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1. 发明授权

US07596410B1 Tiered antitachycardia pacing and pre-pulsing therapy 有权
标题翻译：分层抗心动过速起搏和预脉冲治疗
公开(公告)号：US07596410B1
公开(公告)日：2009-09-29
申请号：US11413772
申请日：2006-04-28
申请人： Mark W. Kroll , Michael Benser , Euljoon Park
发明人： Mark W. Kroll , Michael Benser , Euljoon Park
IPC分类号： A61N1/368
CPC分类号： A61N1/3962 , A61N1/0563 , A61N1/36071 , A61N1/3622
摘要： An implantable system applies tiered antitachycardia pacing (ATP) that may be combined with pre-pulsing therapy in order to reduce pain. In one implementation, an exemplary system applies a progression of increasingly potent pacing vectors, progressing in an initial tier from small electrodes inside the heart to later tiers that increasingly use a large electrode surface outside the heart. In the latter tiers, a pre-pulse may be added prior to each ATP pulse to reduce the sensation of pain.
摘要翻译：植入式系统应用分层抗心动过速起搏（ATP），可与预脉冲治疗相结合，以减轻疼痛。在一个实施方案中，示例性系统应用越来越有效的起搏向量的进展，在初始层级内从心脏内的小电极进行到越来越多地使用心脏外的大电极表面的后续层级。在后一级，可以在每个ATP脉冲之前加入预脉冲以减少疼痛的感觉。

2. 发明授权

US07371220B1 System and method for real-time apnea/hypopnea detection using an implantable medical system 有权
标题翻译：使用植入式医疗系统实时呼吸暂停/呼吸不足检测的系统和方法
公开(公告)号：US07371220B1
公开(公告)日：2008-05-13
申请号：US10883857
申请日：2004-06-30
申请人： Steve Koh , Euljoon Park , Michael Benser
发明人： Steve Koh , Euljoon Park , Michael Benser
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/4519 , A61B5/4818 , A61B5/7239
摘要： Techniques are provided for detecting the onset of an episode of apnea/hypopnea substantially in real-time. A moving threshold is generated based on recent respiration cycles and differences are accumulated between amplitudes of new respiration cycles and the moving threshold. Apnea/hypopnea is then detected based upon a comparison of the accumulated differences against a fixed threshold. The technique exploits the fact that many episodes of hypopnea begin with a sharp drop in respiration and many episodes of apnea are preceded by a sharp drop in respiration. By accumulating differences between new respiration amplitudes and a short term moving average, any sharp drop in respiration is thereby promptly detected. In many cases, by the time the amplitudes of individual respiration cycles drop to levels directly indicative of apnea/hypopnea, the episode of apnea/hypopnea will have already been detected based upon the sudden sharp drop in respiration amplitude and therapy will have already been initiated.
摘要翻译：提供了用于基本上实时检测呼吸暂停/呼吸不足发作的技术。基于最近的呼吸循环产生移动阈值，并且在新呼吸循环的振幅和移动阈值之间累积差异。然后基于累积差异与固定阈值的比较来检测呼吸暂停/呼吸不足。该技术利用了许多次呼吸不畅的情况，呼吸急剧下降，许多呼吸暂停发作前呼吸急剧下降。通过累积新的呼吸振幅和短期移动平均值之间的差异，因此迅速检测到呼吸中的任何急剧下降。在许多情况下，当个别呼吸周期的振幅下降到直接指示呼吸暂停/呼吸不全的水平时，呼吸暂停/呼吸不足的发作将基于呼吸振幅的突然急剧下降而被检测到，并且已经开始治疗。

