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1. 发明授权

US06818437B1 Instrument for monitoring polymerase chain reaction of DNA 有权
标题翻译：监测DNA聚合酶链反应的仪器
公开(公告)号：US06818437B1
公开(公告)日：2004-11-16
申请号：US09700536
申请日：2001-11-29
申请人： Michael R. Gambini , John G. Atwood , Eugene F. Young , Edward J. Lakatos , Anthony L. Cerrone
发明人： Michael R. Gambini , John G. Atwood , Eugene F. Young , Edward J. Lakatos , Anthony L. Cerrone
IPC分类号： C12M134
CPC分类号： G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
摘要： An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
摘要翻译：光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶反应成分，包括在双链DNA存在下发荧光的染料。分束器将激发光束传递到小瓶以使染料发荧光。来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。自动调整曝光时间以保持CCD和处理器的最佳动态范围。分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。

2. 发明授权

US08557566B2 Instrument for monitoring polymerase chain reaction of DNA 有权
公开(公告)号：US08557566B2
公开(公告)日：2013-10-15
申请号：US11333483
申请日：2006-01-17
申请人： Michael R. Gambini , Eugene F. Young , Edward J. Lakatos , Anthony L. Cerrone , Susan Atwood Stone , Judith K. Atwood
发明人： Michael R. Gambini , John G. Atwood , Eugene F. Young , Edward J. Lakatos , Anthony L. Cerrone
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
摘要： An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

3. 发明授权

US08921098B2 Instrument for monitoring DNA replication 有权
标题翻译：用于监测DNA复制的仪器
公开(公告)号：US08921098B2
公开(公告)日：2014-12-30
申请号：US11406148
申请日：2006-04-18
申请人： Michael R. Gambini , Edward J. Lakatos , Anthony L. Cerrone , Eugene F. Young , Susan Atwood Stone , Judith K. Atwood
发明人： Michael R. Gambini , John G. Atwood , Edward J. Lakatos , Anthony L. Cerrone , Eugene F. Young
IPC分类号： C12M1/34 , C12M3/00 , G01N21/27 , B01L7/00 , B01L3/00 , G01N21/64
CPC分类号： G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
摘要： An instrument for monitoring replication of DNA is provided.
摘要翻译：提供了一种用于监测DNA复制的工具。

4. 发明授权

US09671342B2 Instrument for monitoring polymerase chain reaction of DNA 有权
公开(公告)号：US09671342B2
公开(公告)日：2017-06-06
申请号：US11804151
申请日：2007-05-17
申请人： Michael R. Gambini , Edward J. Lakatos , Anthony L. Cerrone , Eugene F. Young , Susan Atwood Stone
发明人： Michael R. Gambini , Edward J. Lakatos , Anthony L. Cerrone , Eugene F. Young , Susan Atwood Stone
IPC分类号： C12M1/34 , C12M3/00 , G01N21/64 , C12Q1/68 , B01L7/00 , G01N21/27 , B01L3/00
CPC分类号： G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/0303 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
摘要： An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

5. 发明授权

US07831012B2 Radiation scanning systems and methods 有权
标题翻译：辐射扫描系统和方法
公开(公告)号：US07831012B2
公开(公告)日：2010-11-09
申请号：US11704905
申请日：2007-02-09
申请人： Andrew D. Foland , Richard Franklin Eilbert , Michael R. Gambini , Boris Oreper , Nikolay Rolshud
发明人： Andrew D. Foland , Richard Franklin Eilbert , Michael R. Gambini , Boris Oreper , Nikolay Rolshud
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： G01N23/04
摘要： An apparatus may comprise a frame supporting at least first and second skewed radiation sources and at least first and second radiation detectors. The first and second radiation detectors may be substantially non-contiguous such that a substantial gap exists between the first and second radiation detectors that is free of any radiation detectors. Each of the first and second radiation detectors may also configured and arranged to detect radiation emitted by each of the first and second skewed radiation sources.
摘要翻译：装置可以包括支撑至少第一和第二偏斜辐射源的框架，以及至少第一和第二辐射检测器。第一和第二辐射检测器可以基本上不连续，使得在没有任何辐射检测器的第一和第二辐射检测器之间存在实质的间隙。第一和第二辐射检测器中的每一个也可以被配置和布置成检测由第一和第二偏斜辐射源中的每一个发射的辐射。

