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1. 发明授权

US5633496A Mass spectrometry apparatus 失效
标题翻译：质谱仪
公开(公告)号：US5633496A
公开(公告)日：1997-05-27
申请号：US405767
申请日：1995-03-17
申请人： Minoru Sakairi , Tadao Mimura , Yoichi Ose , Atsumu Hirabayashi , Yasuaki Takada
发明人： Minoru Sakairi , Tadao Mimura , Yoichi Ose , Atsumu Hirabayashi , Yasuaki Takada
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/06 , B01D59/44 , H01J49/00
CPC分类号： H01J49/067 , G01N30/7233
摘要： A mass spectrometry apparatus which includes an ion source which ionizes a sample under atmospheric pressure and outputs the ionized sample, a differential pumping region, provided with apertures, for receiving under vacuum ions in the ionized sample from the ion source and outputting the ions and an ion accelerating and focusing region, having a plurality of ion accelerating electrodes each having applied thereto a voltage, for accelerating and focusing under vacuum the ions from the differential pumping region. The ions from the accelerating and focusing region are introduced under vacuum to a mass spectrometer which detects and analyzes the ions.
摘要翻译：一种质谱装置，其包括离子源，所述离子源在大气压下离子化样品并输出所述离子化样品，具有孔的差分泵浦区，用于在离子源的离子化样品中的真空离子下接收并输出离子，离子加速和聚焦区域，具有多个离子加速电极，每个离子加速电极都施加有电压，用于在真空下加速和聚焦来自差动泵浦区域的离子。来自加速和聚焦区域的离子被真空引入到检测和分析离子的质谱仪中。

2. 发明授权

US6157030A Ion trap mass spectrometer 有权
标题翻译：离子阱质谱仪
公开(公告)号：US6157030A
公开(公告)日：2000-12-05
申请号：US143398
申请日：1998-08-28
申请人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
发明人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
IPC分类号： H01J49/42
CPC分类号： H01J49/424
摘要： Disclosed is an ion trap mass spectrometer improved to obtain a high sensitivity without the lowering of resolution. By fitting a mesh electrode to an aperture (an ion sampling aperture or an ion extracting aperture) made in endcap electrodes constituting an ion trap mass analysis region, a radio frequency electric field in the mass analysis region is not disturbed even if the diameter of the aperture is set to a large value to heighten ion transmission efficiency. By fitting a shield electrode for preventing collision of ions with an insulated ring constituting an outer wall of the mass analysis region, charging up of the insulated ring is prevented to improve stability of detection signals. Furthermore, by arranging a shield member for shielding stray charged particles detouring through the circumference of the mass analysis region to approach an ion detector, generation of noises based on these stray charged particles is prevented.
摘要翻译：公开了一种改进的离子阱质谱仪，可以在不降低分辨率的情况下获得高灵敏度。通过将网状电极装配到构成离子阱质量分析区域的端盖电极中的孔（离子取样孔或离子提取孔）上，即使直径为孔径被设定为大的值以提高离子传输效率。通过安装用于防止离子与构成质量分析区域的外壁的绝缘环碰撞的屏蔽电极，防止了绝缘环的充电以提高检测信号的稳定性。此外，通过设置用于屏蔽通过质量分析区域的圆周去除杂散带电粒子的屏蔽构件以接近离子检测器，防止了基于这些杂散带电粒子的噪声的产生。

3. 发明授权

US5663560A Method and apparatus for mass analysis of solution sample 失效
标题翻译：溶液样品质量分析方法和装置
公开(公告)号：US5663560A
公开(公告)日：1997-09-02
申请号：US555192
申请日：1995-11-08
申请人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： H01J49/04 , H01J49/06 , H01J49/40
CPC分类号： H01J49/044 , H01J49/061
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译：将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。

4. 发明授权

US6005245A Method and apparatus for ionizing a sample under atmospheric pressure and selectively introducing ions into a mass analysis region 失效
标题翻译：用于在大气压下电离样品并选择性地将离子引入质量分析区域的方法和装置
公开(公告)号：US6005245A
公开(公告)日：1999-12-21
申请号：US919785
申请日：1997-08-29
申请人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： H01J49/04 , H01J49/06
CPC分类号： H01J49/061 , H01J49/044
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译：将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。

