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1. 发明授权

US06803229B2 Procedure for the analysis of biological substances in a conductive liquid medium 有权
标题翻译：导电液体介质中生物物质分析程序
公开(公告)号：US06803229B2
公开(公告)日：2004-10-12
申请号：US10395262
申请日：2003-03-25
申请人： Jean-Rene Martin , Eliane Souteyrand , Marcus Francois Lawrence , Susan Rosalie Mikkelsen
发明人： Jean-Rene Martin , Eliane Souteyrand , Marcus Francois Lawrence , Susan Rosalie Mikkelsen
IPC分类号： C12M134
CPC分类号： G01N33/5438
摘要： The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essentially linked to the specific pairings of the biological substances with their complementary ligands included in the sensitive membrane; and interpreting the collected signals in order to identify and/or quantify the substances in question.
摘要翻译：本发明涉及通过至少一种亲和力传感器对存在于导电液体介质中的优选生物物质进行定性和/或定量分析的方法，所述亲和力传感器包括至少一种结构，包括至少一种半导体材料，其在其一个表面上涂覆有至少一层隔离材料，所述隔离材料层又粘附于至少一个与导电介质接触的敏感膜并且其包括配体它们与所讨论的生物物质互补，并且能够并且适合于与后一种生物物质特异性地形成对，所述方法的特征在于其基本上由半导体和导电介质; 收集由电荷效应现象引起的电信号的变化，直接和基本上与生物物质与敏感膜中包含的互补配体的特定配对相关; 并解释收集的信号，以便识别和/或量化所讨论的物质。

2. 发明授权

US06770471B2 Integrated chemical microreactor, thermally insulated from detection electrodes, and manufacturing and operating methods therefor 有权
公开(公告)号：US06770471B2
公开(公告)日：2004-08-03
申请号：US09965128
申请日：2001-09-26
申请人： Gabriele Barlocchi , Flavio Villa
发明人： Gabriele Barlocchi , Flavio Villa
IPC分类号： C12M134
CPC分类号： B01L7/52 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0825 , B01L2300/1827 , B01L2300/1883
摘要： Integrated microreactor, formed in a monolithic body and including a semiconductor material region and an insulating layer; a buried channel extending in the semiconductor material region; a first and a second access trench extending in the semiconductor material region and in the insulating layer, and in communication with the buried channel; a first and a second reservoir formed on top of the insulating layer and in communication with the first and the second access trench; a suspended diaphragm formed by the insulating layer, laterally to the buried channel; and a detection electrode, supported by the suspended diaphragm, above the insulating layer, and inside the second reservoir.

3. 发明授权

US06750053B1 Apparatus and method for assaying coagulation in fluid samples 有权
标题翻译：用于测定流体样品中凝血的装置和方法
公开(公告)号：US06750053B1
公开(公告)日：2004-06-15
申请号：US09712209
申请日：2000-11-15
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andy Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andy Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： C12M134
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

4. 发明授权

US06730510B2 Culture dish and bioreactor system 失效
标题翻译：培养皿和生物反应器系统
公开(公告)号：US06730510B2
公开(公告)日：2004-05-04
申请号：US10189300
申请日：2002-07-02
申请人： Eric Roos , Christopher O'Reilly , Ruben Chevere , Leon M. Wilkins
发明人： Eric Roos , Christopher O'Reilly , Ruben Chevere , Leon M. Wilkins
IPC分类号： C12M134
CPC分类号： C12M23/24 , C12M23/12 , C12M23/38
摘要： A bioreactor has a base for defining a well, a dish with a membrane suspended in the base, and a lid with gas permeable membranes and self-sealing ports.
摘要翻译：生物反应器具有用于限定孔的基底，具有悬浮在基底中的膜的盘，以及具有透气膜和自密封端口的盖。

