPING , MATSUMOTO KENJI , YU LEI
IPC分类号： A61K47/48 , A61K48/00 , C08L59/00 , C12N15/87
CPC分类号： C08L59/00 , A61K47/59 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
摘要翻译：公开了多核苷酸和可生物降解的聚缩醛肽的组合的复合物。所公开的复合物可用于细胞转染。

10. 发明申请

WO2006124205A2 HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF 审中-公开
标题翻译：具有辅助功能组的亲水聚合物及其方法
公开(公告)号：WO2006124205A2
公开(公告)日：2006-11-23
申请号：PCT/US2006015447
申请日：2006-04-24
申请人： NITTO DENKO CORP , VAN SANG , YU LEI
发明人： VAN SANG , YU LEI
CPC分类号： C08G69/26 , A61K47/595 , A61K47/60 , C08G69/02
摘要： A polymer comprising a recurring unit of the formula (I) as defined herein is described. In the formula (I), X is selected from the group consisting of -(CH2CH2O)m-CH2CH2- and -CH2CH2CH2O-(CH2CH2O)m-CH2CH2CH2-, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of -C*HCH2-, -C*HCH2CH2-, -C*H-NHC(=O)-CH2CH2-, -C*H-NHC(=O)-CH2CH2CH2-, -CH2CH2N*CH2CH2-, -CH2CH2CH2N* CH2CH2CH2-, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of -NHR1, -NH-C(=O)-(CH2)nC(=O)NR1R2, -NH-C(=O)-(CH2)nC(=O)OR1, -(CH2)nC(=O)NR1R2, -(CH2)nC(=O)OR1, -(CH2)nC(=O)SR1, and -(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.
摘要翻译：描述了包含如本文所定义的式（I）的重复单元的聚合物。在式（I）中，X选自 - （CH 2 CH 2 O）m -CH 2 CH 2 - 和-CH 2 CH 2 CH 2 O-（CH 2 CH 2 O）m -CH 2 CH 2 CH 2 - ，其中m是1至100的整数; Y选自-C * HCH 2 - ， - C * HCH 2 CH 2 - ， - C * H-NHC（= O）-CH 2 CH 2 - ， - C * H-NHC（= O）-CH 2 CH 2 CH 2 - ， - CH 2 CH 2 N * CH 2 CH 2 - ， - CH 2 CH 2 CH 2 N * CH 2 CH 2 CH 2 - ，C 2至C 20烷基和C 6至C 20芳基，其中C *和N *表示与Z键合的原子; 并且Z选自-NHR1，-NH-C（= O） - （CH2）nC（= O）NR1R2，-NH-C（= O） - （CH2）nC（= O）OR1， - （CH2）nC（= O）NR1R2， - （CH2）nC（= O）OR1， - （CH2）nC（= O）SR1和 - （CH2）nNR1R2，其中n是1 3，其中R1和R2各自独立地选自氢，C1至C20烷基，C6至C20芳基，抗癌药物，肽，抗体片段，乳糖，半乳糖，甘露糖，转铁蛋白，磁共振成像剂，琥珀酰基，和碱金属。

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