5. 发明授权

US5532483A Mass spectrometer and ion source 失效
标题翻译：质谱仪和离子源
公开(公告)号：US5532483A
公开(公告)日：1996-07-02
申请号：US403980
申请日：1995-03-15
申请人： Yoichi Ose , Kiyomi Yoshinari , Masayoshi Yano , Tadao Mimura
发明人： Yoichi Ose , Kiyomi Yoshinari , Masayoshi Yano , Tadao Mimura
IPC分类号： H01J49/06 , H01J49/10
CPC分类号： H01J49/10 , H01J49/06
摘要： An ion beam having a good converging property and a good quality is provided by satisfying the limitations controlling both angle of dispersion and the width of beam at the same time. The voltage 12d of a repeller electrode 1f in an ion source of electron bombardment type is input to an ion source state monitor 11 and the ion source state monitor 11 output a predicted value 12e of the voltage applied to an extractor electrode 1g to an extractor power source 9. As for the extractor electrode system, the width of a slit in the acceleration electrode 1b is made larger than the width of a slit of the extractor electrode 1g, and the extractor electrode 1g is set in a position apart from the acceleration electrode 1b by the distance nearly equal to the distance between the acceleration electrode 1b and the ion generating region 2a. By doing so, the electric field leaked from the slit of the acceleration electrode 1b to the inside of the ionization chamber 1a expands to the vicinity of the ion generating region. As the result, the ion beam 2 is effectively extracted to pass through the slits in the acceleration electrode 1b and the extractor 1g. The amount of the current passing through the slits is measured with an ion current monitor 8a and the voltage 12f of a converging electrode 1d is adjusted so that the value of the current becomes the maximum.
摘要翻译：通过满足同时控制分散角和宽度的限制来提供具有良好的会聚特性和良好质量的离子束。电子轰击型离子源中的斥极电极1f的电压12d被输入到离子源状态监视器11，离子源状态监视器11将施加到抽出电极1g的电压的预测值12e输出到提取电力对于提取器电极系统，使加速电极1b中的狭缝的宽度大于提取电极1g的狭缝的宽度，并且将提取电极1g设置在离开加速电极1的位置 1b的距离几乎等于加速电极1b和离子产生区域2a之间的距离。通过这样做，从加速电极1b的狭缝向电离室1a的内部泄漏的电场扩大到离子产生区域附近。结果，有效地提取离子束2以通过加速电极1b和提取器1g中的狭缝。通过离子电流监视器8a测量通过狭缝的电流量，调节会聚电极1d的电压12f，使得电流值变为最大值。

6. 发明授权

US06683303B2 Ion trap mass spectrometer and spectrometry 失效
标题翻译：离子阱质谱仪和光谱仪
公开(公告)号：US06683303B2
公开(公告)日：2004-01-27
申请号：US10087743
申请日：2002-03-05
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/0063
摘要： An ion trap mass spectrometer and spectrometry capable of dissociating ions to be dissociated efficiently regardless of ionic species without useless time and performing high-sensitive MS/MS spectrometry, lengthens a period for applying a CID voltage in accordance with a mass number or characteristics of ions to be dissociated in proportion to a mass-to-charge ratio of ions to be dissociated to thereby optimize the application period of the supplementary AC voltage applied in superposition manner in order to dissociate specific ionic species, so that ions to be dissociated are dissociated efficiently and high-sensitive analysis of dissociated ions can be attained without useless time.
摘要翻译：离子阱质谱仪和光谱测定能够离子离子有效解离而无需离子物质无需时间，并进行高灵敏度的MS / MS光谱测定，延长了根据离子的质量数或特征施加CID电压的时间要与待离解的离子的质荷比成比例地离解，从而优化以叠加方式施加的辅助AC电压的施加周期，以便解离特定的离子物质，使得要解离的离子有效解离并且可以在没有无用的时间的情况下获得离解离子的高灵敏度分析。

7. 发明授权

US5789746A Liquid chromatograph mass spectrometry and liquid chromatograph mass spectrometer 失效
标题翻译：液相色谱质谱和液相色谱质谱仪
公开(公告)号：US5789746A
公开(公告)日：1998-08-04
申请号：US886465
申请日：1997-07-01
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： G01N27/62 , G01N30/62 , G01N30/72 , G01N30/74 , G01N30/78 , G01N30/86 , H01J49/04 , H01J49/26 , H01J49/00
CPC分类号： G01N30/7233 , G01N2030/625 , G01N30/74
摘要： An eluant is supplied to an analyzer column, a sample solution is supplied through a sample inlet. The analyzer column separates the components of the sample solution. The separated components are eluted by the analyzer column, the eluted components are detected by an eluted component detector, the results of detection provided by the eluted component detector is processed by a data processor to produce a liquid chromatogram having peaks indicating the components of the sample. The components of the sample is supplied through a capillary pipe to an ion source and the ion source ionizes the components of the sample. A mass spectrometer subjects the ions produced by the ion source to mass analysis, an ion detector detects the ions included in a mass spectrum to produce an ion chromatogram having peaks. A time difference between the chromatograms is determined beforehand through an experiment using a standard sample, and the liquid chromatogram is shifted on its time axis by the time difference.
摘要翻译：将洗脱液供应到分析器柱，通过样品入口提供样品溶液。分析仪柱分离样品溶液的组分。分离的组分被分析器柱洗脱，洗脱组分由洗脱组分检测器检测，由洗脱组分检测器提供的检测结果由数据处理器处理，以产生具有表示样品成分的峰的液相色谱图。样品的组分通过毛细管供给到离子源，离子源将样品的组分电离。质谱仪将由离子源产生的离子进行质量分析，离子检测器检测质谱中包含的离子，产生具有峰值的离子色谱图。通过使用标准样品的实验预先确定色谱图之间的时间差，并且液相色谱在其时间轴上偏移时间差。

