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1. 发明授权

US06780361B1 Process of making polymer articles 有权
标题翻译：制造聚合物制品的方法
公开(公告)号：US06780361B1
公开(公告)日：2004-08-24
申请号：US10174073
申请日：2002-06-17
申请人： Srinivasan Sridharan , Murthy V. Simhambhatla
发明人： Srinivasan Sridharan , Murthy V. Simhambhatla
IPC分类号： B29C5504
CPC分类号： B29D7/01 , A61L27/16 , A61L27/507 , A61L27/56 , A61L29/041 , B29C55/005 , B29C55/065 , B29K2023/0683 , B29K2105/0061 , Y10T428/1352 , Y10T428/1372 , C08L23/06
摘要： A method including forming a pseudo-gel of a semi-crystalline polymer material and a solvent. The pseudo-gel is shaped into a first form and stretched. A portion of the solvent is removed to create a second form. The second form is stretched into a microstructure including nodes interconnected by fibrils. A method including forming a first form of a pseudo-gel including an ultra-high molecular weight polyethylene material and a solvent; stretching the first form; removing the solvent to form a second form; stretching the second form into a microstructure including nodes interconnected by fibrils; and annealing the stretched second form. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a polyolefin polymer including a node and a fibril microstructure. An apparatus including a body portion including an ultra-high molecular weight polyolefin material including a node and a fibril microstructure.
摘要翻译：一种包括形成半结晶聚合物材料和溶剂的假凝胶的方法。假凝胶成型为第一种形式并拉伸。除去一部分溶剂以产生第二种形式。第二种形式被拉伸成包括由原纤维相互连接的节点的微结构。一种包括形成包含超高分子量聚乙烯材料和溶剂的第一种形式的假凝胶的方法; 拉伸第一种形式; 除去溶剂以形成第二种形式; 将第二形式拉伸成包括通过纤维互连的节点的微结构; 并退火拉伸的第二种形式。一种装置，包括由适于医疗装置应用的尺寸形成的主体部分，并且包括包含节点和原纤维微结构的聚烯烃聚合物。一种包括主体部分的装置，其包括包含节点和原纤维微结构的超高分子量聚烯烃材料。

2. 发明授权

US06743388B2 Process of making polymer articles 有权
标题翻译：制造聚合物制品的方法
公开(公告)号：US06743388B2
公开(公告)日：2004-06-01
申请号：US10038816
申请日：2001-12-31
申请人： Srinivasan Sridharan , Murthy V. Simhambhatla
发明人： Srinivasan Sridharan , Murthy V. Simhambhatla
IPC分类号： B29C5504
CPC分类号： B29D7/01 , A61L27/16 , A61L27/507 , A61L27/56 , A61L29/041 , B29C55/005 , B29C55/065 , B29K2023/0683 , B29K2105/0061 , Y10T428/1352 , Y10T428/1372 , C08L23/06
摘要： A method including forming a semi-crystalline polymer material into a lamella; and stretching the lamella into a polymer including a node of folded lamella and a fibril orientation. A method including extruding a pseudo-gel including an ultrahigh molecular weight polyethylene material into a lamella; stretching the lamella into a polymer including a node of folded lamella and a fibril orientation; and annealing the polymer at a temperature sufficient to define the node and fibril orientation. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a semi-crystalline polymer arrayed in a node of folded lamella and a fibril orientation. An apparatus including a body portion including an ultra-high molecular polyethylene material arrayed in a node of folded lamella and a fibril orientation.
摘要翻译：一种包括将半结晶聚合物材料形成薄片的方法; 并将薄片拉伸成包括折叠薄片的节点和原纤取向的聚合物。一种包括将包含超高分子量聚乙烯材料的假凝胶挤出到薄片中的方法; 将薄片拉伸成包括折叠薄片的节点和原纤取向的聚合物; 并在足以限定节点和原纤取向的温度下退火聚合物。一种装置，包括由适于医疗装置应用的尺寸形成的主体部分，并且包括排列在折叠薄片的节点和原纤取向中的半结晶聚合物。一种装置，包括主体部分，其包括排列在折叠薄片的节点中的超高分子量聚乙烯材料和原纤取向。

3. 发明授权

US06702744B2 Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery 失效
公开(公告)号：US06702744B2
公开(公告)日：2004-03-09
申请号：US10011071
申请日：2001-11-30
申请人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
发明人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
IPC分类号： A61B812
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/02007 , A61B5/4839 , A61B17/3478 , Y10S977/905 , Y10S977/915
摘要： A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.

