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1. 发明授权

US5973160A Methods for the preparation of novel sidechain-bearing taxanes 失效
标题翻译：制备新型侧链紫杉烷的方法
公开(公告)号：US5973160A
公开(公告)日：1999-10-26
申请号：US600787
申请日：1996-02-13
申请人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
发明人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
IPC分类号： C07C233/82 , C07C271/22 , C07D305/14 , C07D407/12 , C07D409/12 , C07D413/12
CPC分类号： C07D407/12 , C07C233/82 , C07C271/22 , C07D305/14 , C07D409/12 , C07D413/12
摘要： Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
摘要翻译：用于制备侧链紫杉烷的新方法，包括制备恶唑啉化合物，将恶唑啉化合物与在C-13直接键合的羟基的紫杉烷结合以形成含有恶唑啉侧链的紫杉烷，并开启恶唑啉环恶唑啉侧链紫杉烷如此形成。还提供了通过本发明的方法制备的新型化合物。

2. 发明授权

US06515151B1 Method for the preparation of novel sidechain-bearing taxanes and intermediates thereof 失效
标题翻译：制备新型侧链紫杉烷的方法及其中间体
公开(公告)号：US06515151B1
公开(公告)日：2003-02-04
申请号：US09592879
申请日：2000-06-13
申请人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
发明人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
IPC分类号： C07D30514
CPC分类号： C07D407/12 , C07C233/82 , C07C271/22 , C07D305/14 , C07D409/12 , C07D413/12
摘要： Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.
摘要翻译：制备侧链紫杉烷的方法，包括制备恶唑啉化合物，将恶唑啉化合物与其C-13直接键合的羟基的紫杉烷结合，形成含有恶唑啉侧链的紫杉烷，并开启恶唑啉环的恶唑啉侧链紫杉烷如此形成。还公开了通过本发明的方法制备的化合物。

3. 发明授权

US06090951A Methods for the preparation of novel sidechain-bearing taxanes and intermediates 失效
标题翻译：制备新型侧链紫杉烷类和中间体的方法
公开(公告)号：US06090951A
公开(公告)日：2000-07-18
申请号：US917158
申请日：1997-08-25
申请人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
发明人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
IPC分类号： C07C233/82 , C07C271/22 , C07D305/14 , C07D407/12 , C07D409/12 , C07D413/12
CPC分类号： C07D407/12 , C07C233/82 , C07C271/22 , C07D305/14 , C07D409/12 , C07D413/12
摘要： Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
摘要翻译：用于制备侧链紫杉烷的新方法，包括制备恶唑啉化合物，将恶唑啉化合物与在C-13直接键合的羟基的紫杉烷结合以形成含有恶唑啉侧链的紫杉烷，并开启恶唑啉环恶唑啉侧链紫杉烷如此形成。还提供了通过本发明的方法制备的新型化合物。

4. 发明授权

US5808102A Phosphorus bearing taxanes intermediates 失效
标题翻译：含磷紫杉烷中间体
公开(公告)号：US5808102A
公开(公告)日：1998-09-15
申请号：US916298
申请日：1997-08-22
申请人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
发明人： Michael A. Poss , Jerome L. Moniot , Ivan D. Trifunovich , David J. Kucera , John K. Thottahil , Shu-Hui Chen , Jianmei Wei
IPC分类号： C07C233/82 , C07C271/22 , C07D305/14 , C07D407/12 , C07D409/12 , C07D413/12
CPC分类号： C07D407/12 , C07C233/82 , C07C271/22 , C07D305/14 , C07D409/12 , C07D413/12
摘要： Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
摘要翻译：用于制备侧链紫杉烷的新方法，包括制备恶唑啉化合物，将恶唑啉化合物与在C-13直接键合的羟基的紫杉烷结合以形成含有恶唑啉侧链的紫杉烷，并开启恶唑啉环恶唑啉侧链紫杉烷如此形成。还提供了通过本发明的方法制备的新型化合物。