5. 发明授权

US06723554B1 Apparatus and method for measuring optical properties by feedback control 有权
标题翻译：通过反馈控制测量光学性质的装置和方法
公开(公告)号：US06723554B1
公开(公告)日：2004-04-20
申请号：US09554110
申请日：2000-05-26
申请人： Laurent Gaillon , Robert Longin , Thanh Dung Luu
发明人： Laurent Gaillon , Robert Longin , Thanh Dung Luu
IPC分类号： C12M134
CPC分类号： G01N21/51 , C12M23/08 , C12M23/38 , C12M29/26 , C12M41/36 , G01N21/03 , G01N21/31
摘要： The invention concerns an apparatus and a method for measuring at least one optical characteristic, which can include in particular turbidity (T), absorbance (A) and fluorescence (F), of a medium (1), and a micro-bioreactor, a connector and associated male and female parts. The apparatus comprises a light source (3) provided with means for controlling (6) the intensity of the beam transmitted (11) by the source, a photodetector (4) for measuring the intensity of the beam reflected (12) by the medium, a feedback regulating system (7) operating on the control means such that the measured intensity of the reflected beam is equal to a predetermined nominal intensity, and means for reading the transmitted beam intensity, said intensity representing the medium optical characteristic(s). The apparatus also comprises means for adjusting the nominal intensity, such that the transmitted beam stabilised intensity is within a predetermined range. The invention is applicable to micro-bioreactors.
摘要翻译：本发明涉及用于测量至少一种光学特性的装置和方法，其可以包括介质（1）和微生物反应器的特别是浊度（T），吸光度（A）和荧光（F）连接器和相关的男性和女性部件。该装置包括光源（3），该光源（3）设有用于控制（6）由光源透射的光束的强度的装置，用于测量由介质反射（12）的光束的强度的光电检测器（4）反馈调节系统（7），其在所述控制装置上操作，使得所测量的所述反射光束的强度等于预定的标称强度;以及用于读取所述发射光束强度的装置，所述强度表示介质光学特性。该装置还包括用于调节标称强度的装置，使得透射光束稳定强度在预定范围内。本发明适用于微生物反应器。

6. 发明授权

US06709855B1 Methods for detection and use of differentially expressed genes in disease states 有权
标题翻译：在疾病状态下检测和使用差异表达基因的方法
公开(公告)号：US06709855B1
公开(公告)日：2004-03-23
申请号：US09461912
申请日：1999-12-15
申请人： Lawrence W. Stanton , R. Tyler White , Deborah L. Damm , John A. Lewicki , Alison Joly , George F. Schreiner
发明人： Lawrence W. Stanton , R. Tyler White , Deborah L. Damm , John A. Lewicki , Alison Joly , George F. Schreiner
IPC分类号： C12M134
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods useful in the diagnosis, prevention and therapeutic treatment of a disease, specifically cardiac, kidney or inflammatory disease. Specifically, methods and compositions are provided for the diagnostic evaluation and prognosis of conditions involving a disease, specifically cardiac, kidney or inflammatory disease, for the identification of subjects exhibiting a predisposition to such conditions, for modulating the effect of these differentially expressed genes, for monitoring patients undergoing clinical evaluation for the prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and its disorders, and for monitoring the efficacy of compounds used in clinical trials.
摘要翻译：本发明涉及用于检测，诊断，预防和治疗疾病，特别是心脏，肾脏或炎症性疾病以及相关疾病的方法和组合物。本发明还涉及用于诊断，预防和治疗疾病，特别是心脏，肾脏或炎性疾病的组合物和方法。具体地，提供方法和组合物用于诊断评估和预后涉及疾病，特别是心脏，肾脏或炎性疾病的疾病，用于鉴定表现出对这些病症倾向的受试者，用于调节这些差异表达基因的作用，用于监测接受临床评估的患者，用于预防和治疗疾病，特别是心脏，肾脏或炎症疾病及其疾病，并监测临床试验中使用的化合物的功效。

7. 发明授权

US06696286B1 Method and devices for detecting and enumerating microorganisms 失效
标题翻译：用于检测和列举微生物的方法和装置
公开(公告)号：US06696286B1
公开(公告)日：2004-02-24
申请号：US09495092
申请日：2000-02-01
申请人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
发明人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
IPC分类号： C12M134
CPC分类号： C12Q1/02
摘要： A method for detecting a microorganism in a test sample is described. The method involves distributing microvolumes of a sample to a plurality of microcompartments of a culture device, incubating for a time sufficient to permit at least one cell division cycle of the microorganism, then detecting the presence or absence of the microorganism in the microcompartments. Also disclosed are devices for carrying out these methods.
摘要翻译：描述了测试样品中微生物检测方法。该方法包括将样品的微量体积分配到培养装置的多个微室中，孵育足以允许微生物的至少一个细胞分裂周期的时间，然后检测微室中的微生物的存在或不存在。还公开了用于执行这些方法的装置。