4. 发明授权

US06602224B1 Medical device formed of ultrahigh molecular weight polyolefin 有权
标题翻译：由超高分子量聚烯烃形成的医疗器械
公开(公告)号：US06602224B1
公开(公告)日：2003-08-05
申请号：US09713642
申请日：2000-11-14
申请人： Murthy V. Simhambhatla
发明人： Murthy V. Simhambhatla
IPC分类号： A61M2900
CPC分类号： A61L27/16 , A61L29/041 , C08L23/06 , C08L2207/068 , Y10T156/1038 , Y10T428/1352 , Y10T428/139
摘要： Medical devices having at least a component, such as a catheter balloon, stent cover and vascular graft, formed of ultrahigh molecular weight polyolefin, such as ultrahigh molecular weight polyethylene. The device component is formed from ultrahigh molecular weight polyethylene that has been processed so that it is microporous and has an oriented node and fibril structure. The device component expands compliantly at low strains and are substantially less compliant at higher strains. The invention also comprises methods for making such medical devices, including the steps of compacting a polyethylene powder and deforming it to impart the oriented structure.
摘要翻译：至少具有由超高分子量聚烯烃（例如超高分子量聚乙烯）形成的至少一种成分的医疗装置，例如导管球囊，支架盖和血管移植物。该器件组件由超高分子量聚乙烯形成，该聚乙烯已被加工成微孔并具有取向的节点和原纤维结构。器件部件在低应变下易于扩展，并且在较高应变下基本不太顺应。本发明还包括制造这种医疗装置的方法，包括压制聚乙烯粉末并变形以赋予定向结构的步骤。

5. 发明授权

US06336936B2 High pressure catheter balloon 有权
标题翻译：高压导管气囊
公开(公告)号：US06336936B2
公开(公告)日：2002-01-08
申请号：US09880983
申请日：2001-06-13
申请人： Murthy V. Simhambhatla , Venu Ghanta , Timoteo Tomas
发明人： Murthy V. Simhambhatla , Venu Ghanta , Timoteo Tomas
IPC分类号： A61F206
CPC分类号： B29C49/18 , A61L29/06 , A61L29/14 , A61M25/1029 , B29C49/6481 , B29C2049/0089 , B29K2105/258 , B29L2022/022 , B29L2031/7542 , C08L67/02
摘要： A balloon formed of a single layer of polybutylene terephthalate and polytetramethylene ether glycol terephthalate copolymer in a substantially unblended form. The copolymer has a flexural modulus of greater than about 150,000 psi. The presently preferred copolymer is Hytrel® 8238 by DuPont. The balloon of the invention would be substantially unblended, defined as greater than about 60% by weight to about 100% by weight of the copolymer. The balloon is formed in a series of molds. The balloon of the invention exhibits high rupture pressure and low compliance coupled with good lesion cross and recross ability.
摘要翻译：由单层聚对苯二甲酸丁二醇酯和聚四亚甲基醚二醇对苯二甲酸乙二醇酯共聚物形成的气囊，基本上是非混合形式。共聚物的挠曲模量大于约150,000psi。目前优选的共聚物是DuPont的Hytrel 8238。本发明的气囊将基本上未共混，定义为大于约60重量％至约100重量％的共聚物。气球形成一系列模具。本发明的气囊显示出高的破裂压力和低顺应性，同时具有良好的病变交叉和回交能力。

6. 发明授权

US08021678B2 Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics 有权
标题翻译：具有聚合物涂层的植入式医疗装置，其表面积与体积比提供了表面侵蚀特性
公开(公告)号：US08021678B2
公开(公告)日：2011-09-20
申请号：US11351598
申请日：2006-02-10
申请人： Syed Faiyaz Ahmed Hossainy , Stephen D. Pacetti , Murthy V. Simhambhatla
发明人： Syed Faiyaz Ahmed Hossainy , Stephen D. Pacetti , Murthy V. Simhambhatla
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61K31/395 , A61K31/4745 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics.
摘要翻译：本发明涉及可植入医疗装置，其包括使用展示表面侵蚀特征的药物储存层的聚酯涂覆在该装置上的治疗剂。

7. 发明申请

US20090326574A1 DEVICE FOR TREATING VULNERABLE PLAQUE 审中-公开
标题翻译：用于处理易爆液体的装置
公开(公告)号：US20090326574A1
公开(公告)日：2009-12-31
申请号：US12486639
申请日：2009-06-17
申请人： Deborah L. Kilpatrick , Robert D. Ainsworth , Murthy V. Simhambhatla , Jeong S. Lee
发明人： Deborah L. Kilpatrick , Robert D. Ainsworth , Murthy V. Simhambhatla , Jeong S. Lee
IPC分类号： A61B17/22 , A61M29/02
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译：一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。该过程在损伤或破裂部位产生ECM合成的显着增加。因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。本发明的方法特别可用于治疗纤维腺瘤型易损斑块。在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

