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    • 1. 发明授权
    • System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
    • 使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
    • US07454250B1
    • 2008-11-18
    • US11192779
    • 2005-07-29
    • Anders BjorlingEuljoon ParkMichael Benser
    • Anders BjorlingEuljoon ParkMichael Benser
    • A61N1/36
    • A61N1/3601
    • Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
    • 提供了使用植入式医疗系统治疗周期性呼吸的技术,例如Cheyne-Stokes呼吸。 在一种技术中,通过膈神经的电刺激,在定期呼吸的呼吸过度期间传送膈肌刺激。 膈肌刺激与固有吸气同步,以增加吸气期间膈肌收缩的幅度。 这往往会降低导致呼吸道气道闭塞的胸腔内压力。 闭塞减少呼吸过程中的实际通气,从而减少持续周期性呼吸的循环血液化学不平衡,以减轻周期性呼吸或完全消除呼吸。 在另一种技术中,通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度,在呼吸的呼吸过度期间,呼吸反而被抑制。 还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。
    • 3. 发明授权
    • System and method for real-time apnea/hypopnea detection using an implantable medical system
    • 使用植入式医疗系统实时呼吸暂停/呼吸不足检测的系统和方法
    • US07371220B1
    • 2008-05-13
    • US10883857
    • 2004-06-30
    • Steve KohEuljoon ParkMichael Benser
    • Steve KohEuljoon ParkMichael Benser
    • A61B5/08
    • A61B5/0809A61B5/4519A61B5/4818A61B5/7239
    • Techniques are provided for detecting the onset of an episode of apnea/hypopnea substantially in real-time. A moving threshold is generated based on recent respiration cycles and differences are accumulated between amplitudes of new respiration cycles and the moving threshold. Apnea/hypopnea is then detected based upon a comparison of the accumulated differences against a fixed threshold. The technique exploits the fact that many episodes of hypopnea begin with a sharp drop in respiration and many episodes of apnea are preceded by a sharp drop in respiration. By accumulating differences between new respiration amplitudes and a short term moving average, any sharp drop in respiration is thereby promptly detected. In many cases, by the time the amplitudes of individual respiration cycles drop to levels directly indicative of apnea/hypopnea, the episode of apnea/hypopnea will have already been detected based upon the sudden sharp drop in respiration amplitude and therapy will have already been initiated.
    • 提供了用于基本上实时检测呼吸暂停/呼吸不足发作的技术。 基于最近的呼吸循环产生移动阈值,并且在新呼吸循环的振幅和移动阈值之间累积差异。 然后基于累积差异与固定阈值的比较来检测呼吸暂停/呼吸不足。 该技术利用了许多次呼吸不畅的情况,呼吸急剧下降,许多呼吸暂停发作前呼吸急剧下降。 通过累积新的呼吸振幅和短期移动平均值之间的差异,因此迅速检测到呼吸中的任何急剧下降。 在许多情况下,当个别呼吸周期的振幅下降到直接指示呼吸暂停/呼吸不全的水平时,呼吸暂停/呼吸不足的发作将基于呼吸振幅的突然急剧下降而被检测到,并且已经开始治疗 。
    • 4. 发明授权
    • System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
    • 使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
    • US07245971B2
    • 2007-07-17
    • US10829719
    • 2004-04-21
    • Euljoon ParkMichael Benser
    • Euljoon ParkMichael Benser
    • A61N1/36
    • A61N1/3601
    • Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