8. 发明授权

US06689603B2 Device for in situ analysis and/or treatment consisting of a flexible rod and micro system fixed at one end of said flexible rod 有权
标题翻译：用于原位分析和/或处理的装置，其由固定在所述柔性杆的一端的柔性杆和微系统组成
公开(公告)号：US06689603B2
公开(公告)日：2004-02-10
申请号：US09926351
申请日：2002-01-30
申请人： Alain Pompidou , Albert-Claude Benhamou
发明人： Alain Pompidou , Albert-Claude Benhamou
IPC分类号： C12M134
CPC分类号： A61B5/145 , G01N33/54366 , G01N2333/40 , G01N2333/78
摘要： This invention concerns an apparatus for chemical or biological analysis or treatment in situ comprising (i) a microsystem for investigation of a substrate and/or for delivery of active agents in a substrate and (ii) a flexible rod to one end of which the microsystem is attached and the other end of which is intended for the control of said microsystem. The microsystem is advantageously of the type comprising a support on the surface of which predefined regions are arrayed, each containing different chemical or biological substances for investigation or treatment of the substrate where the microsystem is brought in contact thanks to the flexible rod.
摘要翻译：本发明涉及一种用于原位化学或生物分析或处理的装置，包括（i）用于研究底物和/或在基质中递送活性剂的微系统，和（ii）柔性棒，其一端为微系统并且其另一端用于控制所述微系统。微系统有利地是包括其表面上的支撑体的类型，其中排列有预定义的区域，每个含有不同的化学或生物物质用于研究或处理基底，其中微系统由于柔性杆而接触。

9. 发明授权

US06653121B2 Roughened and oxidized well chips and method of making same 失效
公开(公告)号：US06653121B2
公开(公告)日：2003-11-25
申请号：US10010312
申请日：2001-11-09
申请人： Jeffrey L. May
发明人： Jeffrey L. May
IPC分类号： C12M134
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00542 , B01J2219/00722 , B01L2300/0819 , B01L2300/168 , C40B40/06 , C40B60/14 , C40B70/00
摘要： A chip for holding DNA samples and method of making same by masking a silicon substrate for spaced apart wells with a photoabrasive masking material, blasting the masked surface with microabrasive beads to produce roughened wells in the substrate and forming an oxide coating over the masked and roughened surface of the substrate.

10. 再颁专利

USRE38323E1 Cell potential measurement apparatus having a plurality of microelectrodes 有权
标题翻译：具有多个微电极的电池电位测量装置
公开(公告)号：USRE38323E1
公开(公告)日：2003-11-18
申请号：US09169188
申请日：1998-10-08
申请人： Hirokazu Sugihara , Akihito Kamei , Yasushi Kobayashi , Makoto Taketani , Tadayasu Mitsumata
发明人： Hirokazu Sugihara , Akihito Kamei , Yasushi Kobayashi , Makoto Taketani , Tadayasu Mitsumata
IPC分类号： C12M134
CPC分类号： G01N33/4836 , C12M41/46
摘要： A cell potential measurement apparatus, which uses a planar electrode enabling a multi-point simultaneous measurement of potential change arising from cell activities, is provided which can conduct measurements accurately and efficiently as well as can improve convenience of arranging measurement results. According to the configuration of the cell potential measurement apparatus of this invention, it includes an integrated cell holding instrument, which includes a planar electrode provided with a plurality of microelectrodes arranged in a matrix form on the surface of a substrate, a cell holding part for placing cells thereon, drawer patterns from the microelectrodes, and electric contact points for outside connections; an optical observation means for optical observations of cells; a stimulation signal supply means to be connected to the cell holding instrument for providing electric stimulation to the cells; and a signal processing means to be connected to the cell holding instrument for processing an output signal arising from electric physiological activities of the cells. It is preferable that a cell culturing means is also provided for maintaining a culture atmosphere of the cells placed on the integrated cell holding instrument.

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