3. 发明授权

US07363085B1 Augmenting hypoventilation 有权
标题翻译：增强通气不足
公开(公告)号：US07363085B1
公开(公告)日：2008-04-22
申请号：US10765625
申请日：2004-01-26
申请人： Michael Benser , Ruth Lyons , Eric Falkenberg
发明人： Michael Benser , Ruth Lyons , Eric Falkenberg
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/091 , A61B5/4818
摘要： An exemplary method includes sensing respiratory information related to tidal volume, based at least in part on the respiratory information, determining if the tidal volume is less than a limit and, if the tidal volume is less than the limit, calling for diaphragm activation at a stimulation power based on a nonincreasing monotonic relationship with respect to decreasing difference between the tidal volume and the limit. Various other technologies are also disclosed.
摘要翻译：一种示例性方法包括：至少部分地基于呼吸信息来感测与潮气量相关的呼吸信息，确定潮气量是否小于极限，并且如果潮气量小于极限，则呼叫振膜激活相对于减少潮气量和极限之间的差异，基于不增加的单调关系的刺激功率。还公开了各种其它技术。

4. 发明授权

US07245971B2 System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device 有权
标题翻译：使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
公开(公告)号：US07245971B2
公开(公告)日：2007-07-17
申请号：US10829719
申请日：2004-04-21
申请人： Euljoon Park , Michael Benser
发明人： Euljoon Park , Michael Benser
IPC分类号： A61N1/36
CPC分类号： A61N1/3601
摘要： Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
摘要翻译：提供了使用植入式医疗系统治疗周期性呼吸的技术，例如Cheyne-Stokes呼吸。在一种技术中，通过膈神经的电刺激，在定期呼吸的呼吸过度期间传送膈肌刺激。膈肌刺激与固有吸气同步，以增加吸气期间膈肌收缩的幅度。这往往会降低导致呼吸道气道闭塞的胸腔内压力。闭塞减少呼吸过程中的实际通气，从而减少持续周期性呼吸的循环血液化学不平衡，以减轻周期性呼吸或完全消除呼吸。在另一种技术中，通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度，在呼吸的呼吸过度期间，呼吸反而被抑制。还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。

5. 发明申请

US20050004605A1 Bachmann's bundle electrode for atrial defibrillation 失效
标题翻译：巴赫曼的束电极用于心房除颤
公开(公告)号：US20050004605A1
公开(公告)日：2005-01-06
申请号：US10896648
申请日：2004-07-22
申请人： Xiangsheng Zheng , Michael Benser , Raymond Ideker , Gregory Walcott , Steven Girouard
发明人： Xiangsheng Zheng , Michael Benser , Raymond Ideker , Gregory Walcott , Steven Girouard
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0563 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned to stimulate Bachmann's bundle, or positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.
摘要翻译：用于对患者心脏的心房进行除颤的可植入系统包括（a）构造成用于插入心脏右心房的第一导管; 由第一导管携带并定位成刺激巴赫曼氏束或定位在心脏的心房隔膜（即心房隔膜电极）处的第一心房除颤电极; （b）第二心房除颤电极，与第一心房除颤电极一起提供一对心房除颤电极，其构造成用于在患者心脏内或周围定向以实现心房除颤，以及（c）与一对心房除颤电极，用于将第一心房除颤脉冲输送到患者的心脏。第二电极可以被配置用于定位穿过冠状窦口和冠状窦或左心室表面的静脉，例如大静脉。还可以包括配置用于定位在上腔静脉，右心房（包括右心耳或右心室）中的附加电极，并且脉冲发生器可以被配置或编程为用于同时递送第一除颤脉冲通过附加电极以及通过心房隔膜电极和第二电极的第二除颤脉冲，还公开了用于实施本发明的电极组件和方法。

6. 发明授权

US07421296B1 Termination of respiratory oscillations characteristic of Cheyne-Stokes respiration 有权
标题翻译：终止Cheyne-Stokes呼吸特征的呼吸振荡
公开(公告)号：US07421296B1
公开(公告)日：2008-09-02
申请号：US10765624
申请日：2004-01-26
申请人： Michael Benser , Gene A. Bornzin
发明人： Michael Benser , Gene A. Bornzin
IPC分类号： A61N1/36
CPC分类号： A61N1/36514 , A61N1/3601
摘要： An exemplary method includes sensing respiratory information related to tidal volume, based at least in part on the respiratory information, determining if tidal volume is less than a limit and, if the tidal volume is less than the limit, calling for diaphragm activation at a stimulation power based on a nondecreasing monotonic relationship with respect to increasing tidal volume. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：至少部分地基于呼吸信息来确定潮气量是否小于极限，并且如果潮气量小于极限，则呼吸在刺激下进行隔膜激活的示例性方法包括感测与潮气量有关的呼吸信息基于相对于增加潮气量的非递减单调关系的能量。还公开了其它示例性方法，装置，系统等。

