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1. 发明授权

US06572813B1 Balloon forming process 有权
标题翻译：气球成型工艺
公开(公告)号：US06572813B1
公开(公告)日：2003-06-03
申请号：US09483390
申请日：2000-01-13
申请人： Michael Y. Zhang , Kerry J. Williams , Johann J. Skinner , Chicheng Wang
发明人： Michael Y. Zhang , Kerry J. Williams , Johann J. Skinner , Chicheng Wang
IPC分类号： B29C4964
CPC分类号： A61M25/1029 , B29C35/045 , B29C49/6472 , B29C55/24 , B29C67/0014 , B29C2049/0089 , B29K2105/258 , B29L2031/7542 , Y10S264/903 , Y10S264/904
摘要： The present invention is directed to apparatus and method for forming balloons with improved dimensional stability and balloons formed by the same. The method of the present invention provides for a very accurate control of the temperature profile of the balloon material during its making. The attributes of the balloon can be affected by how the balloon is treated during the blowing stage and after the initial blowing, i.e., heat-setting. Using the present method, the balloon will form more uniformly and evenly (e.g., wall thickness and outer diameter of the balloon). The present method significantly increases the dimensional stability of the balloon which provides a balloon that is more predictable, in use. The present heat-set process also provides the means for the working length to be located more accurately on dilation catheters and stent delivery systems.
摘要翻译：本发明涉及用于形成具有改善的尺寸稳定性的球囊的装置和方法以及由其形成的球囊。本发明的方法提供了气球材料在其制造期间的温度分布的非常精确的控制。气球的属性可以受到在吹塑阶段和初始吹塑之后气球如何处理，即热定形的影响。使用本方法，气球将更均匀和均匀地形成（例如，球囊的壁厚和外径）。本方法显着增加了气囊的尺寸稳定性，其提供了在使用中更可预测的气球。本发明的热定形方法还提供了将工作长度更准确地定位在扩张导管和支架输送系统上的手段。

2. 发明授权

US06702834B1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US06702834B1
公开(公告)日：2004-03-09
申请号：US09727102
申请日：2000-11-28
申请人： John F. Boylan , William J. Boyle , Andy E. Denison , Debashis Dutta , Benjamin C. Huter , Scott J. Huter , Paul F. Muller , Samir Patel , Christopher J. Tarapata , Chicheng Wang , Francisco Sanchez , Kent C. B. Stalker
发明人： John F. Boylan , William J. Boyle , Andy E. Denison , Debashis Dutta , Benjamin C. Huter , Scott J. Huter , Paul F. Muller , Samir Patel , Christopher J. Tarapata , Chicheng Wang , Francisco Sanchez , Kent C. B. Stalker
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

3. 发明授权

US06290722B1 Tacky attachment method of covered materials on stents 有权
标题翻译：支架上覆盖材料的粘性附着方法
公开(公告)号：US06290722B1
公开(公告)日：2001-09-18
申请号：US09523635
申请日：2000-03-13
申请人： Chicheng Wang
发明人： Chicheng Wang
IPC分类号： A61F204
CPC分类号： A61F2/92 , A61F2210/0076 , A61F2250/0067
摘要： The present invention includes a stent. The stent comprises a structural support and a polymeric film or sheet or tube that overlays the structural support. The stent also includes a tacky portion that adheres the polymeric film or sheet or tube to the structural support. The tacky portion comprises sugar or starch or polyvinylalcohol or degradation products of these materials.
摘要翻译：本发明包括支架。支架包括结构支撑件和覆盖结构支撑件的聚合物膜或片或管。支架还包括将聚合物膜或片或管粘合到结构支撑件上的粘性部分。粘性部分包括糖或淀粉或聚乙烯醇或这些材料的降解产物。

4. 发明授权

US06800089B1 Mechanical attachment method of cover materials on stents 有权
标题翻译：支架上覆盖材料的机械附着方法
公开(公告)号：US06800089B1
公开(公告)日：2004-10-05
申请号：US09583263
申请日：2000-05-31
申请人： Chicheng Wang
发明人： Chicheng Wang
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/915 , A61F2002/075
摘要： The present invention relates to a stent comprising a structural support and a polymeric film or sheet or tube. The structural support comprises an outer surface that is roughened patterned. The polymeric film or sheet or tube is retained to the structural support by the roughened or patterned outer surface of the structural support.
摘要翻译：本发明涉及包括结构支架和聚合物膜或片或管的支架。结构支撑件包括粗糙化或图案化的外表面。聚合物膜或片或管通过结构支撑体的粗糙化或图案化外表面保持在结构支撑体上。