6. 发明授权

US07435602B2 Reducing effects of spectral nonuniformity 有权
标题翻译：降低光谱不均匀的影响
公开(公告)号：US07435602B2
公开(公告)日：2008-10-14
申请号：US10757903
申请日：2004-01-14
申请人： Stephen J. Gunstream , Mark F. Oldham , Michael R. Gambini , John C. Voyta
发明人： Stephen J. Gunstream , Mark F. Oldham , Michael R. Gambini , John C. Voyta
IPC分类号： G01N21/64 , G01N35/00
CPC分类号： G01N21/31 , G01N21/253 , G01N21/276 , Y10T436/10 , Y10T436/11 , Y10T436/113332 , Y10T436/143333
摘要： Method and system providing calibration of light detected from biological samples with a correction factor including components for each of a plurality of spectrally distinguishable species and/or for each well and/or for each filter.
摘要翻译：方法和系统提供从生物样品检测到的光的校准，其校正因子包括多个光谱可区分物种和/或每个孔和/或每个过滤器中的每一个的分量。

7. 发明授权

US4223221A Scintillation camera uniformity correction 失效
公开(公告)号：US4223221A
公开(公告)日：1980-09-16
申请号：US917070
申请日：1978-06-19
申请人： Michael R. Gambini , Gary Benenson
发明人： Michael R. Gambini , Gary Benenson
IPC分类号： A61B6/00 , G01T1/164 , G01T1/20 , G01T1/208
CPC分类号： G01T1/1642
摘要： A two-stage system for enhancing the imaging uniformity of a scintillation camera is disclosed. The camera includes means for detecting radiation events and for producing radiation count signals indicating the location and energy level of individual detected radiation events. The uniformity correction system compensates for imprecision in the camera's indication of both radiation event regional image count density and event energy level. Compensation for energy indication errors is done by a first stage, prior to a second stage correction for residual nonuniformity in regional image count density. The operations of both stages are carried out in real time for each individual radiation count, independently of the production of other counts.The first stage location and stores a representation of the respective peaks of the detected energy pulse height distribution for each of a plurality of regions in the camera's field of view. This regional profile of the camera's energy response characteristic is used to successively realign for each count the pulse height energy window defined by the camera imaging circuitry, to align the window over the respective energy peak for each count as a function of the count's location indication.The second uniformity correction stage, a flood correction circuit, produces and stores a profile of regional variation in the image count density indicated by the camera in response to a uniform radiation flood over its field. This stored information is used for calculating regional count density correction factors for different regions of the camera field. The correction factors are used for controlling the ratio of radiation counts corresponding to each region which are actually imaged, thus eliminating residual nonuniformity caused by nonuniform regional image count density produced by the camera.No scintillation camera is capable of producing radiation count signals which define either the location or the energy level of radiation events with absolute precision. Minute inaccuracies in the location, and energy level decoding cause nonuniformity in the image count density of the scintillation camera systems.The uniformity of image count density of a scintillation camera detector can be degraded by factors including inaccuracies in energy level decoding, inaccuracies in location (x-y) decoding, nonlinearity), regional variations in detector sensitivity, and other factors.