    • 提供了使用植入式医疗系统治疗周期性呼吸的技术,例如Cheyne-Stokes呼吸。 在一种技术中,通过膈神经的电刺激,在定期呼吸的呼吸过度期间传送膈肌刺激。 膈肌刺激与固有吸气同步,以增加吸气期间膈肌收缩的幅度。 这往往会降低导致呼吸道气道闭塞的胸腔内压力。 闭塞减少呼吸过程中的实际通气,从而减少持续周期性呼吸的循环血液化学不平衡,以减轻周期性呼吸或完全消除呼吸。 在另一种技术中,通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度,在呼吸的呼吸过度期间,呼吸反而被抑制。 还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。
    • 6. 发明授权
    • System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
    • 使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
    • US07082331B1
    • 2006-07-25
    • US10830357
    • 2004-04-21
    • Euljoon ParkMichael Benser
    • Euljoon ParkMichael Benser
    • A61N1/00
    • A61N1/3601
    • Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
    • 提供了使用植入式医疗系统治疗周期性呼吸的技术,例如Cheyne-Stokes呼吸。 在一种技术中,通过膈神经的电刺激,在定期呼吸的呼吸过度期间传送膈肌刺激。 膈肌刺激与固有吸气同步,以增加吸气期间膈肌收缩的幅度。 这往往会降低导致呼吸道气道闭塞的胸腔内压力。 闭塞减少呼吸过程中的实际通气,从而减少持续周期性呼吸的循环血液化学不平衡,以减轻周期性呼吸或完全消除呼吸。 在另一种技术中,通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度,在呼吸的呼吸过度期间,呼吸反而被抑制。 还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。
    • 7. 发明申请
    • System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
    • 使用可植入医疗器械在周期性呼吸的呼吸过度期使用治疗的系统和方法
    • US20050240240A1
    • 2005-10-27
    • US10829719
    • 2004-04-21
    • Euljoon ParkMichael Benser
    • Euljoon ParkMichael Benser
    • A61N1/36A61N1/18
    • A61N1/3601
    • Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.
    • 提供了使用植入式医疗系统治疗周期性呼吸的技术,例如Cheyne-Stokes呼吸。 在一种技术中,通过膈神经的电刺激,在定期呼吸的呼吸过度期间传送膈肌刺激。 膈肌刺激与固有吸气同步,以增加吸气期间膈肌收缩的幅度。 这往往会降低导致呼吸道气道闭塞的胸腔内压力。 闭塞减少呼吸过程中的实际通气,从而减少持续周期性呼吸的循环血液化学不平衡,以减轻周期性呼吸或完全消除呼吸。 在另一种技术中,通过阻止膈神经信号到减少通气以终止周期性呼吸或至少减轻其严重程度所必需的程度,在呼吸的呼吸过度期间,呼吸反而被抑制。 还描述了用于控制响应于周期性呼吸所应用的治疗类型的技术。
    • 9. 发明授权
    • Implantable cardiac device to promote intrinsic rhythm to alleviate orthostatic hypotension
    • 植入性心脏器械促进内在节律,减轻直立性低血压
    • US07171270B1
    • 2007-01-30
    • US10748486
    • 2003-12-29
    • Euljoon ParkMichael BenserRuth Lyons
    • Euljoon ParkMichael BenserRuth Lyons
    • A61N1/00
    • A61N1/36514A61N1/36535A61N1/36542A61N1/36564
    • An implantable cardiac device is programmed to promote intrinsic rhythm of a patient's heart to alleviate orthostatic hypotension. In one implementation, the cardiac device is set in a reduced rate mode while the patient is in a less upright position, such as when resting in a supine position. If the patient is in intrinsic rhythm when transitioning to a more upright position, the cardiac device disables administration of any increased pacing rate for a programmed duration. In this manner, the patient will experience a more natural variation in heart rate during transition from the less upright posture to the more upright posture (e.g., from supine to sitting or standing). On the other hand, if the patient is being paced during the transition, the cardiac device administers an increased base rate or triggers an orthostatic response algorithm.
    • 可植入心脏装置被编程以促进患者心脏的内在节律以减轻直立性低血压。 在一个实施方案中,当患者处于较不直立的位置时,例如在仰卧位置休息时,将心脏装置设置为降低速率模式。 如果患者在过渡到更直立的位置时处于内在节律,则心脏设备会禁止在编程持续时间内施加任何增加的起搏速率。 以这种方式,患者将在从较不直立的姿势到更直立的姿势(例如,从仰卧到坐或站立)的过渡期间经历更加自然的心率变化。 另一方面,如果在转换期间患者正在起搏,则心脏装置管理增加的基本速率或触发立体响应算法。