5. 发明授权

US06761732B2 Catheter apparatus for treating occluded vessels and filtering embolic debris and method of use 有权
标题翻译：用于治疗闭塞血管和过滤栓塞性碎屑的导管装置及其使用方法
公开(公告)号：US06761732B2
公开(公告)日：2004-07-13
申请号：US10259920
申请日：2002-09-27
申请人： David H. Burkett , Arkady Kokish , Chicheng Wang
发明人： David H. Burkett , Arkady Kokish , Chicheng Wang
IPC分类号： A61F206
CPC分类号： A61F2/958 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/008
摘要： A catheter apparatus includes a lesion dilating member disposable at a lesion position in a vessel (e.g. a patient's artery) which is dilatable to open the vessel at the lesion position. An emboli-capturing assembly having a perfusion member and filter is displaced downstream from the lesion dilating member to capture embolic debris released in the fluid flow. The perfusion member may illustratively have peaks and channels formed between adjacent peaks which cooperate with the filter to create trapping pockets that capture embolic debris. The filter may be made from any flexible and porous material with dimensions to pass the fluid and block the emboli. The perfusion member is thereafter deflated to provide for emboli retention in the perfusion member.
摘要翻译：导管装置包括在容器（例如患者的动脉）中的损伤位置处一次性的病变扩张构件，其可扩张以在病变位置打开血管。具有灌注构件和过滤器的栓塞捕获组件从病变扩张构件的下游位移，以捕获在流体流中释放的栓塞碎片。灌注构件可以示例性地具有在相邻峰之间形成的峰和通道，其与过滤器配合以产生捕获栓塞碎片的捕集袋。过滤器可以由具有尺寸的任何柔性和多孔材料制成以通过流体并阻塞栓塞。然后灌注构件放气以提供灌注构件中的栓塞保留。

6. 发明授权

US06695813B1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US06695813B1
公开(公告)日：2004-02-24
申请号：US09476159
申请日：1999-12-30
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device includes a filtering assembly having a self-expanding strut assembly and a filter element. The filtering assembly can be attached to a guidewire and deployed within the patient's vasculature into an area of treatment. A restraining sheath maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Interventional devices can be delivered over the guidewire and any embolic debris created and released into the blood stream will enter the filtering assembly. The filtering assembly can be rotatably mounted on the guide wire and may include a dampening element which helps to prevent some shock force that may be transmitted along the guide to the deployed filtering assembly.
摘要翻译：栓塞保护装置包括具有自扩张支柱组件和过滤元件的过滤组件。过滤组件可以附接到导丝并且部署在患者的脉管系统内进入治疗区域。限制护套将过滤组件保持在其折叠位置，直到其准备好被医生部署为止。介入装置可以通过导线传送，并且产生并释放到血流中的任何栓塞碎片将进入过滤组件。过滤组件可以可旋转地安装在导丝上，并且可以包括阻尼元件，该阻尼元件有助于防止可能沿着引导件传递到部署的过滤组件的一些冲击力。

7. 发明申请

US20070167975A1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US20070167975A1
公开(公告)日：2007-07-19
申请号：US11651667
申请日：2007-01-10
申请人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
发明人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好被医师部署为止。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

8. 发明授权

US06719774B1 Method for forming low profile balloon and low profile balloon for use with a catheter 有权
标题翻译：用于形成用于导管的低轮廓气囊和低轮廓气囊的方法
公开(公告)号：US06719774B1
公开(公告)日：2004-04-13
申请号：US09471199
申请日：1999-12-23
申请人： Chicheng Wang
发明人： Chicheng Wang
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M25/10
摘要： Methods for forming low profile balloons for use with a catheter by providing a polymeric tube, removing material from the outer surface of the polymeric tube around at least one of its end portions, and inflating a region of the polymeric tube between the two end portions to form the balloon. Low profile balloons having end portions with an outer diameter below 30 mils are also disclosed.
摘要翻译：用于通过提供聚合物管形成用于导管的低轮廓气囊的方法，从聚合物管的外表面围绕其至少一个端部移除材料，以及将聚合物管的两个端部之间的区域充气至形成气球还公开了具有外径低于30密耳的端部的低轮廓气囊。