5. 发明授权

US07670686B2 Long-term hydrophilic modification of PDMS substrate and method for manufacturing the same 失效
标题翻译： PDMS基材的长期亲水改性及其制造方法
公开(公告)号：US07670686B2
公开(公告)日：2010-03-02
申请号：US11436664
申请日：2006-05-19
申请人： Shu-Hui Chen , Makamba Honest , Ya-Yu Hsieh , Wang-Chou Sung
发明人： Shu-Hui Chen , Makamba Honest , Ya-Yu Hsieh , Wang-Chou Sung
IPC分类号： B32B25/20
CPC分类号： C08J7/04 , B32B27/00 , B32B27/08 , B32B27/16 , B32B27/18 , B32B27/283 , B32B27/302 , B32B27/308 , B32B27/34 , B32B27/42 , B32B2250/24 , B32B2307/552 , B32B2307/554 , B32B2307/714 , B32B2307/7145 , B32B2307/728 , B32B2535/00 , C08J2383/04 , Y10T428/31663 , Y10T428/31667 , Y10T428/31906
摘要： The present invention relates to a hydrophilic surface structure of the non-hydrophilic substrate and the manufacturing method for using the same. The hydrophilic substrate surface structure is fabricated by forming an amphiphilic polymer layer, a cross-linked stacking layer, and a hydrophilic layer in sequence on the surface of a non-hydrophilic substrate. For example, the hydrophobic surface of poly(dimethylsiloxane) (PDMS) can be made from hydrophobic to hydrophilic and the hydrophilicity can be retained for a long period of time and resist protein adsorption. The hydrophilic thin films give long term stability to the PDMS surface by resisting hydrophobicity recovery, which is the major problem with PDMS. The disclosed method can further be used in the immobilization of protein and other molecules. This method can also be used for modifying other substrates which suffer problems of surface instability.
摘要翻译：本发明涉及非亲水性基材的亲水性表面结构体及其制造方法。通过在非亲水性基材的表面上依次形成两亲性聚合物层，交联层叠层和亲水层来制造亲水性基材表面结构。例如，聚（二甲基硅氧烷）（PDMS）的疏水表面可以由疏水性制成亲水性，并且亲水性可以长时间保留并抵抗蛋白质吸附。亲水薄膜通过抵抗疏水性恢复对PDMS表面产生长期稳定性，这是PDMS的主要问题。所公开的方法可以进一步用于固定蛋白质和其他分子。该方法也可以用于改变其它具有表面不稳定性问题的基板。

6. 发明申请

US20090267719A1 SPLITTER 有权
标题翻译：分机
公开(公告)号：US20090267719A1
公开(公告)日：2009-10-29
申请号：US12191778
申请日：2008-08-14
申请人： Hung-Chieh Tseng , Ying-Chian Kang , Tsung-Hsien Lee , Shu-Hui Chen , Hua-Sheng Shih
发明人： Hung-Chieh Tseng , Ying-Chian Kang , Tsung-Hsien Lee , Shu-Hui Chen , Hua-Sheng Shih
IPC分类号： H01F27/02
CPC分类号： H01F17/043 , H01F3/12 , H01F5/02 , H01F27/266 , H01F2005/043
摘要： The present invention provides a splitter including a seat, a first inner core, a second inner core, a first coil, an outer core and a second coil. The seat has a bobbin, and the first coil is wound on the bobbin. The first inner core and the second inner core, disposed on the bobbin, are assembled with each other to cover the bobbin. The outer core and the first inner core are assembled with each other. The second coil is disposed between the outer core and the first inner core.
摘要翻译：本发明提供了一种分离器，包括座，第一内芯，第二内芯，第一线圈，外芯和第二线圈。座椅具有线轴，第一线圈缠绕在线轴上。设置在线轴上的第一内芯和第二内芯彼此组装以覆盖线轴。外芯和第一内芯彼此组装。第二线圈设置在外芯和第一内芯之间。