7. 发明授权

US07082331B1 System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device 失效
标题翻译：使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
公开(公告)号：US07082331B1
公开(公告)日：2006-07-25
申请号：US10830357
申请日：2004-04-21
申请人： Euljoon Park , Michael Benser
发明人： Euljoon Park , Michael Benser
IPC分类号： A61N1/00
CPC分类号： A61N1/3601
摘要： Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
摘要翻译：提供了使用植入式医疗系统治疗周期性呼吸的技术，例如Cheyne-Stokes呼吸。在一种技术中，通过膈神经的电刺激，在定期呼吸的呼吸过度期间传送膈肌刺激。膈肌刺激与固有吸气同步，以增加吸气期间膈肌收缩的幅度。这往往会降低导致呼吸道气道闭塞的胸腔内压力。闭塞减少呼吸过程中的实际通气，从而减少持续周期性呼吸的循环血液化学不平衡，以减轻周期性呼吸或完全消除呼吸。在另一种技术中，通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度，在呼吸的呼吸过度期间，呼吸反而被抑制。还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。

8. 发明申请

US20060136026A1 Inter-atrial septum or superior vena cava electrodes for atrial defibrillation 失效
公开(公告)号：US20060136026A1
公开(公告)日：2006-06-22
申请号：US11333503
申请日：2006-01-17
申请人： Xiangsheng Zheng , Michael Benser , Raymond Ideker , Gregory Walcott , Steven Girouard
发明人： Xiangsheng Zheng , Michael Benser , Raymond Ideker , Gregory Walcott , Steven Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

9. 发明申请

US20060058852A1 Multi-variable feedback control of stimulation for inspiratory facilitation 审中-公开
标题翻译：吸气辅助刺激的多变量反馈控制
公开(公告)号：US20060058852A1
公开(公告)日：2006-03-16
申请号：US10938114
申请日：2004-09-10
申请人： Steve Koh , Michael Benser
发明人： Steve Koh , Michael Benser
IPC分类号： A61N1/08
CPC分类号： A61N1/3601
摘要： An exemplary method includes delivering stimulation according to one or more stimulation parameters to cause contraction of the diaphragm, monitoring chest activity related to respiration and, in response to the monitoring, adjusting one or more of the one or more stimulation parameters during contraction of the diaphragm and continuing the delivering. Various other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括根据一个或多个刺激参数递送刺激以引起隔膜的收缩，监测与呼吸相关的胸部活动，并且响应于该监测，在隔膜收缩期间调整一个或多个刺激参数中的一个或多个并继续交付。还公开了各种其它示例性方法，装置，系统等。

10. 发明申请

US20050240240A1 System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device 有权
标题翻译：使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
公开(公告)号：US20050240240A1
公开(公告)日：2005-10-27
申请号：US10829719
申请日：2004-04-21
申请人： Euljoon Park , Michael Benser
发明人： Euljoon Park , Michael Benser
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/3601
摘要： Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
摘要翻译：提供了使用植入式医疗系统治疗周期性呼吸的技术，例如Cheyne-Stokes呼吸。在一种技术中，通过膈神经的电刺激，在定期呼吸的呼吸过度期间传送膈肌刺激。膈肌刺激与固有吸气同步，以增加吸气期间膈肌收缩的幅度。这往往会降低导致呼吸道气道闭塞的胸腔内压力。闭塞减少呼吸过程中的实际通气，从而减少持续周期性呼吸的循环血液化学不平衡，以减轻周期性呼吸或完全消除呼吸。在另一种技术中，通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度，在呼吸的呼吸过度期间，呼吸反而被抑制。还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。

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