8. 发明授权

US06759652B2 Ion trap mass analyzing apparatus 有权
标题翻译：离子阱质量分析仪
公开(公告)号：US06759652B2
公开(公告)日：2004-07-06
申请号：US10252699
申请日：2002-09-24
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译：一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。

9. 发明授权

US5986260A Mass analyzer 失效
标题翻译：质量分析仪
公开(公告)号：US5986260A
公开(公告)日：1999-11-16
申请号：US921365
申请日：1997-08-29
申请人： Mitsuru Oonuma , Seiji Kamimura , Tadao Mimura
发明人： Mitsuru Oonuma , Seiji Kamimura , Tadao Mimura
IPC分类号： H01J49/04
CPC分类号： H01J49/04
摘要： A mass analyzer comprising a sample preparation mechanism for preliminarily preparing an analyzing sample, an interface mechanism for preparing the sample into ions after the required preliminary preparation, an ion trapping part and analyzing part for analyzing the ions, and a controller. The ion trapping part and analyzing part is placed in a box portion of the body, while the interface mechanism is arranged on the front top of the box portion of the body. When the cover at the front top is removed, the front, top and right side of the interface mechanism are opened.
摘要翻译：一种质量分析器，包括用于预先制备分析样品的样品制备机构，用于在所需预备制剂之后将样品制备成离子的界面机构，离子捕获部分和用于分析离子的分析部分以及控制器。离子捕获部分和分析部分被放置在主体的盒部分中，而界面机构布置在主体的盒部分的前顶部。拆下前盖的盖子后，打开接口机构的前，右，右侧。

10. 发明授权

US5612534A Atmospheric pressure ionization mass spectrometer 失效
标题翻译：大气压电离质谱仪
公开(公告)号：US5612534A
公开(公告)日：1997-03-18
申请号：US689952
申请日：1996-08-16
申请人： Tadao Mimura , Masayoshi Yano
发明人： Tadao Mimura , Masayoshi Yano
IPC分类号： G01N27/62 , H01J49/04 , H01J49/10
CPC分类号： H01J49/0422
摘要： An atmospheric pressure ionization spectrometer capable for continuously detecting impurities included in air or gas can be realized. The air or gas is stored in a daily storage such as a bag, a package, a pocket or the like. An air suction probe is connected to an ion source through an insulation pipe, and the ion source is connected to an air exhaust pump through an exhaust port and an insulation pipe. The ion source has a needle electrode, a first small hole electrode, an intermediate pressure portion and a second small hole electrode, and the needle electrode is connected to a power source, and the first and second small hole electrodes are connected to an ion accelerating power source. The intermediate pressure portion is connected to a vacuum pump through the exhaust port. An electrostatic lens is disposed in the stage following the intermediate pressure portion, and a mass spectrometric portion and a detector are disposed in the stage following the electrostatic lens. A detection signal from the detector is supplied to a data processing portion through an amplifier. The data processing portion determines a plurality of M/Z values indicating a special drug to thereby determine whether or not the special drug is included in the sample gas.
摘要翻译：可以实现能够连续检测包含在空气或气体中的杂质的大气压电离光谱仪。空气或气体储存在诸如袋子，包装，口袋等的日常存储器中。吸气探头通过绝缘管连接到离子源，离子源通过排气口和绝缘管连接到排气泵。离子源具有针状电极，第一小孔电极，中间压力部和第二小孔电极，针状电极与电源连接，第一和第二小孔电极与加速离子能量源。中间压力部分通过排气口连接到真空泵。静电透镜设置在跟随中间压力部分的阶段中，并且质谱部分和检测器设置在跟随静电透镜的阶段中。来自检测器的检测信号通过放大器提供给数据处理部分。数据处理部分确定指示特殊药物的多个M / Z值，从而确定样品气体中是否包含特殊药物。

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