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    • 1. 发明授权
    • Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration
    • Cheyne-Stokes呼吸特征的分层治疗呼吸振荡
    • US07519425B2
    • 2009-04-14
    • US10968730
    • 2004-10-18
    • Michael BenserEric Falkenberg
    • Michael BenserEric Falkenberg
    • A61N1/00
    • A61N1/36514A61N1/3601
    • An exemplary method includes delivering a maintenance therapy that aims to prevent occurrence of apnea, sensing information, based at least in part on the information, determining if apnea exists and, if apnea exists, delivering a termination therapy that aims to terminate the apnea. An exemplary implantable device includes an input for information pertaining to respiration and control logic to call for overdrive pacing at a first rate that aims to minimize occurrence of a respiratory condition, to analyze the information for occurrence of the respiratory condition and, upon occurrence of the respiratory condition, to call for overdrive pacing at a higher rate. Other exemplary methods, devices, systems, etc., are also disclosed.
    • 一种示例性方法包括:至少部分地基于信息来确定是否存在呼吸暂停,并且如果存在呼吸暂停,则提供旨在防止呼吸暂停发生的感测信息,感测信息,传递旨在终止呼吸暂停的终止疗法。 示例性可植入装置包括用于与呼吸和控制逻辑相关的信息的输入,以以旨在最小化呼吸状况发生的第一速率来呼叫超速起搏,分析呼吸状况发生的信息,并且在出现 呼吸状况,以更高的速度呼叫超速起搏。 还公开了其它示例性方法,装置,系统等。
    • 4. 发明授权
    • System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
    • 使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
    • US07454250B1
    • 2008-11-18
    • US11192779
    • 2005-07-29
    • Anders BjorlingEuljoon ParkMichael Benser
    • Anders BjorlingEuljoon ParkMichael Benser
    • A61N1/36
    • A61N1/3601
    • Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
    • 提供了使用植入式医疗系统治疗周期性呼吸的技术,例如Cheyne-Stokes呼吸。 在一种技术中,通过膈神经的电刺激,在定期呼吸的呼吸过度期间传送膈肌刺激。 膈肌刺激与固有吸气同步,以增加吸气期间膈肌收缩的幅度。 这往往会降低导致呼吸道气道闭塞的胸腔内压力。 闭塞减少呼吸过程中的实际通气,从而减少持续周期性呼吸的循环血液化学不平衡,以减轻周期性呼吸或完全消除呼吸。 在另一种技术中,通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度,在呼吸的呼吸过度期间,呼吸反而被抑制。 还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。
    • 8. 发明授权
    • System and method for real-time apnea/hypopnea detection using an implantable medical system
    • 使用植入式医疗系统实时呼吸暂停/呼吸不足检测的系统和方法
    • US07371220B1
    • 2008-05-13
    • US10883857
    • 2004-06-30
    • Steve KohEuljoon ParkMichael Benser
    • Steve KohEuljoon ParkMichael Benser
    • A61B5/08
    • A61B5/0809A61B5/4519A61B5/4818A61B5/7239
    • Techniques are provided for detecting the onset of an episode of apnea/hypopnea substantially in real-time. A moving threshold is generated based on recent respiration cycles and differences are accumulated between amplitudes of new respiration cycles and the moving threshold. Apnea/hypopnea is then detected based upon a comparison of the accumulated differences against a fixed threshold. The technique exploits the fact that many episodes of hypopnea begin with a sharp drop in respiration and many episodes of apnea are preceded by a sharp drop in respiration. By accumulating differences between new respiration amplitudes and a short term moving average, any sharp drop in respiration is thereby promptly detected. In many cases, by the time the amplitudes of individual respiration cycles drop to levels directly indicative of apnea/hypopnea, the episode of apnea/hypopnea will have already been detected based upon the sudden sharp drop in respiration amplitude and therapy will have already been initiated.
    • 提供了用于基本上实时检测呼吸暂停/呼吸不足发作的技术。 基于最近的呼吸循环产生移动阈值,并且在新呼吸循环的振幅和移动阈值之间累积差异。 然后基于累积差异与固定阈值的比较来检测呼吸暂停/呼吸不足。 该技术利用了许多次呼吸不畅的情况,呼吸急剧下降,许多呼吸暂停发作前呼吸急剧下降。 通过累积新的呼吸振幅和短期移动平均值之间的差异,因此迅速检测到呼吸中的任何急剧下降。 在许多情况下,当个别呼吸周期的振幅下降到直接指示呼吸暂停/呼吸不全的水平时,呼吸暂停/呼吸不足的发作将基于呼吸振幅的突然急剧下降而被检测到,并且已经开始治疗 。
    • 9. 发明授权
    • System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
    • 使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
    • US07245971B2
    • 2007-07-17
    • US10829719
    • 2004-04-21
    • Euljoon ParkMichael Benser
    • Euljoon ParkMichael Benser
    • A61N1/36
    • A61N1/3601
    • Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
    • 提供了使用植入式医疗系统治疗周期性呼吸的技术,例如Cheyne-Stokes呼吸。 在一种技术中,通过膈神经的电刺激,在定期呼吸的呼吸过度期间传送膈肌刺激。 膈肌刺激与固有吸气同步,以增加吸气期间膈肌收缩的幅度。 这往往会降低导致呼吸道气道闭塞的胸腔内压力。 闭塞减少呼吸过程中的实际通气,从而减少持续周期性呼吸的循环血液化学不平衡,以减轻周期性呼吸或完全消除呼吸。 在另一种技术中,通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度,在呼吸的呼吸过度期间,呼吸反而被抑制。 还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。
    • 10. 发明申请
    • Bachmann's bundle electrode for atrial defibrillation
    • 巴赫曼的束电极用于心房除颤
    • US20050004605A1
    • 2005-01-06
    • US10896648
    • 2004-07-22
    • Xiangsheng ZhengMichael BenserRaymond IdekerGregory WalcottSteven Girouard
    • Xiangsheng ZhengMichael BenserRaymond IdekerGregory WalcottSteven Girouard
    • A61N1/05A61N1/39
    • A61N1/0563A61N2001/0585
    • An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned to stimulate Bachmann's bundle, or positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.
    • 用于对患者心脏的心房进行除颤的可植入系统包括(a)构造成用于插入心脏右心房的第一导管; 由第一导管携带并定位成刺激巴赫曼氏束或定位在心脏的心房隔膜(即心房隔膜电极)处的第一心房除颤电极; (b)第二心房除颤电极,与第一心房除颤电极一起提供一对心房除颤电极,其构造成用于在患者心脏内或周围定向以实现心房除颤,以及(c)与 一对心房除颤电极,用于将第一心房除颤脉冲输送到患者的心脏。 第二电极可以被配置用于定位穿过冠状窦口和冠状窦或左心室表面的静脉,例如大静脉。 还可以包括配置用于定位在上腔静脉,右心房(包括右心耳或右心室)中的附加电极,并且脉冲发生器可以被配置或编程为用于同时递送第一除颤脉冲通过附加电极 以及通过心房隔膜电极和第二电极的第二除颤脉冲,还公开了用于实施本发明的电极组件和方法。