7. 发明授权

US07387765B2 Microfluidic chip system integrated with nano-electrospray interface and method using thereof 有权
标题翻译：集成纳米电喷雾界面的微流控芯片系统及其使用方法
公开(公告)号：US07387765B2
公开(公告)日：2008-06-17
申请号：US10822650
申请日：2004-04-13
申请人： Shu-Hui Chen , Wang-Chou Sung , Pao-Chi Liao , Gwo-Bin Lee
发明人： Shu-Hui Chen , Wang-Chou Sung , Pao-Chi Liao , Gwo-Bin Lee
IPC分类号： B01L3/02 , G01N1/10
CPC分类号： H01J49/04 , G01N27/44717 , Y10T436/24 , Y10T436/2575
摘要： The present invention provides an integrated microfluidic electrospray chip system and analytical method thereof, characterized in which the proteinase reaction, solid-phase extraction mechanism, electrophoresis and mass spectrometry are integrated into one system. This system allows continuous, fast and on-line detection and identification of a sample, where the sample is firstly hydrolyzed and desalted, and then introduced into the microfluidic electrospray chip to undergo electrophoresis. Finally, the separated sample is introduced into a mass spectrometer by means of electrospray for continuous detection and identification. This system applies mainly in the identification of biochemical substances, such as proteins.
摘要翻译：本发明提供了一种集成微流体电喷雾芯片系统及其分析方法，其特征在于将蛋白酶反应，固相萃取机理，电泳和质谱法整合到一个体系中。该系统允许连续，快速和在线检测和鉴定样品，样品首先水解和脱盐，然后引入微流控电喷雾芯片进行电泳。最后，通过电喷雾将分离的样品引入质谱仪进行连续检测和鉴定。该系统主要适用于生物化学物质如蛋白质的鉴定。

8. 发明授权

US06942777B2 Sample analysis system with chip-based electrophoresis device 失效
标题翻译：带芯片电泳装置的样品分析系统
公开(公告)号：US06942777B2
公开(公告)日：2005-09-13
申请号：US09880801
申请日：2001-06-15
申请人： Shu-Hui Chen , Gwo-Bin Lee , Chung-Shi Yang , Yi-Hung Lin , Wan-Chou Sung , Guan-Ruey Huang
发明人： Shu-Hui Chen , Gwo-Bin Lee , Chung-Shi Yang , Yi-Hung Lin , Wan-Chou Sung , Guan-Ruey Huang
IPC分类号： G01N27/447 , C25B11/00 , G01N27/453
CPC分类号： G01N27/44743 , G01N27/44721 , G01N27/44791
摘要： The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.
摘要翻译：本发明涉及一种具有基于芯片的电泳装置的样品分析系统，特别地，芯片电泳连接到基于动态流量的自动采样装置，以将样品引入基于芯片的电泳装置。通过利用衍生生物化学方法在样品加载通道上进行表面改性，可以防止样品粘附到样品加载通道的壁上，从而增加样品加载速率，减少样品的交叉污染，并执行特定的通过使用固定化物质（包括抗原，抗体，蛋白质或酶）进行生物反应。本发明利用连续分流和电压控制与检测单元，信号采集单元和信号处理单元一起工作，使得样品经过及时，快速，连续的分析，而不会受到其他时间样品的干扰。

