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1. 发明申请

US20100248387A1 Method for Measuring Luminescence at a Luminescence Detection Workstation 有权
标题翻译：发光检测工作站测量发光的方法
公开(公告)号：US20100248387A1
公开(公告)日：2010-09-30
申请号：US12716219
申请日：2010-03-02
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用适合发光和均匀性校正。

2. 发明授权

US07670848B2 Method for measuring luminescence at a luminescence detection workstation 有权
标题翻译：用于在发光检测工作站测量发光的方法
公开(公告)号：US07670848B2
公开(公告)日：2010-03-02
申请号：US11251873
申请日：2005-10-18
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone, legal representative , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76 , G01T1/10
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).
摘要翻译：在用于分析发光样品的发光检测装置和方法中，将发光样品放置在托盘中的多个样品孔中，并将该托盘放置在包含电荷耦合器件相机的可见光不透过室中。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，红外滤光镜和照相机镜头，由相机上的光学器件产生聚焦图像。使用红外滤光器可抑制板状磷光产生的杂散红外辐射（可能导致摄像机接收的图像异常高的背景和/或变化）。

3. 发明申请

US20120309103A1 METHOD FOR MEASURING LUMINESCENCE AT A LUMINESCENCE DETECTION WORKSTATION 有权
标题翻译：用于在发光检测工作站测量发光的方法
公开(公告)号：US20120309103A1
公开(公告)日：2012-12-06
申请号：US13584628
申请日：2012-08-13
申请人： Michael Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用适合发光和均匀性校正。

4. 发明授权

US06518068B1 Luminescence detection workstation 有权
标题翻译：发光检测工作站
公开(公告)号：US06518068B1
公开(公告)日：2003-02-11
申请号：US09621961
申请日：2000-07-21
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N2164
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常剃刮，掩蔽，操纵多个积分时间以扩展动态范围，串扰校正，暗减法内插和漂移校正的元件，专门用于发光的多分量分析应用，均匀性校正。

5. 发明授权

US08865473B2 Luminescence detecting apparatuses and methods 有权
标题翻译：发光检测装置及方法
公开(公告)号：US08865473B2
公开(公告)日：2014-10-21
申请号：US13584628
申请日：2012-08-13
申请人： Michael Gambini , Jeff Levi , John Voyta , Bruce E. DeSimas, II , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang , Susan A. Atwood-Stone
发明人： Michael Gambini , Jeff Levi , John Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76 , G01T1/10 , G01N21/64 , G01N21/27 , G01N21/31 , G01N21/15
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. A detecting apparatus may be configured so that light from luminescent samples pass through a collimator, a first lens, a filter, and a camera lens, whereupon an image is created by the optics on the charge-coupled device (CCD) camera. The detecting apparatus may further include central processing control of all operations, multiple wavelength filter wheel, and/or a robot for handling of samples and reagents.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。检测装置可以被配置为使得来自发光样品的光通过准直仪，第一透镜，滤光器和相机透镜，于是由电荷耦合器件（CCD）照相机上的光学器件产生图像。检测装置还可以包括用于处理样品和试剂的所有操作，多波长滤光轮和/或机器人的中央处理控制。

6. 发明授权

US08278114B2 Method for measuring luminescence at a luminescence detection workstation 有权
标题翻译：用于在发光检测工作站测量发光的方法
公开(公告)号：US08278114B2
公开(公告)日：2012-10-02
申请号：US12716219
申请日：2010-03-02
申请人： Michael Gambini , Jeff Levi , John Voyta , John Atwood , Susan Atwood-Stone, legal representative , Bruce De Simas , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , Jeff Levi , John Voyta , John Atwood , Bruce De Simas , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76 , G01T1/10
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. A detecting apparatus may be configured so that light from luminescent samples pass through a collimator, a a first lens, a filter, and a camera lens, whereupon an image is created by the optics on the charge-coupled device (CCD) camera. The detecting apparatus may further include central processing control of all operations, multiple wavelength filter wheel, and/or a robot for handling of samples and reagents.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。检测装置可以被配置为使得来自发光样品的光通过准直仪，第一透镜，滤光器和相机透镜，于是由电荷耦合器件（CCD）照相机上的光学器件产生图像。检测装置还可以包括用于处理样品和试剂的所有操作，多波长滤光轮和/或机器人的中央处理控制。

7. 发明申请

US20060088444A1 Luminescence detection workstation 有权
标题翻译：发光检测工作站
公开(公告)号：US20060088444A1
公开(公告)日：2006-04-27
申请号：US11251873
申请日：2005-10-18
申请人： Michael Gambini , John Voyta , John Atwood , Susan Atwood Stone , Bruce DeSimas , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , John Voyta , John Atwood , Susan Atwood Stone , Bruce DeSimas , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/64
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).
摘要翻译：在用于分析发光样品的发光检测装置和方法中，将发光样品放置在托盘中的多个样品孔中，并将该托盘放置在包含电荷耦合器件相机的可见光不透过室中。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，红外滤光镜和照相机镜头，由相机上的光学器件产生聚焦图像。使用红外滤光器可抑制板状磷光产生的杂散红外辐射（可能导致摄像机接收的图像异常高的背景和/或变化）。

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