9. 发明授权

US06506202B1 Expandable stent dimensional retention system and method 有权
标题翻译：可扩展支架尺寸保持系统和方法
公开(公告)号：US06506202B1
公开(公告)日：2003-01-14
申请号：US09612855
申请日：2000-07-10
申请人： Debashis Dutta , Chicheng Wang
发明人： Debashis Dutta , Chicheng Wang
IPC分类号： A61M2900
CPC分类号： A61F2/958 , A61F2002/9583 , A61M25/10 , A61M2025/1075
摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of treating an entire affected area in a blood vessel while preventing adverse effects for healthy tissue. The system includes a catheter which is positionable in a blood vessel at the interventional procedure site. The system further includes an expandable interventional instrument such as an expandable stent which is expandable and which may be deployed in the blood vessel at the interventional procedure site, which includes an unexpanded axial dimension. The system also includes an expandable member such as an expandable balloon, for expanding the expandable stent. The expandable balloon is capable of expanding so as to expand and deploy the expandable stent, and to substantially retain the unexpanded axial dimension of the expandable stent. The expansion of the expandable balloon prevents lengthening or shortening of the expandable stent, so as to enable the entire affected lesion area to be covered precisely without affecting the surrounding healthy tissue upon deployment of the expandable stent.
摘要翻译：当在狭窄或闭塞的区域进行介入手术时在血管中使用的系统，其能够治疗血管中的整个受影响区域，同时防止对健康组织的不利影响。该系统包括可在介入手术部位的血管中定位的导管。该系统还包括可扩张的介入器械，例如可扩张的支架，其是可扩张的并且可以在包括未膨胀的轴向尺寸的介入手术部位的血管中展开。该系统还包括可膨胀构件，例如可膨胀气囊，用于扩张可扩张支架。可膨胀气囊能够膨胀以扩张和展开可扩张支架，并且基本上保持可扩张支架的未膨胀的轴向尺寸。可膨胀气囊的膨胀防止了可扩张支架的延长或缩短，从而使整个受影响的损伤区域能够精确地覆盖，而不会在展开支架时展开周围的健康组织。

10. 发明授权

US06447521B1 Foamed inner member cover stent retention and method of use 失效
标题翻译：发泡内部构件覆盖支架保留和使用方法
公开(公告)号：US06447521B1
公开(公告)日：2002-09-10
申请号：US09662551
申请日：2000-09-15
申请人： Steven L. Mouw , Murthy V. Simhambhatla , Chicheng Wang
发明人： Steven L. Mouw , Murthy V. Simhambhatla , Chicheng Wang
IPC分类号： A61F1100
CPC分类号： A61F2/958 , A61F2002/9583
摘要： A catheter system for removably securing a stent which generally includes an inner tubular member and an outer tubular member with an expandable member disposed about the inner tubular member. A foamed cover is disposed between the expandable member and the inner tubular member. An expandable stent is crimped onto the expandable member and is retained in place by compressing the foamed cover. Used with a stent delivery system, the catheter system is inserted into a body lumen such as an artery. The stent is secured in place while advancing the system through tortuous body lumen passages. The stent is advanced to the desired location in the body lumen and implanted by inflating the expandable member and thereby expanding the stent into the body lumen. The stent is released from the system by deflating the expandable member and withdrawing the catheter system from the body.
摘要翻译：一种用于可拆卸地固定支架的导管系统，其通常包括内部管状构件和具有围绕内部管状构件设置的可扩张构件的外部管状构件。泡沫盖布置在可膨胀构件和内管状构件之间。可扩张支架被卷曲到可膨胀构件上并通过压缩发泡盖保持在适当的位置。与支架输送系统一起使用时，将导管系统插入诸如动脉的体腔内。支架固定在适当的位置，同时使系统通过曲折的体腔通道。支架前进到体腔内的所需位置，并且通过使可膨胀构件膨胀并从而将支架扩张到体腔中而植入。支架通过使可膨胀构件放气并将导管系统从身体上取出而从系统释放。

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