9. 发明授权

US06794744B2 Layout structure and method for supporting two different package techniques of CPU 有权
标题翻译：支持CPU的两种不同封装技术的布局结构和方法
公开(公告)号：US06794744B2
公开(公告)日：2004-09-21
申请号：US10064426
申请日：2002-07-12
申请人： Nai-Shung Chang , Tsai-Sheng Chen , Shu-Hui Chen
发明人： Nai-Shung Chang , Tsai-Sheng Chen , Shu-Hui Chen
IPC分类号： H01L2352
CPC分类号： H05K1/0295 , H05K1/0298 , H05K1/18 , H05K2201/09345 , H05K2201/09954 , H05K2201/10522 , H05K2201/10704 , H05K2201/10734
摘要： A layout structure of a central processing unit (CPU) that supports two different package techniques, having a motherboard that comprising the layout structure and a layout method. The layout structure of the preferred embodiment according to the present invention from up to down sequentially placed a top signal layer, a grounded layer, a power layer having an operating potential area and a grounded potential area, and a bottom solder layer in the area where the signals of the CPU are coupled to the signals of the control chip, so that the signals that are placed on the bottom solder layer can refer to a grounded potential area of the power layer.
摘要翻译：中央处理单元（CPU）的布局结构，其支持两种不同的封装技术，具有包括布局结构的主板和布局方法。根据本发明的优选实施例的布局结构从上到下顺序地放置了顶部信号层，接地层，具有工作电位区域的功率层和接地电位区域，以及底部焊料层， CPU的信号耦合到控制芯片的信号，使得放置在底部焊料层上的信号可以指功率层的接地电位区域。

10. 发明授权

US5767134A Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP 失效
标题翻译：核苷酸还原酶抑制剂3-AP和3-AMP的前药形式
公开(公告)号：US5767134A
公开(公告)日：1998-06-16
申请号：US856568
申请日：1997-05-15
申请人： Jun Li , Chuan-Sheng Niu , Xiuyan Li , Terrence W. Doyle , Shu-Hui Chen
发明人： Jun Li , Chuan-Sheng Niu , Xiuyan Li , Terrence W. Doyle , Shu-Hui Chen
IPC分类号： C07D213/74 , A61K31/44 , A61K31/4409 , A61P35/00 , A61P43/00 , C07D213/75 , C07F9/09 , C07F9/58 , C07D213/02
CPC分类号： C07D213/75 , C07F9/588
摘要： The present invention relates to novel prodrug forms of ribonucleoside diphosphate reductase inhibitors 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) which have increased water solubility, bioavailablity and resistance to in vivo acetylation of their amino functions. Novel compounds according to the present invention relate to those of the formula: ##STR1## where R.sup.4 is H or CH.sub.3 and R.sup.5 is CHR, benzyl or ortho or para substituted benzyl; R is H, CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.3 or ##STR2## R' is a free acid phosphate, phosphate salt or an --S--S--R" group; R" is CH.sub.2 CH.sub.2 NHR.sup.6, CH.sub.2 CH.sub.2 OH, CH.sub.2 COOR.sup.7, an ortho or para substituted alkylphenyl and ortho or para substituted nitro-phenyl; R.sup.6 is H, C.sub.1 -C.sub.4 acyl group, trifluoroacetyl, benzoyl or substituted benzoyl group, and R.sup.7 is H, C.sub.1 -C.sub.4 alkyl or a benzyl or substituted benzyl.
摘要翻译：本发明涉及核糖核苷二磷酸还原酶抑制剂3-氨基吡啶-2-甲醛缩氨基硫脲（3-AP）3-氨基-4-甲基吡啶-2-甲醛缩氨基硫脲（3-AMP）的新型前药形式，其具有增加的水溶性，生物可利用性和其对氨基功能的体内乙酰化的抗性。根据本发明的新化合物涉及下式的化合物：其中R 4是H或CH 3且R 5是CHR，苄基或邻位或对位取代的苄基; R是H，CH 3，CH 2 CH 3，CH 2 CH 2 CH 3或R 3是游离酸式磷酸酯，磷酸盐或-S-S-R“基团; R“是CH 2 CH 2 NHR 6，CH 2 CH 2 OH，CH 2 COOR 7，邻或对位取代的烷基苯基和邻位或对位取代的硝基苯基; R6是H，C1-C4酰基，三氟乙酰基，苯甲酰基或取代的苯甲酰基，R7是H，C1-C4烷基或苄基或取代的苄基。

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