8. 发明申请

US20110186739A1 MOBILE TOMOGRAPHIC CARGO INSPECTION SYSTEM 审中-公开
标题翻译：手机肉眼检查系统
公开(公告)号：US20110186739A1
公开(公告)日：2011-08-04
申请号：US13021194
申请日：2011-02-04
申请人： Andrew D. Foland , Richard Franklin Eilbert , Michael R. Gambini , Nicholas Danvers Penrose Gillett , Ronald S. McNabb , Boris Oreper , David Perticone , Vitaliy Ziskin
发明人： Andrew D. Foland , Richard Franklin Eilbert , Michael R. Gambini , Nicholas Danvers Penrose Gillett , Ronald S. McNabb , Boris Oreper , David Perticone , Vitaliy Ziskin
IPC分类号： G01N23/04
CPC分类号： G01V5/0008
摘要： Apparatus for scanning large cargo to detect concealed contents include a mobile platform configured to carry and position at least one X-ray or gamma-ray source and at least one detector array at a plurality of positions with respect to a stationary cargo. The detector array may be mounted on a boom moveably affixed to the mobile platform. Multiple measurements of radiation passing through the cargo for various source-detector orientations can be used to compute volumetric images of concealed content within the cargo.
摘要翻译：用于扫描大货物以检测隐藏内容物的装置包括移动平台，该移动平台被配置为在相对于静止货物的多个位置处运送和定位至少一个X射线或γ射线源和至少一个检测器阵列。检测器阵列可以安装在可移动地固定到移动平台上的吊杆上。用于各种源 - 检测器取向的通过货物的辐射的多次测量可用于计算货物内的隐藏内容的体积图像。

9. 发明申请

US20100248387A1 Method for Measuring Luminescence at a Luminescence Detection Workstation 有权
标题翻译：发光检测工作站测量发光的方法
公开(公告)号：US20100248387A1
公开(公告)日：2010-09-30
申请号：US12716219
申请日：2010-03-02
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用适合发光和均匀性校正。

10. 发明授权

US4645933A Emissive computed tomography 失效
标题翻译：发射计算机断层扫描
公开(公告)号：US4645933A
公开(公告)日：1987-02-24
申请号：US522309
申请日：1983-07-29
申请人： Michael R. Gambini , Ronald J. Martone , Donald S. Kearns , Gary W. Enos , Rudi Franke , Herbert Schoeppy
发明人： Michael R. Gambini , Ronald J. Martone , Donald S. Kearns , Gary W. Enos , Rudi Franke , Herbert Schoeppy
IPC分类号： A61B6/00 , G01T1/164 , G01T1/166
CPC分类号： A61B6/447 , A61B6/037 , A61B6/4405
摘要： A medical diagnostic system utilizing the principles of nuclear medicine is disclosed. The system includes a gantry having a detector support section supported by a carriage section located on a rail system for movement along a linear path. A nuclear detector is supported on a pair of weighted arms pivotally mounted on the detector support system about an axis perpendicular to the rail system. The detector is itself pivotally mounted near an end of the weighted arm pair for tilting rotation about an axis parallel to the arm pivot axis. Mechanism is provided for rotating the weighted arms additionally about an axis parallel to the rail system, in order to accomplish orbital motion of the detector. All three of these rotational movements are power actuated. A stationary pedestal and cantilevered patient support table is located between the rails of the rail system, with the patient table extending longitudinally with respect to the rails. The upper, or detector supporting section, of the gantry is additionally provided with a degree of freedom wherein it may be rotated about a vertical axis extending through the middle portion of the carriage system, thus disposing the detector for operation at a location alongside, and not between the rails.
摘要翻译： PCT No.PCT / US82 / 00813 Sec。 371日期1983年7月29日第 102（e）日期1983年7月29日PCT申请1982年6月16日。公开了利用核医学原理的医疗诊断系统。该系统包括具有检测器支撑部分的台架，该检测器支撑部分由位于轨道系统上的用于沿着线性路径移动的托架部分支撑。核检测器支撑在围绕垂直于轨道系统的轴线枢转地安装在检测器支撑系统上的一对加重臂上。检测器本身可枢转地安装在加重臂对的端部附近，用于围绕平行于臂枢转轴线的轴线倾斜旋转。提供了用于围绕平行于轨道系统的轴线旋转加权臂的机构，以便完成检测器的轨道运动。所有这三个旋转运动都是动力驱动的。固定基座和悬臂患者支撑台位于轨道系统的轨道之间，患者台相对于轨道纵向延伸。机架的上部或检测器支撑部分另外提供了一个自由度，其中它可以围绕延伸穿过滑架系统的中间部分的垂直轴线旋转，从而将检测器设置在一起的位置，并且不在轨道之间。

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