8. 发明授权

US06972024B1 Method of treating vulnerable plaque 失效
标题翻译：治疗易损斑块的方法
公开(公告)号：US06972024B1
公开(公告)日：2005-12-06
申请号：US10032322
申请日：2001-12-21
申请人： Deborah L. Kilpatrick , Robert D. Ainsworth , Murthy V. Simhambhatla , Jeong S. Lee
发明人： Deborah L. Kilpatrick , Robert D. Ainsworth , Murthy V. Simhambhatla , Jeong S. Lee
IPC分类号： A61F2/06 , A61F2/84 , A61F11/00 , A61M29/00
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译：一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。该过程在损伤或破裂部位产生ECM合成的显着增加。因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。本发明的方法特别可用于治疗纤维腺瘤型易损斑块。在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

9. 发明授权

US06875197B1 Dimensionally stable and growth controlled inflatable member for a catheter 有权
标题翻译：用于导管的尺寸稳定和生长控制的可充气构件
公开(公告)号：US06875197B1
公开(公告)日：2005-04-05
申请号：US09713384
申请日：2000-11-14
申请人： Murthy V. Simhambhatla , Robert P. Saltman
发明人： Murthy V. Simhambhatla , Robert P. Saltman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00 , A61M29/02 , A61M31/00 , A61M37/00
CPC分类号： A61L29/06 , A61M25/1006 , A61M25/1029 , A61M25/104 , A61M2025/1086 , A61M2025/1088
摘要： A dimensionally stable and growth controlled inflatable member formed by adding a multifunctional agent to a soft polymer to form a compound, extruding an inflatable member from the compound, and crosslinking the compound. The inflatable member is configured to be formed-in-place with a body lumen. Preferably, the inflatable member is blown to a working diameter prior to use and then heated to the glass transition temperature of the polymer to shrink the diameter of the blown inflatable member back to about the nominal diameter of the tubing. In another embodiment, the invention is a dimensionally stable and growth controlled inflatable member comprising longitudinal zones of crosslinked material symmetrically spaced about the circumference of the inflatable member and a uniform working diameter. Preferably, there are three or more longitudinal zones that run the working length of the inflatable member. The selectively irradiated inflatable members are formed in a mold having symmetrically spaced longitudinal windows.
摘要翻译：通过向软质聚合物中添加多官能剂以形成化合物，从化合物挤出可膨胀构件，并使化合物交联而形成尺寸稳定和生长控制的可膨胀构件。可膨胀构件构造成与体腔成形就位。优选地，可充气构件在使用之前被吹送到工作直径，然后被加热到聚合物的玻璃化转变温度，以将吹制的可充气构件的直径收缩回到管道的公称直径。在另一个实施方案中，本发明是尺寸稳定和生长控制的可膨胀构件，其包括围绕可膨胀构件的圆周对称地间隔的交联材料的纵向区域和均匀的加工直径。优选地，存在延伸可膨胀构件的工作长度的三个或更多个纵向区域。选择性照射的充气构件形成在具有对称间隔的纵向窗口的模具中。

10. 发明授权

US06620128B1 Balloon blowing process with metered volumetric inflation 有权
标题翻译：气球吹风过程与计量体积膨胀
公开(公告)号：US06620128B1
公开(公告)日：2003-09-16
申请号：US09693063
申请日：2000-10-20
申请人： Murthy V. Simhambhatla
发明人： Murthy V. Simhambhatla
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , B29C2049/4655
摘要： A balloon for a balloon catheter and a method of manufacture The method entails providing a polymeric tubular member having an inner lumen and a longitudinal axis. An incompressible fluid is introduced into the inner lumen at a predetermined volumetric flow rate, expanding the polymeric tubular member to a desired outer diameter. The volumetric flow rate of fluid may be predetermined to not over-inflate the balloon. The balloon is blown slower because no initial pressure need be exceeded, so higher blow up ratios may be achieved without sacrificing any strength of the balloon. The balloons embodying features of the invention have thinner walls, yet maintain the same physical and mechanical properties of a thicker walled balloon manufactured in today's methods. Therefore, the process of the invention will lead to lower profile balloon catheters for balloon catheters with the same outer diameter balloon on them. Alternatively, a balloon with the same wall thickness as a balloon made from standard techniques will yield a much stronger balloon.
摘要翻译：用于气囊导管的球囊和制造方法该方法需要提供具有内腔和纵向轴线的聚合物管状构件。将不可压缩的流体以预定的体积流速引入内腔，将聚合物管状构件膨胀到期望的外径。流体的体积流量可以被预先确定，以使气囊不会过度膨胀。气球被吹得较慢，因为不需要超过初始压力，因此可以在不牺牲球囊的任何强度的情况下实现更高的吹胀比。体现本发明特征的气球具有更薄的壁，但是在当今的方法中制造的较厚壁球囊保持相同的物理和机械性能。因此，本发明的方法将导致用于具有相同外径球囊的球囊导管的下部轮廓导管。或者，具有与由标准技术制成的球囊相同的壁厚的气球将产生更强的气球。

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